ATE391505T1 - Benzothiazole derivative - Google Patents

Benzothiazole derivative

Info

Publication number: ATE391505T1
Authority: AT; Austria
Prior art keywords: benzothiazole derivatives; benzothiazole; derivatives
Prior art date: 2001-11-27

Application number

AT02787718T

Other languages

English (en)

Inventor

Alexander Flohr

Roland Jakob-Roetne

Roger Norcross

Claus Riemer

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-27

Filing date

2002-11-18

Publication date

2008-04-15

2002-11-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE391505T1 publication Critical patent/ATE391505T1/de

Links

IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Toxicology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

AT02787718T 2001-11-27 2002-11-18 Benzothiazole derivative ATE391505T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01127442		2001-11-27

Publications (1)

Publication Number	Publication Date
ATE391505T1 true ATE391505T1 (de)	2008-04-15

Family

ID=8179277

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02787718T ATE391505T1 (de)	2001-11-27	2002-11-18	Benzothiazole derivative

Country Status (21)

Country	Link
US (1)	US6596718B1 (de)
EP (1)	EP1450796B1 (de)
JP (1)	JP4216193B2 (de)
KR (1)	KR100613197B1 (de)
CN (1)	CN1325052C (de)
AR (1)	AR037418A1 (de)
AT (1)	ATE391505T1 (de)
AU (1)	AU2002352045B2 (de)
BR (1)	BR0214455A (de)
CA (1)	CA2467825A1 (de)
DE (1)	DE60226063T2 (de)
ES (1)	ES2303558T3 (de)
GT (1)	GT200200240A (de)
MX (1)	MXPA04004982A (de)
PA (1)	PA8558201A1 (de)
PE (1)	PE20030735A1 (de)
PL (1)	PL370978A1 (de)
RU (1)	RU2293083C2 (de)
TW (1)	TW200408391A (de)
UY (1)	UY27551A1 (de)
WO (1)	WO2003045385A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6678828B1 (en) *	2002-07-22	2004-01-13	Vormetric, Inc.	Secure network file access control system
AU2004251814B2 (en) *	2003-05-19	2009-07-23	F. Hoffmann-La Roche Ag	Benzothiazole derivatives as adenosine receptor ligands
EP1669348A4 (de) *	2003-09-30	2009-03-11	Eisai R&D Man Co Ltd	Neues antipilzmittel, das eine heterocyclische verbindung enthält
CA2543707A1 (en)	2003-10-31	2005-05-19	Takeda Pharmaceutical Company Limited	Nitrogen-containing fused heterocyclic compounds
JPWO2005073210A1 (ja) *	2004-01-28	2007-09-06	キッセイ薬品工業株式会社	新規なベンゾフラン誘導体、それを含有する医薬組成物およびそれらの用途
KR101101493B1 (ko) *	2004-03-30	2012-01-03	칼 짜이스 에스엠티 게엠베하	투영 대물렌즈, 투영 노광 장치 및 마이크로리소그래피용반사형 레티클
KR100818028B1 (ko) *	2004-07-22	2008-03-31	에프. 호프만-라 로슈 아게	치환된 벤조티아졸
US20090227799A1 (en) *	2004-08-09	2009-09-10	Kazutaka Nakamoto	Novel Antimalarial Agent Containing Heterocyclic Compound
WO2006106711A1 (ja)	2005-03-30	2006-10-12	Eisai R & D Management Co., Ltd.	ピリジン誘導体を含有する抗真菌剤
JPWO2006115134A1 (ja) *	2005-04-22	2008-12-18	キッセイ薬品工業株式会社	新規なベンゾフラン誘導体、それを含有する医薬組成物およびそれらの用途
TWI385169B (zh) *	2005-10-31	2013-02-11	Eisai R&D Man Co Ltd	經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP2044055A4 (de) *	2006-07-21	2011-03-23	Takeda Pharmaceutical	Amidverbindungen
WO2008035726A1 (en) *	2006-09-21	2008-03-27	Eisai R & D Management Co., Ltd.	Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
JP2010511661A (ja)	2006-12-07	2010-04-15	エフ．ホフマン−ラロシュアーゲー	Ｖ１ａ受容体アンタゴニストとしてのスピロ−ピペリジン誘導体
MX2009006454A (es)	2006-12-22	2009-06-26	Hoffmann La Roche	Derivados de espiro-piperidina.
CN101563323B (zh)	2006-12-22	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物
CA2685194A1 (en) *	2007-04-27	2008-11-13	Eisai R&D Management Co., Ltd.	Heterocycle-substituted pyridine derivatives salt or crystal thereof
TW200841879A (en)	2007-04-27	2008-11-01	Eisai R&D Man Co Ltd	Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8513287B2 (en)	2007-12-27	2013-08-20	Eisai R&D Management Co., Ltd.	Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) *	2008-10-24	2012-05-29	Eisai R&D Management Co., Ltd	Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2014517074A (ja)	2011-06-24	2014-07-17	アムジエン・インコーポレーテツド	Ｔｒｐｍ８アンタゴニストおよび治療におけるそれらの使用
MY157429A (en)	2011-06-24	2016-06-15	Amgen Inc	Trpm8 antagonists and their use in treatments
WO2013042137A1 (en) *	2011-09-19	2013-03-28	Aurigene Discovery Technologies Limited	Bicyclic heterocycles as irak4 inhibitors
US8940742B2 (en) *	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US8952009B2 (en)	2012-08-06	2015-02-10	Amgen Inc.	Chroman derivatives as TRPM8 inhibitors
PE20160685A1 (es)	2013-10-04	2016-07-23	Infinity Pharmaceuticals Inc	Compuestos heterociclicos y usos de los mismos
US9751888B2 (en)	2013-10-04	2017-09-05	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
SG10201808053XA (en)	2014-03-19	2018-10-30	Infinity Pharmaceuticals Inc	Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US9708348B2 (en)	2014-10-03	2017-07-18	Infinity Pharmaceuticals, Inc.	Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10160761B2 (en)	2015-09-14	2018-12-25	Infinity Pharmaceuticals, Inc.	Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
WO2017161116A1 (en)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en)	2016-06-08	2021-02-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
KR20190078646A (ko) *	2016-11-18	2019-07-04	머크 샤프 앤드 돔 코포레이션	디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체
JP7233809B2 (ja) *	2018-09-04	2023-03-07	エフ．ホフマン－ラロシュアーゲー	自己免疫疾患の処置のためのベンゾチアゾール化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8717068D0 (en) *	1987-07-20	1987-08-26	Fujisawa Pharmaceutical Co	Nitric ester derivative
NZ522928A (en) *	2000-06-21	2005-05-27	F	Benzothiazole derivatives

2002
- 2002-11-18 US US10/298,347 patent/US6596718B1/en not_active Expired - Fee Related
- 2002-11-18 AT AT02787718T patent/ATE391505T1/de active
- 2002-11-18 EP EP02787718A patent/EP1450796B1/de not_active Expired - Lifetime
- 2002-11-18 ES ES02787718T patent/ES2303558T3/es not_active Expired - Lifetime
- 2002-11-18 CN CNB028236041A patent/CN1325052C/zh not_active Expired - Fee Related
- 2002-11-18 RU RU2004119438/04A patent/RU2293083C2/ru not_active IP Right Cessation
- 2002-11-18 KR KR1020047007929A patent/KR100613197B1/ko not_active Expired - Fee Related
- 2002-11-18 BR BR0214455-7A patent/BR0214455A/pt not_active IP Right Cessation
- 2002-11-18 AU AU2002352045A patent/AU2002352045B2/en not_active Ceased
- 2002-11-18 WO PCT/EP2002/012907 patent/WO2003045385A1/en not_active Ceased
- 2002-11-18 JP JP2003546887A patent/JP4216193B2/ja not_active Expired - Fee Related
- 2002-11-18 CA CA002467825A patent/CA2467825A1/en not_active Abandoned
- 2002-11-18 PL PL02370978A patent/PL370978A1/xx not_active Application Discontinuation
- 2002-11-18 MX MXPA04004982A patent/MXPA04004982A/es active IP Right Grant
- 2002-11-18 DE DE60226063T patent/DE60226063T2/de not_active Expired - Lifetime
- 2002-11-22 GT GT200200240A patent/GT200200240A/es unknown
- 2002-11-22 TW TW091134083A patent/TW200408391A/zh unknown
- 2002-11-22 PA PA20028558201A patent/PA8558201A1/es unknown
- 2002-11-25 PE PE2002001132A patent/PE20030735A1/es not_active Application Discontinuation
- 2002-11-25 AR ARP020104516A patent/AR037418A1/es unknown
- 2002-11-26 UY UY27551A patent/UY27551A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP4216193B2 (ja)	2009-01-28
TW200408391A (en)	2004-06-01
ES2303558T3 (es)	2008-08-16
EP1450796A1 (de)	2004-09-01
KR20040062968A (ko)	2004-07-09
RU2004119438A (ru)	2006-01-10
DE60226063T2 (de)	2009-05-20
PE20030735A1 (es)	2003-08-29
BR0214455A (pt)	2004-11-03
PL370978A1 (en)	2005-06-13
AR037418A1 (es)	2004-11-10
MXPA04004982A (es)	2004-08-11
US6596718B1 (en)	2003-07-22
RU2293083C2 (ru)	2007-02-10
AU2002352045B2 (en)	2006-08-17
CA2467825A1 (en)	2003-06-05
JP2005526007A (ja)	2005-09-02
EP1450796B1 (de)	2008-04-09
GT200200240A (es)	2003-07-30
PA8558201A1 (es)	2003-09-05
WO2003045385A1 (en)	2003-06-05
CN1325052C (zh)	2007-07-11
KR100613197B1 (ko)	2006-08-21
DE60226063D1 (en)	2008-05-21
CN1731999A (zh)	2006-02-08
AU2002352045A1 (en)	2003-06-10
UY27551A1 (es)	2003-06-30

Legal Events

Date

Code

Title

Description

2008-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1450796

Country of ref document: EP

Publication	Publication Date	Title
NO20025978D0 (no)	2002-12-12	Benzotiazol-derivater
ATE376831T1 (de)	2007-11-15	Nicotin- oder isonicotin benzothiazole derivaten
ATE319451T1 (de)	2006-03-15	Tetrahydrochinolin-derivate
ATE312827T1 (de)	2005-12-15	3-substituierte-4-pyrimidonderivate
ATE478870T1 (de)	2010-09-15	Spiroindolinpiperidinderivate
ATE460418T1 (de)	2010-03-15	Heterocyclocarboxamidderivate
ATE450506T1 (de)	2009-12-15	Indol-3-schwefelderivate
ATE467631T1 (de)	2010-05-15	Chinuclidinamidderivate
ATE438644T1 (de)	2009-08-15	Chinazolinderivate
IS7720A (is)	2005-03-01	Píperidín-N-oxíð-afleiður
DK1474408T3 (da)	2012-06-25	N-Phenyl-2-pyrimidinaminderivater
DE50210090D1 (de)	2007-06-14	Substituierte phenylderivate
DE60226063D1 (en)	2008-05-21	Benzothiazole derivative
EE200300447A (et)	2003-12-15	Asendatud bensofuraan-2-karboksamiidide derivaadid
DE60307512D1 (de)	2006-09-21	3h-chinazoline -4-on derivaten
ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate
DE60223031D1 (de)	2007-11-29	Arylpiperazin gebundene tetrahydroindolonderivate
ATE457299T1 (de)	2010-02-15	4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ
DE60212694D1 (de)	2006-08-03	Benzothiazolderivaten
DE50306277D1 (de)	2007-02-22	4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate
ATE309242T1 (de)	2005-11-15	Benzothiazole
ATE346045T1 (de)	2006-12-15	Heteroaryl-substituierte aminocyclohexan-derivate
DK1246791T3 (da)	2005-02-14	Aminomethyl-phenyl-cyklohexanonderivater
ATE382601T1 (de)	2008-01-15	Substituierte 4-aminocyclohexanolderivate
DE60202381D1 (de)	2005-01-27	Paroxetin-n-formyl-derivate