ATE385746T1 - Methode zur intrazellulären elektro-manipulation - Google Patents

Methode zur intrazellulären elektro-manipulation

Info

Publication number
ATE385746T1
ATE385746T1 AT00955350T AT00955350T ATE385746T1 AT E385746 T1 ATE385746 T1 AT E385746T1 AT 00955350 T AT00955350 T AT 00955350T AT 00955350 T AT00955350 T AT 00955350T AT E385746 T1 ATE385746 T1 AT E385746T1
Authority
AT
Austria
Prior art keywords
target cells
pulse
electric field
ultrashort
ultrashort electric
Prior art date
Application number
AT00955350T
Other languages
English (en)
Inventor
Stephen Beebe
Karl Schoenbach
E Buescher
Original Assignee
Eastern Virginia Med School
Old Dominion University Res Fo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastern Virginia Med School, Old Dominion University Res Fo filed Critical Eastern Virginia Med School
Application granted granted Critical
Publication of ATE385746T1 publication Critical patent/ATE385746T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206Generators therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Secondary Cells (AREA)
AT00955350T 1999-08-04 2000-08-02 Methode zur intrazellulären elektro-manipulation ATE385746T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14709999P 1999-08-04 1999-08-04
US09/546,754 US6326177B1 (en) 1999-08-04 2000-04-11 Method and apparatus for intracellular electro-manipulation

Publications (1)

Publication Number Publication Date
ATE385746T1 true ATE385746T1 (de) 2008-03-15

Family

ID=26844575

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00955350T ATE385746T1 (de) 1999-08-04 2000-08-02 Methode zur intrazellulären elektro-manipulation

Country Status (8)

Country Link
US (1) US6326177B1 (de)
EP (1) EP1207797B1 (de)
JP (2) JP4728546B2 (de)
AT (1) ATE385746T1 (de)
AU (1) AU785506B2 (de)
DE (1) DE60038026T2 (de)
ES (1) ES2300272T3 (de)
WO (1) WO2001010319A1 (de)

Families Citing this family (242)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456012B2 (en) * 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US7805201B2 (en) * 2000-02-17 2010-09-28 Standen Ltd. Treating a tumor or the like with an electric field
US20030216784A1 (en) * 2000-02-22 2003-11-20 Richard Heller Cellular electromanipulation waveforms
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US8251986B2 (en) * 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7481781B2 (en) * 2000-11-17 2009-01-27 Gendel Limited Ultrasound therapy
US20050043726A1 (en) * 2001-03-07 2005-02-24 Mchale Anthony Patrick Device II
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
CA2468424A1 (en) 2001-11-27 2003-06-05 Cecilia Farre A method for combined parallel agent delivery and electroporation for cell structures and use thereof
US20030170898A1 (en) * 2001-12-04 2003-09-11 Gundersen Martin A. Method for intracellular modifications within living cells using pulsed electric fields
AU2003205132A1 (en) * 2002-02-12 2003-09-04 Celectricon AB Systems and methods for rapidly changing the solution environment around sensors
US7697981B2 (en) * 2002-03-22 2010-04-13 The Regents Of The University Of California Method and apparatus for using an electromagnetic field in cellular transplantation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
US7211083B2 (en) * 2003-03-17 2007-05-01 Minnesota Medical Physics, Llc Apparatus and method for hair removal by electroporation
EP1648555B1 (de) * 2003-07-18 2015-09-02 Eastern Virginia Medical School Verfahren zur Einführung eines Agens in eine Zelle
CN100542482C (zh) * 2003-09-12 2009-09-23 肾脏研究所有限公司 生物阻抗方法和仪器
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
EP1696812B1 (de) 2003-12-24 2015-07-22 The Regents of The University of California Gewebeablation mit irreversibler elektroporation
AU2012220523B2 (en) * 2003-12-24 2015-01-22 The Regents Of The University Of California Tissue ablation with irreversible electroporation
US20050261672A1 (en) * 2004-05-18 2005-11-24 Mark Deem Systems and methods for selective denervation of heart dysrhythmias
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7565201B2 (en) * 2004-12-17 2009-07-21 Eastern Virginia Medical School Activation of calcium-mediated cell functions in cells and tissues, including aggregation of human platelets. by nanosecond pulsed electric fields
US7933647B2 (en) * 2005-06-07 2011-04-26 Transfert Plus, S.E.C. Methods of increasing lipolysis
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US20070149901A1 (en) * 2005-12-08 2007-06-28 Em-Probe, Inc. Methods and apparatus for pulsed electromagnetic therapy
US8150421B2 (en) * 2005-12-30 2012-04-03 Trueposition, Inc. User plane uplink time difference of arrival (U-TDOA)
ES2342790T3 (es) * 2006-01-03 2010-07-14 Alcon, Inc. Sistema para la disociacion y retirada de tejido proteinico.
US9028748B2 (en) * 2006-02-24 2015-05-12 Nanovibronix Inc System and method for surface acoustic wave treatment of medical devices
AU2007221182B2 (en) * 2006-02-24 2011-11-03 Eastern Virginia Medical School Nanosecond pulsed electric fields cause melanomas to self-destruct
US7750605B2 (en) * 2006-09-21 2010-07-06 Bio-Rad Laboratories, Inc. Controlling an electrical signal sent to a sample load using a pulse modulated resistance
US7674249B2 (en) 2006-10-16 2010-03-09 The Regents Of The University Of California Gels with predetermined conductivity used in electroporation of tissue
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US7815662B2 (en) 2007-03-08 2010-10-19 Ethicon Endo-Surgery, Inc. Surgical suture anchors and deployment device
US8075572B2 (en) 2007-04-26 2011-12-13 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
US8100922B2 (en) 2007-04-27 2012-01-24 Ethicon Endo-Surgery, Inc. Curved needle suturing tool
US8642306B2 (en) * 2007-06-14 2014-02-04 Mitsui Engineering & Shipbuilding Co., Ltd. Flow cytometer having cell-sorting function and method of separating living cells
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8673623B2 (en) * 2007-08-31 2014-03-18 Board Of Regents, The University Of Texas System Apparatus for performing magnetic electroporation
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
WO2009042501A1 (en) * 2007-09-28 2009-04-02 Board Of Regents, The University Of Texas System Apparatus for performing electrodistention on algae cells
US20090112059A1 (en) 2007-10-31 2009-04-30 Nobis Rudolph H Apparatus and methods for closing a gastrotomy
US8480657B2 (en) 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
WO2009076246A2 (en) * 2007-12-06 2009-06-18 Massachusetts Institute Of Technology Methods to treat unwanted tissue with electric pulses
US8262680B2 (en) 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
US20090248012A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Irreversible electroporation device and method for attenuating neointimal
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US9598691B2 (en) 2008-04-29 2017-03-21 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US8348938B2 (en) 2008-05-06 2013-01-08 Old Dominian University Research Foundation Apparatus, systems and methods for treating a human tissue condition
WO2009137800A2 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US8114072B2 (en) 2008-05-30 2012-02-14 Ethicon Endo-Surgery, Inc. Electrical ablation device
US8070759B2 (en) 2008-05-30 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical fastening device
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8652150B2 (en) 2008-05-30 2014-02-18 Ethicon Endo-Surgery, Inc. Multifunction surgical device
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
WO2009155526A2 (en) 2008-06-20 2009-12-23 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US20090324786A1 (en) * 2008-06-25 2009-12-31 Mcnaughton James L Underwater Pressure Arc Discharge System for Disinfection of Food and Food Products
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8211125B2 (en) 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US8529563B2 (en) 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8480689B2 (en) 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8114119B2 (en) 2008-09-09 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
WO2010057021A1 (en) 2008-11-13 2010-05-20 Eastern Virginia Medical School Activation and aggregation of human platelets and formation of platelet gels by nanosecond pulsed electric fields
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8172772B2 (en) 2008-12-11 2012-05-08 Ethicon Endo-Surgery, Inc. Specimen retrieval device
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8828031B2 (en) 2009-01-12 2014-09-09 Ethicon Endo-Surgery, Inc. Apparatus for forming an anastomosis
US8753335B2 (en) 2009-01-23 2014-06-17 Angiodynamics, Inc. Therapeutic energy delivery device with rotational mechanism
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
US9226772B2 (en) 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US8037591B2 (en) 2009-02-02 2011-10-18 Ethicon Endo-Surgery, Inc. Surgical scissors
WO2010093692A2 (en) 2009-02-10 2010-08-19 Hobbs Eamonn P Irreversible electroporation and tissue regeneration
US20100240995A1 (en) * 2009-03-17 2010-09-23 Bioelectromed Corp. System and method for treating tumors
US8632534B2 (en) * 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
WO2010120847A1 (en) * 2009-04-14 2010-10-21 Old Dominion University Research Foundation System and method for applying plasma sparks to tissue
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
WO2010138919A2 (en) 2009-05-28 2010-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US8772004B2 (en) 2009-06-25 2014-07-08 Old Dominion University Research Foundation System and method for high-voltage pulse assisted aggregation of algae
WO2011028937A1 (en) * 2009-09-04 2011-03-10 The Regents Of The University Of California Extracellular matrix material created using non-thermal irreversible electroporation
US20110065161A1 (en) * 2009-09-14 2011-03-17 Board Of Regents, The University Of Texas System Bipolar solid state marx generator
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US20110118729A1 (en) * 2009-11-13 2011-05-19 Alcon Research, Ltd High-intensity pulsed electric field vitrectomy apparatus with load detection
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US20110135626A1 (en) * 2009-12-08 2011-06-09 Alcon Research, Ltd. Localized Chemical Lysis of Ocular Tissue
US20110144562A1 (en) * 2009-12-14 2011-06-16 Alcon Research, Ltd. Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields
US20110144638A1 (en) * 2009-12-14 2011-06-16 Alcon Research, Ltd. Localized Shockwave-Induced Tissue Disruption
US20110144641A1 (en) * 2009-12-15 2011-06-16 Alcon Research, Ltd. High-Intensity Pulsed Electric Field Vitrectomy Apparatus
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US8353487B2 (en) 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8546979B2 (en) 2010-08-11 2013-10-01 Alcon Research, Ltd. Self-matching pulse generator with adjustable pulse width and pulse frequency
US8652130B2 (en) 2010-08-18 2014-02-18 Invasix Ltd. Method and device for soft tissue ablation
EP2627274B1 (de) 2010-10-13 2022-12-14 AngioDynamics, Inc. System zur elektrischen ableitung des gewebes eines patienten
CN103313671B (zh) 2010-10-25 2017-06-06 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10092291B2 (en) 2011-01-25 2018-10-09 Ethicon Endo-Surgery, Inc. Surgical instrument with selectively rigidizable features
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US9656055B2 (en) 2011-08-03 2017-05-23 Pulse Biosciences, Inc. In vivo treatment of skin lesions by electrical nanopulses
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
WO2013090206A1 (en) 2011-12-12 2013-06-20 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Electrical pulse generators
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
JP6195856B2 (ja) 2012-03-08 2017-09-13 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US8673154B2 (en) 2012-07-12 2014-03-18 Heliae Development, Llc Tunable electrical field for aggregating microorganisms
US8709258B2 (en) 2012-07-12 2014-04-29 Heliae Development, Llc Patterned electrical pulse microorganism aggregation
US8702991B2 (en) 2012-07-12 2014-04-22 Heliae Development, Llc Electrical microorganism aggregation methods
US8668827B2 (en) 2012-07-12 2014-03-11 Heliae Development, Llc Rectangular channel electro-acoustic aggregation device
US8709250B2 (en) 2012-07-12 2014-04-29 Heliae Development, Llc Tubular electro-acoustic aggregation device
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
FR2998813B1 (fr) * 2012-12-04 2015-02-13 Commissariat Energie Atomique Dispositif d'application de champ electromagnetique sur un echantillon biologique
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
AU2014275297B2 (en) * 2013-06-03 2017-02-16 Pulse Biosciences, Inc. Methods and devices for stimulating an immune response using nanosecond pulsed electric fields
US9078862B2 (en) * 2013-06-06 2015-07-14 General Electric Company Platelet activation using long electric field pulses
EP3030185B1 (de) * 2013-08-06 2023-05-10 Memorial Sloan Kettering Cancer Center System und computerzugängliches medium zur in-vivo-gewebeablation und/oder -schädigung
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US10421956B2 (en) 2014-01-17 2019-09-24 General Electric Company Electric pulse generation systems using capacitive coupling
US9452199B2 (en) 2014-01-17 2016-09-27 General Electric Company Platelet activation and growth factor release using electric pulses
US9708597B2 (en) * 2014-01-17 2017-07-18 General Electric Company Electric pulse generation systems using capacitive coupling
EP3113605B1 (de) 2014-03-04 2018-10-31 Pulse Biosciences, Inc. Markierung von gewebeoberflächen zur behandlung von läsionen durch elektrische nanoimpulse
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
AU2015259303B2 (en) 2014-05-12 2021-10-28 Arena, Christopher B. Selective modulation of intracellular effects of cells using pulsed electric fields
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
WO2016089781A1 (en) 2014-12-01 2016-06-09 Electroblate, Inc. Nanoelectroablation control and vaccination
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US9752120B2 (en) 2015-03-31 2017-09-05 General Electric Company Activated platelet composition with tunable growth factor level
AU2016335755B2 (en) 2015-10-07 2021-07-01 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
US10548665B2 (en) 2016-02-29 2020-02-04 Pulse Biosciences, Inc. High-voltage analog circuit pulser with feedback control
US10874451B2 (en) 2016-02-29 2020-12-29 Pulse Biosciences, Inc. High-voltage analog circuit pulser and pulse generator discharge circuit
US10821283B2 (en) * 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US20170319851A1 (en) 2016-05-06 2017-11-09 Pulse Biosciences, Inc. Low-voltage impedance check pulse generator
US10252050B2 (en) 2016-05-16 2019-04-09 Pulse Biosciences, Inc. Pulse applicator
WO2017201394A1 (en) 2016-05-20 2017-11-23 Pulse Biosciences, Inc. Optimizing total energy delivered in nanosecond pulses for triggering apoptosis in cultured cells
EP3474760B1 (de) 2016-06-27 2023-01-11 Galvanize Therapeutics, Inc. Generator und ein katheter mit einer elektrode zur behandlung eines lungengangs
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
US10543357B2 (en) 2016-09-19 2020-01-28 Pulse Biosciences, Inc. High voltage connectors for pulse generators
US10792088B2 (en) 2016-10-20 2020-10-06 Old Dominion University Research Foundation Methods and devices for using sub-microsecond electric pulses to trigger apoptosis
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US20180154142A1 (en) 2016-12-05 2018-06-07 Old Dominion University Research Foundation Methods and devices for treatment of tumors with nano-pulse stimulation
US10946193B2 (en) 2017-02-28 2021-03-16 Pulse Biosciences, Inc. Pulse generator with independent panel triggering
US10850095B2 (en) 2017-08-08 2020-12-01 Pulse Biosciences, Inc. Treatment of tissue by the application of energy
US11590345B2 (en) 2017-08-08 2023-02-28 Pulse Biosciences, Inc. Treatment of tissue by the application of energy
IL272603B2 (en) 2017-08-16 2024-05-01 Old Dominion Univ Res Found Remotely targeted electrical stimulation using bipolar nanosecond pulses
US10857347B2 (en) 2017-09-19 2020-12-08 Pulse Biosciences, Inc. Treatment instrument and high-voltage connectors for robotic surgical system
US11045648B2 (en) 2017-11-14 2021-06-29 Boston Scientific Scimed, Inc. Irreversible electroporation through a combination of substance injection and electrical field application
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
DK3731771T3 (da) 2017-12-26 2023-08-28 Galvanize Therapeutics Inc V462033dk00
US11364070B2 (en) 2018-01-23 2022-06-21 Boston Scientific Scimed, Inc. Enhanced needle array and therapies for tumor ablation
AU2019222659B2 (en) 2018-02-13 2024-04-04 Nanovis, LLC Inactivating bacteria with electric pulses and antibiotics
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
WO2019177987A1 (en) 2018-03-13 2019-09-19 Pulse Biosciences, Inc. Moving electrodes for the application of electrical therapy within a tissue
US12178496B2 (en) 2018-10-10 2024-12-31 Pulse Biosciences, Inc. Treatment of dermal glands by the application of non-thermal energy
EP3877042A4 (de) * 2018-11-08 2021-12-29 Old Dominion University Research Foundation Megahertz-kompression von nanosekunden-impulsstössen
US11043745B2 (en) 2019-02-11 2021-06-22 Old Dominion University Research Foundation Resistively loaded dielectric biconical antennas for non-invasive treatment
US11571569B2 (en) 2019-02-15 2023-02-07 Pulse Biosciences, Inc. High-voltage catheters for sub-microsecond pulsing
CN113853174B (zh) 2019-03-15 2024-10-11 波士顿科学国际有限公司 用于选择性细胞消融的时间多路复用波形
WO2020190693A1 (en) 2019-03-15 2020-09-24 Boston Scientific Scimed, Inc. Waveform generator and control for selective cell ablation
US12133674B2 (en) 2019-03-21 2024-11-05 Pulse Biosciences, Inc. Tattoo removal
CN118203401A (zh) 2019-04-18 2024-06-18 盖能适治疗股份有限公司 用于治疗异常组织的装置、系统和方法
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
EP3998973A4 (de) 2019-07-16 2023-07-26 Galvanize Therapeutics, Inc. Behandlung des fortpflanzungstraktes mit gepulsten elektrischen feldern
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
KR20220054843A (ko) 2019-10-01 2022-05-03 펄스 바이오사이언스, 인크. 나노초 펄스 전원에서 부하 전류를 제한하기 위한 장치 및 방법
CN114945338A (zh) 2019-10-15 2022-08-26 波士顿科学国际有限公司 用于消融系统的控制系统和用户界面
CN114786605A (zh) 2019-10-21 2022-07-22 英杜基奈克斯公司 用于十二指肠脉冲电场治疗的装置、系统和方法
US11452870B2 (en) 2019-12-18 2022-09-27 Pulse Biosciences, Inc. Nanosecond pulsed power sources having multi-core transformers
US11992260B2 (en) 2020-03-31 2024-05-28 Boston Scientific Scimed, Inc. Smart probe identification for ablation modalities
US11904164B2 (en) 2020-07-27 2024-02-20 Pulse Biosciences, Inc. Nanosecond pulsed electric field system
AU2021337517B2 (en) 2020-09-02 2024-08-29 Pulse Biosciences, Inc. Universal handpiece for electrical treatment applicator
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
CA3215962A1 (en) 2021-04-26 2022-11-03 Roman Turovskiy Circumferential ablation devices and methods
US12564440B2 (en) 2021-04-26 2026-03-03 Pulse Biosciences, Inc. Multi-strut ablation and sensing catheter devices and methods
US12446944B2 (en) 2021-04-26 2025-10-21 Pulse Biosciences, Inc. Mapping and ablation applicators
US12042653B2 (en) 2021-12-30 2024-07-23 Pulse Biosciences, Inc. Electrical applicators with non-penetrating electrodes for applying energy to tissue surfaces

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1481480A (en) 1974-02-02 1977-07-27 Kernforschungsanlage Juelich Process and apparatus for increasing the permeability of the membrane of cells of organisms
US4429694A (en) 1981-07-06 1984-02-07 C. R. Bard, Inc. Electrosurgical generator
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
DE68925030T2 (de) 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5545130A (en) 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5688233A (en) 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US5464386A (en) 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5386837A (en) 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5527352A (en) * 1994-08-05 1996-06-18 Vona; Matthew J. Time focused induction of preferential necrosis
US5810762A (en) 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US5859327A (en) 1995-08-22 1999-01-12 Genetronics, Inc. Electroporation-mediated molecular transfer in intact plants
US5776175A (en) 1995-09-29 1998-07-07 Esc Medical Systems Ltd. Method and apparatus for treatment of cancer using pulsed electromagnetic radiation
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
EP1003847A4 (de) * 1997-09-04 2005-04-06 Science Res Lab Inc Zelltrennung mittels elektrischer felder
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6120493A (en) 1998-01-27 2000-09-19 Genetronics, Inc. Method for the introduction of therapeutic agents utilizing an electroporation apparatus
US6027488A (en) 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy

Also Published As

Publication number Publication date
EP1207797A1 (de) 2002-05-29
ES2300272T3 (es) 2008-06-16
US6326177B1 (en) 2001-12-04
EP1207797B1 (de) 2008-02-13
WO2001010319A1 (en) 2001-02-15
WO2001010319A8 (en) 2001-06-14
AU785506B2 (en) 2009-09-10
AU6756800A (en) 2001-03-05
DE60038026D1 (de) 2008-03-27
JP4728546B2 (ja) 2011-07-20
JP2011137025A (ja) 2011-07-14
JP2003506064A (ja) 2003-02-18
JP5503575B2 (ja) 2014-05-28
DE60038026T2 (de) 2009-02-05

Similar Documents

Publication Publication Date Title
ATE385746T1 (de) Methode zur intrazellulären elektro-manipulation
WO2003043696A3 (en) Device and method for skin treatment using electrical current
WO2002098501A3 (en) Method and apparatus for treating tumors using low strength electric fields
WO2002068040A3 (en) Apparatus for stimulating a muscle of a subject
AU6922200A (en) Method and apparatus for characterizing high-energy electrochemical cells using power functions obtained from calorimetry
WO2007001747A3 (en) Methods and systems for treating tumors using electroporation
DK0506879T3 (da) Fremgangsmåde og apparatur til pulseret iontophoretisk afgivelse af lægemiddel
CA2425090A1 (en) System and method for varying characteristics of electrical therapy
DE68901893D1 (de) Vorrichtung zur erzeugung elektrischer energie.
DE50011717D1 (de) Vorrichtung zur versorgung eines elektro-pens mit elektrischer energie
DE69803141D1 (de) Verfahren und Einrichtung zur Versorgung von medizinischen Geräten mit elektrischer Energie
WO2004109717A3 (en) High energy polyenergetic ion beam systems
IT8720807A0 (it) Metodo per produrre una pila elettrochimica.
WO2003069634A3 (de) Verfahren und vorrichtung zum steuern einer nach dem rasterscanverfahren arbeitenden bestrahlungseinrichtung für schwere ionen oder protonen mit strahlextraktion
DE69703365D1 (de) Autonomer Generator zur Erzeugung elektrischer Energie
DE68907398D1 (de) System zur erzeugung elektrischer energie mit gebrauch von brennstoffzellen des geschmolzenen karbonattyps.
AU4214700A (en) Apparatus and method for aligning an energy beam
DE3586098D1 (de) System und verfahren zur kompensation von gehoerschaeden.
DE3867665D1 (de) Verfahren zur herstellung eines elektrochemischen generators mit alkalischem elektrolyten und spiralfoermig gewickelten elektroden.
WO2005001845A3 (en) Fusion apparatus and methods
DE69931476D1 (de) Verfahren und vorrichtung zur herstellung von günstigen spannungen rundum löcher mittels der anwendung von fokussierten spannungswellen
DE3779850D1 (de) Laservorrichtung mit hochspannungsimpulsgenerator, hochspannungsimpulsgenerator und verfahren zur impulserzeugung.
DE60106901D1 (de) Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit
DE69838102D1 (de) Gerät zur erzeugung orthogonal polarisierter strahlen mit verschiedenen frequenzen
PT1073504E (pt) Metodo e aparelho para desidratacao de um material poroso

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties