ATE384780T1 - Verfahren und vorrichtung zur zuchtung und mechanischen konditionierung von zellkulturen - Google Patents

Verfahren und vorrichtung zur zuchtung und mechanischen konditionierung von zellkulturen

Info

Publication number
ATE384780T1
ATE384780T1 AT01992069T AT01992069T ATE384780T1 AT E384780 T1 ATE384780 T1 AT E384780T1 AT 01992069 T AT01992069 T AT 01992069T AT 01992069 T AT01992069 T AT 01992069T AT E384780 T1 ATE384780 T1 AT E384780T1
Authority
AT
Austria
Prior art keywords
cells
flexible membrane
trough
cell cultures
anchor
Prior art date
Application number
AT01992069T
Other languages
English (en)
Inventor
Albert Banes
Original Assignee
Flexcell Internat Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flexcell Internat Corp filed Critical Flexcell Internat Corp
Application granted granted Critical
Publication of ATE384780T1 publication Critical patent/ATE384780T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Circuit Arrangement For Electric Light Sources In General (AREA)
AT01992069T 2000-12-08 2001-12-10 Verfahren und vorrichtung zur zuchtung und mechanischen konditionierung von zellkulturen ATE384780T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25414400P 2000-12-08 2000-12-08

Publications (1)

Publication Number Publication Date
ATE384780T1 true ATE384780T1 (de) 2008-02-15

Family

ID=22963095

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01992069T ATE384780T1 (de) 2000-12-08 2001-12-10 Verfahren und vorrichtung zur zuchtung und mechanischen konditionierung von zellkulturen

Country Status (8)

Country Link
US (1) US6998265B2 (de)
EP (1) EP1356022B1 (de)
JP (1) JP3950797B2 (de)
AT (1) ATE384780T1 (de)
AU (1) AU2002232543A1 (de)
CA (1) CA2411524C (de)
DE (1) DE60132626T2 (de)
WO (1) WO2002046365A2 (de)

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US20060270023A1 (en) * 2003-04-18 2006-11-30 Carnege Mellon University Three-dimentioal, flexible cell growth substrate and related methods
US20060134779A1 (en) * 2004-03-10 2006-06-22 Banes Albert J Modulation of cell intrinsic strain to control cell modulus, matrix synthesis, secretion, organization, material properties and remodeling of tissue engineered constructs
US7547525B2 (en) * 2004-08-12 2009-06-16 Neuro Probe Incorporated Point source diffusion cell activity assay
JP2006081468A (ja) * 2004-09-16 2006-03-30 Kaneka Corp 細胞を三次元多孔性支持体に内在化させるための装置および方法
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
EP1679366A1 (de) * 2005-01-07 2006-07-12 Ecole Polytechnique Federale de Lausanne EPFL-SRI Vorrichtung für Zellkulturen auf verformbaren Oberflächen
US7277348B2 (en) * 2005-12-12 2007-10-02 Klp International, Ltd. Memory cell comprising an OTP nonvolatile memory unit and a SRAM unit
EP1988156A1 (de) * 2007-04-30 2008-11-05 Brossel, Rémy Zellkonstrukt, dessen Herstellungsverfahren sowie Vorrichtungsimplantation und Verfahren zur mechanischen Stimulation von Zellen in vivo und in vitro
US20100041128A1 (en) * 2008-01-08 2010-02-18 Medtrain Technologies, Llc Microfluidic Device for Application of Shear Stress and Tensile Strain
US8058057B2 (en) 2008-05-30 2011-11-15 Corning Incorporated Cell culture apparatus and method
KR102667365B1 (ko) * 2008-07-16 2024-05-21 칠드런'즈 메디컬 센터 코포레이션 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법
US20100217390A1 (en) * 2009-02-24 2010-08-26 The Curators Of The University Of Missouri Rotator cuff bone-tendon allograft
CN102918376B (zh) 2010-05-28 2015-07-15 奥林巴斯株式会社 细胞分份装置、细胞分份系统及细胞分份方法
US9303257B2 (en) 2010-07-01 2016-04-05 Empire Technology Development Llc Method and system for cell and tissue cultivation
EP2629078B1 (de) 2010-11-19 2019-04-17 Olympus Corporation Verfahren zur herstellung biologischer proben
EP2681306B1 (de) 2011-02-28 2019-01-09 President and Fellows of Harvard College Zellkultursystem
EP2711683B1 (de) 2011-05-20 2016-08-03 Olympus Corporation Verfahren zur herstellung einer grundfolie
US8691262B2 (en) * 2011-08-09 2014-04-08 Matthew Thomas Harris Method for aligning cells and applying homogenous strain throughout deformable engineered tissue constructs
EP2784472A4 (de) 2011-11-24 2015-03-11 Olympus Corp Zellsortierungsvorrichtung und zellsortierungsverfahren
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
WO2013126556A1 (en) * 2012-02-21 2013-08-29 Indiana University Research And Technology Corporation Ultrahigh throughput microinjection device
US20130337565A1 (en) 2012-06-19 2013-12-19 Medtrain Technologies, Llc Method and Apparatus for Patterning Cells
JP6153357B2 (ja) * 2013-03-22 2017-06-28 株式会社スペース・バイオ・ラボラトリーズ 細胞培養容器
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
GB2584034B (en) 2013-12-20 2021-03-24 Harvard College Organomimetic devices and methods of use and manufacturing thereof
WO2015138034A2 (en) 2013-12-20 2015-09-17 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
EP3169626A4 (de) 2014-07-14 2018-04-04 President and Fellows of Harvard College Systeme und verfahren zur verbesserten leistung fluidischer und mikrofluidischer systeme
US10167444B2 (en) * 2015-07-15 2019-01-01 The Regents Of The University Of Michigan Bioreactor and method of forming complex three-dimensional tissue constructs
US10384207B2 (en) 2015-07-21 2019-08-20 Neuro Probe Incorporated Assay apparatus and methods
US10202569B2 (en) 2015-07-24 2019-02-12 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
CA3036378A1 (en) 2016-09-13 2018-03-22 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
EP3583199B1 (de) * 2017-02-15 2021-10-06 IFOM - Fondazione Istituto FIRC di Oncologia Molecolare Vorrichtung zum strecken von zellen
US11124763B2 (en) * 2017-10-27 2021-09-21 Georgia Tech Research Corporation Systems and methods for growing cell cultures
USD911550S1 (en) 2019-10-17 2021-02-23 King Abdulaziz University Cell blocker for multi-well cell culture plate
NL2027836B1 (en) * 2021-03-25 2022-10-10 Meatable B V Apparatus and process for culturing tissue
CN113583846A (zh) * 2021-07-29 2021-11-02 中国科学院长春光学精密机械与物理研究所 一种供压设备及使用该设备的细胞的加载装置
CN113604357A (zh) * 2021-07-29 2021-11-05 中国科学院长春光学精密机械与物理研究所 一种三维力细胞的加载装置及气动控制方法
CN113604349B (zh) * 2021-07-29 2023-10-13 中国科学院长春光学精密机械与物理研究所 一种使用样品架的三维细胞的加载装置
WO2023225034A1 (en) * 2022-05-16 2023-11-23 The Regents Of The University Of Colorado, A Body Corporate Cell stressor devices and methods for analyzing a biomechanical response
DE102023200679B4 (de) * 2023-01-27 2024-11-28 Friedrich-Alexander-Universität Erlangen-Nürnberg, Körperschaft des öffentlichen Rechts Konditionierungskammer für eine konditionierung von gewebekonstrukten
DE102024200470A1 (de) * 2024-01-18 2025-07-24 2Mag Ag Konditionierungskammer für eine Konditionierung von Gewebezellen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839280A (en) * 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
US4851354A (en) * 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US5153136A (en) * 1988-07-22 1992-10-06 Vandenburgh Herman H Apparatus for growing tissue specimens in vitro
US5217899A (en) * 1990-08-24 1993-06-08 The General Hospital Corporation Cell stretching apparatus
US5518909A (en) * 1994-11-18 1996-05-21 Banes; Albert J. Flexion enhanced transfection of genetic material
US5686303A (en) * 1994-12-30 1997-11-11 Korman; Joshua Method of growing vertebrate skin in vitro
US6048723A (en) * 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
US6218178B1 (en) * 1998-05-08 2001-04-17 Flexcell International Corporation Loading station assembly
US6037141A (en) * 1998-06-04 2000-03-14 Banes; Albert J. Culture compression device
US6207451B1 (en) * 1998-09-15 2001-03-27 The Regents Of The University Of Michigan Mammalian muscle construct and method for producing same

Also Published As

Publication number Publication date
WO2002046365A2 (en) 2002-06-13
EP1356022B1 (de) 2008-01-23
AU2002232543A1 (en) 2002-06-18
WO2002046365A3 (en) 2002-10-31
EP1356022A2 (de) 2003-10-29
JP2004515237A (ja) 2004-05-27
CA2411524A1 (en) 2002-06-13
DE60132626T2 (de) 2009-01-29
US20040014205A1 (en) 2004-01-22
US6998265B2 (en) 2006-02-14
CA2411524C (en) 2007-02-27
EP1356022A4 (de) 2006-09-20
JP3950797B2 (ja) 2007-08-01
DE60132626D1 (de) 2008-03-13

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