ATE391707T1 - Verfahren zur synthese von aminen wie ephedrin und zwischenprodukten - Google Patents
Verfahren zur synthese von aminen wie ephedrin und zwischenproduktenInfo
- Publication number
- ATE391707T1 ATE391707T1 AT02764370T AT02764370T ATE391707T1 AT E391707 T1 ATE391707 T1 AT E391707T1 AT 02764370 T AT02764370 T AT 02764370T AT 02764370 T AT02764370 T AT 02764370T AT E391707 T1 ATE391707 T1 AT E391707T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- optionally substituted
- alkyl
- formula
- ephedrine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001412 amines Chemical class 0.000 title abstract 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 title 1
- 229960002179 ephedrine Drugs 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
- C07C209/26—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR7326A AUPR732601A0 (en) | 2001-08-28 | 2001-08-28 | Methods for the synthesis of amines such as ephedrine and inter mediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE391707T1 true ATE391707T1 (de) | 2008-04-15 |
Family
ID=3831278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02764370T ATE391707T1 (de) | 2001-08-28 | 2002-08-26 | Verfahren zur synthese von aminen wie ephedrin und zwischenprodukten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7176332B2 (de) |
| EP (1) | EP1421055B1 (de) |
| JP (1) | JP2005500399A (de) |
| AT (1) | ATE391707T1 (de) |
| AU (2) | AUPR732601A0 (de) |
| DE (1) | DE60226038T2 (de) |
| WO (1) | WO2003018531A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0406125D0 (en) | 2004-03-18 | 2004-04-21 | Univ Cambridge Tech | Methods of amination |
| WO2005100299A1 (en) * | 2004-04-15 | 2005-10-27 | Emmellen Biotech Pharmaceuticals Limited | Process for preparation of optically active 1-erythro-2-amino-1-phenyl-1-propanol |
| SG156644A1 (en) | 2005-03-28 | 2009-11-26 | Albemarle Corp | Diimines and secondary diamines |
| US7964695B2 (en) | 2005-03-28 | 2011-06-21 | Albemarle Corporation | Chain extenders |
| US8076518B2 (en) | 2005-03-28 | 2011-12-13 | Albemarle Corporation | Chain extenders |
| WO2007077140A1 (de) * | 2006-01-06 | 2007-07-12 | Basf Aktiengesellschaft | Hydroxy-norephedrin-derivate und verfahren zu ihrer herstellung |
| GB0607911D0 (en) * | 2006-04-21 | 2006-05-31 | Ineos Fluor Holdings Ltd | Process |
| US8143365B2 (en) | 2007-01-10 | 2012-03-27 | Albemarle Corporation | Formulations for reaction injection molding and for spray systems |
| US8654740B2 (en) | 2009-03-03 | 2014-02-18 | Intel Corporation | Polar cap reset method for differential codebook for wireless communications |
| CN103113239B (zh) * | 2013-03-11 | 2014-04-30 | 苏州立新制药有限公司 | 盐酸利托君的制备方法 |
| CN103113237B (zh) * | 2013-03-11 | 2014-04-30 | 苏州立新制药有限公司 | 一种盐酸利托君的制备方法 |
| CN103113238B (zh) * | 2013-03-11 | 2014-04-30 | 苏州立新制药有限公司 | 一种利托君的制备方法 |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| CN107111673B (zh) | 2014-09-29 | 2021-03-23 | 周格尼克斯国际有限公司 | 控制药物分配的控制系统 |
| WO2017112701A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| ES3024232T3 (en) * | 2015-12-22 | 2025-06-04 | Zogenix International Ltd | Fenfluramine compositions and methods of preparing the same |
| SG11201900975XA (en) | 2016-08-24 | 2019-03-28 | Zogenix International Ltd | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
| CN107311875A (zh) * | 2017-06-30 | 2017-11-03 | 暨明医药科技（苏州）有限公司 | 重酒石酸间羟胺的合成方法 |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| WO2019216919A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EA202191079A1 (ru) | 2018-11-19 | 2021-09-20 | Зодженикс Интернэшнл Лимитед | Способы лечения синдрома ретта с применением фенфлурамина |
| FR3102480B1 (fr) | 2019-10-29 | 2022-02-04 | Commissariat Energie Atomique | Matériaux spécifiques utilisables pour la détection d’au moins un élément alcalin |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1956950A (en) | 1930-04-08 | 1934-05-01 | Bilhuber Inc E | Manufacture of laevo-1-phenyl-2-methylaminopropanol-1 |
| DE3275643D1 (en) | 1982-07-20 | 1987-04-16 | Union Carbide Corp | Continuous process for preparing alkanolamines |
| KR19990063939A (ko) * | 1995-10-04 | 1999-07-26 | 그레이스 스티븐 에스. | 아민 캡핑된 폴리에테르 및 이의 제조방법 |
| GB9607917D0 (en) * | 1996-04-17 | 1996-06-19 | Swan Thomas & Co Ltd | Supercritical hydrogenation |
| EP1142864A4 (de) | 1998-12-24 | 2003-06-25 | Nagase & Co Ltd | Verfahren zur herstellung von l-erythro-(1r,2s)-2-amino-1-phenylpropan-1-ol |
| AUPQ462599A0 (en) | 1999-12-13 | 2000-01-13 | Polychip Pharmaceuticals Pty Ltd | Yeast-based process for production of l-pac |
| AU769421B2 (en) * | 1999-12-13 | 2004-01-29 | Victoria University | Yeast-based process for production of L-pac |
-
2001
- 2001-08-28 AU AUPR7326A patent/AUPR732601A0/en not_active Abandoned
-
2002
- 2002-08-26 AT AT02764370T patent/ATE391707T1/de not_active IP Right Cessation
- 2002-08-26 JP JP2003523196A patent/JP2005500399A/ja active Pending
- 2002-08-26 DE DE60226038T patent/DE60226038T2/de not_active Expired - Lifetime
- 2002-08-26 EP EP02764370A patent/EP1421055B1/de not_active Expired - Lifetime
- 2002-08-26 AU AU2002328659A patent/AU2002328659B2/en not_active Ceased
- 2002-08-26 WO PCT/AU2002/001148 patent/WO2003018531A1/en not_active Ceased
- 2002-08-26 US US10/488,034 patent/US7176332B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1421055B1 (de) | 2008-04-09 |
| EP1421055A4 (de) | 2005-01-19 |
| WO2003018531A1 (en) | 2003-03-06 |
| DE60226038D1 (de) | 2008-05-21 |
| DE60226038T2 (de) | 2009-05-14 |
| US7176332B2 (en) | 2007-02-13 |
| AUPR732601A0 (en) | 2001-09-20 |
| JP2005500399A (ja) | 2005-01-06 |
| EP1421055A1 (de) | 2004-05-26 |
| AU2002328659B2 (en) | 2009-07-30 |
| US20040249212A1 (en) | 2004-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |