ATE389658T1 - Heterocyclische kondensierte pyrazolderivate als kinaseinhibitoren - Google Patents

Heterocyclische kondensierte pyrazolderivate als kinaseinhibitoren

Info

Publication number: ATE389658T1
Authority: AT; Austria
Prior art keywords: kinase inhibitors; pyrazole derivatives; heterocyclic condensed; condensed pyrazole; heterocyclic
Prior art date: 2002-07-25

Application number

AT03766152T

Other languages

English (en)

Inventor

Roberto Tonani

Simona Bindi

Daniele Fancelli

Valeria Pittala

Mario Varasi

Original Assignee

Pfizer Italia Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-25

Filing date

2003-07-11

Publication date

2008-04-15

2003-07-11 Application filed by Pfizer Italia Srl filed Critical Pfizer Italia Srl

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE389658T1 publication Critical patent/ATE389658T1/de

Links

WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Oncology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT03766152T 2002-07-25 2003-07-11 Heterocyclische kondensierte pyrazolderivate als kinaseinhibitoren ATE389658T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39812102P	2002-07-25	2002-07-25

Publications (1)

Publication Number	Publication Date
ATE389658T1 true ATE389658T1 (de)	2008-04-15

Family

ID=31495717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766152T ATE389658T1 (de)	2002-07-25	2003-07-11	Heterocyclische kondensierte pyrazolderivate als kinaseinhibitoren

Country Status (13)

Country	Link
US (3)	US7541378B2 (de)
EP (1)	EP1530573B1 (de)
JP (1)	JP4533138B2 (de)
AR (1)	AR040520A1 (de)
AT (1)	ATE389658T1 (de)
AU (1)	AU2003250040A1 (de)
BR (1)	BR0312961A (de)
CA (1)	CA2493680C (de)
DE (1)	DE60319836T2 (de)
ES (1)	ES2303601T3 (de)
MX (1)	MXPA05000946A (de)
TW (1)	TW200413383A (de)
WO (1)	WO2004013146A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7572914B2 (en)	2003-12-19	2009-08-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
TW200526204A (en) *	2004-02-03	2005-08-16	Pharmacia Italia Spa	1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors
WO2006023931A2 (en)	2004-08-18	2006-03-02	Takeda San Diego, Inc.	Kinase inhibitors
EP1812439B2 (de)	2004-10-15	2017-12-06	Takeda Pharmaceutical Company Limited	Kinaseinhibitoren
FR2878442B1 (fr) *	2004-11-29	2008-10-24	Aventis Pharma Sa	THIENO(2,3-c)PYRAZOLES SUBSTITUES, PROCEDE DE PREPARATION, COMPOSITIONS LES CONTENANT ET UTILISATION
US7485661B2 (en) *	2005-01-18	2009-02-03	Pfizer Italia S.R.L.	Heterobicyclic pyrazole derivatives as kinase inhibitors
FR2882751B1 (fr) *	2005-03-04	2007-09-14	Aventis Pharma Sa	Hydrazinocarbonyl-thieno[2,3-c]pyrazoles, procede de preparation, compositions les contenant et utilisation
JP5303271B2 (ja) *	2005-07-19	2013-10-02	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	キナーゼ阻害剤として有用な１Ｈ−チエノ［２，３−ｃ］ピラゾール化合物
US20090306169A1 (en) *	2005-10-06	2009-12-10	Brandish Philip E	Use of Fused Pyrrole Carboxylic Acids for the Treatment of Neurodegenerative and Psychiatric Diseases and D-Amino Acid Oxidase Inhibitors
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
FR2904626B1 (fr)	2006-08-03	2008-09-19	Sanofi Aventis	Derives de pyrazolo[4,3]thiazole, leur preparation et leur application en therapeutique
JP2010505962A (ja)	2006-10-09	2010-02-25	武田薬品工業株式会社	キナーゼ阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4249804B2 (ja) *	1995-04-03	2009-04-08	ノバルティス・アクチエンゲゼルシャフト	ピラゾール誘導体およびその製造法
CA2416527C (en) *	2000-08-10	2009-12-22	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
AU2001287898A1 (en) *	2000-09-22	2002-04-02	Stephen Garland	Pyrazolopyridines and pyrazolopyridazines as antidiabetics
TW200526204A (en) *	2004-02-03	2005-08-16	Pharmacia Italia Spa	1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors

2003
- 2003-07-11 EP EP03766152A patent/EP1530573B1/de not_active Expired - Lifetime
- 2003-07-11 JP JP2004525180A patent/JP4533138B2/ja not_active Expired - Fee Related
- 2003-07-11 CA CA2493680A patent/CA2493680C/en not_active Expired - Lifetime
- 2003-07-11 US US10/522,250 patent/US7541378B2/en not_active Expired - Lifetime
- 2003-07-11 BR BR0312961-6A patent/BR0312961A/pt not_active IP Right Cessation
- 2003-07-11 WO PCT/EP2003/007531 patent/WO2004013146A1/en not_active Ceased
- 2003-07-11 ES ES03766152T patent/ES2303601T3/es not_active Expired - Lifetime
- 2003-07-11 DE DE60319836T patent/DE60319836T2/de not_active Expired - Lifetime
- 2003-07-11 AT AT03766152T patent/ATE389658T1/de not_active IP Right Cessation
- 2003-07-11 AU AU2003250040A patent/AU2003250040A1/en not_active Abandoned
- 2003-07-11 MX MXPA05000946A patent/MXPA05000946A/es not_active Application Discontinuation
- 2003-07-24 TW TW092120201A patent/TW200413383A/zh unknown
- 2003-07-24 AR AR20030102654A patent/AR040520A1/es unknown
2009
- 2009-05-27 US US12/472,513 patent/US7786048B2/en not_active Expired - Lifetime
2010
- 2010-07-21 US US12/840,425 patent/US8017643B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2493680C (en)	2010-09-07
US20060122249A1 (en)	2006-06-08
MXPA05000946A (es)	2005-05-16
TW200413383A (en)	2004-08-01
JP4533138B2 (ja)	2010-09-01
ES2303601T3 (es)	2008-08-16
US7786048B2 (en)	2010-08-31
DE60319836T2 (de)	2009-05-07
US8017643B2 (en)	2011-09-13
CA2493680A1 (en)	2004-02-12
BR0312961A (pt)	2005-06-14
EP1530573A1 (de)	2005-05-18
US20090233813A1 (en)	2009-09-17
JP2005537288A (ja)	2005-12-08
US7541378B2 (en)	2009-06-02
DE60319836D1 (de)	2008-04-30
US20100286223A1 (en)	2010-11-11
WO2004013146A1 (en)	2004-02-12
EP1530573B1 (de)	2008-03-19
AU2003250040A1 (en)	2004-02-23
AR040520A1 (es)	2005-04-06

Legal Events

Date	Code	Title	Description
2008-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
IS7599A (is)	2004-12-15	Heterósýklískir kínasatálmar
ATE393159T1 (de)	2008-05-15	Heterobicyclische pyrazolderivate als kinaseinhibitoren
ATE404564T1 (de)	2008-08-15	Diazepinoindolderivate als kinaseinhibitoren
ATE452891T1 (de)	2010-01-15	Pyrimidopyrimidone als kinaseinhibitoren
ATE520671T1 (de)	2011-09-15	Pyrimidin-harnstoff-derivate als kinase-hemmer
ATE445613T1 (de)	2009-10-15	Indolylmaleimidderivative als proteinkinase-c- inhibitoren
ATE494287T1 (de)	2011-01-15	Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase
ATE455546T1 (de)	2010-02-15	Aminotriazol-verbindungen als proteinkinase- hemmer
DE60315516D1 (de)	2007-09-20	Pyridazinon-derivate als cdk2-hemmer
ATE318814T1 (de)	2006-03-15	Kondensierte pyrazol derivate als protein kinase inhibitoren
DE60304911D1 (de)	2006-06-08	Xanthin-Derivate als DPP-IV-Inhibitoren
ATE388148T1 (de)	2008-03-15	Chinolinderivate als phosphodiesterase inhibitoren
ATE505471T1 (de)	2011-04-15	Azaindol-kinaseinhibitoren
ATE326463T1 (de)	2006-06-15	Pyrazolverbindungen als protein-kinasehemmer
ATE346064T1 (de)	2006-12-15	Pyrazolverbindungen als protein-kinasehemmer
CY2016042I1 (el)	2017-03-15	Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
ATE489387T1 (de)	2010-12-15	Pyridoä2,1-aü-isochinolinderivate als dpp-iv inhibitoren
ATE444292T1 (de)	2009-10-15	Pyrazolderivate als faktor-xa-inhibitoren
DE60315862D1 (de)	2007-10-04	Dihydropyridinonderivate als hne-inhibitoren
DE60106252D1 (de)	2004-11-11	Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren
PL378116A1 (pl)	2006-03-06	Heterocykliczne inhibitory kinazy
DE60322544D1 (de)	2008-09-11	Glycinamid-derivate als raf-kinase-hemmer
DE602004026905D1 (de)	2010-06-10	2-aminoaryloxazol-verbindungen als tyrosinkinase-hemmer
DE60319836D1 (de)	2008-04-30	Heterocyclische kondensierte pyrazolderivate als kinaseinhibitoren
ZA200703835B (en)	2008-11-26	Heterocyclic substituted bisarylurea derivatives as kinase inhibitors