ATE392896T1 - 4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6- tetrahydropyridin-derivate als serotonin- wiederaufnahme-hemmer - Google Patents
4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6- tetrahydropyridin-derivate als serotonin- wiederaufnahme-hemmerInfo
- Publication number
- ATE392896T1 ATE392896T1 AT04725298T AT04725298T ATE392896T1 AT E392896 T1 ATE392896 T1 AT E392896T1 AT 04725298 T AT04725298 T AT 04725298T AT 04725298 T AT04725298 T AT 04725298T AT E392896 T1 ATE392896 T1 AT E392896T1
- Authority
- AT
- Austria
- Prior art keywords
- reuppost
- phenyloxyphenyl
- serotonin
- piperidine
- inhibitors
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- YWIYMDPWBAXEKQ-UHFFFAOYSA-N 4-(2-phenoxyphenyl)piperidine Chemical compound C1CNCCC1C1=CC=CC=C1OC1=CC=CC=C1 YWIYMDPWBAXEKQ-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940076279 serotonin Drugs 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000017194 Affective disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46026503P | 2003-04-04 | 2003-04-04 | |
| DKPA200300519 | 2003-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE392896T1 true ATE392896T1 (de) | 2008-05-15 |
Family
ID=33132908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04725298T ATE392896T1 (de) | 2003-04-04 | 2004-04-02 | 4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6- tetrahydropyridin-derivate als serotonin- wiederaufnahme-hemmer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060293360A1 (de) |
| EP (1) | EP1635828B1 (de) |
| JP (1) | JP2006522027A (de) |
| AT (1) | ATE392896T1 (de) |
| AU (1) | AU2004226837A1 (de) |
| BR (1) | BRPI0408320A (de) |
| CO (1) | CO5640133A2 (de) |
| DE (1) | DE602004013314T2 (de) |
| DK (1) | DK1635828T3 (de) |
| ES (1) | ES2303062T3 (de) |
| HR (1) | HRP20080262T3 (de) |
| MX (1) | MXPA05010627A (de) |
| NO (1) | NO20055206L (de) |
| NZ (1) | NZ540891A (de) |
| PL (1) | PL1635828T3 (de) |
| PT (1) | PT1635828E (de) |
| SI (1) | SI1635828T1 (de) |
| WO (1) | WO2004087155A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004087156A1 (en) | 2003-04-04 | 2004-10-14 | H. Lundbeck A/S | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
| CA2656057C (en) * | 2006-06-16 | 2012-10-02 | H. Lundbeck A/S | Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
| TWI432194B (zh) * | 2007-03-20 | 2014-04-01 | Lundbeck & Co As H | ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途 |
| TWI396689B (zh) | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶１０抑制劑之吡衍生物 |
| NZ592543A (en) | 2008-11-14 | 2013-02-22 | Theravance Inc | 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds |
| TW201030001A (en) | 2008-11-14 | 2010-08-16 | Amgen Inc | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
| ES2397934T3 (es) | 2008-12-17 | 2013-03-12 | Amgen Inc. | Compuestos de aminopiridina y carboxipiridina como inhibidores de fosfodiesterasa 10 |
| US8778949B2 (en) * | 2010-01-11 | 2014-07-15 | Theravance Biopharma R&D Ip, Llc | 1-(2-phenoxymethylphenyl)piperazine compounds |
| JP5769348B2 (ja) * | 2010-03-22 | 2015-08-26 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | １−（２−フェノキシメチルヘテロアリール）ピペリジン化合物および１−（２−フェノキシメチルヘテロアリール）ピペラジン化合物 |
| EP2560646B1 (de) * | 2010-04-22 | 2014-12-17 | Theravance Biopharma R&D IP, LLC | Kombination aus einem serotonin- und norepinephrin-wiederaufnahmehemmer sowie einem opioid zur schmerzbehandlung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| US4198417A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
| GEP20043296B (en) * | 1999-02-23 | 2004-01-12 | Pfizer Prod Inc | Monoamine Reuptake Inhibitors for Treatment of CNS Disorders |
| WO2001027068A1 (en) * | 1999-10-13 | 2001-04-19 | Pfizer Products Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
-
2004
- 2004-04-02 NZ NZ540891A patent/NZ540891A/en unknown
- 2004-04-02 HR HR20080262T patent/HRP20080262T3/xx unknown
- 2004-04-02 ES ES04725298T patent/ES2303062T3/es not_active Expired - Lifetime
- 2004-04-02 MX MXPA05010627A patent/MXPA05010627A/es active IP Right Grant
- 2004-04-02 AT AT04725298T patent/ATE392896T1/de not_active IP Right Cessation
- 2004-04-02 PT PT04725298T patent/PT1635828E/pt unknown
- 2004-04-02 DE DE602004013314T patent/DE602004013314T2/de not_active Expired - Fee Related
- 2004-04-02 AU AU2004226837A patent/AU2004226837A1/en not_active Abandoned
- 2004-04-02 EP EP04725298A patent/EP1635828B1/de not_active Expired - Lifetime
- 2004-04-02 BR BRPI0408320-2A patent/BRPI0408320A/pt not_active IP Right Cessation
- 2004-04-02 JP JP2006504346A patent/JP2006522027A/ja not_active Withdrawn
- 2004-04-02 SI SI200430746T patent/SI1635828T1/sl unknown
- 2004-04-02 DK DK04725298T patent/DK1635828T3/da active
- 2004-04-02 PL PL04725298T patent/PL1635828T3/pl unknown
- 2004-04-02 US US10/551,870 patent/US20060293360A1/en not_active Abandoned
- 2004-04-02 WO PCT/DK2004/000241 patent/WO2004087155A1/en not_active Ceased
-
2005
- 2005-10-20 CO CO05106876A patent/CO5640133A2/es unknown
- 2005-11-04 NO NO20055206A patent/NO20055206L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO5640133A2 (es) | 2006-05-31 |
| EP1635828A1 (de) | 2006-03-22 |
| WO2004087155A1 (en) | 2004-10-14 |
| AU2004226837A1 (en) | 2004-10-14 |
| DE602004013314D1 (de) | 2008-06-05 |
| US20060293360A1 (en) | 2006-12-28 |
| NZ540891A (en) | 2008-07-31 |
| SI1635828T1 (sl) | 2008-08-31 |
| HRP20080262T3 (hr) | 2009-04-30 |
| PT1635828E (pt) | 2008-07-01 |
| ES2303062T3 (es) | 2008-08-01 |
| JP2006522027A (ja) | 2006-09-28 |
| DK1635828T3 (da) | 2008-08-11 |
| NO20055206L (no) | 2005-11-04 |
| BRPI0408320A (pt) | 2006-03-07 |
| MXPA05010627A (es) | 2005-12-12 |
| DE602004013314T2 (de) | 2008-08-07 |
| PL1635828T3 (pl) | 2008-10-31 |
| EP1635828B1 (de) | 2008-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1635828 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |