ATE385253T1 - Nhibitor-resistente hcv ns3 protease - Google Patents

Nhibitor-resistente hcv ns3 protease

Info

Publication number: ATE385253T1
Authority: AT; Austria
Prior art keywords: protease; resistant; inhibitor; hcv; nhibitor
Prior art date: 2002-10-29

Application number

AT03770808T

Other languages

English (en)

Inventor

George Kukolj

Lisette Lagace

Martin Marquis

Daniel Lamarre

Arnim Pause

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-29

Filing date

2003-10-24

Publication date

2008-02-15

2003-10-24 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE385253T1 publication Critical patent/ATE385253T1/de

Links

108091005804 Peptidases Proteins 0.000 title abstract 3
239000004365 Protease Substances 0.000 title abstract 3
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 abstract 4
101800001838 Serine protease/helicase NS3 Proteins 0.000 abstract 3
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
238000009877 rendering Methods 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Materials For Photolithography (AREA)
Chemical Or Physical Treatment Of Fibers (AREA)
External Artificial Organs (AREA)

AT03770808T 2002-10-29 2003-10-24 Nhibitor-resistente hcv ns3 protease ATE385253T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US42194302P	2002-10-29	2002-10-29

Publications (1)

Publication Number	Publication Date
ATE385253T1 true ATE385253T1 (de)	2008-02-15

Family

ID=32230287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03770808T ATE385253T1 (de)	2002-10-29	2003-10-24	Nhibitor-resistente hcv ns3 protease

Country Status (13)

Country	Link
US (1)	US7208309B2 (de)
EP (1)	EP1558730B1 (de)
JP (1)	JP4295222B2 (de)
AT (1)	ATE385253T1 (de)
AU (1)	AU2003280239B2 (de)
CA (1)	CA2498653C (de)
DE (1)	DE60318954T2 (de)
DK (1)	DK1558730T3 (de)
ES (1)	ES2298585T3 (de)
IL (1)	IL168254A (de)
MX (1)	MXPA05004276A (de)
NZ (1)	NZ540292A (de)
WO (1)	WO2004039970A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050009877A1 (en) *	2003-05-15	2005-01-13	Henry Lu	Methods of identifying HCV NS5B polymerase inhibitors and their uses
ES2389201T3 (es)	2003-10-27	2012-10-24	Vertex Pharmaceuticals Incorporated	Mutantes de resistencia de la proteasa NS3/4A de HCV
ES2336009T3 (es)	2004-01-30	2010-04-07	Medivir Ab	Inhibidores de la ns-3 serina proteasa del vhc.
US20090081636A1 (en) *	2005-04-11	2009-03-26	Mingjun Huang	Pharmaceutical compositions for and methods of inhibiting HCV replication
US7465537B2 (en) *	2005-05-01	2008-12-16	The Board Of Trustees Of The University Of Arkansas	Compounds and methods for inhibiting hepatitis C virus replication
WO2007014174A2 (en) *	2005-07-25	2007-02-01	Gilead Sciences, Inc.	Drug-resistant mutants of hepatitis c virus
PE20070211A1 (es)	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
NZ568324A (en) *	2005-11-11	2012-01-12	Vertex Pharma	Hepatitis C virus variants
US7705138B2 (en)	2005-11-11	2010-04-27	Vertex Pharmaceuticals Incorporated	Hepatitis C virus variants
EP2527474A1 (de)	2006-10-20	2012-11-28	Innogenetics N.V.	Verfahren zur Analyse von Sequenzvariationen innerhalb des HCV-NS3/4A-Genombereichs
US20100143886A1 (en) *	2007-03-09	2010-06-10	Ludmerer Steven W	In vivo hcv resistance to anti-viral inhibitors
WO2008121487A2 (en) *	2007-03-29	2008-10-09	The Govt. Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Sevices.	Live attenuated virus vaccines for la crosse virus and other bunyaviridae
EP3199630B1 (de)	2008-09-05	2019-05-08	President and Fellows of Harvard College	Kontinuierliche gerichtete evolution von proteinen und nukleinsäuren
EP3202903B1 (de)	2010-12-22	2020-02-12	President and Fellows of Harvard College	Kontinuierliche gerichtete evolution
CN103687869A (zh) *	2011-07-06	2014-03-26	吉利德科学股份有限公司	Hcv基因型3复制子
AU2012278959B2 (en)	2011-07-06	2015-08-27	Gilead Sciences, Inc.	HCV genotype 4 replicons
EP3097196B1 (de)	2014-01-20	2019-09-11	President and Fellows of Harvard College	Negativauswahl und stringenzmodulation in systemen der kontinuierlichen evolution
US10920208B2 (en)	2014-10-22	2021-02-16	President And Fellows Of Harvard College	Evolution of proteases
US11299729B2 (en)	2015-04-17	2022-04-12	President And Fellows Of Harvard College	Vector-based mutagenesis system
US10392674B2 (en)	2015-07-22	2019-08-27	President And Fellows Of Harvard College	Evolution of site-specific recombinases
US11524983B2 (en)	2015-07-23	2022-12-13	President And Fellows Of Harvard College	Evolution of Bt toxins
US10612011B2 (en)	2015-07-30	2020-04-07	President And Fellows Of Harvard College	Evolution of TALENs
US11447809B2 (en)	2017-07-06	2022-09-20	President And Fellows Of Harvard College	Evolution of tRNA synthetases
US12060553B2 (en)	2017-08-25	2024-08-13	President And Fellows Of Harvard College	Evolution of BoNT peptidases
US11624130B2 (en)	2017-09-18	2023-04-11	President And Fellows Of Harvard College	Continuous evolution for stabilized proteins
US11913044B2 (en)	2018-06-14	2024-02-27	President And Fellows Of Harvard College	Evolution of cytidine deaminases
CA3135428A1 (en)	2019-03-29	2020-10-08	Trustees Of Boston University	Chimeric antigen receptor (car) modulation
US12655182B2 (en)	2019-07-15	2026-06-16	President And Fellows Of Harvard College	Evolved botulinum neurotoxins and uses thereof
US11572565B2 (en)	2020-07-21	2023-02-07	Trustees Of Boston University	Inducible control of gene expression

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843752A (en) *	1995-05-12	1998-12-01	Schering Corporation	Soluble active hepatitis C virus protease
IT1277914B1 (it) *	1995-08-22	1997-11-12	Angeletti P Ist Richerche Bio	Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e
US5990276A (en) *	1996-05-10	1999-11-23	Schering Corporation	Synthetic inhibitors of hepatitis C virus NS3 protease
US6608027B1 (en) *	1999-04-06	2003-08-19	Boehringer Ingelheim (Canada) Ltd	Macrocyclic peptides active against the hepatitis C virus
UA74546C2 (en) *	1999-04-06	2006-01-16	Boehringer Ingelheim Ca Ltd	Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6326137B1 (en) *	1999-06-25	2001-12-04	Schering Corporation	Hepatitis C virus protease-dependent chimeric pestivirus
US6986892B1 (en) *	1999-11-24	2006-01-17	Chiron Corporation	Immunogenic Hepatitis C virus non-structural polypeptides
US20050074465A1 (en) *	1999-11-24	2005-04-07	Michael Houghton	HCV fusion proteins with modified NS3 domains
ES2287074T3 (es) *	2000-12-22	2007-12-16	Boehringer Ingelheim (Canada) Ltd.	Molecula de rna autorreplicante del virus de la hepatitis c.
AU2002254077A1 (en) *	2001-02-28	2002-09-12	Michael A. Hanson	Small molecule design against drug resistant mutants using directed evolution
ES2389201T3 (es)	2003-10-27	2012-10-24	Vertex Pharmaceuticals Incorporated	Mutantes de resistencia de la proteasa NS3/4A de HCV

2003
- 2003-10-24 WO PCT/CA2003/001636 patent/WO2004039970A1/en not_active Ceased
- 2003-10-24 NZ NZ540292A patent/NZ540292A/en not_active IP Right Cessation
- 2003-10-24 AT AT03770808T patent/ATE385253T1/de active
- 2003-10-24 AU AU2003280239A patent/AU2003280239B2/en not_active Expired
- 2003-10-24 CA CA2498653A patent/CA2498653C/en not_active Expired - Lifetime
- 2003-10-24 JP JP2004547307A patent/JP4295222B2/ja not_active Expired - Lifetime
- 2003-10-24 MX MXPA05004276A patent/MXPA05004276A/es active IP Right Grant
- 2003-10-24 ES ES03770808T patent/ES2298585T3/es not_active Expired - Lifetime
- 2003-10-24 EP EP03770808A patent/EP1558730B1/de not_active Expired - Lifetime
- 2003-10-24 DE DE60318954T patent/DE60318954T2/de not_active Expired - Lifetime
- 2003-10-24 DK DK03770808T patent/DK1558730T3/da active
- 2003-10-28 US US10/695,140 patent/US7208309B2/en not_active Expired - Lifetime
2005
- 2005-04-27 IL IL168254A patent/IL168254A/en unknown

Also Published As

Publication number	Publication date
AU2003280239A1 (en)	2004-05-25
US7208309B2 (en)	2007-04-24
EP1558730B1 (de)	2008-01-30
DE60318954D1 (de)	2008-03-20
DK1558730T3 (da)	2008-05-26
IL168254A (en)	2010-11-30
CA2498653A1 (en)	2004-05-13
WO2004039970A1 (en)	2004-05-13
AU2003280239B2 (en)	2009-03-12
US20050019753A1 (en)	2005-01-27
EP1558730A1 (de)	2005-08-03
CA2498653C (en)	2010-12-14
NZ540292A (en)	2006-09-29
JP4295222B2 (ja)	2009-07-15
DE60318954T2 (de)	2009-01-22
MXPA05004276A (es)	2005-08-03
JP2006503584A (ja)	2006-02-02
ES2298585T3 (es)	2008-05-16

Legal Events

Date

Code

Title

Description

2008-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1558730

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