ATE387459T1 - Verbindungen und methoden zur senkung des cholesterinspiegels ohne induktion von hypertriglyceridämie - Google Patents
Verbindungen und methoden zur senkung des cholesterinspiegels ohne induktion von hypertriglyceridämieInfo
- Publication number
- ATE387459T1 ATE387459T1 AT01926716T AT01926716T ATE387459T1 AT E387459 T1 ATE387459 T1 AT E387459T1 AT 01926716 T AT01926716 T AT 01926716T AT 01926716 T AT01926716 T AT 01926716T AT E387459 T1 ATE387459 T1 AT E387459T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compounds
- lowering cholesterol
- cholesterol levels
- inducing hypertriglyceridemia
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 5
- 208000006575 hypertriglyceridemia Diseases 0.000 title abstract 3
- 230000001939 inductive effect Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 2
- 101150037123 APOE gene Proteins 0.000 abstract 1
- 101100216294 Danio rerio apoeb gene Proteins 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54438600A | 2000-04-06 | 2000-04-06 | |
| US67908800A | 2000-10-04 | 2000-10-04 | |
| US09/827,854 US20020123093A1 (en) | 2000-04-06 | 2001-04-05 | Compounds and methods for lowering cholesterol levels without inducing hypertrigylceridemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE387459T1 true ATE387459T1 (de) | 2008-03-15 |
Family
ID=27415432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01926716T ATE387459T1 (de) | 2000-04-06 | 2001-04-06 | Verbindungen und methoden zur senkung des cholesterinspiegels ohne induktion von hypertriglyceridämie |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060142200A1 (de) |
| EP (1) | EP1274717B1 (de) |
| JP (1) | JP2003530835A (de) |
| AT (1) | ATE387459T1 (de) |
| AU (2) | AU2001253233B2 (de) |
| CA (1) | CA2405870A1 (de) |
| MX (1) | MXPA02009804A (de) |
| NO (1) | NO20024769L (de) |
| WO (1) | WO2001077136A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675072A (zh) * | 2006-12-13 | 2010-03-17 | 加利福尼亚大学董事会 | 胆固醇流出的有效和选择性的介质 |
| EP3842514A1 (de) * | 2014-09-12 | 2021-06-30 | Whitehead Institute for Biomedical Research | Zellen zur expression von apolipoprotein e und verwendungen davon |
| WO2019070891A1 (en) | 2017-10-03 | 2019-04-11 | Prevail Therapeutics, Inc. | GENE THERAPIES FOR LYSOSOMAL DISORDERS |
| WO2019070894A1 (en) | 2017-10-03 | 2019-04-11 | Prevail Therapeutics, Inc. | GENE THERAPIES FOR LYSOSOMIAL DISORDERS |
| JP7616995B2 (ja) * | 2018-11-28 | 2025-01-17 | プリベイル セラピューティクス，インコーポレーテッド | 神経変性疾患のための遺伝子治療 |
| IL303156A (en) * | 2020-11-25 | 2023-07-01 | Prevail Therapeutics Inc | Gene therapies for neurodegenerative disease |
| WO2025144884A1 (en) * | 2023-12-26 | 2025-07-03 | Kisbee Therapeutics, Inc. | Apoe lipoprotein mimetics and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE404683T1 (de) * | 1992-09-25 | 2008-08-15 | Aventis Pharma Sa | Adenovirus vektoren für die übertragung fremder gene in zellen des zentralen nervensystems, insbesondere im gehirn |
| WO1994027612A1 (en) * | 1993-05-20 | 1994-12-08 | Baylor College Of Medicine | Genetic therapy for cardiovascular disease |
| US5811243A (en) * | 1993-08-31 | 1998-09-22 | Duke University | Methods and compositions for binding tau and MAP2c proteins |
| US5958684A (en) * | 1995-10-02 | 1999-09-28 | Van Leeuwen; Frederik Willem | Diagnosis of neurodegenerative disease |
-
2001
- 2001-04-06 CA CA002405870A patent/CA2405870A1/en not_active Abandoned
- 2001-04-06 MX MXPA02009804A patent/MXPA02009804A/es active IP Right Grant
- 2001-04-06 JP JP2001575606A patent/JP2003530835A/ja not_active Withdrawn
- 2001-04-06 EP EP01926716A patent/EP1274717B1/de not_active Expired - Lifetime
- 2001-04-06 WO PCT/US2001/011358 patent/WO2001077136A1/en not_active Ceased
- 2001-04-06 AT AT01926716T patent/ATE387459T1/de not_active IP Right Cessation
- 2001-04-06 AU AU2001253233A patent/AU2001253233B2/en not_active Ceased
- 2001-04-06 AU AU5323301A patent/AU5323301A/xx active Pending
-
2002
- 2002-10-03 NO NO20024769A patent/NO20024769L/no not_active Application Discontinuation
-
2006
- 2006-02-24 US US11/361,788 patent/US20060142200A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02009804A (es) | 2003-07-14 |
| AU5323301A (en) | 2001-10-23 |
| AU2001253233B2 (en) | 2006-12-07 |
| EP1274717A1 (de) | 2003-01-15 |
| NO20024769L (no) | 2002-11-26 |
| US20060142200A1 (en) | 2006-06-29 |
| EP1274717B1 (de) | 2008-02-27 |
| EP1274717A4 (de) | 2004-07-14 |
| JP2003530835A (ja) | 2003-10-21 |
| NO20024769D0 (no) | 2002-10-03 |
| WO2001077136A1 (en) | 2001-10-18 |
| CA2405870A1 (en) | 2001-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |