ATE389415T1 - Verfahren und mittel zur erhöhung der darmabsorption - Google Patents
Verfahren und mittel zur erhöhung der darmabsorptionInfo
- Publication number
- ATE389415T1 ATE389415T1 AT03760706T AT03760706T ATE389415T1 AT E389415 T1 ATE389415 T1 AT E389415T1 AT 03760706 T AT03760706 T AT 03760706T AT 03760706 T AT03760706 T AT 03760706T AT E389415 T1 ATE389415 T1 AT E389415T1
- Authority
- AT
- Austria
- Prior art keywords
- increase intestinal
- egf
- intestinal absorption
- relates
- producing
- Prior art date
Links
- 230000031891 intestinal absorption Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 abstract 1
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 1
- 244000199866 Lactobacillus casei Species 0.000 abstract 1
- 235000013958 Lactobacillus casei Nutrition 0.000 abstract 1
- 241000194035 Lactococcus lactis Species 0.000 abstract 1
- 206010049416 Short-bowel syndrome Diseases 0.000 abstract 1
- 235000014897 Streptococcus lactis Nutrition 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 229940116977 epidermal growth factor Drugs 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 229940017800 lactobacillus casei Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Surgery (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Radio Relay Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077532 | 2002-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE389415T1 true ATE389415T1 (de) | 2008-04-15 |
Family
ID=29797233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03760706T ATE389415T1 (de) | 2002-06-19 | 2003-06-19 | Verfahren und mittel zur erhöhung der darmabsorption |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7601799B2 (de) |
| EP (1) | EP1513545B1 (de) |
| JP (1) | JP2005529622A (de) |
| AT (1) | ATE389415T1 (de) |
| AU (1) | AU2003250250B2 (de) |
| CA (1) | CA2489930A1 (de) |
| DE (1) | DE60319822T2 (de) |
| ES (1) | ES2302945T3 (de) |
| WO (1) | WO2004001020A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005529622A (ja) | 2002-06-19 | 2005-10-06 | ヴェーイーベー・ヴェーゼットウェー | 腸吸収を促進するための方法および手段 |
| ES2405552T3 (es) | 2005-11-29 | 2013-05-31 | Actogenix N.V. | Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos |
| WO2008090223A2 (en) | 2007-01-25 | 2008-07-31 | Actogenix N.V. | Treatment of immune disease by mucosal delivery of antigens using genetically modified lactobacillus |
| EP3181682B1 (de) * | 2008-09-29 | 2021-04-21 | Intrexon Actobiotics NV | Reduzierte mikrobenkolonisierung an der schleimhaut |
| BR112012016982B8 (pt) | 2010-01-14 | 2022-12-20 | Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement | bactéria de ácido lático recombinante de grau alimentício e composição terapêutica |
| CA3008794C (en) | 2012-03-29 | 2021-03-16 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| AU2014239883B2 (en) | 2013-03-14 | 2019-01-17 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| CN103710351B (zh) * | 2013-12-23 | 2015-12-09 | 江苏众红生物工程创药研究院有限公司 | 表皮生长因子重组乳酸菌及其应用 |
| CN107325998A (zh) * | 2017-06-20 | 2017-11-07 | 江西嘉博生物工程有限公司 | 一种表达猪表皮生长因子基因的重组乳酸乳球菌及构建方法 |
| JP7316802B2 (ja) * | 2019-02-19 | 2023-07-28 | 雪印メグミルク株式会社 | 糖吸収促進用組成物 |
| IT201900014550A1 (it) * | 2019-08-09 | 2021-02-09 | Abiogen Pharma Spa | Uso di colecalciferolo come agente attivo nel trattamento della celiachia |
| CN116676246A (zh) * | 2023-06-16 | 2023-09-01 | 华中农业大学 | 重组乳酸乳球菌、益生菌制剂、构建方法、cECF表达方法及应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4100495A (en) * | 1975-11-27 | 1978-07-11 | Cselt - Centro Studi E Laboratori Telecomunicazioni | Adaptive method of and means for recovering digital signals |
| US4190495A (en) * | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4874702A (en) * | 1980-09-08 | 1989-10-17 | Biogen, Inc. | Vectors and methods for making such vectors and for expressive cloned genes |
| US4888170A (en) * | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
| US5417986A (en) * | 1984-03-16 | 1995-05-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5032510A (en) * | 1984-09-26 | 1991-07-16 | Eli Lilly And Company | Method for expression and secretion in bacillus |
| DE3578852D1 (de) | 1984-09-26 | 1990-08-30 | Lilly Co Eli | Verfahren zur expression und sekretion in bacillus. |
| WO1988006626A1 (en) | 1987-03-02 | 1988-09-07 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial vaccine |
| US5591632A (en) * | 1987-03-02 | 1997-01-07 | Beth Israel Hospital | Recombinant BCG |
| US5504005A (en) * | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| US5330753A (en) * | 1987-04-29 | 1994-07-19 | President And Fellows Of Harvard College | Cholera vaccines |
| US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| US5972685A (en) | 1988-07-21 | 1999-10-26 | Iowa State University Research Foundation, Inc. | Oral administration of coprostanol producing microorganisms to humans to decrease plasma cholesterol concentration |
| IE892131A1 (en) | 1989-06-30 | 1991-01-02 | Univ Cork | Marker genes for genetic manipulation |
