ATE386939T1 - Direktes screeningverfahren - Google Patents

Direktes screeningverfahren

Info

Publication number
ATE386939T1
ATE386939T1 AT00977784T AT00977784T ATE386939T1 AT E386939 T1 ATE386939 T1 AT E386939T1 AT 00977784 T AT00977784 T AT 00977784T AT 00977784 T AT00977784 T AT 00977784T AT E386939 T1 ATE386939 T1 AT E386939T1
Authority
AT
Austria
Prior art keywords
polypeptides
target
support
molecules
nucleic acid
Prior art date
Application number
AT00977784T
Other languages
English (en)
Inventor
Lucy Jessica Holt
Wildt Rudolf De
Ian Tomlinson
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd filed Critical Domantis Ltd
Application granted granted Critical
Publication of ATE386939T1 publication Critical patent/ATE386939T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of Radiation (AREA)
  • Peptides Or Proteins (AREA)
  • Position Fixing By Use Of Radio Waves (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Eye Examination Apparatus (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Farming Of Fish And Shellfish (AREA)
AT00977784T 1999-12-03 2000-12-04 Direktes screeningverfahren ATE386939T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9928787.2A GB9928787D0 (en) 1999-12-03 1999-12-03 Direct screening method

Publications (1)

Publication Number Publication Date
ATE386939T1 true ATE386939T1 (de) 2008-03-15

Family

ID=10865784

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00977784T ATE386939T1 (de) 1999-12-03 2000-12-04 Direktes screeningverfahren

Country Status (13)

Country Link
US (1) US20030039958A1 (de)
EP (2) EP1242821B8 (de)
JP (1) JP2003515745A (de)
AT (1) ATE386939T1 (de)
AU (1) AU1541701A (de)
CA (1) CA2392981A1 (de)
DE (1) DE60038124T2 (de)
DK (1) DK1242821T3 (de)
ES (1) ES2300279T3 (de)
GB (1) GB9928787D0 (de)
NO (1) NO20022312L (de)
PT (1) PT1242821E (de)
WO (1) WO2001040803A1 (de)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
US7354721B2 (en) 2000-09-22 2008-04-08 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods, and kits and systems for practicing the same
ATE538380T1 (de) 2001-01-23 2012-01-15 Harvard College Nukleinsäure-programmierbare protein-arrays
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US20050019942A1 (en) * 2001-03-16 2005-01-27 Proteome Systems Ltd. Array-based biomolecule analysis
WO2003000404A1 (en) * 2001-06-22 2003-01-03 Domantis Limited Matrix screening method
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US6797393B2 (en) 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
US6815078B2 (en) 2002-03-06 2004-11-09 Eastman Kodak Company Substrate for protein microarray containing functionalized polymer
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
AU2003304409A1 (en) * 2002-06-07 2005-03-07 President And Fellows Of Harvard College Evaluating protein signatures
EP2314629B2 (de) 2002-07-18 2022-11-16 Merus N.V. Rekombinante Herstellung von Mischungen aus Aantikörpern
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
JP2007524348A (ja) 2003-01-07 2007-08-30 ダイアックス、コープ クニッツドメインライブラリー
GB0304832D0 (en) * 2003-03-04 2003-04-09 Secr Defence Assay method
WO2004106375A1 (en) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Fab library for the preparation of anti vegf and anti rabies virus fabs
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1668111A4 (de) 2003-08-08 2008-07-02 Genenews Inc Osteoarthritis-biomarker und verwendungen davon
US7153896B2 (en) 2003-11-14 2006-12-26 Eastman Kodak Company Element for protein microarrays
AU2005205412B2 (en) 2004-01-20 2011-08-11 Merus N.V. Mixtures of binding proteins
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
CN103497993A (zh) 2005-02-07 2014-01-08 基因信息公司 轻度骨关节炎生物标志物及其用途
US20080145364A1 (en) * 2005-02-15 2008-06-19 Yale University Method for High Throughput Screening for Anitbodies and Proteins Inducing Apoptosis
WO2006111424A1 (en) * 2005-04-22 2006-10-26 Life & Brain Gmbh Methods for identifying modulators of cb1 and cb2 cannabinoid receptors and their use in wound healing
JP5237817B2 (ja) 2005-10-21 2013-07-17 ジーンニュース インコーポレーティッド バイオマーカー産物レベルを疾患に相関させるための方法および装置
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
NZ596269A (en) 2006-07-05 2012-12-21 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
WO2008008858A2 (en) * 2006-07-12 2008-01-17 Trellis Bioscience, Inc. Cellspot™ applications
CA2657576C (en) 2006-07-14 2023-10-31 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
EP2481797A1 (de) 2007-04-13 2012-08-01 Catalyst Biosciences, Inc. Modifizierte Faktor-VII-Polypeptide und Verwendungen dafür
CL2008001887A1 (es) 2007-06-29 2008-10-03 Amgen Inc Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende.
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
EP2229473A4 (de) 2007-12-07 2011-02-02 Steven A Goldstein Identifizierung von toxinliganden
ES2334084B1 (es) 2007-12-21 2011-01-24 Inst Cientifico Tecnol Navarra Marcadores geneticos para el pronostico de la esclerosis multiple.
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
WO2009132287A2 (en) 2008-04-24 2009-10-29 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
TWI593423B (zh) 2008-04-25 2017-08-01 戴埃克斯有限公司 Ｆｃ受體結合蛋白
WO2010033229A2 (en) 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of molecules and displayed molecules and collections
EP2169078A1 (de) 2008-09-26 2010-03-31 Fundacion Gaiker Verfahren und Kits zur Diagnose und Abstufung von Kolorektalkrebs
WO2010045315A1 (en) 2008-10-14 2010-04-22 Dyax Corp. Use of igf-ii/igf-iie binding for the treatment and prevention of systemic sclerosis associated pulmonary fibrosis
WO2010107752A2 (en) 2009-03-20 2010-09-23 Amgen Inc. Alpha-4-beta-7 heterodimer specific antagonist antibody
EP2459213A1 (de) 2009-07-31 2012-06-06 Amgen Inc. Metalloproteinase-typ-3 (timp-3)-gewebehemmer bindende polypeptide, zusammensetzungen und verfahren
JP2013504602A (ja) 2009-09-14 2013-02-07 ダイアックス コーポレーション 新しく設計したｈｃｃｄｒ３を含む遺伝子パッケージライブラリー
US20110189183A1 (en) 2009-09-18 2011-08-04 Robert Anthony Williamson Antibodies against candida, collections thereof and methods of use
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
ES2688093T3 (es) 2010-01-06 2018-10-30 Dyax Corp. Proteínas de unión a calicreína plasmática
JP2013523184A (ja) 2010-04-15 2013-06-17 アムジエン・インコーポレーテツド ヒトＦＧＦ受容体およびβ−ＫＬＯＴＨＯ結合性タンパク質
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
EP2601212A1 (de) 2010-08-04 2013-06-12 Cizzle Biotechnology Limited Verfahren und verbindungen zur diagnose und behandlung von
CA2808382A1 (en) 2010-08-16 2012-02-23 Amgen Inc. Antibodies that bind myostatin, compositions and methods
EP2428583A1 (de) 2010-09-10 2012-03-14 Bioftalmik, S.L. Verfahren zur Prognose des Erfolgs einer Filtrationsoperation und zur Bestimmung des Heilungsprozesses
CN105924519B (zh) 2010-12-31 2019-08-23 生物蛋白有限公司 全面单克隆抗体产生
AU2012212075A1 (en) 2011-02-02 2013-07-18 Amgen Inc. Methods and compositons relating to inhibition of IGF-1R
CA2835721A1 (en) 2011-05-12 2012-11-15 Traslational Cancer Drugs Pharma, S.L. Kiaa1456 expression predicts survival in patients with colon cancer
PH12013502378A1 (en) 2011-06-02 2014-01-06 Dyax Corp Fc RECEPTOR BINDING PROTEINS
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
US20120316077A1 (en) * 2011-06-07 2012-12-13 Charles Greef System And Method For Detection And Analysis Of A Molecule In A Sample
WO2013063298A1 (en) 2011-10-26 2013-05-02 Amgen Inc. Methods of reducing or eliminating protein modification and degradation arising from exposure to uv light
CN104053788A (zh) 2011-11-28 2014-09-17 加泰罗尼亚调查和高级研究机构 结肠直肠癌的预后方法和试剂盒
WO2013092960A1 (en) 2011-12-22 2013-06-27 Fundacion Gaiker Methods and kits for the diagnosis of colorectal cancer
DK2838918T3 (da) 2012-04-20 2019-08-12 Merus Nv Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler
EP2847219A1 (de) 2012-05-07 2015-03-18 Amgen Inc. Anti-erythropoietin-antikörper
AU2013267161A1 (en) 2012-05-31 2014-11-20 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-L1
JP6429771B2 (ja) 2012-06-21 2018-11-28 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ｃ−Ｍｅｔに結合する抗原結合タンパク質
WO2013192596A2 (en) 2012-06-22 2013-12-27 Sorrento Therapeutics Inc. Antigen binding proteins that bind ccr2
WO2013190081A1 (en) 2012-06-22 2013-12-27 Proyecto De Biomedicina Cima, S.L. Methods and reagents for the prognosis of cancer
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
WO2014022102A1 (en) 2012-08-01 2014-02-06 Amgen Inc. Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture
ES2791627T3 (es) 2012-11-12 2020-11-05 Inst Catalana Recerca Estudis Avancats Métodos y kits para el pronóstico del cáncer colorrectal
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
SG11201505960VA (en) 2013-02-01 2015-08-28 Santa Maria Biotherapeutics Inc Administration of an anti-activin-a compound to a subject
CA2904713A1 (en) 2013-03-11 2014-10-09 Amgen Inc. Protein formulations comprising darbepoetin
US20140271629A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Chrdl-1 antigen binding proteins and methods of treatment
WO2014144495A1 (en) 2013-03-15 2014-09-18 Abvitro, Inc. Single cell bar-coding for antibody discovery
ES3030960T3 (en) 2013-10-31 2025-07-02 Amgen Inc Use of monensin to regulate glycosylation of recombinant proteins
BR112016017606A2 (pt) 2014-01-29 2017-10-10 Amgen Inc superexpressão de reguladores de via de n-glicosilação para modular a glicosilação de proteínas recombinantes
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
EP3183000A4 (de) 2014-08-22 2018-04-25 Sorrento Therapeutics, Inc. Antigenbindende proteine zur bindung von cxcr3
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
KR102541849B1 (ko) 2014-09-15 2023-06-09 에이비비트로, 엘엘씨 고-처리량 뉴클레오티드 라이브러리 서열결정
MX2017004986A (es) 2014-10-17 2017-08-18 Amgen Inc Anticuerpos dirigidos a angiopoyetina-1 y angiopoyetina-2 para terapias oculares.
CN105669863B (zh) 2014-12-05 2019-09-13 鸿运华宁（杭州）生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其应用
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
CN108271359B (zh) 2015-02-13 2021-11-09 索伦托药业有限公司 结合ctla4的抗体治疗剂
CA2979219A1 (en) 2015-03-10 2016-09-15 Sorrento Therapeutics, Inc. Antibody therapeutics that bind psma
CN113527495A (zh) 2015-04-08 2021-10-22 索伦托药业有限公司 与cd38结合的抗体治疗剂
JP7628764B2 (ja) 2015-09-29 2025-02-12 アムジエン・インコーポレーテツド Ａｓｇｒ阻害剤
KR102927822B1 (ko) 2016-01-29 2026-02-13 주식회사유한양행 Pd-l1에 결합하는 항원 결합 단백질
BR112018073316A2 (pt) 2016-05-11 2019-06-04 Amgen Inc seleção direta de células que expressam altos níveis de proteínas heteroméricas usando vetores de complementação intragênica da glutamina sintetase
EP3246415A1 (de) 2016-05-18 2017-11-22 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
TWI826351B (zh) 2016-05-31 2023-12-21 大陸商鴻運華寧（杭州）生物醫藥有限公司 Ｒ抗體,其藥物組合物及其應用
ES2688737A1 (es) 2017-05-04 2018-11-06 Universidad Del País Vasco / Euskal Herriko Unibertsitatea Método para diagnosticar placa ateroesclerótica inestable
MA49352A (fr) 2017-05-26 2020-04-08 Abvitro Llc Séquençage de bibliothèque de polynucléotides à haut rendement et analyse de transcriptome
CN107563133B (zh) * 2017-08-30 2021-05-04 大连理工大学 采用定量结构-活性关系模型预测有机化学品的氯自由基反应速率常数的方法
MA50079A (fr) 2017-09-07 2020-07-15 Juno Therapeutics Inc Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire
CN117003874A (zh) 2018-03-20 2023-11-07 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
CN110357959B (zh) 2018-04-10 2023-02-28 鸿运华宁（杭州）生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
CN119613548A (zh) 2018-06-13 2025-03-14 鸿运华宁（杭州）生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质，以及其药物组合物和应用
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
CN113271943A (zh) 2018-11-26 2021-08-17 比奥基内生物科学协会合作研究中心 用于诊断和/或治疗急性或慢性肝、肾或肺病的方法
EP3674421A1 (de) 2018-12-28 2020-07-01 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
JP2022531113A (ja) 2019-04-30 2022-07-06 ギガジェン，インコーポレイティッド 組換えポリクローナルタンパク質およびその使用方法
CN112239507A (zh) 2019-07-17 2021-01-19 鸿运华宁（杭州）生物医药有限公司 ETA抗体与TGF-β Trap的融合蛋白质，以及其药物组合物和应用
CN112521501A (zh) 2019-09-18 2021-03-19 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
MX2022006787A (es) 2019-12-05 2022-07-19 Sorrento Therapeutics Inc Composiciones y metodos que comprenden un anticuerpo anti-cd47 en combinacion con un anticuerpo dirigido al tumor.
CN115485300A (zh) 2020-02-26 2022-12-16 索伦托药业有限公司 具有通用掩蔽部分的可活化的抗原结合蛋白
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
MX2022013296A (es) 2020-04-24 2022-12-13 Sorrento Therapeutics Inc Dispositivo de flujo lateral para deteccion anticuerpos neutralizantes contra sars-cov-2.
WO2021217083A1 (en) 2020-04-24 2021-10-28 Sorrento Therapeutics, Inc. Memory dimeric antigen receptors
CA3177152A1 (en) 2020-06-12 2021-12-16 David Scott Johnson Recombinant polyclonal proteins targeting covid-19 and methods of use thereof
WO2021263166A1 (en) 2020-06-26 2021-12-30 Sorrento Therapeutics, Inc. Anti-pd1 antibodies and uses thereof
WO2022003146A1 (en) 2020-07-03 2022-01-06 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Methods for predicting the risk of local invasion and/or metastasis induced by an antiangiogenic treatment
WO2022031834A1 (en) 2020-08-05 2022-02-10 Gigagen, Inc. Recombinant polyclonal proteins targeting zika and methods of use thereof
TW202233660A (zh) 2020-10-30 2022-09-01 美商安進公司 過表現胰島素樣生長因子受體突變體以調節ｉｇｆ補充
CN117280211A (zh) 2020-11-04 2023-12-22 索伦托药业有限公司 用于冠状病毒感染的高灵敏度检测的侧向流动装置及其制造和使用方法
WO2022192594A2 (en) 2021-03-11 2022-09-15 Sorrento Therapeutics, Inc. Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease
CN115141276A (zh) 2021-03-31 2022-10-04 鸿运华宁（杭州）生物医药有限公司 一种能与人内皮素受体特异性结合的抗体及其在糖尿病肾病和慢性肾病治疗中的应用
CA3221925A1 (en) 2021-06-09 2022-12-15 Sorrento Therapeutics, Inc. Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device
TW202328442A (zh) 2021-09-10 2023-07-16 美商安進公司 平臺宿主對ｉｇｆ—培養基之適應
JP2025531814A (ja) 2022-09-08 2025-09-25 ジーマックス バイオファーム エルエルシー Ｇｉｐｒ抗体、ｆｇｆ２１との融合タンパク質、その医薬組成物及びその使用
EP4743560A1 (de) 2023-07-11 2026-05-20 Amgen Inc Alternierende rezirkulierende tangentialflussfilterung (artf) für zellkulturmedienperfusion und bioreaktorernte
KR20260042226A (ko) 2023-07-21 2026-03-30 암젠 인크 선택 가능한 마커 발현을 유도하는 프로모터의 조합을 포함하는 벡터
TW202515895A (zh) 2023-08-15 2025-04-16 美商吉加根公司 靶向ｂ型肝炎病毒（ｈｂｖ）之重組多株蛋白及其使用方法
IL327356A (en) 2023-10-18 2026-05-01 Amgen Inc Quantitative assessment of mRNA transcript levels using DDPCR for initial pool characterization and evaluation of single-cell clones in the cell line development process
WO2025129128A1 (en) 2023-12-15 2025-06-19 Vivasor, Inc. Compositions and methods for non-viral delivery of therapeutic compounds
WO2025155774A2 (en) 2024-01-19 2025-07-24 Amgen Inc. Vector engineering strategies to enhance volumetric productivity and decrease impurity formation across a diverse set of modalities
TW202546234A (zh) 2024-01-19 2025-12-01 美商安進公司 具有兩個輕鏈拷貝的表現載體系統
WO2025184493A1 (en) 2024-02-29 2025-09-04 Amgen Inc. Dual selection expression vector systems for multi-chain biologics
WO2026019782A2 (en) 2024-07-16 2026-01-22 Amgen Inc. Methods for reducing filter fouling in perfusion cell cultures with recirculating tangential flow filtration
WO2026024904A1 (en) 2024-07-24 2026-01-29 Gigagen, Inc. Custom recombinant polyclonal proteins and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US31006A (en) 1861-01-01 Feeding mechanism for spoke-machines
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
ES2155822T3 (es) 1990-12-06 2001-06-01 Affymetrix Inc Compuestos y su utilizacion en una estrategia de sintesis binaria.
US5326691A (en) 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
DE4237113B4 (de) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
US5516637A (en) * 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5736388A (en) * 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
CA2319828A1 (en) * 1998-01-29 1999-08-05 Miller, Samuel High density arrays for proteome analysis and methods and compositions therefor
WO1999041383A1 (en) * 1998-02-11 1999-08-19 Maxygen, Inc. Antigen library immunization

Also Published As

Publication number Publication date
US20030039958A1 (en) 2003-02-27
EP2000804A2 (de) 2008-12-10
DK1242821T3 (da) 2008-06-09
JP2003515745A (ja) 2003-05-07
EP1242821A1 (de) 2002-09-25
GB9928787D0 (en) 2000-02-02
PT1242821E (pt) 2008-07-14
AU1541701A (en) 2001-06-12
WO2001040803A1 (en) 2001-06-07
DE60038124T2 (de) 2009-02-12
EP1242821B1 (de) 2008-02-20
NO20022312L (no) 2002-06-03
EP2000804A3 (de) 2009-06-03
DE60038124D1 (de) 2008-04-03
NO20022312D0 (no) 2002-05-15
EP1242821B8 (de) 2008-05-28
ES2300279T3 (es) 2008-06-16
CA2392981A1 (en) 2001-06-07

Similar Documents

Publication Publication Date Title
DK1242821T3 (da) Direkte screeningsfremgangmåde
Nikolaiev et al. Peptide-encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested on solid-phase supports.
WO2005108615A3 (en) Nucleic-acid programmable protein arrays
JP2021501577A5 (de)
Szostak Introduction: combinatorial chemistry
DE60335000D1 (de) In vitro peptid-expressionsbank
CA2353868A1 (en) Composite arrays utilizing microspheres
DK0859841T3 (da) Protein/(poly)peptidbiblioteker
CA2310267A1 (en) Rapid screening assay methods and devices
ATE395137T1 (de) Individuell addressierbarer mikro- elektromagnetischer einheitsmatrix-chip
DK1297338T3 (da) Mikroopstillinger til udförelse af proteomikanalyser
US20200064354A1 (en) Systems and methods for high throughput analysis of conformation in biological entities
Campbell et al. Use of a novel micro-fluidic device to create arrays for multiplex analysis of large and small molecular weight compounds by surface plasmon resonance
ATE311443T1 (de) Methoden zur durchforstung (screenen) von proteinen
Chin et al. Magic angle spinning NMR for reaction monitoring and structure determination of molecules attached to multipin crowns
KR100470825B1 (ko) 치료제로서의 엔티티 조합의 동정 방법
Elia et al. Affinity-capture reagents for protein arrays
WO2002066984A8 (en) Arrays for determining binding of biomolecules
Hwang et al. OBOC small-molecule combinatorial library encoded by halogenated mass-tags
DK0774116T3 (da) Fremgangsmåde til screening af biblioteker af forbindelser
Seitz et al. Enzymatic cross-linking of purple membranes catalyzed by bacterial transglutaminase
DE602006011350D1 (de) In situ protein mikroarray zusammenbau
KR100953558B1 (ko) 표면 플라즈몬 공명을 이용한 ｐｓ-ｓｐｃｌ 탐색 장치 및방법
PL2282206T3 (pl) Metoda i urządzenie do równoległego oznaczania kilku analitów z kontrolą wewnętrzną
Seneci Encoding techniques for pool libraries of small organic molecules

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1242821

Country of ref document: EP