ATE387219T1 - Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysacchariden - Google Patents
Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysaccharidenInfo
- Publication number
- ATE387219T1 ATE387219T1 AT02808078T AT02808078T ATE387219T1 AT E387219 T1 ATE387219 T1 AT E387219T1 AT 02808078 T AT02808078 T AT 02808078T AT 02808078 T AT02808078 T AT 02808078T AT E387219 T1 ATE387219 T1 AT E387219T1
- Authority
- AT
- Austria
- Prior art keywords
- dna fragments
- chromosomal dna
- immuno
- stimulating
- bacterial chromosomal
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 239000013611 chromosomal DNA Substances 0.000 title abstract 2
- 239000002158 endotoxin Substances 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 title abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 title abstract 2
- 231100000252 nontoxic Toxicity 0.000 title abstract 2
- 230000003000 nontoxic effect Effects 0.000 title abstract 2
- 230000004957 immunoregulator effect Effects 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2002-0028505A KR100456681B1 (ko) | 2002-05-22 | 2002-05-22 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE387219T1 true ATE387219T1 (de) | 2008-03-15 |
Family
ID=36697647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02808078T ATE387219T1 (de) | 2002-05-22 | 2002-09-26 | Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysacchariden |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7507802B2 (de) |
| EP (1) | EP1507560B1 (de) |
| JP (1) | JP2006506399A (de) |
| KR (1) | KR100456681B1 (de) |
| CN (1) | CN100344329C (de) |
| AT (1) | ATE387219T1 (de) |
| AU (1) | AU2002335560A1 (de) |
| DE (1) | DE60225349T2 (de) |
| ES (1) | ES2303568T3 (de) |
| WO (1) | WO2004039413A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| JP4836145B2 (ja) * | 2005-01-28 | 2011-12-14 | クウォン,ヒュン−ジョ | マイコバクテリアに由来する、免疫機能刺激用、免疫疾患治療用、アトピー性皮膚炎治療用および/または正常免疫細胞保護用オリゴヌクレオチド |
| KR100740237B1 (ko) * | 2005-05-10 | 2007-07-18 | 아이진 주식회사 | 올리고뉴클레오타이드 및 비독성 다당체를 포함하는면역보조제 |
| WO2007089051A1 (en) * | 2006-02-01 | 2007-08-09 | Eyegene Inc. | Composition for treating cancer comprising oligonucleotide and non-toxic lps |
| JP2010511408A (ja) * | 2006-12-04 | 2010-04-15 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 癌をCpGリッチDNAおよびキュプレドキシンで治療するための組成物および方法 |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| CN103800906B (zh) | 2009-03-25 | 2017-09-22 | 德克萨斯大学系统董事会 | 用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物 |
| CN104288763B (zh) * | 2009-06-19 | 2018-03-06 | 艾金株式会社 | 宫颈癌疫苗 |
| KR20120068647A (ko) * | 2010-12-18 | 2012-06-27 | 아이진 주식회사 | 개선된 면역반응을 유도하는 백신 |
| KR101452830B1 (ko) | 2012-04-06 | 2014-10-21 | 아이진 주식회사 | 두 가지 항암물질을 동시에 제공하는 대장균 균주 |
| UA130246C2 (uk) | 2013-09-19 | 2025-12-31 | Зоетіс Сервісіз Ллс | Ад'ювант на основі олії |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| CN115317600A (zh) | 2015-01-16 | 2022-11-11 | 硕腾服务有限责任公司 | 口蹄疫疫苗 |
| JP6189402B2 (ja) * | 2015-12-04 | 2017-08-30 | 三井農林株式会社 | 顆粒状ココア |
| KR102042993B1 (ko) * | 2016-10-31 | 2019-11-11 | 아이진 주식회사 | 면역반응 조절물질 및 이를 포함하는 면역보조제 조성물 |
| US10874733B2 (en) | 2016-10-31 | 2020-12-29 | Eyegene Inc. | Composition for enhancing immunity comprising immune modulator and cationic liposome, and use of same |
| US10918709B2 (en) | 2016-10-31 | 2021-02-16 | Eyegene Inc. | Immune modulator and vaccine composition containing the same |
| CN120988950B (zh) * | 2025-10-27 | 2026-03-06 | 中国科学院杭州医学研究所 | 一种肿瘤抑制性大肠杆菌18及其用途 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US86067A (en) * | 1869-01-19 | Improvement in piston steam-valves | ||
| US9774A (en) * | 1853-06-07 | Machine for boring rock | ||
| US71571A (en) * | 1867-12-03 | pieeke | ||
| US62262A (en) * | 1867-02-19 | freylinghousen | ||
| US98680A (en) * | 1870-01-11 | Improvement in vapor-burners | ||
| US12026A (en) * | 1854-12-05 | Machibtb for rounding the backs op books | ||
| US71150A (en) * | 1867-11-19 | Improvement in holders foe lamp and gas-shades | ||
| US64515A (en) * | 1867-05-07 | Impeovemeit | ||
| US91079A (en) * | 1869-06-08 | Improvement in device for operating throttle-valves | ||
| US53880A (en) * | 1866-04-10 | Fire-place | ||
| US32685A (en) * | 1861-07-02 | Improvement in fire-arms | ||
| US52656A (en) * | 1866-02-13 | Improvement in the manufacture of iron | ||
| US67905A (en) * | 1867-08-20 | Improved tbayelling-trum | ||
| US92472A (en) * | 1869-07-13 | Improvement in umbrella-frames | ||
| US50263A (en) * | 1865-10-03 | Improved blasting-plug | ||
| US43112A (en) * | 1864-06-14 | Improvement in artificial fuel | ||
| US98688A (en) * | 1870-01-11 | Improvement in globe-valves | ||
| US527A (en) * | 1837-12-20 | Machine for | ||
| US62258A (en) * | 1867-02-19 | Improvement in boileimpeeders | ||
| US26782A (en) * | 1860-01-10 | Washbuen race | ||
| US44416A (en) * | 1864-09-27 | Improvement in bodkins for passing enlarged shanks of buttons through cloth | ||
| US24010A (en) * | 1859-05-17 | Drawing-head foe | ||
| US91599A (en) * | 1869-06-22 | Improvement in low-water indicators | ||
| US52657A (en) * | 1866-02-20 | Improved head-block for holding boots and shoes | ||
| US6568A (en) * | 1849-07-03 | Machinery fob jointing staves | ||
| US29835A (en) * | 1860-08-28 | Surveyor s instrument | ||
| US42469A (en) * | 1864-04-26 | Improved apparatus for vaporizing hydrocarbon liquids for illuminating | ||
| US67089A (en) * | 1867-07-23 | Photo-litho | ||
| US47468A (en) * | 1865-04-25 | Improvement in corn-planters | ||
| US81045A (en) * | 1868-08-11 | Improvement in harvester-rakes | ||
| US52649A (en) * | 1866-02-13 | Improvement in hinges | ||
| US87534A (en) * | 1869-03-09 | Improvement in feather-renovators | ||
| US87538A (en) * | 1869-03-09 | Improvement in steam-engine rotary valves | ||
| US4062A (en) * | 1845-05-29 | Walter hunt | ||
| US4061A (en) * | 1845-05-24 | Spring-saddle | ||
| US64341A (en) * | 1867-04-30 | Improvement in plane-ieons | ||
| US9949A (en) * | 1853-08-16 | Boat or scow | ||
| US50261A (en) * | 1865-10-03 | Improvement in umbrella-holders | ||
| US4454119A (en) * | 1981-06-29 | 1984-06-12 | Mitsubishi Chemical Industries Limited | Therapeutic agents |
| US4818817A (en) * | 1983-11-30 | 1989-04-04 | Petroleum Fermentations N.V. | Enzymatic degradation of lipopolysaccharide bioemulsifiers |
| US4929604A (en) | 1986-05-28 | 1990-05-29 | Board Of Regents, The University Of Texas System | Lipopolysaccharides of reduced toxicity and the production thereof |
| US5158939A (en) | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
| EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1167379A3 (de) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatorische Oligonukleotide |
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US20030050263A1 (en) | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| GB2325233B (en) | 1997-05-16 | 2001-07-18 | Norsk Hydro As | Substrates having bound polysaccharides and bacterial nucleic acids |
| EP1003531B1 (de) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
| US6368604B1 (en) | 1997-09-26 | 2002-04-09 | University Of Maryland Biotechnology Institute | Non-pyrogenic derivatives of lipid A |
| AU760549B2 (en) | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| NZ517929A (en) | 1999-09-25 | 2004-02-27 | Univ Iowa Res Found | Immunostimulatory nucleic acids |
| US20010044416A1 (en) | 2000-01-20 | 2001-11-22 | Mccluskie Michael J. | Immunostimulatory nucleic acids for inducing a Th2 immune response |
| AU2002244337B2 (en) | 2000-10-18 | 2005-08-11 | Glaxosmithkline Biologicals S.A. | Vaccines |
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| US20040009949A1 (en) | 2002-06-05 | 2004-01-15 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids |
| US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7576066B2 (en) | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| CA2502015A1 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
-
2002
- 2002-05-22 KR KR10-2002-0028505A patent/KR100456681B1/ko not_active Expired - Lifetime
- 2002-09-26 AU AU2002335560A patent/AU2002335560A1/en not_active Abandoned
- 2002-09-26 AT AT02808078T patent/ATE387219T1/de not_active IP Right Cessation
- 2002-09-26 JP JP2004548113A patent/JP2006506399A/ja active Pending
- 2002-09-26 DE DE60225349T patent/DE60225349T2/de not_active Expired - Lifetime
- 2002-09-26 CN CNB028290097A patent/CN100344329C/zh not_active Expired - Lifetime
- 2002-09-26 EP EP02808078A patent/EP1507560B1/de not_active Expired - Lifetime
- 2002-09-26 ES ES02808078T patent/ES2303568T3/es not_active Expired - Lifetime
- 2002-09-26 WO PCT/KR2002/001813 patent/WO2004039413A1/en not_active Ceased
- 2002-09-26 US US10/515,353 patent/US7507802B2/en not_active Expired - Lifetime
-
2006
- 2006-03-24 US US11/389,357 patent/US8883987B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1507560A4 (de) | 2005-08-10 |
| AU2002335560A1 (en) | 2004-05-25 |
| EP1507560B1 (de) | 2008-02-27 |
| EP1507560A1 (de) | 2005-02-23 |
| AU2002335560A8 (en) | 2004-05-25 |
| JP2006506399A (ja) | 2006-02-23 |
| US20050163806A1 (en) | 2005-07-28 |
| KR20030090897A (ko) | 2003-12-01 |
| WO2004039413A1 (en) | 2004-05-13 |
| CN1627960A (zh) | 2005-06-15 |
| US8883987B2 (en) | 2014-11-11 |
| DE60225349T2 (de) | 2009-03-12 |
| KR100456681B1 (ko) | 2004-11-10 |
| US7507802B2 (en) | 2009-03-24 |
| DE60225349D1 (de) | 2008-04-10 |
| US20060166923A1 (en) | 2006-07-27 |
| ES2303568T3 (es) | 2008-08-16 |
| CN100344329C (zh) | 2007-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |