ATE390167T1 - Mikronadelanordnungen - Google Patents

Mikronadelanordnungen

Info

Publication number
ATE390167T1
ATE390167T1 AT06101150T AT06101150T ATE390167T1 AT E390167 T1 ATE390167 T1 AT E390167T1 AT 06101150 T AT06101150 T AT 06101150T AT 06101150 T AT06101150 T AT 06101150T AT E390167 T1 ATE390167 T1 AT E390167T1
Authority
AT
Austria
Prior art keywords
microneedles
microneedle
channels
methods
elongated
Prior art date
Application number
AT06101150T
Other languages
English (en)
Inventor
Michael D Delmore
Patrick R Fleming
Douglas A Huntley
Jamieson C Keister
Cristina U Thomas
Richard H Ferber
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of ATE390167T1 publication Critical patent/ATE390167T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Optics & Photonics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
AT06101150T 2001-09-05 2002-07-15 Mikronadelanordnungen ATE390167T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/947,195 US6881203B2 (en) 2001-09-05 2001-09-05 Microneedle arrays and methods of manufacturing the same

Publications (1)

Publication Number Publication Date
ATE390167T1 true ATE390167T1 (de) 2008-04-15

Family

ID=25485700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06101150T ATE390167T1 (de) 2001-09-05 2002-07-15 Mikronadelanordnungen

Country Status (8)

Country Link
US (2) US6881203B2 (de)
EP (2) EP1652551B1 (de)
JP (1) JP2005501615A (de)
AT (1) ATE390167T1 (de)
DE (1) DE60225859T2 (de)
ES (1) ES2304758T3 (de)
TW (1) TW550101B (de)
WO (1) WO2003020359A2 (de)

Families Citing this family (331)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
DE10057832C1 (de) 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
NZ529029A (en) * 2001-04-20 2005-07-29 Alza Corp Microprojection array having a beneficial agent containing coating
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
ATE485766T1 (de) 2001-06-12 2010-11-15 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
JP4209767B2 (ja) 2001-06-12 2009-01-14 ペリカン テクノロジーズ インコーポレイテッド 皮膚の性状の一時的変化に対する適応手段を備えた自動最適化形切開器具
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
DE60239132D1 (de) 2001-06-12 2011-03-24 Pelikan Technologies Inc Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
ATE494837T1 (de) 2001-06-12 2011-01-15 Pelikan Technologies Inc Integriertes system zur blutprobenanalyse mit mehrfach verwendbarem probennahmemodul
EP1404232B1 (de) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Gerät und verfahren zur entnahme von blutproben
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
DK1594559T3 (da) 2002-03-26 2013-05-27 Becton Dickinson Co Flertrins fluidumudleveringsapparat
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7481776B2 (en) 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2004009172A1 (en) 2002-07-19 2004-01-29 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
CA2493728C (en) 2002-07-22 2013-10-29 Becton, Dickinson And Company Patch-like infusion device
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
ES2490740T3 (es) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Aparato para toma de muestras de fluido sanguíneo y detección de analitos
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
EP2609948B1 (de) 2003-08-12 2020-01-08 Becton, Dickinson and Company Pflasterähnliche Infusionsvorrichtung
CA2536249A1 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
KR20060115722A (ko) * 2003-08-26 2006-11-09 알자 코포레이션 진피내 세포 이식용 장치 및 방법
EP1671096A4 (de) 2003-09-29 2009-09-16 Pelikan Technologies Inc Verfahren und apparatur für eine verbesserte probeneinfangvorrichtung
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
EP1699524A4 (de) * 2003-11-18 2009-07-15 Nanopass Technologies Ltd Verbessertes penetrationssystem und verfahren zum schieben von mikronadeln
WO2005060621A2 (en) * 2003-11-21 2005-07-07 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
CA2552385C (en) 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005082593A1 (en) * 2004-02-17 2005-09-09 Avery Dennison Corporation Method of making microneedles
JP2007523771A (ja) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの成形方法
JP2005246595A (ja) * 2004-03-05 2005-09-15 Ritsumeikan マイクロニードルアレイ及びその製造方法
US8671544B2 (en) * 2004-03-12 2014-03-18 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
AU2005228145B2 (en) * 2004-03-24 2011-03-03 Corium Pharma Solutions, Inc. Transdermal delivery device
EP3108925B1 (de) * 2004-04-12 2019-09-04 Allergan, Inc. Multisitus-injektionssystem
MXPA06013168A (es) 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP3329960A1 (de) 2004-06-10 2018-06-06 3M Innovative Properties Company Vorrichtung und kit zur pflasterapplikation
EP1789127A2 (de) * 2004-08-05 2007-05-30 Apogee Technology, Inc. System und verfahren zur arzneiabgabe und mikrofluidische applikationen mit mikronadeln
WO2006016364A2 (en) 2004-08-10 2006-02-16 Hellman De Picciotto, Tania Drug delivery devices
EP1790375A4 (de) * 2004-08-12 2009-06-17 Hisamitsu Pharmaceutical Co Transdermale arzneimittelverabreichungsvorrichtung mit mikronadel
EP2289646B1 (de) 2004-08-16 2014-02-12 Functional Microstructures Limited Vorrichtung zum Auftragen auf eine biologische Barriere
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
GB0420256D0 (en) 2004-09-13 2004-10-13 Cassells John M Method and apparatus for sampling and analysis of fluids
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
KR20070102669A (ko) 2004-11-18 2007-10-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 로우-프로파일 미세 바늘 어레이 인가 장치
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
WO2006055844A2 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
US20080307849A1 (en) * 2004-11-26 2008-12-18 Agency For Science, Technology And Research Method And Apparatus For Forming Microstructures
ATE468961T1 (de) * 2004-12-07 2010-06-15 3M Innovative Properties Co Verfahren zum formen einer mikronadel
JP5133697B2 (ja) * 2004-12-10 2013-01-30 スリーエム イノベイティブ プロパティズ カンパニー 医療用デバイス
CA2594291C (en) * 2004-12-28 2012-03-06 Nabtesco Corporation Skin needle manufacturing apparatus and skin needle manufacturing method
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
WO2006075689A1 (ja) * 2005-01-14 2006-07-20 Fujikura Ltd. 医薬物運搬用器具とその製造方法
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
GB0509863D0 (en) * 2005-05-16 2005-06-22 Cambridge Biostability Ltd Apparatus for administrating substances into a body
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
CA2613111C (en) 2005-06-27 2015-05-26 3M Innovative Properties Company Microneedle array applicator device and method of array application
US20100256568A1 (en) * 2005-06-27 2010-10-07 Frederickson Franklyn L Microneedle cartridge assembly and method of applying
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
KR20080047600A (ko) * 2005-09-15 2008-05-29 티티아이 엘뷰 가부시키가이샤 로드형 이온토포레시스 장치
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070073212A1 (en) * 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
KR20080080087A (ko) * 2005-09-30 2008-09-02 티티아이 엘뷰 가부시키가이샤 신규 약학 담체를 이용한 경피 약물 전달시스템, 장치 및방법
KR20080066712A (ko) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
JP2009509685A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 損傷組織の治癒を増強するための血管新生因子の送達のためのイオントフォレーシス装置及び方法
JP2009509677A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 小胞封入活性物質のイオントフォレーシス送達
US20070078376A1 (en) * 2005-09-30 2007-04-05 Smith Gregory A Functionalized microneedles transdermal drug delivery systems, devices, and methods
JP2009509657A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
WO2007064486A1 (en) 2005-11-30 2007-06-07 3M Innovative Properties Company Microneedle arrays and methods of use thereof
EP1959731A1 (de) * 2005-12-14 2008-08-27 Ariana Holdings Pty Ltd Chemikalienapplikator
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
WO2007079116A1 (en) * 2005-12-28 2007-07-12 Tti Ellebeau, Inc. Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
EP1965856A2 (de) * 2005-12-30 2008-09-10 Tti Ellebeau, Inc. Iontophoretische systeme, vorrichtungen und verfahren zur abgabe von wirkstoffen an eine biologische schnittstelle
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
US9610459B2 (en) * 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
JPWO2007091608A1 (ja) * 2006-02-10 2009-07-02 久光製薬株式会社 マイクロニードル付き経皮薬物投与装置
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
GB0605003D0 (en) * 2006-03-13 2006-04-19 Microsample Ltd Method and apparatus for piercing the skin and delivery or collection of liquids
EP1998844A4 (de) * 2006-03-24 2017-03-01 3M Innovative Properties Company Verfahren zur herstellung von mikronadeln, mikronadelanordnung, vorlage und replikationswerkzeug
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
WO2007123707A1 (en) * 2006-03-30 2007-11-01 Tti Ellebeau, Inc. Controlled release membrane and methods of use
JP4908893B2 (ja) * 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
CN100441388C (zh) * 2006-04-06 2008-12-10 上海交通大学 基于多层加工技术的微针制备方法
EP2005990B1 (de) * 2006-04-07 2013-08-28 Hisamitsu Pharmaceutical Co., Inc. Mikronadelvorrichtung und transdermale verabreichungsvorrichtung mit mikronadeln
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
JP4904964B2 (ja) * 2006-07-24 2012-03-28 凸版印刷株式会社 針状体の製造方法
DE102006036331A1 (de) 2006-08-03 2008-02-14 Stephan Hammelbacher Vorrichtung und Verfahren zum Markieren von Objekten
WO2008020632A1 (en) * 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Microneedle and microneedle patch
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
DE102006040642A1 (de) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika
WO2008030497A2 (en) * 2006-09-05 2008-03-13 Tti Ellebeau, Inc. Transdermal drug delivery systems, devices, and methods using inductive power supplies
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
JP2010505471A (ja) * 2006-10-02 2010-02-25 エムキネティクス， インコーポレイテッド 磁気誘導療法のための方法および装置
TW200838576A (en) 2006-12-01 2008-10-01 Transcu Ltd Systems, devices and methods for powering and/or controlling transdermal delivery devices
JP5553612B2 (ja) * 2007-01-22 2014-07-16 コリウム インターナショナル， インコーポレイテッド マイクロニードルアレイ用アプリケータ
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
JP5090032B2 (ja) * 2007-03-20 2012-12-05 凸版印刷株式会社 針状体および針状体製造方法
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
EP2444226A3 (de) 2007-06-20 2012-08-29 3M Innovative Properties Company Ultraschallspritzgiessen auf einer bahn
JP2009039171A (ja) * 2007-08-06 2009-02-26 Dai Ichi Kasei Kk 微細針形状突起物及びその成形金型及びその製造方法
JP5173332B2 (ja) * 2007-09-10 2013-04-03 凸版印刷株式会社 マイクロニードルおよびマイクロニードル製造方法
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009065078A1 (en) * 2007-11-14 2009-05-22 Pathway Medical Technologies, Inc. Delivery and administration of compositions using interventional catheters
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
CN102007066B (zh) 2008-02-07 2013-06-26 昆士兰大学 贴片制造
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US20090234322A1 (en) * 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
FR2929135A1 (fr) * 2008-03-31 2009-10-02 Commissariat Energie Atomique Dispositif d'aliquotage et de dispense d'un liquide
WO2009146072A1 (en) 2008-04-01 2009-12-03 The General Hospital Corporation Method and apparatus for tissue expansion
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
USD610690S1 (en) 2008-04-16 2010-02-23 Hisamitsu Pharmaceutical Co., Inc. Combined medical patch and package
USD617463S1 (en) 2008-04-16 2010-06-08 Hisamitsu Pharmaceutical Co., Inc. Combined medical patch and package
WO2009142741A1 (en) 2008-05-21 2009-11-26 Theraject, Inc. Method of manufacturing solid solution peforator patches and uses thereof
EP2294415A4 (de) 2008-05-23 2011-10-05 Univ Queensland Analytnachweis mittels mikronadelpflaster mit analytselektiven reagentien
WO2010016218A1 (ja) * 2008-08-05 2010-02-11 国立大学法人 香川大学 マイクロニードルとその冶具
US8906046B2 (en) * 2008-09-20 2014-12-09 Microkoll Inc. Apparatus and method for tissue adhesion
KR20160150109A (ko) 2008-11-18 2016-12-28 쓰리엠 이노베이티브 프로퍼티즈 컴파니 중공 마이크로니들 어레이
KR101004014B1 (ko) 2008-12-18 2010-12-31 (주)마이티시스템 측면에 유로가 형성된 미세바늘의 구조 및 그 제작방법
US20110021996A1 (en) * 2008-12-18 2011-01-27 Miti Systems Inc. Structure of micro-needle with side channel and manufacturing method thereof
CN102325563A (zh) 2008-12-22 2012-01-18 昆士兰大学 贴剂制备
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
AU2010209763B2 (en) 2009-01-30 2016-05-12 Mycartis N.V. Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof
US20220071534A9 (en) * 2009-03-02 2022-03-10 Yourbio Health, Inc. Delivering and/or receiving fluids
US20110009847A1 (en) 2009-03-02 2011-01-13 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
JP4779084B2 (ja) * 2009-03-25 2011-09-21 国立大学法人 香川大学 マイクロニードルおよびその製造方法と金型
CN101829396B (zh) * 2009-03-27 2013-01-30 清华大学 微针阵列芯片及利用其的经皮给药贴剂及其制备方法
FI20095433A0 (fi) 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
JP5820805B2 (ja) * 2009-04-24 2015-11-24 コリウム インターナショナル， インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
EP2491400B1 (de) 2009-10-21 2015-10-07 MyCartis N.V. Biomarker zur diagnose, vorhersage und/oder prognose eines akuten herzversagens und verwendungen davon
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
ES2729928T3 (es) 2009-12-16 2019-11-07 Becton Dickinson Co Dispositivo de auto inyección
DK2512579T3 (en) 2009-12-16 2017-03-13 Becton Dickinson Co Self Injection Device
US10195340B2 (en) 2009-12-16 2019-02-05 Becton, Dickinson And Company Self-injection device
DK2781228T3 (en) 2009-12-16 2016-03-21 Becton Dickinson Co A device for self-injection
ES2862501T3 (es) 2009-12-16 2021-10-07 Becton Dickinson Co Dispositivo de autoinyección
DK2512560T3 (en) 2009-12-16 2018-07-16 Becton Dickinson Co Even injector device
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
DE102010000843A1 (de) * 2010-01-13 2011-07-14 Robert Bosch GmbH, 70469 Glukose-Sensorvorrichtung mit poröser Mikronadelanordnung, entsprechendes Herstellungsverfahren und Glukose-Messverfahren
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US20110237513A1 (en) 2010-03-26 2011-09-29 Pronota N.V. Ltbp2 as a biomarker for renal dysfunction
CN103038645B (zh) 2010-04-13 2016-05-04 迈卡蒂斯股份有限公司 用于妊娠的高血压疾病的生物标志物
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
CN102958556B (zh) * 2010-04-28 2017-02-15 金伯利-克拉克环球有限公司 细胞相互作用增强的纳米图案化医疗装置
EP2563450B1 (de) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Vorrichtung zur verabreichung eines medikaments gegen rheumatoide arthritis
US9586044B2 (en) 2010-04-28 2017-03-07 Kimberly-Clark Worldwide, Inc. Method for increasing the permeability of an epithelial barrier
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
EP4278986B1 (de) 2010-05-07 2026-08-19 The General Hospital Corporation Vorrichtung zum gewebetransplantation und -kopieren
AU2011258288B2 (en) 2010-05-28 2015-02-12 Kindeva Drug Delivery L.P. Aqueous formulations for coating microneedle arrays
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
DE102010030864A1 (de) * 2010-07-02 2012-01-05 Robert Bosch Gmbh Herstellungsverfahren für eine Mikronadelanordnung und entsprechende Mikronadelanordnung und Verwendung
WO2012006677A1 (en) * 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
ES2561824T3 (es) * 2010-07-16 2016-03-01 Seventh Sense Biosystems, Inc. Ambiente a baja presión para dispositivos de transferencia de fluidos
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
CN101912663B (zh) * 2010-08-18 2013-09-04 清华大学 空心微针阵列芯片、经皮给药贴片、器件及制备方法
EP2611478B1 (de) 2010-09-02 2022-08-17 Becton, Dickinson and Company Selbstinjektionsvorrichtung mit nadelschutz mit aktivierungsverhinderung
WO2012054518A1 (en) * 2010-10-18 2012-04-26 Lanco Biosciences, Inc. Delivery of copolymers by microinjection systems
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
ES2565805T3 (es) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Sistemas e interfaces para el muestreo de sangre
ES2580834T3 (es) 2010-12-02 2016-08-29 3M Innovative Properties Company Microagujas de polímero cristalino líquido
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
AU2012225608B2 (en) 2011-03-07 2015-07-02 Kindeva Drug Delivery L.P. Microneedle devices and methods
CN103429222B (zh) 2011-03-07 2015-09-09 3M创新有限公司 微针装置和方法
JP2014519344A (ja) 2011-03-18 2014-08-14 ユニヴェルシテ リブル ドゥ ブリュッセル 人間または動物の体の膜に穴をあけるための装置
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
KR102237667B1 (ko) 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. 유체들의 전달 및/또는 수용
US8636696B2 (en) * 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
HK1198956A1 (en) * 2011-08-05 2015-06-19 Unitract Syringe Pty Ltd Cannula with controlled depth of insertion
CN102319066B (zh) * 2011-08-16 2014-05-07 中国人民解放军广州军区武汉总医院 多通道矩阵式空间叠加心电检测系统
US11179553B2 (en) * 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
AU2012323392A1 (en) 2011-10-12 2014-04-24 3M Innovative Properties Company Integrated microneedle array delivery system
EP3542851B1 (de) 2011-10-27 2021-12-15 Sorrento Therapeutics, Inc. Implantierbare vorrichtungen zur freisetzung bioaktiver wirkstoffe
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
BR112014009713A2 (pt) 2011-10-27 2017-04-18 Kimberly Clark Co administração transdérmica de agentes bioativos de alta viscosidade
AU2012345777B2 (en) 2011-11-30 2016-05-12 Kindeva Drug Delivery L.P. Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
EP4112112A1 (de) 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Spitzenbelastete mikronadelanordnungen zum transdermalen einführen
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
CA2882129C (en) 2012-08-14 2022-06-21 The General Hospital Corporation Method and apparatus for tissue harvesting
EP2931356B1 (de) 2012-12-14 2019-03-06 Mindera Corporation Verfahren und vorrichtungen zur erkennung und erfassung von biomarkern
RU2698095C2 (ru) 2012-12-21 2019-08-22 Кориум Интернэшнл, Инк. Микроматрица для доставки терапевтического средства и способы использования
US10105524B2 (en) 2012-12-27 2018-10-23 3M Innovative Properties Company Article with hollow microneedles and method of making
WO2014112854A1 (ko) * 2013-01-21 2014-07-24 부경약품 ㈜ 미세 니들, 이의 제조용 몰드 및 이의 제조 방법
US10543127B2 (en) 2013-02-20 2020-01-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
BR122020006959B1 (pt) 2013-03-12 2022-04-26 Corium, Inc Aplicador de microprojeções
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10555754B2 (en) 2013-08-09 2020-02-11 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
DE102013219432A1 (de) * 2013-09-26 2015-03-26 Peter Röhr Blutentnahmevorrichtung und Verfahren zum Entnehmen von Blut
US20150174386A1 (en) * 2013-12-19 2015-06-25 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
WO2015119906A1 (en) * 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
ES2939940T3 (es) 2014-03-28 2023-04-28 Univ Duke Tratamiento del cáncer de mama utilizando moduladores selectivos de los receptores de estrógenos
WO2015164840A1 (en) * 2014-04-24 2015-10-29 Georgia Tech Research Corporation Microneedles and methods of manufacture thereof
EP3169261B1 (de) 2014-07-15 2021-11-10 The General Hospital Corporation Vorrichtung für gewebekopien und -transplantate
CN107073210B (zh) * 2014-09-03 2020-11-10 新南创新私人有限公司 微流体装置和制造
EP3188714A1 (de) 2014-09-04 2017-07-12 Corium International, Inc. Mikrostrukturanordnung, verfahren zur herstellung und verfahren zur verwendung
BR112017009805A2 (pt) 2014-11-14 2017-12-26 Cytrellis Biosystems Inc dispositivos e métodos para ablação da pele
EP4218892A1 (de) 2015-02-02 2023-08-02 Vaxxas Pty Limited Mikroprojektionsarrayapplikator
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP2016195651A (ja) * 2015-04-02 2016-11-24 日本写真印刷株式会社 マイクロニードルシート
US10070886B2 (en) 2015-04-22 2018-09-11 Medline Industries, Inc. Method of harvesting tissue using sequential sections of a two dimensional array of needles
MX384605B (es) 2015-04-29 2025-03-14 Radius Pharmaceuticals Inc Combinación de palbociclib y rad1901 para usarse en el tratamiento de cáncer de mama en un sujeto con cáncer positivo a receptor de estrógeno.
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
AU2016333148B2 (en) 2015-09-28 2021-10-14 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
JP6499598B2 (ja) 2015-10-06 2019-04-10 富士フイルム株式会社 経皮吸収シートの製造方法
DK3359129T3 (da) 2015-10-09 2022-05-09 Kindeva Drug Delivery Lp Zinksammensætninger til belagte mikronåleanordninger
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
KR101811513B1 (ko) 2015-11-25 2017-12-20 주식회사 파이안에스테틱스 마이크로 스피큘과 이의 제조용 몰드 및 이의 제조방법
US11160963B2 (en) 2015-12-04 2021-11-02 Ascilion Ab Microneedle and a chip
US10987502B2 (en) * 2015-12-15 2021-04-27 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US10939912B2 (en) 2016-03-01 2021-03-09 Kitotech Medical, Inc. Microstructure-based systems, apparatus, and methods for wound closure
KR20230117470A (ko) 2016-03-29 2023-08-08 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
JP2017176652A (ja) * 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
ES2904891T3 (es) 2016-04-18 2022-04-06 Radius Health Inc Formulaciones de abaloparatida, parche transdérmico de la misma y usos de la misma
WO2018057630A1 (en) 2016-09-21 2018-03-29 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
US12415058B2 (en) 2016-12-22 2025-09-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery
AU2017379879C1 (en) * 2016-12-22 2023-10-12 Ohio State Innovation Foundation Interpentrating microstructures for nanochannel-based cargo delivery
EP3565542B1 (de) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphe formen von rad1901-2hcl
US11642453B2 (en) 2017-01-10 2023-05-09 A.T. Still University Fluid infusion system
EP4306803B1 (de) 2017-03-31 2026-05-06 Vaxxas Pty Limited Vorrichtung und verfahren zur beschichtung von oberflächen
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
JP1601442S (de) * 2017-07-28 2018-04-09
AU2018309562A1 (en) * 2017-08-04 2020-02-20 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
WO2019033361A1 (zh) * 2017-08-17 2019-02-21 深圳华迈兴微医疗科技有限公司 一种采血装置及其控制设备
JP7204748B2 (ja) 2017-10-16 2023-01-16 トラスティーズ オブ タフツ カレッジ 微細針を作製するためのシステムおよび方法
CN108744258B (zh) * 2018-05-04 2024-03-08 陈彦彪 一种蜂刺疗法用微针设备及其制备方法
US11318292B2 (en) * 2018-05-28 2022-05-03 Microneedles Inc. Microneedle patch for transdermal injections
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
JP6959453B2 (ja) * 2018-08-28 2021-11-02 Ｎｉｓｓｈａ株式会社 肌改質シート
JP2020078363A (ja) * 2018-11-10 2020-05-28 コスメディ製薬株式会社 マイクロニードルアレイの製造方法
US12441745B2 (en) 2019-02-12 2025-10-14 Radius Pharmaceuticals, Inc. Processes and compounds
JP2022532215A (ja) 2019-05-16 2022-07-13 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 皮膚および非皮膚薬物送達のためのアンダーカット特徴を有するマイクロニードルアレイ
EP3795358B1 (de) * 2019-09-20 2026-03-25 Axenoll Life Sciences AG Mikronadel und verfahren zur herstellung einer mikronadel
WO2021146554A1 (en) * 2020-01-16 2021-07-22 Kansas State University Research Foundation Microneedle, microcone, and photolithography fabrication methods
US11986613B2 (en) 2020-02-19 2024-05-21 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
WO2021221973A1 (en) 2020-04-28 2021-11-04 Ticona Llc Microneedle assembly
TWI757205B (zh) * 2020-06-30 2022-03-01 財團法人工業技術研究院 微針電轉染裝置
KR20230165746A (ko) 2020-11-30 2023-12-05 민데라 코포레이션 마이크로니들 디바이스 및 방법, 및 피부 병태 어세이
CN112618945B (zh) * 2020-12-14 2022-06-21 北京航空航天大学 中空封闭型微针及其制备方法和包括该微针的操作装置
CN113712547B (zh) * 2021-09-07 2023-12-29 集美大学 多槽微针阵列及其制备方法、生物检测微针传感器
CN114209975B (zh) * 2021-12-14 2022-07-26 优微（珠海）生物科技有限公司 一种基底易撕微针贴
CN218685709U (zh) * 2021-12-23 2023-03-24 苏州纳生微电子有限公司 微针阵列芯片
WO2023159181A1 (en) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
TWI856848B (zh) * 2023-10-19 2024-09-21 達運精密工業股份有限公司 微針裝置
WO2026093721A1 (en) * 2024-10-31 2026-05-07 SAVA Technologies Limited Wearable sensing device

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4018938A (en) 1975-06-30 1977-04-19 International Business Machines Corporation Fabrication of high aspect ratio masks
US4165395A (en) 1977-06-30 1979-08-21 International Business Machines Corporation Process for forming a high aspect ratio structure by successive exposures with electron beam and actinic radiation
JPS5590931A (en) 1978-12-29 1980-07-10 Canon Inc Production of micro structure element array
US4568632A (en) 1982-10-07 1986-02-04 International Business Machines Corporation Patterning of polyimide films with far ultraviolet light
FR2535602B1 (fr) * 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US4508749A (en) 1983-12-27 1985-04-02 International Business Machines Corporation Patterning of polyimide films with ultraviolet light
US4822975A (en) 1984-01-30 1989-04-18 Canon Kabushiki Kaisha Method and apparatus for scanning exposure
DE3517729A1 (de) 1985-05-17 1986-11-20 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe Verfahren zum herstellen von spinnduesenplatten
US4768358A (en) 1986-08-04 1988-09-06 Robert Viola Security handle lock
JPH01245993A (ja) 1988-03-27 1989-10-02 Semiconductor Energy Lab Co Ltd 薄膜加工装置
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3842354A1 (de) 1988-12-16 1990-06-21 Kernforschungsz Karlsruhe Verfahren zur lithographischen herstellung von galvanisch abformbaren mikrostrukturen mit dreieckigem oder trapezfoermigem querschnitt
DE3842610C1 (de) 1988-12-17 1990-06-21 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe, De
CA2016900A1 (en) * 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
US5697901A (en) * 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
DE4010669C1 (de) 1990-04-03 1991-04-11 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe, De
ATE176416T1 (de) 1990-11-21 1999-02-15 Canon Kk Laserbearbeitungsgerät
US5160823A (en) 1991-01-03 1992-11-03 Hutchinson Technology, Inc. Moving mask laser imaging
DE4222856C1 (de) 1992-07-11 1993-05-27 Buerkert Gmbh
JP3211525B2 (ja) 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
WO1996007954A1 (en) 1994-09-09 1996-03-14 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microstructures and methods for manufacturing microstructures
AU5325596A (en) 1995-04-26 1996-11-18 Minnesota Mining And Manufacturing Company Method and apparatus for step and repeat exposures
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
ATE234129T1 (de) * 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
AU2189400A (en) * 1998-12-18 2000-07-03 Minimed, Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
WO2000074763A2 (en) 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
MXPA02004863A (es) * 1999-11-15 2003-01-28 Velcro Ind Miembro de sujecion dermica.
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP2002079499A (ja) * 2000-09-08 2002-03-19 Terumo Corp 針形状物の作製方法および作製された針
ES2317940T3 (es) * 2000-10-13 2009-05-01 Alza Corporation Dispositivo de retencion para un elemento de microsalientes para aplicador de impactos.
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography

Also Published As

Publication number Publication date
US20030045837A1 (en) 2003-03-06
JP2005501615A (ja) 2005-01-20
TW550101B (en) 2003-09-01
DE60225859T2 (de) 2009-04-09
US20050143713A1 (en) 2005-06-30
WO2003020359A3 (en) 2003-07-31
EP1652551A3 (de) 2006-05-31
EP1425062A2 (de) 2004-06-09
EP1652551A2 (de) 2006-05-03
EP1652551B1 (de) 2008-03-26
DE60225859D1 (de) 2008-05-08
US6881203B2 (en) 2005-04-19
WO2003020359A2 (en) 2003-03-13
ES2304758T3 (es) 2008-10-16

Similar Documents

Publication Publication Date Title
DE60225859D1 (de) Mikronadelanordnungen
DE60111125D1 (de) Herstellungsverfahren für eine medizinische elektrode
DE60224842D1 (de) Mikronadel-vorrichtungen und verfahren zur herstellung
TW200613029A (en) System and method for drug delivery and microfluidic applications using microneedles
DE60113293D1 (de) Doppelnadeleinführgerät für eine cochleaimplantatelektroden-anordung
ATE518500T1 (de) Vorgeformtes implantat mit einer reihe von elektroden zur anwendung in der gehörschnecke
EP1181947A3 (de) Elektrodenleitung zur Stimulation von Wirbelsaülen
WO2002085447A3 (en) Microprojection array having a beneficial agent containing coating
WO2008028087A3 (en) Methods and apparatus incorporating a surface penetration device
WO2002015960A3 (en) Microneedle array module and method of fabricating the same
WO2002100459A3 (en) Electroporation microneedle and methods for its use
WO2003026733A3 (en) Microneedle with membrane
CY1105070T1 (el) Μεθοδος και συνθεσεις που χρησιμοποιουν κιναζολινονες
BR0312671A (pt) Dispositivo de microagulhas, método para utilizar um dispositivo de microagulhas, e, método para aplicar um dispositivo de microagulhas
WO2004020015A3 (en) Microprotrusion arrays and methods for using same to deliver substances into tissue
WO2002100476A3 (en) Device for manipulating a needle or abrader array
WO2004045671A2 (en) Microstructure roller system
ATE489986T1 (de) Haltemuffe mit manschette zur einführung in subkutane regionen
WO2005018530A3 (en) Penetrating pharmaceutical foam
WO2006000568A3 (de) Marker
WO2002064193A3 (en) Microneedle devices and production thereof
ATE390163T1 (de) Katheter für die nervenblockade
DE502007005362D1 (de) Biegeweiche vorrichtung zum einbringen einer medizinischen vorrichtung in den körper
EP1326674A2 (de) Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut
DE502004006613D1 (de) Vorrichtung zur transdermalen Verabreichung von Wirkstoffen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties