ATE412634T1 - Piperazinderivate von alkyloxindolen - Google Patents

Piperazinderivate von alkyloxindolen

Info

Publication number
ATE412634T1
ATE412634T1 AT05745442T AT05745442T ATE412634T1 AT E412634 T1 ATE412634 T1 AT E412634T1 AT 05745442 T AT05745442 T AT 05745442T AT 05745442 T AT05745442 T AT 05745442T AT E412634 T1 ATE412634 T1 AT E412634T1
Authority
AT
Austria
Prior art keywords
alkyloxindoles
piperazine derivatives
derivatives
new
disorders
Prior art date
Application number
AT05745442T
Other languages
English (en)
Inventor
Balazs Volk
Jozsef Barkoczy
Gyula Simig
Tibor Mezei
Dezsofi Rita Kapillerne
Istvan Gacsalyi
Katalin Pallagi
Gabor Gigler
Gyoergy Levay
Krisztina Moricz
Csilla Leveleki
Nora Sziray
Gabor Szenasi
Andras Egyed
Laszlo Harsing
Original Assignee
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0400954A external-priority patent/HU0400954D0/hu
Priority claimed from HU0500461A external-priority patent/HUP0500461A3/hu
Application filed by Egis Gyogyszergyar Nyrt filed Critical Egis Gyogyszergyar Nyrt
Application granted granted Critical
Publication of ATE412634T1 publication Critical patent/ATE412634T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT05745442T 2004-05-11 2005-05-10 Piperazinderivate von alkyloxindolen ATE412634T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0400954A HU0400954D0 (en) 2004-05-11 2004-05-11 Piperazine derivatives of alkyl oxindoles
HU0500461A HUP0500461A3 (en) 2005-05-05 2005-05-05 Pyperazine derivatives of alkyl-oxindoles

Publications (1)

Publication Number Publication Date
ATE412634T1 true ATE412634T1 (de) 2008-11-15

Family

ID=89985994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05745442T ATE412634T1 (de) 2004-05-11 2005-05-10 Piperazinderivate von alkyloxindolen

Country Status (24)

Country Link
US (1) US20070219209A1 (de)
EP (1) EP1751106B1 (de)
JP (1) JP2007537226A (de)
KR (1) KR20070011551A (de)
AT (1) ATE412634T1 (de)
AU (1) AU2005240842B2 (de)
BG (1) BG109768A (de)
CA (1) CA2564009A1 (de)
CZ (1) CZ2006778A3 (de)
DE (1) DE602005010694D1 (de)
DK (1) DK1751106T3 (de)
EA (1) EA011280B1 (de)
ES (1) ES2317241T3 (de)
HR (2) HRP20060401A2 (de)
IL (1) IL178759A0 (de)
MX (1) MXPA06013064A (de)
NO (1) NO20065697L (de)
NZ (1) NZ551542A (de)
PL (1) PL1751106T3 (de)
PT (1) PT1751106E (de)
RS (1) RS20060620A (de)
SI (1) SI1751106T1 (de)
SK (1) SK51112006A3 (de)
WO (1) WO2005108363A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005015223D1 (de) * 2004-05-11 2009-08-13 Egis Gyogyszergyar Nyrt 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivate und verwandte verbindungen zur behandlung von erkrankungen des zentralnervensystems
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (en) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Oxindole derivatives and psychotropic drugs

Also Published As

Publication number Publication date
SI1751106T1 (sl) 2009-06-30
AU2005240842B2 (en) 2011-10-06
AU2005240842A1 (en) 2005-11-17
SK51112006A3 (sk) 2007-05-03
HRP20060401A2 (en) 2007-03-31
EA200602080A1 (ru) 2007-04-27
DE602005010694D1 (de) 2008-12-11
EA011280B1 (ru) 2009-02-27
CA2564009A1 (en) 2005-11-17
EP1751106B1 (de) 2008-10-29
DK1751106T3 (da) 2009-03-09
BG109768A (bg) 2008-03-31
NO20065697L (no) 2007-02-02
JP2007537226A (ja) 2007-12-20
CZ2006778A3 (cs) 2007-03-07
ES2317241T3 (es) 2009-04-16
NZ551542A (en) 2010-06-25
US20070219209A1 (en) 2007-09-20
EP1751106A1 (de) 2007-02-14
PT1751106E (pt) 2009-02-10
KR20070011551A (ko) 2007-01-24
PL1751106T3 (pl) 2009-07-31
WO2005108363A1 (en) 2005-11-17
RS20060620A (sr) 2008-09-29
MXPA06013064A (es) 2007-04-27
HRP20090054T3 (hr) 2009-03-31
IL178759A0 (en) 2007-02-11

Similar Documents

Publication Publication Date Title
SE0303180D0 (sv) Novel compounds
SE0302232D0 (sv) Novel Compounds
NO20056130L (no) Nye substituerte 3-svovelindoler
SE0202241D0 (sv) Novel Compounds
EA200600048A1 (ru) Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
SE0201635D0 (sv) Novel compounds
EA200702470A1 (ru) Производные пиррола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов
NO20082136L (no) 1,5-substituerte indol-2-yl-amidderivater
MX2007014444A (es) Derivados de oxadiazol sustituido como moduladores aloestericos positivos de los receptores de glutamato metabotropicos.
DE602004014190D1 (de) 2-(1h-indolylsulfanyl)-benzylaminderivate als ssri
NO20065768L (no) Karbonsamid-opioidforbindelser
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
ATE412634T1 (de) Piperazinderivate von alkyloxindolen
ATE534638T1 (de) Piperazin-derivate
EA200602083A1 (ru) Новые пиперазиновые производные диалкилоксиндолов
ATE423772T1 (de) Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin
EA200602084A1 (ru) Пиперазиновые производные алкилоксиндолов
UA86809C2 (en) Piperazine derivatives of alkyl oxindoles
IL179030A0 (en) Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
ECSP066555A (es) Derivados de morfolina como inhibidores de la reabsorcion de norepinefrina
ATE479691T1 (de) 4,5,6,7-tetrahydrothienoä2,3-cüpyridine als h3- modulatoren
SE0301795D0 (sv) New use I

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1751106

Country of ref document: EP