ATE393171T1 - Funktionelle chitosanderivate - Google Patents

Funktionelle chitosanderivate

Info

Publication number
ATE393171T1
ATE393171T1 AT99954422T AT99954422T ATE393171T1 AT E393171 T1 ATE393171 T1 AT E393171T1 AT 99954422 T AT99954422 T AT 99954422T AT 99954422 T AT99954422 T AT 99954422T AT E393171 T1 ATE393171 T1 AT E393171T1
Authority
AT
Austria
Prior art keywords
functional
chitosand
derivatives
derivative
chitosan
Prior art date
Application number
AT99954422T
Other languages
English (en)
Inventor
Hirofumi Yura
Yoshio Saito
Masayuki Ishihara
Katsuaki Ono
Shiro Saeki
Original Assignee
Netech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netech Inc filed Critical Netech Inc
Application granted granted Critical
Publication of ATE393171T1 publication Critical patent/ATE393171T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99954422T 1998-11-10 1999-11-08 Funktionelle chitosanderivate ATE393171T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31920998 1998-11-10

Publications (1)

Publication Number Publication Date
ATE393171T1 true ATE393171T1 (de) 2008-05-15

Family

ID=18107634

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99954422T ATE393171T1 (de) 1998-11-10 1999-11-08 Funktionelle chitosanderivate

Country Status (8)

Country Link
US (2) US6806260B1 (de)
EP (1) EP1152013B1 (de)
JP (1) JP4606586B2 (de)
AT (1) ATE393171T1 (de)
AU (1) AU755683B2 (de)
CA (1) CA2351177C (de)
DE (1) DE69938612T2 (de)
WO (1) WO2000027889A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE393171T1 (de) * 1998-11-10 2008-05-15 Netech Inc Funktionelle chitosanderivate
FR2831534B1 (fr) 2001-10-29 2004-01-30 Oreal Composition photoactivable et utilisations
JP3947391B2 (ja) * 2001-11-28 2007-07-18 独立行政法人 日本原子力研究開発機構 橋かけ構造を有するキチン誘導体及び／又はキトサン誘導体の製造方法
CA2484453A1 (en) * 2002-04-23 2003-11-06 Netech Inc. Medicinal compositions containing photocrosslinkable chitosan derivative
EP1567559A4 (de) * 2002-11-12 2008-04-16 Polymer Technology Group Inc Steuerung der molekularen architektur einer polymeroberfläche über amphipatische endgruppen
CN1835723B (zh) * 2003-06-16 2011-06-22 洛马林达大学医学中心 可展开的多功能止血剂
WO2005041811A2 (en) * 2003-06-16 2005-05-12 Loma Linda University Medical Center Deployable hemostatic agent
JP2006347883A (ja) * 2003-09-08 2006-12-28 Neetec:Kk 糖鎖含有キトサン誘導体及びグリコサミノグリカンを含有する医療用組成物
CA2543148A1 (en) * 2003-10-21 2005-04-28 Netech Inc. Mucous membrane bulging humor composition comprising chitosan derivative containing saccharide chain for use in condoscopic surgery
JP2005154477A (ja) * 2003-11-20 2005-06-16 Tottori Univ 紫外線硬化型キトサン誘導体を用いた医療用接着剤および医療用被覆剤
US7332179B2 (en) 2003-12-12 2008-02-19 Kimberly-Clark Worldwide, Inc. Tissue products comprising a cleansing composition
WO2005081866A2 (en) 2004-02-23 2005-09-09 Loma Linda University Medical Center Hemostatic agent for topical and internal use
US7642395B2 (en) 2004-12-28 2010-01-05 Kimberly-Clark Worldwide, Inc. Composition and wipe for reducing viscosity of viscoelastic bodily fluids
CA2593256A1 (en) * 2005-01-05 2006-07-13 Board Of Regents, The University Of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
AU2006244873A1 (en) * 2005-05-13 2006-11-16 Netech Inc. Medical composition for promotion of skin regeneration
US20070031468A1 (en) * 2005-08-04 2007-02-08 Endomedix, Inc. Modified chitosan for vascular embolization
US20070031467A1 (en) * 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
GB0526505D0 (en) * 2005-12-29 2006-02-08 Medtrade Products Ltd Hemostatic material
US20070243130A1 (en) * 2006-04-18 2007-10-18 Weiliam Chen Biopolymer system for tissue sealing
US20080075657A1 (en) * 2006-04-18 2008-03-27 Abrahams John M Biopolymer system for tissue sealing
US7854923B2 (en) 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
DE102006020035A1 (de) * 2006-04-26 2007-10-31 B. Braun Melsungen Ag Herstellung und Verwendung von Poly(hydroxyethylstärke)chitin- und Poly(Carboxymethylstärke)chitin-Verbindungen
EP2110131A1 (de) 2007-02-07 2009-10-21 Yaizu Suisankagaku Industry Co., Ltd. Antitumor-zusammensetzung mit gewebeakkumulierendem chitosangel
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
AU2008320877B2 (en) * 2007-10-30 2013-03-14 Viscogel Ab Chitosan composition
US8653319B2 (en) 2008-04-24 2014-02-18 Medtronic, Inc. Cold ionizing radiation sterilization
AU2009240512B2 (en) 2008-04-24 2014-07-10 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
US9198997B2 (en) 2008-04-24 2015-12-01 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
CN102883715B (zh) 2008-04-24 2014-11-12 麦德托尼克公司 包含壳聚糖的保护性组合物
GB0816783D0 (en) 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
KR101723247B1 (ko) * 2008-12-06 2017-04-04 베. 브라운 멜중엔 악티엔게젤샤프트 수송-매개 콜로이드 약제학적 화합물
US8877170B2 (en) * 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
ES2859625T3 (es) 2009-03-31 2021-10-04 Braun Melsungen Ag Productos de enlace de polisacáridos aminados
US9133578B2 (en) 2009-05-27 2015-09-15 Cellutech Ab Polymer made of a primary amine functionalized polymer and a hemicellulose
EP2498820B1 (de) 2009-11-13 2019-01-09 University of Maryland, College Park Erweiterter funktioneller biokompatibler schaumstoff als hämostasemittel für komprimierbare und nicht komprimierbare akute wunden
CN102844053B (zh) 2009-11-25 2015-08-05 洛马林达大学医学中心 基于壳聚糖的止血织物
JP5777239B2 (ja) * 2010-02-09 2015-09-09 国立大学法人鳥取大学 新規キチン誘導体
US11773188B2 (en) 2012-01-20 2023-10-03 Immunophotonics, Inc Chitosan-derived compositions
KR20180123727A (ko) 2012-01-20 2018-11-19 임무노포토닉스 인코퍼레이티드 키토산 유래 조성물
KR101461162B1 (ko) * 2013-01-29 2014-11-13 서울대학교산학협력단 접착성 물질을 이용하여 신체 이식 후 이동을 최소화하는 스텐트 및 방법
RU2526183C1 (ru) * 2013-02-28 2014-08-20 Федеральное государственное унитарное предприятие Научно-производственный центр "Фармзащита" Федерального медико-биологического агентства (ФГУП НПЦ "Фармзащита" ФМБА России) Гемостатическая противоожоговая ранозаживляющая композиция
WO2014160136A1 (en) 2013-03-13 2014-10-02 University Of Maryland, Office Of Technology Commercialization Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
CN108610437A (zh) 2013-03-14 2018-10-02 金珂生物医疗公司 生物相容的和生物可吸收的衍生的壳聚糖组合物
DE102013112048A1 (de) * 2013-10-31 2015-04-30 Technische Universität Darmstadt Photoreaktive Polymere, Verfahren zur Herstellung von nassfesten Papierprodukten und nassfestes Papierprodukt
KR101664444B1 (ko) * 2013-12-13 2016-10-12 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 생분해성 의료용 접착제 또는 실란트 조성물
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
US20190002594A1 (en) 2014-07-16 2019-01-03 Immunophotonics, Inc. Chitosan-Derived Compositions
FR3026300B1 (fr) * 2014-09-30 2020-01-10 L'oreal Procede cosmetique pour attenuer les rides
FR3029788B1 (fr) * 2014-12-16 2018-03-02 L'oreal Procede cosmetique pour attenuer les odeurs
CN105191940A (zh) * 2015-08-25 2015-12-30 江苏科技大学 一种壳聚糖衍生物在防治青枯病中的应用
US20230213525A1 (en) 2016-03-30 2023-07-06 Qualizyme Diagnostics Gmbh & Co Kg Detecting microbial infection in wounds
KR101829136B1 (ko) 2016-08-11 2018-02-13 가톨릭대학교 산학협력단 가시광선 광경화 수용성 키토산 유도체, 키토산 하이드로겔 및 이의 제조방법
US10836872B2 (en) 2016-08-11 2020-11-17 The Catholic University Of Korea Industry-Academy Cooperation Visible light-curable water-soluble chitosan derivative, chitosan hydrogel, and preparation method therefor
CN108567644B (zh) * 2018-07-17 2021-01-12 浙江伊瑟奇医药科技有限公司 一种长效保湿防晒化妆品及制备方法
EP3883615B1 (de) 2018-11-19 2024-06-12 Endomedix, Inc. Verfahren und zusammensetzungen zur erzielung von hämostase und stabiler blutgerinnselbildung
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
CN114225098B (zh) * 2021-11-24 2023-04-11 中国科学院理化技术研究所 一种具有抗菌和促进伤口愈合的医用敷料
CN115105624B (zh) * 2022-08-26 2022-11-08 广东海洋大学 一种海洋多糖基高效抗菌膜敷料及其制备方法
CN115651095B (zh) * 2022-09-14 2024-02-23 中海油能源发展股份有限公司 一种钻井防水锁剂及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5684701A (en) * 1979-12-14 1981-07-10 Kohjin Co Ltd Production of absorbing material
FR2490648A1 (fr) * 1980-09-03 1982-03-26 Centre Nat Rech Scient Resines photoactivables, leur preparation et leur application a la fixation de molecules d'interet biologique
JP2511675B2 (ja) * 1987-07-07 1996-07-03 川研ファインケミカル株式会社 ポリオキシエチレン化キチンの製造方法
JP2687141B2 (ja) * 1988-07-20 1997-12-08 川研ファインケミカル株式会社 新規なキトサン化合物、該化合物の製造方法および該化合物を含む保湿剤
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
DE3912122A1 (de) * 1989-04-13 1990-10-25 Wella Ag Uv-strahlen absorbierende chitosan- und chitinderivate, verfahren zu deren herstellung und diese verbindungen enthaltendes kosmetisches mittel
JPH041139A (ja) * 1990-04-17 1992-01-06 Nippon Soda Co Ltd 徐放性薬剤組成物
SE470006B (sv) 1991-09-26 1993-10-25 Corline Systems Ab Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
US5512474A (en) * 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
JPH0790245A (ja) * 1993-09-24 1995-04-04 Daiichi Seimo Kk 加熱ゲル化組成物
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el
AU721276B2 (en) 1995-04-04 2000-06-29 Wound Healing Of Oklahoma Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant
JP3955652B2 (ja) * 1996-10-15 2007-08-08 株式会社ネーテック 合成アミノ糖類誘導体及びその製造方法
JP3977470B2 (ja) * 1996-12-20 2007-09-19 株式会社ノエビア 両親媒性キトサン誘導体及びこれを含有する皮膚外用剤
GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
JPH1143441A (ja) * 1997-07-29 1999-02-16 Ichimaru Pharcos Co Ltd 魚介類の疾病予防治療剤
ATE393171T1 (de) * 1998-11-10 2008-05-15 Netech Inc Funktionelle chitosanderivate

Also Published As

Publication number Publication date
AU755683B2 (en) 2002-12-19
AU1078600A (en) 2000-05-29
JP4606586B2 (ja) 2011-01-05
EP1152013A4 (de) 2003-06-25
US7125968B2 (en) 2006-10-24
DE69938612T2 (de) 2009-07-09
EP1152013A1 (de) 2001-11-07
WO2000027889A1 (en) 2000-05-18
CA2351177A1 (en) 2000-05-18
EP1152013B1 (de) 2008-04-23
DE69938612D1 (de) 2008-06-05
US6806260B1 (en) 2004-10-19
US20040192646A1 (en) 2004-09-30
CA2351177C (en) 2008-08-12

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