ATE386747T1 - Antikörper gegen ep-cam - Google Patents

Antikörper gegen ep-cam

Info

Publication number: ATE386747T1
Authority: AT; Austria
Prior art keywords: cam; library; antibodies against; epitope; selecting
Prior art date: 1999-12-27

Application number

AT02077516T

Other languages

English (en)

Inventor

Ton Logtenberg

Original Assignee

Crucell Holland Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-27

Filing date

2000-12-21

Publication date

2008-03-15

2000-12-21 Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv

2008-03-15 Application granted granted Critical

2008-03-15 Publication of ATE386747T1 publication Critical patent/ATE386747T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Food Science & Technology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02077516T 1999-12-27 2000-12-21 Antikörper gegen ep-cam ATE386747T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99204561		1999-12-27

Publications (1)

Publication Number	Publication Date
ATE386747T1 true ATE386747T1 (de)	2008-03-15

Family

ID=8241110

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT04102692T ATE353920T1 (de)	1999-12-27	2000-12-21	Menschlischer monoklonaler antikörper gegen ep- cam und dessen verwendung in krebstherapie
AT00991344T ATE366419T1 (de)	1999-12-27	2000-12-21	Auswahl von epitop-bindungsfähigen verbindungen aus bibliotheken
AT02077516T ATE386747T1 (de)	1999-12-27	2000-12-21	Antikörper gegen ep-cam

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT04102692T ATE353920T1 (de)	1999-12-27	2000-12-21	Menschlischer monoklonaler antikörper gegen ep- cam und dessen verwendung in krebstherapie
AT00991344T ATE366419T1 (de)	1999-12-27	2000-12-21	Auswahl von epitop-bindungsfähigen verbindungen aus bibliotheken

Country Status (11)

Country	Link
US (2)	US20030096225A1 (de)
EP (3)	EP1273918B1 (de)
JP (1)	JP2003518391A (de)
AT (3)	ATE353920T1 (de)
AU (1)	AU783148B2 (de)
CA (1)	CA2396029A1 (de)
DE (3)	DE60035434T2 (de)
DK (1)	DK1479696T3 (de)
ES (1)	ES2282797T3 (de)
NZ (2)	NZ531590A (de)
WO (1)	WO2001048485A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7658924B2 (en)	2001-10-11	2010-02-09	Amgen Inc.	Angiopoietin-2 specific binding agents
US7521053B2 (en)	2001-10-11	2009-04-21	Amgen Inc.	Angiopoietin-2 specific binding agents
ATE374255T1 (de) *	2002-04-17	2007-10-15	Bioren Inc	Doping bei der walk-through-mutagenese
DK2314629T4 (da)	2002-07-18	2023-02-06	Merus Nv	Rekombinant produktion af blandinger af antistoffer
USRE47770E1 (en)	2002-07-18	2019-12-17	Merus N.V.	Recombinant production of mixtures of antibodies
US20100069614A1 (en)	2008-06-27	2010-03-18	Merus B.V.	Antibody producing non-human mammals
WO2004106375A1 (en)	2003-05-30	2004-12-09	Merus Biopharmaceuticals B.V. I.O.	Fab library for the preparation of anti vegf and anti rabies virus fabs
CA2503838C (en) *	2003-09-08	2014-08-19	E. I. Du Pont De Nemours And Company	Peptide-based conditioners and colorants for hair
EP1737971B1 (de)	2004-01-20	2017-08-16	Merus N.V.	Gemische bindender proteine
JO2913B1 (en)	2008-02-20	2015-09-15	امجين إنك,	Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
US9079942B2 (en)	2009-02-09	2015-07-14	Epitomics, Inc.	CDR-anchored amplification method
GB0909904D0 (en)	2009-06-09	2009-07-22	Affitech As	Product
US8293483B2 (en)	2009-09-11	2012-10-23	Epitomics, Inc.	Method for identifying lineage-related antibodies
EP2726870B1 (de)	2011-06-29	2018-10-03	Academia Sinica	Erfassung, reinigung und freisetzung eines biologischen stoffes anahnd einer oberflächenbeschichtung
CA2791109C (en)	2011-09-26	2021-02-16	Merus B.V.	Generation of binding molecules
EP2819695B1 (de) *	2012-03-02	2018-06-27	Academia Sinica	Antikörper gegen epithelzelladhäsionsmoleküle (epcam) und anwendungsverfahren dafür
US9248181B2 (en)	2012-04-20	2016-02-02	Merus B.V.	Methods and means for the production of Ig-like molecules
TW201623605A (zh)	2014-04-01	2016-07-01	中央研究院	用於癌症診斷及預後之方法及系統
US10112198B2 (en)	2014-08-26	2018-10-30	Academia Sinica	Collector architecture layout design
US10107726B2 (en)	2016-03-16	2018-10-23	Cellmax, Ltd.	Collection of suspended cells using a transferable membrane
WO2019213624A1 (en) *	2018-05-04	2019-11-07	The Regents Of The University Of California	Spiked primers for enrichment of pathogen nucleic acids among background of nucleic acids
US11707487B2 (en)	2020-04-13	2023-07-25	Affyimmune Therapeutics, Inc.	EpCAM antibody and CAR-T cells
WO2022126084A1 (en) *	2020-12-09	2022-06-16	Affyimmune Therapeutics, Inc.	Dual chimeric antigen receptor targeting epcam and icam-1
WO2023174521A1 (en)	2022-03-15	2023-09-21	Genmab A/S	Binding agents binding to epcam and cd137
WO2025056180A1 (en)	2023-09-15	2025-03-20	BioNTech SE	Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5605793A (en) *	1994-02-17	1997-02-25	Affymax Technologies N.V.	Methods for in vitro recombination
US6265150B1 (en) *	1995-06-07	2001-07-24	Becton Dickinson & Company	Phage antibodies
DK0934526T3 (da) *	1996-10-08	2003-05-05	Bisys B V U	Fremgangsmåder og midler til udvælgelse af peptider og proteiner, der har specifik affinitet til et mål
US6787638B1 (en) *	1998-12-02	2004-09-07	Applied Molecular Evolution, Inc.	Tumor specific human monoclonal antibodies and methods of use

2000
- 2000-12-21 ES ES04102692T patent/ES2282797T3/es not_active Expired - Lifetime
- 2000-12-21 NZ NZ531590A patent/NZ531590A/en unknown
- 2000-12-21 JP JP2001549082A patent/JP2003518391A/ja not_active Withdrawn
- 2000-12-21 DE DE60035434T patent/DE60035434T2/de not_active Expired - Lifetime
- 2000-12-21 EP EP02077516A patent/EP1273918B1/de not_active Expired - Lifetime
- 2000-12-21 AT AT04102692T patent/ATE353920T1/de active
- 2000-12-21 EP EP04102692A patent/EP1479696B1/de not_active Expired - Lifetime
- 2000-12-21 CA CA002396029A patent/CA2396029A1/en not_active Abandoned
- 2000-12-21 AT AT00991344T patent/ATE366419T1/de not_active IP Right Cessation
- 2000-12-21 NZ NZ520074A patent/NZ520074A/en unknown
- 2000-12-21 DK DK04102692T patent/DK1479696T3/da active
- 2000-12-21 EP EP00991344A patent/EP1242823B1/de not_active Expired - Lifetime
- 2000-12-21 AT AT02077516T patent/ATE386747T1/de not_active IP Right Cessation
- 2000-12-21 WO PCT/NL2000/000941 patent/WO2001048485A2/en not_active Ceased
- 2000-12-21 AU AU32447/01A patent/AU783148B2/en not_active Ceased
- 2000-12-21 DE DE60038132T patent/DE60038132T2/de not_active Expired - Lifetime
- 2000-12-21 DE DE60033455T patent/DE60033455T2/de not_active Expired - Lifetime
2002
- 2002-06-27 US US10/184,508 patent/US20030096225A1/en not_active Abandoned
- 2002-06-28 US US10/186,186 patent/US7777010B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1479696A1 (de)	2004-11-24
DE60038132D1 (de)	2008-04-03
DE60038132T2 (de)	2009-04-02
JP2003518391A (ja)	2003-06-10
AU3244701A (en)	2001-07-09
EP1273918A2 (de)	2003-01-08
DE60033455D1 (de)	2007-03-29
EP1479696B1 (de)	2007-02-14
NZ520074A (en)	2004-04-30
US7777010B2 (en)	2010-08-17
DE60035434T2 (de)	2008-05-15
DK1479696T3 (da)	2007-05-07
US20030096225A1 (en)	2003-05-22
EP1242823B1 (de)	2007-07-04
NZ531590A (en)	2006-01-27
WO2001048485A9 (en)	2002-09-06
EP1273918B1 (de)	2008-02-20
AU783148B2 (en)	2005-09-29
WO2001048485A3 (en)	2002-01-31
WO2001048485A2 (en)	2001-07-05
EP1242823A2 (de)	2002-09-25
US20030096226A1 (en)	2003-05-22
CA2396029A1 (en)	2001-07-05
ES2282797T3 (es)	2007-10-16
EP1273918A3 (de)	2003-05-02
ATE366419T1 (de)	2007-07-15
ATE353920T1 (de)	2007-03-15
DE60033455T2 (de)	2007-11-29
DE60035434D1 (de)	2007-08-16

Legal Events

Date	Code	Title	Description
2008-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE386747T1 (de)	2008-03-15	Antikörper gegen ep-cam
AU5632700A (en)	2001-01-09	System for sound file recording, analysis, and archiving via the internet for language training and other applications
DE69424019D1 (de)	2000-05-25	System zur Sprachlichen Wiedergabe von Hypertextdokumenten, wie Hilfsdateien
CA2324888A1 (fr)	1999-10-28	Procede d'obtention, reparation ou reconstruction d'un objet, avec une piece ou materiau composite
ATE211552T1 (de)	2002-01-15	Immunoassay für h. pylori in fäkalienproben
ID16966A (id)	1997-11-27	Sediaan antibodi pekat
EP0899665A3 (de)	2001-05-02	Durchsuchen von Dokumenten mit mehreren Elementtypen
EP2302382A3 (de)	2011-10-05	Docetaxel Konjugaten und Immunogenen zur Verwendung in einem Immunassay
ID18335A (id)	1998-03-26	Bagian atau jig untuk tanur pengkarbidaan gas
BR9802456B1 (pt)	2009-01-13	aparelho, e, processo para obtenção de parafinas ou frações de parafinas.
SE9802264D0 (sv)	1998-06-25	A method of isolating cells
ATE250128T1 (de)	2003-10-15	Treponema palladium fusions-antigen, nachweis für anti-treponema palladium antikörpern mit diesen fusions-antigenen
HK1046925A1 (zh)	2003-01-30	Mage-a12抗原肽及其用途
WO2003027236A3 (en)	2006-02-23	Systems, methods and kits for remote genetic analysis and consultation
DE60014616D1 (de)	2004-11-11	Antikörper gegen plazentaprotein 13
WO2000073345A3 (en)	2001-05-25	Antibodies specific for mycobacterial polypeptides and uses thereof
DK1208213T3 (da)	2004-11-01	Fremgangsmåde til fremstilling af proteiner i værtsceller under anvendelse af chaperoniner
NL1004554A1 (nl)	1997-06-24	Compacte fluorescerende lamp en een werkwijze voor het vervaardigen daarvan.
FI980151L (fi)	1999-07-24	Menetelmä toimilaitteen asemoimiseksi
NL1001288A1 (nl)	1996-04-01	Werkwijze en inrichting voor het vervaardigen van een optische schijf van organisch materiaal.
DE69927801D1 (de)	2005-11-24	Bodentest
WO2003009887A3 (en)	2003-09-18	Immuno absorption columns for the subtraction of antibodies from blood with selective plasmafiltration techniques
ES1054552U (es)	2003-08-01	Dispositivo para la fijacion de elementos tubulares
ES1032341Y (es)	1996-09-16	Soporte para guitarras electricas y bajos.
ITTO971020A0 (it)	1997-11-21	Attuatore lineare.