ATE386545T1 - Wachstumsfaktor-modifizierte proteinmatrizes zur geweberekonstruktion (tissue engineering) - Google Patents

Wachstumsfaktor-modifizierte proteinmatrizes zur geweberekonstruktion (tissue engineering)

Info

Publication number
ATE386545T1
ATE386545T1 AT02792510T AT02792510T ATE386545T1 AT E386545 T1 ATE386545 T1 AT E386545T1 AT 02792510 T AT02792510 T AT 02792510T AT 02792510 T AT02792510 T AT 02792510T AT E386545 T1 ATE386545 T1 AT E386545T1
Authority
AT
Austria
Prior art keywords
matrix
heparin
drug
protein
regeneration
Prior art date
Application number
AT02792510T
Other languages
German (de)
English (en)
Inventor
Jeffrey Hubbell
Matthias Lutolf
Jason Schense
Anna Jen
Original Assignee
Eth Zuerich
Univ Zuerich
Hubbell Jeffrey A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/024,918 external-priority patent/US20020168718A1/en
Priority claimed from PCT/EP2002/012458 external-priority patent/WO2003040235A1/en
Priority claimed from US10/323,046 external-priority patent/US7601685B2/en
Application filed by Eth Zuerich, Univ Zuerich, Hubbell Jeffrey A filed Critical Eth Zuerich
Application granted granted Critical
Publication of ATE386545T1 publication Critical patent/ATE386545T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02792510T 2001-12-18 2002-12-18 Wachstumsfaktor-modifizierte proteinmatrizes zur geweberekonstruktion (tissue engineering) ATE386545T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/024,918 US20020168718A1 (en) 1997-04-03 2001-12-18 Enzyme-mediated modification of fibrin for tissue engineering
PCT/EP2002/012458 WO2003040235A1 (en) 2001-11-07 2002-11-07 Synthetic matrix for controlled cell ingrowth and tissue regeneration
US10/323,046 US7601685B2 (en) 1998-08-27 2002-12-17 Growth factor modified protein matrices for tissue engineering

Publications (1)

Publication Number Publication Date
ATE386545T1 true ATE386545T1 (de) 2008-03-15

Family

ID=27807134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02792510T ATE386545T1 (de) 2001-12-18 2002-12-18 Wachstumsfaktor-modifizierte proteinmatrizes zur geweberekonstruktion (tissue engineering)

Country Status (9)

Country Link
JP (2) JP4560291B2 (es)
AT (1) ATE386545T1 (es)
AU (2) AU2002358272B2 (es)
BR (1) BRPI0215192B8 (es)
CA (1) CA2470419A1 (es)
DE (1) DE60225185T2 (es)
ES (1) ES2301697T3 (es)
MX (1) MXPA04006021A (es)
WO (1) WO2003052091A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
EP1862170B1 (en) 2004-12-10 2012-03-14 Straumann Holding AG Enamel formulation with amelogenin
EP1830863A2 (en) * 2004-12-10 2007-09-12 Straumann Holding AG Protein formulation
SE0403014D0 (sv) 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
US20060147443A1 (en) * 2004-12-22 2006-07-06 Kuros Biosurgery Ag Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
MX2007008319A (es) * 2005-01-06 2007-10-04 Kuros Biosurgery Ag Matrices suplementadas para la reparacion de fracturas oseas.
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
CA2930681C (en) 2007-04-09 2019-10-15 The Board Of Trustees Of The University Of Arkansas Fusion protein of collagen-binding domain and parathyroid hormone
DK2136850T3 (da) 2007-04-13 2012-04-10 Kuros Biosurgery Ag Polymervævforsegling
MX2010003969A (es) * 2007-10-12 2010-06-30 Kuros Biosurgery Ag Composiciones inyectables de fibrina que comprenden sal de estroncio para el aumento de tejidos.
WO2009144085A2 (en) 2008-04-18 2009-12-03 Kuros Biosurgery Ag Dispensing device, kit containing the device, and method of operating the device
WO2011025957A2 (en) * 2009-08-28 2011-03-03 Ecole Polytechnique Federal De Lausanne Tg-aprotinin fusion proteins and matrices thereof
JP6120778B2 (ja) * 2011-02-03 2017-04-26 ノースイースタン ユニヴァーシティ 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物
EP2686027B1 (en) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmaceutical formulation for use in spinal fusion
US9579273B2 (en) 2011-12-14 2017-02-28 The Kitasato Institute Delivery of therapeutic agents by a collagen binding protein
WO2013120060A1 (en) 2012-02-09 2013-08-15 The Board Of Trustees Of The University Of Arkansas Delivery of therapeutic agents by a collagen binding protein
CN104619727B (zh) * 2012-06-25 2019-04-05 布里格姆及妇女医院股份有限公司 靶向治疗
US9790264B2 (en) 2012-06-25 2017-10-17 The Brigham And Women's Hospital, Inc. Compounds and methods for modulating pharmacokinetics
ES2883235T3 (es) * 2015-09-09 2021-12-07 Eth Zuerich Hidrogeles macroporosos inyectables
WO2018148573A1 (en) 2017-02-10 2018-08-16 The Board Of Trustees Of The University Of Arkansas Collagen-binding agent compositions and methods of using the same
EP3536353A1 (en) 2018-03-09 2019-09-11 Kuros Biosurgery AG Method and kits for producing a fibrin matrix
US12403179B2 (en) 2021-02-18 2025-09-02 The Board Of Trustees Of The University Of Arkansas Release of growth factors at wound healing stages

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO1997018314A1 (de) * 1995-11-16 1997-05-22 Boehringer Mannheim Gmbh Verfahren zur herstellung von peptiden über streptavidin-fusionsproteine
PL341209A1 (en) * 1997-12-18 2001-03-26 Lilly Co Eli Crystalline teriparatide
DK1181323T3 (da) * 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
JP2001190280A (ja) * 1999-02-19 2001-07-17 Terumo Corp コラーゲン結合性生理活性ポリペプチド

Also Published As

Publication number Publication date
WO2003052091A1 (en) 2003-06-26
AU2002358272B2 (en) 2009-01-22
JP4560291B2 (ja) 2010-10-13
DE60225185D1 (de) 2008-04-03
BRPI0215192B8 (pt) 2021-07-27
BR0215192A (pt) 2005-04-26
ES2301697T3 (es) 2008-07-01
AU2009201588B2 (en) 2011-02-24
JP2009102383A (ja) 2009-05-14
AU2002358272A1 (en) 2003-06-30
WO2003052091A8 (en) 2003-08-07
AU2009201588A1 (en) 2009-05-14
BRPI0215192B1 (pt) 2016-03-22
MXPA04006021A (es) 2005-08-19
CA2470419A1 (en) 2003-06-26
DE60225185T2 (de) 2009-02-19
JP2005517658A (ja) 2005-06-16

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