ATE386519T1 - Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren - Google Patents
Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatorenInfo
- Publication number
- ATE386519T1 ATE386519T1 AT04725057T AT04725057T ATE386519T1 AT E386519 T1 ATE386519 T1 AT E386519T1 AT 04725057 T AT04725057 T AT 04725057T AT 04725057 T AT04725057 T AT 04725057T AT E386519 T1 ATE386519 T1 AT E386519T1
- Authority
- AT
- Austria
- Prior art keywords
- gaba
- receptor complex
- benzimidazole derivatives
- complex modulators
- sub
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 102000004300 GABA-A Receptors Human genes 0.000 title 1
- 108090000839 GABA-A Receptors Proteins 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300510 | 2003-04-03 | ||
| US45997003P | 2003-04-04 | 2003-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386519T1 true ATE386519T1 (de) | 2008-03-15 |
Family
ID=33132906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04725057T ATE386519T1 (de) | 2003-04-03 | 2004-04-01 | Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7335777B2 (de) |
| EP (1) | EP1613312B1 (de) |
| JP (1) | JP2006522069A (de) |
| AT (1) | ATE386519T1 (de) |
| DE (1) | DE602004011914T2 (de) |
| WO (1) | WO2004087137A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006233894A1 (en) | 2005-04-13 | 2006-10-19 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| EP1874758A1 (de) * | 2005-04-19 | 2008-01-09 | Neurosearch A/S | Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes |
| US20090062304A1 (en) * | 2005-04-19 | 2009-03-05 | Lene Teuber | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex |
| CA2632395A1 (en) | 2005-12-05 | 2007-06-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU675484B2 (en) * | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
| US5554630A (en) * | 1993-03-24 | 1996-09-10 | Neurosearch A/S | Benzimidazole compounds |
| BR9608056A (pt) | 1995-04-21 | 1999-11-30 | Neurosearch As | Compostos de benzimidazol, composições farmacêuticas contendo os compostos e sua utilização. |
| PL183853B1 (pl) | 1995-04-21 | 2002-07-31 | Neurosearch As | Nowa pochodna benzimidazolu i środek farmaceutyczny |
| WO1998017651A1 (en) | 1996-10-21 | 1998-04-30 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators |
| GB9702524D0 (en) | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| IL146403A0 (en) | 1999-06-22 | 2002-07-25 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| US6900215B2 (en) * | 2000-12-15 | 2005-05-31 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
-
2004
- 2004-04-01 DE DE602004011914T patent/DE602004011914T2/de not_active Expired - Lifetime
- 2004-04-01 EP EP04725057A patent/EP1613312B1/de not_active Expired - Lifetime
- 2004-04-01 JP JP2006505509A patent/JP2006522069A/ja not_active Ceased
- 2004-04-01 AT AT04725057T patent/ATE386519T1/de not_active IP Right Cessation
- 2004-04-01 WO PCT/EP2004/050415 patent/WO2004087137A1/en not_active Ceased
- 2004-04-01 US US10/546,586 patent/US7335777B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7335777B2 (en) | 2008-02-26 |
| JP2006522069A (ja) | 2006-09-28 |
| DE602004011914T2 (de) | 2008-06-12 |
| WO2004087137A1 (en) | 2004-10-14 |
| EP1613312B1 (de) | 2008-02-20 |
| DE602004011914D1 (de) | 2008-04-03 |
| EP1613312A1 (de) | 2006-01-11 |
| US20060148856A1 (en) | 2006-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY149855A (en) | Benzimidazole derivatives and their use for modulating the gaba? receptor complex | |
| ATE316076T1 (de) | Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen | |
| EA200601798A1 (ru) | Замещенные соединения морфолина для лечения расстройств центральной нервной системы | |
| SE0303180D0 (sv) | Novel compounds | |
| SE0302232D0 (sv) | Novel Compounds | |
| EA200700047A1 (ru) | Новые алкильные производные в качестве метаботропных рецепторов глутамата | |
| EA201000314A1 (ru) | 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2h,1'h-[1,4']бипиридинил-2'-оны | |
| ATE493397T1 (de) | Neuartige tetrazolderivate als positive allosterische modulatoren von metabotropen glutamatrezeptoren | |
| DE602006006712D1 (de) | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren | |
| MA34094B1 (fr) | Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2 | |
| EA201190086A1 (ru) | Сочлененные производные имидазола в качестве антагониста trpv3 | |
| EA201000675A1 (ru) | Производные хромана как модуляторы trpv3 | |
| IL189974A0 (en) | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | |
| EP1617806A4 (de) | Selektive spirocyclische glucocorticoid-rezeptor-modulatoren | |
| WO2004087690A3 (en) | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex | |
| ATE467632T1 (de) | Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors | |
| ATE386519T1 (de) | Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren | |
| WO2007042544A3 (en) | Imidazole derivatives and their use for modulating the gabaa receptor complex | |
| MX2007012624A (es) | Derivados de benzimidazol y su uso para la modulacion del complejo del receptor gaba-a. | |
| ATE423100T1 (de) | Neue chinolinverbindungen, die dazu in der lage sind, sich an den cb2-rezeptor zu binden | |
| ATE496896T1 (de) | 1h-imidazolderivate als modulatoren des cannabinoidrezeptors | |
| DE602007012683D1 (de) | Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente | |
| DE602004013299D1 (de) | Neue benzimidazolderivative und ihre pharmazeutische zusammensetzungen | |
| EA200602081A1 (ru) | Пиридиновые производные алкилоксиндолов в качестве агентов, активных в отношении рецептора 5-нт7 | |
| UA91998C2 (ru) | Производные бензимидазола и их использование для модулирования рецепторного комплекса гамка |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |