ATE407925T1 - 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen - Google Patents

1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen

Info

Publication number
ATE407925T1
ATE407925T1 AT04800640T AT04800640T ATE407925T1 AT E407925 T1 ATE407925 T1 AT E407925T1 AT 04800640 T AT04800640 T AT 04800640T AT 04800640 T AT04800640 T AT 04800640T AT E407925 T1 ATE407925 T1 AT E407925T1
Authority
AT
Austria
Prior art keywords
compounds
myhc
methods
dihydropyridine
cardiovascular diseases
Prior art date
Application number
AT04800640T
Other languages
English (en)
Inventor
Kathy Schreiber
Larry Melvin
Original Assignee
Myogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myogen Inc filed Critical Myogen Inc
Application granted granted Critical
Publication of ATE407925T1 publication Critical patent/ATE407925T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04800640T 2003-11-03 2004-11-03 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen ATE407925T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51682803P 2003-11-03 2003-11-03

Publications (1)

Publication Number Publication Date
ATE407925T1 true ATE407925T1 (de) 2008-09-15

Family

ID=34549573

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04800640T ATE407925T1 (de) 2003-11-03 2004-11-03 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen

Country Status (9)

Country Link
US (1) US7485653B2 (de)
EP (1) EP1685107B1 (de)
JP (1) JP2007510727A (de)
AT (1) ATE407925T1 (de)
AU (1) AU2004285961A1 (de)
CA (1) CA2544763A1 (de)
DE (1) DE602004016547D1 (de)
IL (1) IL175358A0 (de)
WO (1) WO2005042486A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110015246A2 (en) * 2005-03-14 2011-01-20 Agean Llc Lofexidine enantiomers for use as a treatment for cns disease and pathologies and its chiral synthesis
EP1962840A1 (de) * 2005-12-20 2008-09-03 Gilead Colorado, Inc. Verwendung von 4, 7-dihydrothien-[2, 3-b]pyridin-verbindungen bei der behandlung von herzgefässkrankheiten
WO2008022038A1 (en) 2006-08-10 2008-02-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure
US20100291160A1 (en) * 2009-05-13 2010-11-18 Carver David R Pharmaceutical system for trans-membrane delivery
AU2011224241B2 (en) 2010-03-10 2014-05-08 Sri International The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920225A (en) 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
TW215434B (de) 1992-03-07 1993-11-01 Hoechst Ag
JP2002514199A (ja) 1997-02-04 2002-05-14 ブリストル−マイヤーズ スクイブ カンパニー Ｎｐｙ拮抗剤としてのジヒドロピリミドン誘導体
EP1470108B1 (de) * 2002-01-18 2016-08-24 Vittal Mallya Scientific Research Foundation 1,4-dihydropyridin- und pyridinderivate als calcium-kanal-blocker
EP1496905B1 (de) * 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen

Also Published As

Publication number Publication date
EP1685107B1 (de) 2008-09-10
JP2007510727A (ja) 2007-04-26
IL175358A0 (en) 2006-09-05
WO2005042486A1 (en) 2005-05-12
US20050124633A1 (en) 2005-06-09
US7485653B2 (en) 2009-02-03
EP1685107A1 (de) 2006-08-02
DE602004016547D1 (de) 2008-10-23
AU2004285961A1 (en) 2005-05-12
CA2544763A1 (en) 2005-05-12

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties