ATE496896T1 - 1h-imidazolderivate als modulatoren des cannabinoidrezeptors - Google Patents

1h-imidazolderivate als modulatoren des cannabinoidrezeptors

Info

Publication number: ATE496896T1
Authority: AT; Austria
Prior art keywords: imidazole derivatives; modulators; cannabinoid receptor; compounds; preparation
Prior art date: 2003-10-20

Application number

AT04791252T

Other languages

English (en)

Inventor

Josephus H M Lange

Cornelis G Kruse

Stuivenberg Herman H Van

Hiskias G Keizer

Original Assignee

Abbott Healthcare Products Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-20

Filing date

2004-10-19

Publication date

2011-02-15

2004-10-19 Application filed by Abbott Healthcare Products Bv filed Critical Abbott Healthcare Products Bv

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496896T1 publication Critical patent/ATE496896T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 3
102000018208 Cannabinoid Receptor Human genes 0.000 title abstract 3
108050007331 Cannabinoid receptor Proteins 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)

AT04791252T 2003-10-20 2004-10-19 1h-imidazolderivate als modulatoren des cannabinoidrezeptors ATE496896T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US51210503P	2003-10-20	2003-10-20
EP03103867		2003-10-20
PCT/EP2004/052575 WO2005040130A1 (en)	2003-10-20	2004-10-19	1h-imidazole derivatives as cannabinoid receptor modulators

Publications (1)

Publication Number	Publication Date
ATE496896T1 true ATE496896T1 (de)	2011-02-15

Family

ID=34524747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04791252T ATE496896T1 (de)	2003-10-20	2004-10-19	1h-imidazolderivate als modulatoren des cannabinoidrezeptors

Country Status (13)

Country	Link
EP (1)	EP1675833B1 (de)
JP (1)	JP2007509048A (de)
KR (1)	KR20060117952A (de)
AT (1)	ATE496896T1 (de)
AU (1)	AU2004283903B2 (de)
BR (1)	BRPI0414511A (de)
CA (1)	CA2534824A1 (de)
DE (1)	DE602004031245D1 (de)
IL (1)	IL173436A (de)
MX (1)	MXPA06002064A (de)
NO (1)	NO20062249L (de)
RU (1)	RU2337907C2 (de)
WO (1)	WO2005040130A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR046132A1 (es) *	2003-10-24	2005-11-23	Solvay Pharm Gmbh	Composicin farmaceutica que contiene al menos un compuesto con actividad de receptor de cb1, o un profarmaco , tautomero o sal del mismo, como componente activo adecuado para el tratamiento y/o profilaxis de enfermedades relacionadas con el receptor cb1 en pacientes juveniles y/o para el tratamiento
US8084451B2 (en) *	2005-01-10	2011-12-27	University Of Connecticut	Heteropyrrole analogs acting on cannabinoid receptors
US7759352B2 (en)	2006-04-14	2010-07-20	Merck Sharp & Dohme Corp.	Substituted imidazole-4-carboxamides as cholecystokinin-1 receptor modulators
EP2010519B1 (de)	2006-04-14	2011-07-06	Merck Sharp & Dohme Corp.	Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren
AU2007238804A1 (en)	2006-04-14	2007-10-25	Merck Sharp & Dohme Corp.	Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators
WO2008091631A1 (en)	2007-01-26	2008-07-31	Merck & Co., Inc.	Substituted aminopyrimidines as cholecystokinin-1 receptor modulators
WO2010079241A1 (es)	2009-01-12	2010-07-15	Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion	Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2716882B1 (fr) *	1994-03-04	1996-04-05	Roussel Uclaf	Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
TWI231757B (en) *	2001-09-21	2005-05-01	Solvay Pharm Bv	1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
AU2003209388A1 (en) *	2002-01-29	2003-09-02	Merck And Co., Inc.	Substituted imidazoles as cannabinoid receptor modulators
US7145012B2 (en) *	2003-04-23	2006-12-05	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof

2004
- 2004-10-19 KR KR1020067009684A patent/KR20060117952A/ko not_active Ceased
- 2004-10-19 AU AU2004283903A patent/AU2004283903B2/en not_active Ceased
- 2004-10-19 RU RU2006113197/04A patent/RU2337907C2/ru not_active IP Right Cessation
- 2004-10-19 AT AT04791252T patent/ATE496896T1/de not_active IP Right Cessation
- 2004-10-19 MX MXPA06002064A patent/MXPA06002064A/es active IP Right Grant
- 2004-10-19 CA CA002534824A patent/CA2534824A1/en not_active Abandoned
- 2004-10-19 EP EP04791252A patent/EP1675833B1/de not_active Expired - Lifetime
- 2004-10-19 BR BRPI0414511-9A patent/BRPI0414511A/pt not_active IP Right Cessation
- 2004-10-19 WO PCT/EP2004/052575 patent/WO2005040130A1/en not_active Ceased
- 2004-10-19 JP JP2006534770A patent/JP2007509048A/ja not_active Ceased
- 2004-10-19 DE DE602004031245T patent/DE602004031245D1/de not_active Expired - Lifetime
2006
- 2006-01-30 IL IL173436A patent/IL173436A/en not_active IP Right Cessation
- 2006-05-18 NO NO20062249A patent/NO20062249L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2007509048A (ja)	2007-04-12
BRPI0414511A (pt)	2006-11-07
MXPA06002064A (es)	2006-05-19
WO2005040130A1 (en)	2005-05-06
KR20060117952A (ko)	2006-11-17
AU2004283903A1 (en)	2005-05-06
RU2337907C2 (ru)	2008-11-10
IL173436A0 (en)	2006-06-11
NO20062249L (no)	2006-07-11
IL173436A (en)	2011-01-31
DE602004031245D1 (de)	2011-03-10
EP1675833A1 (de)	2006-07-05
CA2534824A1 (en)	2005-05-06
EP1675833B1 (de)	2011-01-26
AU2004283903B2 (en)	2010-12-02
RU2006113197A (ru)	2006-09-10

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO20074710L (no)	2007-09-14	1H-Imidazolderivater som cannabinoid-CB2-receptormodulatorer
TW200517388A (en)	2005-06-01	Thiazole derivatives as cannabinoid receptor modulators
UA87856C2 (ru)	2009-08-25	Алкильные производные как модуляторы метаботропных рецепторов глутамата
WO2003027076A3 (en)	2003-11-20	1h-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1- antagonistic activity
UA83194C2 (ru)	2008-06-25	Производные пиримидина и их применение как модуляторов св2
MXPA04002583A (es)	2004-06-18	Derivados de 4,5-dihidro-1h-pirazol novedosos que tienen actividad antagonistica del canabinoide (cb1).
PL367814A1 (en)	2005-03-07	4,5-dihydro-1h-pyrazole derivatives having potent cb1-antagonistic activity
EA200601266A1 (ru)	2007-02-27	Соединения триазола и их применение в качестве антагонистов метаботропного рецептора глутамата
MY140693A (en)	2010-01-15	[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
MXPA05010824A (es)	2005-12-05	Compuestos biciclicos como antagonistas del receptor nr2b.
PE20030286A1 (es)	2003-03-25	Derivados de 2 pirrolidona como agonistas de prostanoides
WO2005060959A8 (en)	2006-01-12	Pyrazole derivatives and use thereof as orexin receptor antagonists
EP1725536B8 (de)	2009-04-22	Imidazolinderivate mit cb1-antagonistischer wirkung
UA84896C2 (ru)	2008-12-10	Производные гидронопола как агонисты человеческих рецепторов orl1
MX2011006821A (es)	2012-01-03	Derivados de imidazol fusionados como antagonistas de trpv3.
MX2010005704A (es)	2010-08-17	Derivados de cromano como modulares del trpv3.
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