ATE387219T1 - Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysacchariden - Google Patents

Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysacchariden

Info

Publication number
ATE387219T1
ATE387219T1 AT02808078T AT02808078T ATE387219T1 AT E387219 T1 ATE387219 T1 AT E387219T1 AT 02808078 T AT02808078 T AT 02808078T AT 02808078 T AT02808078 T AT 02808078T AT E387219 T1 ATE387219 T1 AT E387219T1
Authority
AT
Austria
Prior art keywords
dna fragments
chromosomal dna
immuno
stimulating
bacterial chromosomal
Prior art date
Application number
AT02808078T
Other languages
English (en)
Inventor
Bo Young Ahn
Yang Je Cho
Won Il Yoo
Sung Ho Lee
Hye Ran Park
Dong Hyun Lee
Na-Gyong Lee
Doo Sik Kim
Original Assignee
Eyegene Inc
Daewoong Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eyegene Inc, Daewoong Co Ltd filed Critical Eyegene Inc
Application granted granted Critical
Publication of ATE387219T1 publication Critical patent/ATE387219T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739Lipopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02808078T 2002-05-22 2002-09-26 Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysacchariden ATE387219T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2002-0028505A KR100456681B1 (ko) 2002-05-22 2002-05-22 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물

Publications (1)

Publication Number Publication Date
ATE387219T1 true ATE387219T1 (de) 2008-03-15

Family

ID=36697647

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02808078T ATE387219T1 (de) 2002-05-22 2002-09-26 Immunstimulierende und regulierende zusammensetzung mit bakteriellen chromosomalen dna-fragmenten und nichttoxischen lipopolysacchariden

Country Status (10)

Country Link
US (2) US7507802B2 (de)
EP (1) EP1507560B1 (de)
JP (1) JP2006506399A (de)
KR (1) KR100456681B1 (de)
CN (1) CN100344329C (de)
AT (1) ATE387219T1 (de)
AU (1) AU2002335560A1 (de)
DE (1) DE60225349T2 (de)
ES (1) ES2303568T3 (de)
WO (1) WO2004039413A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100456681B1 (ko) 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
JP4836145B2 (ja) * 2005-01-28 2011-12-14 クウォン,ヒュン−ジョ マイコバクテリアに由来する、免疫機能刺激用、免疫疾患治療用、アトピー性皮膚炎治療用および/または正常免疫細胞保護用オリゴヌクレオチド
KR100740237B1 (ko) * 2005-05-10 2007-07-18 아이진 주식회사 올리고뉴클레오타이드 및 비독성 다당체를 포함하는면역보조제
WO2007089051A1 (en) * 2006-02-01 2007-08-09 Eyegene Inc. Composition for treating cancer comprising oligonucleotide and non-toxic lps
JP2010511408A (ja) * 2006-12-04 2010-04-15 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 癌をCpGリッチDNAおよびキュプレドキシンで治療するための組成物および方法
ES2569907T3 (es) 2008-06-27 2016-05-13 Zoetis Services Llc Composiciones adyuvantes novedosas
CN103800906B (zh) 2009-03-25 2017-09-22 德克萨斯大学系统董事会 用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物
CN104288763B (zh) * 2009-06-19 2018-03-06 艾金株式会社 宫颈癌疫苗
KR20120068647A (ko) * 2010-12-18 2012-06-27 아이진 주식회사 개선된 면역반응을 유도하는 백신
KR101452830B1 (ko) 2012-04-06 2014-10-21 아이진 주식회사 두 가지 항암물질을 동시에 제공하는 대장균 균주
UA130246C2 (uk) 2013-09-19 2025-12-31 Зоетіс Сервісіз Ллс Ад'ювант на основі олії
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
CN115317600A (zh) 2015-01-16 2022-11-11 硕腾服务有限责任公司 口蹄疫疫苗
JP6189402B2 (ja) * 2015-12-04 2017-08-30 三井農林株式会社 顆粒状ココア
KR102042993B1 (ko) * 2016-10-31 2019-11-11 아이진 주식회사 면역반응 조절물질 및 이를 포함하는 면역보조제 조성물
US10874733B2 (en) 2016-10-31 2020-12-29 Eyegene Inc. Composition for enhancing immunity comprising immune modulator and cationic liposome, and use of same
US10918709B2 (en) 2016-10-31 2021-02-16 Eyegene Inc. Immune modulator and vaccine composition containing the same
CN120988950B (zh) * 2025-10-27 2026-03-06 中国科学院杭州医学研究所 一种肿瘤抑制性大肠杆菌18及其用途

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US86067A (en) * 1869-01-19 Improvement in piston steam-valves
US9774A (en) * 1853-06-07 Machine for boring rock
US71571A (en) * 1867-12-03 pieeke
US62262A (en) * 1867-02-19 freylinghousen
US98680A (en) * 1870-01-11 Improvement in vapor-burners
US12026A (en) * 1854-12-05 Machibtb for rounding the backs op books
US71150A (en) * 1867-11-19 Improvement in holders foe lamp and gas-shades
US64515A (en) * 1867-05-07 Impeovemeit
US91079A (en) * 1869-06-08 Improvement in device for operating throttle-valves
US53880A (en) * 1866-04-10 Fire-place
US32685A (en) * 1861-07-02 Improvement in fire-arms
US52656A (en) * 1866-02-13 Improvement in the manufacture of iron
US67905A (en) * 1867-08-20 Improved tbayelling-trum
US92472A (en) * 1869-07-13 Improvement in umbrella-frames
US50263A (en) * 1865-10-03 Improved blasting-plug
US43112A (en) * 1864-06-14 Improvement in artificial fuel
US98688A (en) * 1870-01-11 Improvement in globe-valves
US527A (en) * 1837-12-20 Machine for
US62258A (en) * 1867-02-19 Improvement in boileimpeeders
US26782A (en) * 1860-01-10 Washbuen race
US44416A (en) * 1864-09-27 Improvement in bodkins for passing enlarged shanks of buttons through cloth
US24010A (en) * 1859-05-17 Drawing-head foe
US91599A (en) * 1869-06-22 Improvement in low-water indicators
US52657A (en) * 1866-02-20 Improved head-block for holding boots and shoes
US6568A (en) * 1849-07-03 Machinery fob jointing staves
US29835A (en) * 1860-08-28 Surveyor s instrument
US42469A (en) * 1864-04-26 Improved apparatus for vaporizing hydrocarbon liquids for illuminating
US67089A (en) * 1867-07-23 Photo-litho
US47468A (en) * 1865-04-25 Improvement in corn-planters
US81045A (en) * 1868-08-11 Improvement in harvester-rakes
US52649A (en) * 1866-02-13 Improvement in hinges
US87534A (en) * 1869-03-09 Improvement in feather-renovators
US87538A (en) * 1869-03-09 Improvement in steam-engine rotary valves
US4062A (en) * 1845-05-29 Walter hunt
US4061A (en) * 1845-05-24 Spring-saddle
US64341A (en) * 1867-04-30 Improvement in plane-ieons
US9949A (en) * 1853-08-16 Boat or scow
US50261A (en) * 1865-10-03 Improvement in umbrella-holders
US4454119A (en) * 1981-06-29 1984-06-12 Mitsubishi Chemical Industries Limited Therapeutic agents
US4818817A (en) * 1983-11-30 1989-04-04 Petroleum Fermentations N.V. Enzymatic degradation of lipopolysaccharide bioemulsifiers
US4929604A (en) 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
US5158939A (en) 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
EP1167379A3 (de) 1994-07-15 2004-09-08 University Of Iowa Research Foundation Immunomodulatorische Oligonukleotide
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US20030050263A1 (en) 1994-07-15 2003-03-13 The University Of Iowa Research Foundation Methods and products for treating HIV infection
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6426334B1 (en) 1997-04-30 2002-07-30 Hybridon, Inc. Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
GB2325233B (en) 1997-05-16 2001-07-18 Norsk Hydro As Substrates having bound polysaccharides and bacterial nucleic acids
EP1003531B1 (de) 1997-05-20 2007-08-22 Ottawa Health Research Institute Verfahren zur Herstellung von Nukleinsäurekonstrukten
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
AU760549B2 (en) 1998-04-03 2003-05-15 University Of Iowa Research Foundation, The Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
NZ517929A (en) 1999-09-25 2004-02-27 Univ Iowa Res Found Immunostimulatory nucleic acids
US20010044416A1 (en) 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
AU2002244337B2 (en) 2000-10-18 2005-08-11 Glaxosmithkline Biologicals S.A. Vaccines
KR100456681B1 (ko) 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
US20040009949A1 (en) 2002-06-05 2004-01-15 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
CA2502015A1 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5' cpg nucleic acids and methods of use

Also Published As

Publication number Publication date
EP1507560A4 (de) 2005-08-10
AU2002335560A1 (en) 2004-05-25
EP1507560B1 (de) 2008-02-27
EP1507560A1 (de) 2005-02-23
AU2002335560A8 (en) 2004-05-25
JP2006506399A (ja) 2006-02-23
US20050163806A1 (en) 2005-07-28
KR20030090897A (ko) 2003-12-01
WO2004039413A1 (en) 2004-05-13
CN1627960A (zh) 2005-06-15
US8883987B2 (en) 2014-11-11
DE60225349T2 (de) 2009-03-12
KR100456681B1 (ko) 2004-11-10
US7507802B2 (en) 2009-03-24
DE60225349D1 (de) 2008-04-10
US20060166923A1 (en) 2006-07-27
ES2303568T3 (es) 2008-08-16
CN100344329C (zh) 2007-10-24

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