ATE435870T1 - Aus ll-37 abgeleiteten peptidinhibitoren von toxinen - Google Patents

Aus ll-37 abgeleiteten peptidinhibitoren von toxinen

Info

Publication number: ATE435870T1
Authority: AT; Austria
Prior art keywords: terminal part; amino acid; peptide inhibitors; toxins derived; sequence
Prior art date: 2003-01-28

Application number

AT04705556T

Other languages

English (en)

Inventor

Johannes Grote

Jan Drijfhout

Original Assignee

Academisch Ziekenhuis Leiden

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-28

Filing date

2004-01-27

Publication date

2009-07-15

2004-01-27 Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden

2009-07-15 Application granted granted Critical

2009-07-15 Publication of ATE435870T1 publication Critical patent/ATE435870T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
239000003053 toxin Substances 0.000 title 1
231100000765 toxin Toxicity 0.000 title 1
108700012359 toxins Proteins 0.000 title 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 2
210000004899 c-terminal region Anatomy 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
239000000688 bacterial toxin Substances 0.000 abstract 1
239000002158 endotoxin Substances 0.000 abstract 1
229920006008 lipopolysaccharide Polymers 0.000 abstract 1
239000002636 mycotoxin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04705556T 2003-01-28 2004-01-27 Aus ll-37 abgeleiteten peptidinhibitoren von toxinen ATE435870T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03075274		2003-01-28
PCT/NL2004/000060 WO2004067563A1 (en)	2003-01-28	2004-01-27	Peptide inhibitors of toxins derived from ll-37

Publications (1)

Publication Number	Publication Date
ATE435870T1 true ATE435870T1 (de)	2009-07-15

Family

ID=32798944

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04705556T ATE435870T1 (de)	2003-01-28	2004-01-27	Aus ll-37 abgeleiteten peptidinhibitoren von toxinen

Country Status (19)

Country	Link
US (1)	US7807617B2 (de)
EP (1)	EP1587830B1 (de)
JP (1)	JP4471968B2 (de)
KR (1)	KR100856819B1 (de)
CN (1)	CN1798764B (de)
AT (1)	ATE435870T1 (de)
AU (1)	AU2004207118B2 (de)
BR (1)	BRPI0407022A (de)
CA (1)	CA2514584C (de)
CR (1)	CR7926A (de)
DE (1)	DE602004021901D1 (de)
DK (1)	DK1587830T3 (de)
ES (1)	ES2328571T3 (de)
MX (1)	MXPA05008080A (de)
NZ (1)	NZ541657A (de)
PT (1)	PT1587830E (de)
RU (1)	RU2346950C2 (de)
WO (1)	WO2004067563A1 (de)
ZA (1)	ZA200506411B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1621205A1 (de) *	2004-07-28	2006-02-01	OctoPlus Technologies B.V.	CAP18 ähnliche Peptide mit antibiotischer Wirkung
US7465784B2 (en) *	2006-10-26	2008-12-16	Board Of Regents Of The University Of Nebraska	Antimicrobial peptides and methods of identifying the same
WO2009015336A2 (en)	2007-07-25	2009-01-29	Biolex Therapeutics, Inc.	Controlled release interferon drug products and treatment of hcv infection using same
EP2538964A4 (de) *	2010-02-25	2013-07-31	Univ Manitoba	Modulation von cytokininduzierten chronischen entzündungsreaktionen
US10723764B2 (en)	2011-11-21	2020-07-28	Board Of Regents Of The University Of Nebraska	Anti-microbial peptides and methods of use thereof
US9580472B2 (en)	2011-11-21	2017-02-28	Board Of Regents Of The University Of Nebraska	Anti-microbial peptides and methods of use thereof
AR092872A1 (es) *	2012-09-17	2015-05-06	Madrigal Pharmaceuticals Inc	Metodo para sintetizar analogos de la hormona tiroidea y polimorfos de los mismos
BR112017009764A2 (pt)	2014-11-10	2018-02-20	Hoffmann La Roche	anticorpos biespecíficos e métodos de uso em oftalmologia
RU2584089C1 (ru) *	2015-06-15	2016-05-20	Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации	Способ снижения летального эффекта бактериального липополисахарида in vitro
CN105859867A (zh) *	2016-05-30	2016-08-17	黄石市中心医院	一种人源抗菌肽ll-37突变体及其应用
CN108892719B (zh) *	2018-07-09	2021-07-30	珠海中科先进技术研究院有限公司	一种新型人源抗菌肽ll-37衍生物及其应用
WO2021143745A1 (zh) *	2020-01-14	2021-07-22	中国科学院上海药物研究所	一种长效罗哌卡因药物组合物及其制备方法和用途
CN113116811A (zh) *	2020-01-14	2021-07-16	中国科学院上海药物研究所	可注射长效镇痛药物组合物及其制备方法和用途
WO2024223883A1 (en)	2023-04-26	2024-10-31	Karl-Franzens-Universität Graz	Peptides for cancer therapy
WO2024223887A1 (en)	2023-04-26	2024-10-31	Karl-Franzens-Universität Graz	Peptides for antimicrobial therapy
CN118754950B (zh) *	2024-06-07	2025-03-07	扬州大学	一种抗菌衍生肽及其组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6103888A (en) *	1992-07-17	2000-08-15	Panorama Research, Inc.	Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity
US5681824A (en) *	1995-06-05	1997-10-28	Eisai Co., Ltd.	Substituted liposaccharides useful in the treatment and prevention of endotoxemia
JP4037525B2 (ja) *	1998-03-25	2008-01-23	生化学工業株式会社	新規抗菌性ペプチド

2004
- 2004-01-27 MX MXPA05008080A patent/MXPA05008080A/es not_active Application Discontinuation
- 2004-01-27 DE DE602004021901T patent/DE602004021901D1/de not_active Expired - Lifetime
- 2004-01-27 AT AT04705556T patent/ATE435870T1/de active
- 2004-01-27 JP JP2006502728A patent/JP4471968B2/ja not_active Expired - Fee Related
- 2004-01-27 NZ NZ541657A patent/NZ541657A/en not_active IP Right Cessation
- 2004-01-27 US US10/543,521 patent/US7807617B2/en not_active Expired - Fee Related
- 2004-01-27 RU RU2005127076/04A patent/RU2346950C2/ru not_active IP Right Cessation
- 2004-01-27 DK DK04705556T patent/DK1587830T3/da active
- 2004-01-27 PT PT04705556T patent/PT1587830E/pt unknown
- 2004-01-27 CA CA2514584A patent/CA2514584C/en not_active Expired - Fee Related
- 2004-01-27 WO PCT/NL2004/000060 patent/WO2004067563A1/en not_active Ceased
- 2004-01-27 ES ES04705556T patent/ES2328571T3/es not_active Expired - Lifetime
- 2004-01-27 CN CN2004800085269A patent/CN1798764B/zh not_active Expired - Fee Related
- 2004-01-27 EP EP04705556A patent/EP1587830B1/de not_active Expired - Lifetime
- 2004-01-27 KR KR1020057013964A patent/KR100856819B1/ko not_active Expired - Fee Related
- 2004-01-27 BR BR0407022-4A patent/BRPI0407022A/pt not_active IP Right Cessation
- 2004-01-27 AU AU2004207118A patent/AU2004207118B2/en not_active Ceased
2005
- 2005-07-28 CR CR7926A patent/CR7926A/es not_active Application Discontinuation
- 2005-08-11 ZA ZA200506411A patent/ZA200506411B/en unknown

Also Published As

Publication number	Publication date
RU2005127076A (ru)	2006-01-20
JP2007528696A (ja)	2007-10-18
WO2004067563A1 (en)	2004-08-12
BRPI0407022A (pt)	2006-01-10
ES2328571T3 (es)	2009-11-16
WO2004067563A8 (en)	2004-12-02
AU2004207118A1 (en)	2004-08-12
CA2514584C (en)	2012-05-29
US20060223755A1 (en)	2006-10-05
PT1587830E (pt)	2009-09-23
RU2346950C2 (ru)	2009-02-20
DK1587830T3 (da)	2009-10-26
JP4471968B2 (ja)	2010-06-02
US7807617B2 (en)	2010-10-05
KR100856819B1 (ko)	2008-09-05
MXPA05008080A (es)	2006-02-08
HK1088613A1 (zh)	2006-11-10
NZ541657A (en)	2009-01-31
CR7926A (es)	2006-02-07
DE602004021901D1 (de)	2009-08-20
AU2004207118B2 (en)	2009-12-17
EP1587830B1 (de)	2009-07-08
CN1798764B (zh)	2010-05-12
ZA200506411B (en)	2006-04-26
CA2514584A1 (en)	2004-08-12
KR20060012261A (ko)	2006-02-07
EP1587830A1 (de)	2005-10-26
CN1798764A (zh)	2006-07-05

Legal Events

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2010-03-15

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ATE435870T1 (de)	2009-07-15	Aus ll-37 abgeleiteten peptidinhibitoren von toxinen
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