ATE385811T1 - Identifizierung zielgerichteter faltungsstellen in peptiden und proteinen - Google Patents
Identifizierung zielgerichteter faltungsstellen in peptiden und proteinenInfo
- Publication number
- ATE385811T1 ATE385811T1 AT01994412T AT01994412T ATE385811T1 AT E385811 T1 ATE385811 T1 AT E385811T1 AT 01994412 T AT01994412 T AT 01994412T AT 01994412 T AT01994412 T AT 01994412T AT E385811 T1 ATE385811 T1 AT E385811T1
- Authority
- AT
- Austria
- Prior art keywords
- interest
- target
- binding
- peptides
- proteins
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 230000027455 binding Effects 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 229910021645 metal ion Inorganic materials 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000005714 functional activity Effects 0.000 abstract 1
- 238000002825 functional assay Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25684200P | 2000-12-19 | 2000-12-19 | |
| US30483501P | 2001-07-11 | 2001-07-11 | |
| US32783501P | 2001-10-04 | 2001-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE385811T1 true ATE385811T1 (de) | 2008-03-15 |
Family
ID=27400993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01994412T ATE385811T1 (de) | 2000-12-19 | 2001-12-19 | Identifizierung zielgerichteter faltungsstellen in peptiden und proteinen |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1379283B1 (de) |
| JP (1) | JP2005501220A (de) |
| AT (1) | ATE385811T1 (de) |
| CA (1) | CA2436789A1 (de) |
| DE (1) | DE60132820D1 (de) |
| WO (1) | WO2002064734A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351690B2 (en) | 2000-12-19 | 2008-04-01 | Palatin Technologies, Inc. | Knockout identification of target-specific sites in peptides |
| FR2835528B1 (fr) * | 2002-02-01 | 2004-03-12 | Inst Europ Biolog Cellulaire | Nouveaux derives peptidiques, leur preparation et leur application therapeutique et cosmetique |
| AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| DE60219215T2 (de) * | 2002-10-23 | 2008-01-03 | Centre For Research And Technology Hellas/Intitute Of Agrobiotechnology In.A, Thermi | Prionen-bindende peptidsequenzen |
| US7785566B2 (en) | 2003-11-06 | 2010-08-31 | Ge Healthcare, Inc. | Pharmaceutical compounds |
| JP2008538204A (ja) | 2005-03-10 | 2008-10-16 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 安定化側鎖を含む放射性標識複合体キレート剤 |
| EP1700608A1 (de) * | 2005-03-10 | 2006-09-13 | Schering AG | Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette |
| CA2632828C (en) | 2005-12-12 | 2012-07-10 | F. Hoffmann-La Roche Ag | Antibodies against amyloid beta with glycosylation in the variable region |
| FR2971784B1 (fr) * | 2011-02-18 | 2015-01-02 | Isp Investments Inc | Nouveaux peptides activateurs de la synthese des proteines de la matrice extracellulaire et compositions cosmetiques les comprenant |
| CR20210429A (es) | 2015-06-24 | 2021-09-24 | Hoffmann La Roche | ANTICUERPOS ANTI-RECEPTOR DE TRANSFERRINA CON AFINIDAD DISEÑADA (Divisional 2017-0562) |
| TWI819458B (zh) | 2015-10-02 | 2023-10-21 | 瑞士商赫孚孟拉羅股份公司 | 雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法 |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| JP7452829B2 (ja) | 2015-11-09 | 2024-03-19 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータのエピトープおよびそれに対する抗体 |
| AU2016354688B2 (en) | 2015-11-09 | 2021-12-16 | The University Of British Columbia | Epitopes in Amyloid beta mid-region and conformationally-selective antibodies thereto |
| KR102550991B1 (ko) | 2016-07-18 | 2023-07-04 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타에 대한 항체 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| CN111909238B (zh) * | 2017-06-29 | 2022-04-08 | 安徽省农业科学院农产品加工研究所 | 一种含有Ser-Cys的高锌螯合活性锌螯合肽及其应用 |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| JP7579812B2 (ja) * | 2019-05-31 | 2024-11-08 | アイバイオ， インク． | メソスケールペプチドを操作するための機械学習ベースの装置およびそのための方法およびシステム |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200504A (en) * | 1990-10-02 | 1993-04-06 | The Scripps Research Institute | Metallopeptides having stabilized secondary structures |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
| US6331285B1 (en) * | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| US6083758A (en) * | 1997-04-09 | 2000-07-04 | California Institute Of Technology | Method for screening peptides for metal coordinating properties and fluorescent chemosensors derived therefrom |
| JP2002536295A (ja) * | 1998-12-14 | 2002-10-29 | パラチン テクノロジーズ， インク． | 金属ペプチド組合せライブラリ及びその利用法 |
| CA2379647A1 (en) * | 1999-08-12 | 2001-02-22 | Palatin Technologies, Inc. | Melanocortin metallopeptide constructs, combinatorial libraries and applications |
-
2001
- 2001-12-19 AT AT01994412T patent/ATE385811T1/de not_active IP Right Cessation
- 2001-12-19 EP EP01994412A patent/EP1379283B1/de not_active Expired - Lifetime
- 2001-12-19 DE DE60132820T patent/DE60132820D1/de not_active Expired - Lifetime
- 2001-12-19 CA CA002436789A patent/CA2436789A1/en not_active Abandoned
- 2001-12-19 WO PCT/US2001/050075 patent/WO2002064734A2/en not_active Ceased
- 2001-12-19 JP JP2002565049A patent/JP2005501220A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002064734A2 (en) | 2002-08-22 |
| DE60132820D1 (de) | 2008-03-27 |
| WO2002064734A3 (en) | 2003-11-20 |
| CA2436789A1 (en) | 2002-08-22 |
| EP1379283A2 (de) | 2004-01-14 |
| EP1379283B1 (de) | 2008-02-13 |
| EP1379283A4 (de) | 2005-01-19 |
| JP2005501220A (ja) | 2005-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |