ATE422501T1 - Template-fixierte peptidomimetika als inhibitoren von serinproteasen - Google Patents

Template-fixierte peptidomimetika als inhibitoren von serinproteasen

Info

Publication number
ATE422501T1
ATE422501T1 AT01985390T AT01985390T ATE422501T1 AT E422501 T1 ATE422501 T1 AT E422501T1 AT 01985390 T AT01985390 T AT 01985390T AT 01985390 T AT01985390 T AT 01985390T AT E422501 T1 ATE422501 T1 AT E422501T1
Authority
AT
Austria
Prior art keywords
template
serine proteases
fixed
inhibitors
amino acid
Prior art date
Application number
AT01985390T
Other languages
English (en)
Inventor
Daniel Obrecht
John Robinson
Anne Descours
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Application granted granted Critical
Publication of ATE422501T1 publication Critical patent/ATE422501T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01985390T 2001-12-11 2001-12-11 Template-fixierte peptidomimetika als inhibitoren von serinproteasen ATE422501T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/014528 WO2003054000A1 (en) 2001-12-11 2001-12-11 Template-fixed peptidomimeticsas inhibitors of serine proteases

Publications (1)

Publication Number Publication Date
ATE422501T1 true ATE422501T1 (de) 2009-02-15

Family

ID=8164720

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01985390T ATE422501T1 (de) 2001-12-11 2001-12-11 Template-fixierte peptidomimetika als inhibitoren von serinproteasen

Country Status (10)

Country Link
US (1) US7417024B2 (de)
EP (1) EP1458747B1 (de)
JP (1) JP4098244B2 (de)
CN (3) CN101157924A (de)
AT (1) ATE422501T1 (de)
AU (1) AU2002234564C1 (de)
BR (2) BRPI0117190B1 (de)
CA (1) CA2466591C (de)
DE (1) DE60137654D1 (de)
WO (1) WO2003054000A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096839A1 (en) 2003-05-02 2004-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
EP1622930B9 (de) * 2003-05-02 2009-10-14 Polyphor AG Matrizenfixierte peptidmimetika als medikamente gegen hiv und krebs
DK1633774T3 (da) 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
DK1689863T3 (da) 2003-11-15 2014-08-25 Polyphor Ltd Template-fikserede beta-hairpinloopmimetika og deres anvendelse i fag-display
CN105111280B (zh) * 2005-02-17 2020-01-24 波利弗尔有限公司 具有蛋白酶抑制活性的模板固定的β-发夹肽模拟物
US8658604B2 (en) * 2005-02-17 2014-02-25 Polyphor Ltd Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) * 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
PL2132221T3 (pl) 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
EP2819688A4 (de) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Triazol- und thioethervernetzte peptidomimetische makrozyklen
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
DK3087094T3 (da) * 2013-12-27 2022-08-29 Polyphor Ag Betahårnål peptidomimetika som selektive elastase inhibitorer
JP6499182B2 (ja) * 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
EP3197478A4 (de) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214336A1 (de) 1999-08-30 2002-06-19 Universität Zürich Synthese matrizen-fixierter beta-hairpinloopmimetika

Also Published As

Publication number Publication date
EP1458747B1 (de) 2009-02-11
JP4098244B2 (ja) 2008-06-11
CN101157924A (zh) 2008-04-09
CN101157720B (zh) 2012-04-04
US7417024B2 (en) 2008-08-26
CA2466591C (en) 2012-09-25
CN1582296A (zh) 2005-02-16
CA2466591A1 (en) 2003-07-03
HK1117541A1 (en) 2009-01-16
BR0117190A (pt) 2004-10-13
BRPI0117190B1 (pt) 2018-10-23
AU2002234564A1 (en) 2003-07-09
WO2003054000A1 (en) 2003-07-03
AU2002234564B2 (en) 2008-11-06
JP2005524613A (ja) 2005-08-18
DE60137654D1 (de) 2009-03-26
AU2002234564C1 (en) 2009-07-02
CN101157720A (zh) 2008-04-09
US20050187145A1 (en) 2005-08-25
EP1458747A1 (de) 2004-09-22

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