ATE388946T1 - Cyanamide als reversible hemmer von cystein proteasen - Google Patents

Cyanamide als reversible hemmer von cystein proteasen

Info

Publication number
ATE388946T1
ATE388946T1 AT03723865T AT03723865T ATE388946T1 AT E388946 T1 ATE388946 T1 AT E388946T1 AT 03723865 T AT03723865 T AT 03723865T AT 03723865 T AT03723865 T AT 03723865T AT E388946 T1 ATE388946 T1 AT E388946T1
Authority
AT
Austria
Prior art keywords
cyanamide
reversible inhibitor
cystein proteases
cysteine proteases
proteases
Prior art date
Application number
AT03723865T
Other languages
English (en)
Inventor
Weimin Liu
Thomas A Gilmore
E R Hickey
P A Nemoto
D M Spero
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE388946T1 publication Critical patent/ATE388946T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • C07C261/04—Cyanamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT03723865T 2002-04-05 2003-04-01 Cyanamide als reversible hemmer von cystein proteasen ATE388946T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37036802P 2002-04-05 2002-04-05

Publications (1)

Publication Number Publication Date
ATE388946T1 true ATE388946T1 (de) 2008-03-15

Family

ID=29250518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03723865T ATE388946T1 (de) 2002-04-05 2003-04-01 Cyanamide als reversible hemmer von cystein proteasen

Country Status (8)

Country Link
EP (1) EP1495009B1 (de)
JP (1) JP2005522489A (de)
AT (1) ATE388946T1 (de)
AU (1) AU2003230772A1 (de)
CA (1) CA2477692A1 (de)
DE (1) DE60319686T2 (de)
ES (1) ES2301793T3 (de)
WO (1) WO2003086325A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090005323A1 (en) * 2005-01-19 2009-01-01 Michael David Percival Cathepsin K Inhibitors and Obesity
US8497271B2 (en) 2009-10-07 2013-07-30 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
US8426414B2 (en) 2009-10-09 2013-04-23 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
US8304577B2 (en) 2009-10-09 2012-11-06 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
US8703953B2 (en) 2012-03-09 2014-04-22 Bristol-Myers Squibb Company Aryl ether-base kinase inhibitors
US8901305B2 (en) 2012-07-31 2014-12-02 Bristol-Myers Squibb Company Aryl lactam kinase inhibitors
US9708337B2 (en) 2013-02-22 2017-07-18 Bristol-Myers Squibb Company Aryl amide-based kinase inhibitors
US10253027B2 (en) 2013-07-08 2019-04-09 Bristol-Myers Squibb Company Aryl lactam kinase inhibitors
EP3292124B1 (de) 2015-04-10 2019-05-22 Bristol-Myers Squibb Company 6h-isochromeno[3,4-c]pyridin- und benzo[c][1,7]naphthyridin-6-(5h)-on-verbindungen als inhibitoren der adapterassoziierten kinase 1 (aak1)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537293A (ja) * 1999-02-20 2002-11-05 アストラゼネカ アクチボラグ カテプシンｌおよび／またはカテプシンｓの阻害剤としてのアセタミドアセトニトリル誘導体
WO2001077073A1 (en) * 2000-04-06 2001-10-18 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors

Also Published As

Publication number Publication date
WO2003086325A2 (en) 2003-10-23
ES2301793T3 (es) 2008-07-01
CA2477692A1 (en) 2003-10-23
EP1495009A2 (de) 2005-01-12
AU2003230772A8 (en) 2003-10-27
DE60319686D1 (de) 2008-04-24
WO2003086325A3 (en) 2004-07-01
JP2005522489A (ja) 2005-07-28
AU2003230772A1 (en) 2003-10-27
DE60319686T2 (de) 2009-04-16
EP1495009B1 (de) 2008-03-12

Similar Documents

Publication Publication Date Title
ATE423108T1 (de) Nitrile verwendbar als reversible cystein- protease inhibitoren
AP1744A (en) Inhibitors of factor XA and other serine proteases involved in the coagulation cascade
MXPA04001016A (es) Derivados de sulfonamida como inhibidores de la gamma secretasa.
YU17003A (sh) Spiroheterociklični nitrili upotrebljivi kao reverzibilni inhibitori cisteinskih proteaza
MY138252A (en) Azabicyclic-substitud fused-heteroaryl compounds for the treatment of disease
ATE516062T1 (de) Quaternäre ammoniumverbindungen enthaltende wasserfreie zusammensetzungen
MXPA05012268A (es) N-arilsulfonilpiperidinas enlazadas como inhibidores de la gamma-secretasa.
EA200400815A1 (ru) Контролируемый синтез зипразидона и его композиции
MXPA05012323A (es) Sulfonamidas ciclicas para la inhibicion de gama-secretasa.
NO20030895D0 (no) Ny anvendelse av dipeptidyl peptidase IV inhibitorer
SE0201976D0 (sv) Novel compounds
DK1485359T3 (da) Natriumkanalblokkere
ATE450534T1 (de) Synthese von epothilonen, zwischenprodukte davon, analoga und ihre verwendung
EA200300970A1 (ru) Энантиоселективный синтез промежуточных соединений для получения азетидинонов
DE60319686D1 (de) Cyanamide als reversible hemmer von cystein proteasen
SG146658A1 (en) Haloalkyl containing compounds as cysteine protease inhibitors
ATE422501T1 (de) Template-fixierte peptidomimetika als inhibitoren von serinproteasen
DE60306934D1 (de) Verwendung von Nitrilenverbindungen als Arztneimittel
DE602004029355D1 (de) Sulfopyrrolderivate
EA200001152A1 (ru) СУКЦИНАМИДНЫЕ ИНГИБИТОРЫ ИНТЕРЛЕЙКИН - 1b - КОНВЕРТИРУЮЩЕГО ФЕРМЕНТА
ATE365702T1 (de) Eisenoxide mit höherem veredelungsgrad
ATE197591T1 (de) 4-substituierte-3-peptidyl-azetidin-2-on-deriva e als cystein-proteinase inhibitoren
WO2004110374A3 (en) 3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors
MXPA04005988A (es) 3,4-dihidro-1h-isoquinolin-2-il-derivados.
ATE427934T1 (de) Nicht-peptidische brs-3-agonisten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1495009

Country of ref document: EP

REN Ceased due to non-payment of the annual fee