| US5149532A (en) | 1989-11-01 | 1992-09-22 | Cedars Sinai Medical Center | Method of vaccine or toxoid preparation and immunization by colonization with recombinant microorganisms |
| DE4006521A1 (de) | 1990-03-02 | 1991-09-05 | Bayer Ag | Zuckerhaltige polymere zur umhuellung und einbettung von arzneistoffen |
| GB9006400D0 (en) * | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
| IL99097A0 (en) * | 1990-09-05 | 1992-07-15 | Akzo Nv | Haemophilus paragallinarum vaccine |
| JP3415145B2 (ja) * | 1991-03-05 | 2003-06-09 | ザ ウエルカム ファウンデーション リミテッド | 弱毒化細菌における組換えタンパク質の発現 |
| CA2120626C (en) | 1991-10-07 | 2009-10-06 | Douglas Wilmore | Method for enhancing gut absorption |
| IL103530A0 (en) * | 1991-10-25 | 1993-03-15 | Duphar Int Res | Treponema hyodysenteriae vaccine |
| WO1993017117A1 (en) | 1992-02-27 | 1993-09-02 | Lynxvale Limited | Heterologous gene expression in lactococcus, and the expression products therefrom |
| US5455034A (en) * | 1992-06-26 | 1995-10-03 | Kansas State University Research Foundation | Fusobacterium necrophorum leukotoxoid vaccine |
| DE4231764A1 (de) | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
| US5691185A (en) | 1993-10-08 | 1997-11-25 | Chr. Hansen A/S | Lactic acid bacterial suppressor mutants and their use as selective markers and as means of containment in lactic acid bacteria |
| BR9407813A (pt) | 1993-10-13 | 1997-05-06 | Gx Biosystems As | Nucleases de staphylococcus recombinantes e seu uso na limitação da sobrevivencia de microorganismos elaborados por engenharia genética |
| IT1270123B (it) * | 1994-10-05 | 1997-04-28 | Dompe Spa | Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia |
| US5733540A (en) * | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
| US5753622A (en) | 1995-05-10 | 1998-05-19 | University Technologies International, Inc. | Use of epidermal growth factor as a gastrointestinal therapeutic agent |
| JPH11507532A (ja) | 1995-06-07 | 1999-07-06 | ワシントン ユニバーシティ | 環境に制限される生存能を有する組換え細菌システム |
| US5824538A (en) * | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
| GB9518323D0 (en) * | 1995-09-07 | 1995-11-08 | Steidler Lothar | Materials and methods relating to the attachment and display of substances on cell surfaces |
| GB9521568D0 (en) | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| CA2252439C (en) * | 1996-04-19 | 2014-09-30 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens |
| US5972887A (en) | 1996-09-19 | 1999-10-26 | The Nemours Foundation | Treatment of intestinal epithelial cell malfunctions with Hepatocyte Growth Factor |
| GB9700939D0 (en) | 1997-01-17 | 1997-03-05 | Microbial Technics Limited | Therapy |
| CA2327387C (en) | 1998-05-07 | 2012-07-03 | Gx Biosystems A/S | Cytotoxin-based biological containment |
| US6190669B1 (en) * | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
| CA2331336A1 (en) | 1998-07-03 | 2000-01-13 | Chr. Hansen A/S | Method of preventing bacteriophage infection of bacterial cultures |
| MXPA01003197A (es) | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| WO2000022909A2 (en) | 1998-10-19 | 2000-04-27 | Biotech Australia Pty. Limited | Systems for oral delivery |
| DE69914932T2 (de) | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| DK1383897T3 (da) | 2001-05-03 | 2006-10-30 | Vlaams Interuniv Inst Biotech | Selv-containing Lactococcus-stamme |
| EP1319410A1 (de) * | 2001-12-11 | 2003-06-18 | Société des Produits Nestlé S.A. | Verwendung von Mikroorganismen zur gezielten Verabreichung von Mitteln in specifischen Teilen des Darms |
| US20040043003A1 (en) * | 2002-01-31 | 2004-03-04 | Wei Chen | Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions |
| JP2005529622A (ja) | 2002-06-19 | 2005-10-06 | ヴェーイーベー・ヴェーゼットウェー | 腸吸収を促進するための方法および手段 |
| AU2003298291A1 (en) | 2002-11-15 | 2004-06-15 | Universiteit Gent | Self-containing lactobacillus strain |
-
2003
- 2003-06-19 JP JP2004514876A patent/JP2005529622A/ja active Pending
- 2003-06-19 AU AU2003250250A patent/AU2003250250B2/en not_active Ceased
- 2003-06-19 ES ES03760706T patent/ES2302945T3/es not_active Expired - Lifetime
- 2003-06-19 DE DE60319822T patent/DE60319822T2/de not_active Expired - Lifetime
- 2003-06-19 CA CA002489930A patent/CA2489930A1/en not_active Abandoned
- 2003-06-19 EP EP03760706A patent/EP1513545B1/de not_active Expired - Lifetime
- 2003-06-19 AT AT03760706T patent/ATE389415T1/de not_active IP Right Cessation
- 2003-06-19 WO PCT/EP2003/050242 patent/WO2004001020A2/en not_active Ceased
-
2004
- 2004-12-20 US US11/018,188 patent/US7601799B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004001020A3 (en) | 2004-03-04 |
| WO2004001020A2 (en) | 2003-12-31 |
| CA2489930A1 (en) | 2003-12-31 |
| AU2003250250B2 (en) | 2008-02-14 |
| DE60319822T2 (de) | 2009-06-04 |
| JP2005529622A (ja) | 2005-10-06 |
| US7601799B2 (en) | 2009-10-13 |
| US20050158282A1 (en) | 2005-07-21 |
| DE60319822D1 (de) | 2008-04-30 |
| AU2003250250A1 (en) | 2004-01-06 |
| ES2302945T3 (es) | 2008-08-01 |
| EP1513545A2 (de) | 2005-03-16 |
| EP1513545B1 (de) | 2008-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |