ATE392183T1 - Hydrophile zyaninfarbstoffe - Google Patents

Hydrophile zyaninfarbstoffe

Info

Publication number: ATE392183T1
Authority: AT; Austria
Prior art keywords: therapy; compounds; imaging; detection; useful
Prior art date: 2000-01-18

Application number

AT01904882T

Other languages

English (en)

Inventor

Samuel Achilefu

Raghavan Rajagopalan

Richard Dorshow

Joseph Bugaj

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-18

Filing date

2001-01-17

Publication date

2008-05-15

2000-01-18 Priority claimed from US09/484,319 external-priority patent/US6180086B1/en

2001-01-17 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2008-05-15 Application granted granted Critical

2008-05-15 Publication of ATE392183T1 publication Critical patent/ATE392183T1/de

Links

239000000975 dye Substances 0.000 title abstract 5
ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 title abstract 3
238000002560 therapeutic procedure Methods 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
206010028980 Neoplasm Diseases 0.000 abstract 3
238000001514 detection method Methods 0.000 abstract 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
238000002059 diagnostic imaging Methods 0.000 abstract 2
238000003384 imaging method Methods 0.000 abstract 2
230000005856 abnormality Effects 0.000 abstract 1
239000012867 bioactive agent Substances 0.000 abstract 1
230000000975 bioactive effect Effects 0.000 abstract 1
229940077731 carbohydrate nutrients Drugs 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
235000014633 carbohydrates Nutrition 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000012216 imaging agent Substances 0.000 abstract 1
NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Indole Compounds (AREA)

AT01904882T 2000-01-18 2001-01-17 Hydrophile zyaninfarbstoffe ATE392183T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/484,319 US6180086B1 (en)	2000-01-18	2000-01-18	Hydrophilic cyanine dyes
US09/757,332 US7011817B2 (en)	2000-01-18	2001-01-09	Hydrophilic cyanine dyes

Publications (1)

Publication Number	Publication Date
ATE392183T1 true ATE392183T1 (de)	2008-05-15

Family

ID=27047953

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01904882T ATE392183T1 (de)	2000-01-18	2001-01-17	Hydrophile zyaninfarbstoffe

Country Status (5)

Country	Link
EP (1)	EP1250091B1 (de)
JP (1)	JP2003529632A (de)
AT (1)	ATE392183T1 (de)
AU (1)	AU2001232818A1 (de)
WO (1)	WO2001052744A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7790144B2 (en) *	2000-01-18	2010-09-07	Mallinckrodt Inc.	Receptor-avid exogenous optical contrast and therapeutic agents
US6663847B1 (en) *	2000-10-13	2003-12-16	Mallinckrodt Inc.	Dynamic organ function monitoring agents
US7556797B2 (en) *	2000-10-16	2009-07-07	Mallinckrodt Inc.	Minimally invasive physiological function monitoring agents
US6733744B1 (en) *	2000-10-16	2004-05-11	Mallinckrodt Inc.	Indole compounds as minimally invasive physiological function monitoring agents
US20030105300A1 (en) *	2001-10-17	2003-06-05	Mallinckrodt Inc.	Tumor targeted photodiagnostic-phototherapeutic agents
US20030105299A1 (en) *	2001-10-17	2003-06-05	Mallinckrodt Inc.	Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US20030152577A1 (en) *	2002-02-07	2003-08-14	Mallinckrodt Inc.	Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications
US6919333B2 (en) *	2002-11-12	2005-07-19	Rutgers, The State University Of New Jersey	Bis-transition-metal-chelate probes
EP1506402A2 (de) *	2002-03-28	2005-02-16	Rutgers, The State University of New Jersey	Bis-übergangsmetall-chelat probe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8615995D0 (en) *	1986-07-01	1986-08-06	Glaxo Group Ltd	Veterinary preparations
DE3721850A1 (de) *	1987-07-02	1989-01-12	Bayer Ag	Indolin-carbocyaninfarbstoffe
JP3354975B2 (ja) *	1992-10-06	2002-12-09	イビデン株式会社	蛍光標識試薬および蛍光免疫測定法
US5631364A (en) *	1994-03-31	1997-05-20	Axis Biochemicals Asa	Labelled boronic acid derivatives
WO1996000902A1 (en) *	1994-06-30	1996-01-11	Biometric Imaging, Inc.	N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
IT1276833B1 (it) *	1995-10-09	1997-11-03	Sorin Biomedica Cardio Spa	Coloranti fluorescenti della famiglia della solfo benz e indocianina
CN1323224A (zh) *	1998-09-17	2001-11-21	日本化药株式会社	光化学疗法治疗剂
DE19911102A1 (de) *	1999-03-12	2000-09-14	Few Chemicals Gmbh Wolfen	Cyanin-Farbstoffe
JP4041613B2 (ja) *	1999-03-12	2008-01-30	富士フイルム株式会社	画像形成材料
US6180086B1 (en) *	2000-01-18	2001-01-30	Mallinckrodt Inc.	Hydrophilic cyanine dyes

2001
- 2001-01-17 AT AT01904882T patent/ATE392183T1/de not_active IP Right Cessation
- 2001-01-17 EP EP01904882A patent/EP1250091B1/de not_active Expired - Lifetime
- 2001-01-17 AU AU2001232818A patent/AU2001232818A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001468 patent/WO2001052744A1/en not_active Ceased
- 2001-01-17 JP JP2001552799A patent/JP2003529632A/ja active Pending

Also Published As

Publication number	Publication date
EP1250091A4 (de)	2003-05-07
JP2003529632A (ja)	2003-10-07
EP1250091B1 (de)	2008-04-16
AU2001232818A1 (en)	2001-07-31
EP1250091A1 (de)	2002-10-23
WO2001052744A1 (en)	2001-07-26

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Legal Events

Date	Code	Title	Description
2008-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties