ATE387629T1 - Gemeinsame epitope von antigenen aus einer multigen-familie - Google Patents

Gemeinsame epitope von antigenen aus einer multigen-familie

Info

Publication number
ATE387629T1
ATE387629T1 AT03732631T AT03732631T ATE387629T1 AT E387629 T1 ATE387629 T1 AT E387629T1 AT 03732631 T AT03732631 T AT 03732631T AT 03732631 T AT03732631 T AT 03732631T AT E387629 T1 ATE387629 T1 AT E387629T1
Authority
AT
Austria
Prior art keywords
antigens
epitopes
common
common epitopes
amino acids
Prior art date
Application number
AT03732631T
Other languages
English (en)
Inventor
Kostas Kosmatopoulos
Stephanie Graff-Dubois
Original Assignee
Roussy Inst Gustave
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussy Inst Gustave, Inst Nat Sante Rech Med filed Critical Roussy Inst Gustave
Application granted granted Critical
Publication of ATE387629T1 publication Critical patent/ATE387629T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT03732631T 2002-03-28 2003-03-27 Gemeinsame epitope von antigenen aus einer multigen-familie ATE387629T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0203888A FR2837837B1 (fr) 2002-03-28 2002-03-28 Epitopes peptidiques communs a des antigenes d'une meme famille multigenique

Publications (1)

Publication Number Publication Date
ATE387629T1 true ATE387629T1 (de) 2008-03-15

Family

ID=27839271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03732631T ATE387629T1 (de) 2002-03-28 2003-03-27 Gemeinsame epitope von antigenen aus einer multigen-familie

Country Status (10)

Country Link
US (1) US7419669B2 (de)
EP (1) EP1485719B1 (de)
AT (1) ATE387629T1 (de)
AU (1) AU2003239659A1 (de)
CA (1) CA2480696C (de)
DE (1) DE60319350T2 (de)
ES (1) ES2301800T3 (de)
FR (1) FR2837837B1 (de)
PT (1) PT1485719E (de)
WO (1) WO2003083124A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2536735C (en) 2003-09-05 2013-01-22 Genencor International, Inc. Methods for determining cd8+ t-cell epitopes
WO2006120038A2 (en) * 2005-05-09 2006-11-16 Vaxon Biotech Use of native peptides and their optimized derivatives for vaccination
US8110194B2 (en) * 2005-12-07 2012-02-07 Medarex, Inc. CTLA-4 antibody dosage escalation regimens
ES2533228T3 (es) * 2009-06-09 2015-04-08 Vaxon Biotech Identificación, optimización y uso de epítopos compartidos de HLA-B*0702 para inmunoterapia
WO2012054825A1 (en) * 2010-10-22 2012-04-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mage-a3 t cell receptors and related materials and methods of use
WO2013048243A1 (en) 2011-09-29 2013-04-04 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
CA2860914A1 (en) * 2012-01-13 2013-07-18 Apo-T B.V. Aberrant cell-restricted immunoglobulins provided with a toxic moiety
EP3937179A1 (de) 2012-05-21 2022-01-12 Distributed Bio Inc Epitopfokussierung durch variable effektive antigenoberflächenkonzentration
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
JP6255360B2 (ja) * 2015-03-04 2017-12-27 ヴァクソン バイオテックＶａｘｏｎ Ｂｉｏｔｅｃｈ 共有ｈｌａ−ｂ＊０７０２エピトープの同定、最適化および免疫療法のための使用
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
US12390514B2 (en) 2017-03-09 2025-08-19 President And Fellows Of Harvard College Cancer vaccine
EP3592853A1 (de) 2017-03-09 2020-01-15 President and Fellows of Harvard College Unterdrückung von schmerzen durch geneditierung
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
US12406749B2 (en) 2017-12-15 2025-09-02 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
FR3087448B1 (fr) 2018-10-23 2023-10-13 Pdc Line Pharma Lignee pdc modifiee pour secreter une cytokine
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
WO2020191233A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
US12473543B2 (en) 2019-04-17 2025-11-18 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291430B1 (en) * 1997-09-12 2001-09-18 Ludwig Institute For Cancer Research Mage-3 peptides presented by HLA class II molecules
IT1309584B1 (it) * 1999-02-26 2002-01-24 San Raffaele Centro Fond Peptidi immunogenici derivati da mage-3 presentati da mhc di classeii e loro uso.
JP2003517310A (ja) * 1999-12-10 2003-05-27 エピミューン， インコーポレイテッド ペプチドおよび核酸組成物を使用する、ｍａｇｅ２／３に対する細胞性免疫応答の誘導
EP1239866A4 (de) * 1999-12-10 2005-02-09 Epimmune Inc Induzierung von zellulärer immunantwort auf her2/neu mit hilfe von peptid- und neukleinsäurezubereitungen

Also Published As

Publication number Publication date
EP1485719B1 (de) 2008-02-27
WO2003083124A2 (fr) 2003-10-09
US20060263381A1 (en) 2006-11-23
US7419669B2 (en) 2008-09-02
AU2003239659A1 (en) 2003-10-13
FR2837837B1 (fr) 2006-09-29
FR2837837A1 (fr) 2003-10-03
DE60319350D1 (de) 2008-04-10
DE60319350T2 (de) 2009-03-26
WO2003083124A3 (fr) 2004-04-01
CA2480696A1 (fr) 2003-10-09
PT1485719E (pt) 2008-05-02
AU2003239659A8 (en) 2003-10-13
EP1485719A2 (de) 2004-12-15
CA2480696C (fr) 2012-10-16
ES2301800T3 (es) 2008-07-01

Similar Documents

Publication Publication Date Title
ATE387629T1 (de) Gemeinsame epitope von antigenen aus einer multigen-familie
NO20063026L (no) Antistoffer
ATE475675T1 (de) Verwendung prokariotischer pest-ähnlicher peptide zur verstärkung der immunogenität von antigenen
EP2360259A3 (de) Promyostatinpeptide und Methoden für deren Verwendung
NZ606427A (en) Extended recombinant polypeptides and compositions comprising same
EA200870237A1 (ru) Последовательности пептидов и композиции
WO2003070760A3 (en) Anti-amyloid beta antibodies and their use
WO2006076410A3 (en) Li-key/antigenic epitope hybrid peptide vaccines
ATE300616T1 (de) Gnrh-leukotoxin-chimäre
ATE433491T1 (de) Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential
MX340772B (es) Medios y metodos para fabricar neurotoxina altamente pura.
ATE435870T1 (de) Aus ll-37 abgeleiteten peptidinhibitoren von toxinen
CY1111630T1 (el) Παραγωγα κυτοκινων
DK1370284T3 (da) Bakteriofag-medieret immunisering
TW200608990A (en) Cetp-vaccines
TW200505943A (en) Polypeptide
DK1368372T3 (da) Peptid med affinitet til det virale gp120-protein samt anvendelse deraf
ATE543906T1 (de) Antigen von streptococcus aus der b-gruppe
NZ591133A (en) Novel melanoma antigen peptide and uses thereof
SG170092A1 (en) Peptides of regulatory or accessory proteins of hiv, compositions and the utilization thereof
WO2006090090A3 (fr) Epitopes de vih et composition pharmaceutique les contenant
DK1913020T3 (da) Immunogene konstrukter
DK1614690T3 (da) Peptidfragment af LYVE-1 og antistof mod dette
WO2004056316A3 (en) Vaccines against hiv-1 tat protein to generate neutralizing antibodies
WO2010088393A3 (en) Li-kay hybrid peptides that modulate the immune response to influenza

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1485719

Country of ref document: EP