ATE385253T1 - Nhibitor-resistente hcv ns3 protease - Google Patents

Nhibitor-resistente hcv ns3 protease

Info

Publication number
ATE385253T1
ATE385253T1 AT03770808T AT03770808T ATE385253T1 AT E385253 T1 ATE385253 T1 AT E385253T1 AT 03770808 T AT03770808 T AT 03770808T AT 03770808 T AT03770808 T AT 03770808T AT E385253 T1 ATE385253 T1 AT E385253T1
Authority
AT
Austria
Prior art keywords
protease
resistant
inhibitor
hcv
nhibitor
Prior art date
Application number
AT03770808T
Other languages
English (en)
Inventor
George Kukolj
Lisette Lagace
Martin Marquis
Daniel Lamarre
Arnim Pause
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of ATE385253T1 publication Critical patent/ATE385253T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Materials For Photolithography (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • External Artificial Organs (AREA)
AT03770808T 2002-10-29 2003-10-24 Nhibitor-resistente hcv ns3 protease ATE385253T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42194302P 2002-10-29 2002-10-29

Publications (1)

Publication Number Publication Date
ATE385253T1 true ATE385253T1 (de) 2008-02-15

Family

ID=32230287

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03770808T ATE385253T1 (de) 2002-10-29 2003-10-24 Nhibitor-resistente hcv ns3 protease

Country Status (13)

Country Link
US (1) US7208309B2 (de)
EP (1) EP1558730B1 (de)
JP (1) JP4295222B2 (de)
AT (1) ATE385253T1 (de)
AU (1) AU2003280239B2 (de)
CA (1) CA2498653C (de)
DE (1) DE60318954T2 (de)
DK (1) DK1558730T3 (de)
ES (1) ES2298585T3 (de)
IL (1) IL168254A (de)
MX (1) MXPA05004276A (de)
NZ (1) NZ540292A (de)
WO (1) WO2004039970A1 (de)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
US20050009877A1 (en) * 2003-05-15 2005-01-13 Henry Lu Methods of identifying HCV NS5B polymerase inhibitors and their uses
JP4890254B2 (ja) 2003-10-27 2012-03-07 バーテックス ファーマシューティカルズ インコーポレイテッド Ｈｃｖｎｓ３−ｎｓ４ａプロテアーゼ耐性突然変異体
KR20120090077A (ko) 2004-01-30 2012-08-16 얀센 알 앤드 디 아일랜드 Ｈｃｖ ｎｓ?３ 세린 프로테아제 저해제
EP1874952A2 (de) * 2005-04-11 2008-01-09 Achillion Pharmaceuticals, Inc. Pharmazeutische zusammensetzungen und verfahren zur hemmung der hcv-replikation
US7465537B2 (en) * 2005-05-01 2008-12-16 The Board Of Trustees Of The University Of Arkansas Compounds and methods for inhibiting hepatitis C virus replication
WO2007014174A2 (en) * 2005-07-25 2007-02-01 Gilead Sciences, Inc. Drug-resistant mutants of hepatitis c virus
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
AU2006315438A1 (en) 2005-11-11 2007-05-24 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
WO2008046923A2 (en) 2006-10-20 2008-04-24 Innogenetics N.V. Methodology for analysis of sequence variations within the hcv ns3/4a genomic region
US20100143886A1 (en) * 2007-03-09 2010-06-10 Ludmerer Steven W In vivo hcv resistance to anti-viral inhibitors
US8298541B2 (en) 2007-03-29 2012-10-30 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Live attenuated virus vaccines for La Crosse virus and other Bunyaviridae
JP5723774B2 (ja) 2008-09-05 2015-05-27 プレジデント アンド フェローズ オブ ハーバード カレッジ タンパク質および核酸の連続的指向性進化
CA2825370A1 (en) 2010-12-22 2012-06-28 President And Fellows Of Harvard College Continuous directed evolution
US8889848B2 (en) 2011-07-06 2014-11-18 Gilead Sciences, Inc. HCV genotype 3 replicons
MX2014000123A (es) 2011-07-06 2014-02-17 Gilead Sciences Inc Replicones de genotipo 4 de hcv.
EP3097196B1 (de) 2014-01-20 2019-09-11 President and Fellows of Harvard College Negativauswahl und stringenzmodulation in systemen der kontinuierlichen evolution
WO2016077052A2 (en) 2014-10-22 2016-05-19 President And Fellows Of Harvard College Evolution of proteases
US11299729B2 (en) 2015-04-17 2022-04-12 President And Fellows Of Harvard College Vector-based mutagenesis system
WO2017015545A1 (en) 2015-07-22 2017-01-26 President And Fellows Of Harvard College Evolution of site-specific recombinases
WO2017015559A2 (en) 2015-07-23 2017-01-26 President And Fellows Of Harvard College Evolution of bt toxins
WO2017019895A1 (en) 2015-07-30 2017-02-02 President And Fellows Of Harvard College Evolution of talens
WO2019010164A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College Evolution of trna synthetases
WO2019040935A1 (en) 2017-08-25 2019-02-28 President And Fellows Of Harvard College EVOLUTION OF PEPTIDASES BONT
WO2019056002A1 (en) 2017-09-18 2019-03-21 President And Fellows Of Harvard College CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
CA3135428A1 (en) 2019-03-29 2020-10-08 Trustees Of Boston University Chimeric antigen receptor (car) modulation
US11572565B2 (en) 2020-07-21 2023-02-07 Trustees Of Boston University Inducible control of gene expression

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843752A (en) * 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
IT1277914B1 (it) * 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e
US5990276A (en) * 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6326137B1 (en) * 1999-06-25 2001-12-04 Schering Corporation Hepatitis C virus protease-dependent chimeric pestivirus
US6986892B1 (en) * 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
US20050074465A1 (en) * 1999-11-24 2005-04-07 Michael Houghton HCV fusion proteins with modified NS3 domains
DE60128835T2 (de) * 2000-12-22 2008-03-20 Boehringer Ingelheim (Canada) Ltd., Laval Selbstreplizierendes rna-molekül aus hepatitis-c-virus
WO2002068933A2 (en) * 2001-02-28 2002-09-06 The Scripps Research Institute Small molecule design against drug resistant mutants using directed evolution
JP4890254B2 (ja) 2003-10-27 2012-03-07 バーテックス ファーマシューティカルズ インコーポレイテッド Ｈｃｖｎｓ３−ｎｓ４ａプロテアーゼ耐性突然変異体

Also Published As

Publication number Publication date
EP1558730B1 (de) 2008-01-30
WO2004039970A1 (en) 2004-05-13
EP1558730A1 (de) 2005-08-03
CA2498653C (en) 2010-12-14
US7208309B2 (en) 2007-04-24
ES2298585T3 (es) 2008-05-16
DE60318954D1 (de) 2008-03-20
DE60318954T2 (de) 2009-01-22
CA2498653A1 (en) 2004-05-13
NZ540292A (en) 2006-09-29
AU2003280239B2 (en) 2009-03-12
MXPA05004276A (es) 2005-08-03
AU2003280239A1 (en) 2004-05-25
JP4295222B2 (ja) 2009-07-15
IL168254A (en) 2010-11-30
JP2006503584A (ja) 2006-02-02
DK1558730T3 (da) 2008-05-26
US20050019753A1 (en) 2005-01-27

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