ATE422501T1 - Template-fixierte peptidomimetika als inhibitoren von serinproteasen - Google Patents

Template-fixierte peptidomimetika als inhibitoren von serinproteasen

Info

Publication number
ATE422501T1
ATE422501T1 AT01985390T AT01985390T ATE422501T1 AT E422501 T1 ATE422501 T1 AT E422501T1 AT 01985390 T AT01985390 T AT 01985390T AT 01985390 T AT01985390 T AT 01985390T AT E422501 T1 ATE422501 T1 AT E422501T1
Authority
AT
Austria
Prior art keywords
template
serine proteases
fixed
inhibitors
amino acid
Prior art date
Application number
AT01985390T
Other languages
English (en)
Inventor
Daniel Obrecht
John Robinson
Anne Descours
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Application granted granted Critical
Publication of ATE422501T1 publication Critical patent/ATE422501T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01985390T 2001-12-11 2001-12-11 Template-fixierte peptidomimetika als inhibitoren von serinproteasen ATE422501T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/014528 WO2003054000A1 (en) 2001-12-11 2001-12-11 Template-fixed peptidomimeticsas inhibitors of serine proteases

Publications (1)

Publication Number Publication Date
ATE422501T1 true ATE422501T1 (de) 2009-02-15

Family

ID=8164720

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01985390T ATE422501T1 (de) 2001-12-11 2001-12-11 Template-fixierte peptidomimetika als inhibitoren von serinproteasen

Country Status (10)

Country Link
US (1) US7417024B2 (de)
EP (1) EP1458747B1 (de)
JP (1) JP4098244B2 (de)
CN (3) CN101157924A (de)
AT (1) ATE422501T1 (de)
AU (1) AU2002234564C1 (de)
BR (2) BRPI0117190B1 (de)
CA (1) CA2466591C (de)
DE (1) DE60137654D1 (de)
WO (1) WO2003054000A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096839A1 (en) 2003-05-02 2004-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
DE60321053D1 (de) 2003-05-02 2008-06-26 Polyphor Ag Matrizenfixierte peptidmimetika als medikamente gegen hiv und krebs
CA2528375C (en) 2003-06-18 2013-11-19 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
CN100595277C (zh) 2003-11-15 2010-03-24 波利弗尔有限公司 模板固定的β发夹环模拟物及其在噬菌体展示中的用途
CA2598360C (en) 2005-02-17 2016-12-20 Universitat Zurich Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
CN105111280B (zh) * 2005-02-17 2020-01-24 波利弗尔有限公司 具有蛋白酶抑制活性的模板固定的β-发夹肽模拟物
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
AU2007345497B2 (en) 2007-01-29 2013-01-17 Polyphor Ltd. Template-fixed peptidomimetics
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
AU2007348171B2 (en) 2007-02-28 2012-09-06 Polyphor Ltd. Template-fixed peptidomimetics
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
EP2768518A4 (de) 2011-10-18 2015-05-27 Aileron Therapeutics Inc Peptidomimetische makrozyklen
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
NZ722025A (en) * 2013-12-27 2019-06-28 Polyphor Ag Beta-hairpin peptidomimetics as selective elastase inhibitors
EA034910B1 (ru) * 2013-12-27 2020-04-06 Полифор Аг Бета-шпилечные пептидомиметики в качестве селективных ингибиторов эластазы
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
EP3197478A4 (de) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
EP3347372A4 (de) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Peptidomimetische makrocyclen als modulatoren von mcl-1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1367789B (zh) * 1999-08-30 2012-06-06 波利弗尔股份公司 模板固定的β-发夹环模拟物的合成

Also Published As

Publication number Publication date
CN101157720A (zh) 2008-04-09
HK1117541A1 (en) 2009-01-16
DE60137654D1 (de) 2009-03-26
CA2466591A1 (en) 2003-07-03
US7417024B2 (en) 2008-08-26
WO2003054000A1 (en) 2003-07-03
AU2002234564C1 (en) 2009-07-02
BR0117190A (pt) 2004-10-13
CN101157720B (zh) 2012-04-04
BRPI0117190B1 (pt) 2018-10-23
US20050187145A1 (en) 2005-08-25
CN1582296A (zh) 2005-02-16
JP4098244B2 (ja) 2008-06-11
CN101157924A (zh) 2008-04-09
EP1458747B1 (de) 2009-02-11
JP2005524613A (ja) 2005-08-18
AU2002234564A1 (en) 2003-07-09
CA2466591C (en) 2012-09-25
EP1458747A1 (de) 2004-09-22
AU2002234564B2 (en) 2008-11-06

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