ATE391183T1 - Vektoren/dna-sequenzen aus humanen kombinatorischen antikörper-bibliotheken - Google Patents

Vektoren/dna-sequenzen aus humanen kombinatorischen antikörper-bibliotheken

Info

Publication number
ATE391183T1
ATE391183T1 AT01110609T AT01110609T ATE391183T1 AT E391183 T1 ATE391183 T1 AT E391183T1 AT 01110609 T AT01110609 T AT 01110609T AT 01110609 T AT01110609 T AT 01110609T AT E391183 T1 ATE391183 T1 AT E391183T1
Authority
AT
Austria
Prior art keywords
dna sequences
human
libraries
combinatory
vectors
Prior art date
Application number
AT01110609T
Other languages
English (en)
Inventor
Achim Knappik
Peter Pack
Liming Ge
Original Assignee
Morphosys Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ip Gmbh filed Critical Morphosys Ip Gmbh
Priority claimed from EP96929278A external-priority patent/EP0859841B1/de
Application granted granted Critical
Publication of ATE391183T1 publication Critical patent/ATE391183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01110609T 1996-08-19 1996-08-19 Vektoren/dna-sequenzen aus humanen kombinatorischen antikörper-bibliotheken ATE391183T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96929278A EP0859841B1 (de) 1995-08-18 1996-08-19 Protein-/(poly)peptidbibliotheken
EP01110609A EP1143006B1 (de) 1996-08-19 1996-08-19 Vektoren/DNA-Sequenzen aus humanen kombinatorischen Antikörper-Bibliotheken

Publications (1)

Publication Number Publication Date
ATE391183T1 true ATE391183T1 (de) 2008-04-15

Family

ID=39869489

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01110609T ATE391183T1 (de) 1996-08-19 1996-08-19 Vektoren/dna-sequenzen aus humanen kombinatorischen antikörper-bibliotheken

Country Status (5)

Country Link
EP (2) EP1143006B1 (de)
AT (1) ATE391183T1 (de)
DE (1) DE69637484T2 (de)
ES (1) ES2305012T3 (de)
PT (1) PT1143006E (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102459591B (zh) 2009-05-20 2015-05-13 诺维莫尼公司 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法
CN105274630A (zh) * 2015-11-25 2016-01-27 苏州泓迅生物科技有限公司 基于组合合成技术合成可控的人源化抗体库的方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0368684B2 (de) 1988-11-11 2004-09-29 Medical Research Council Klonierung von Immunglobulin sequenzen aus den variabelen Domänen.
EP0517768A1 (de) * 1990-02-28 1992-12-16 Schering Corporation Expressionsvektoren für säugetierzellen
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
AU6132994A (en) * 1993-02-02 1994-08-29 Scripps Research Institute, The Methods for producing antibody libraries using universal or randomized immunoglobulin light chains

Also Published As

Publication number Publication date
EP1143006B1 (de) 2008-04-02
EP1143006A3 (de) 2003-12-17
EP2058400B1 (de) 2016-05-18
PT1143006E (pt) 2008-06-27
EP2058400A1 (de) 2009-05-13
EP1143006A2 (de) 2001-10-10
DE69637484T2 (de) 2010-06-24
ES2305012T3 (es) 2008-11-01
DE69637484D1 (de) 2008-05-15

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