ATE394492T1 - Verfahren zur oligomerisation von peptiden - Google Patents

Verfahren zur oligomerisation von peptiden

Info

Publication number
ATE394492T1
ATE394492T1 AT97948802T AT97948802T ATE394492T1 AT E394492 T1 ATE394492 T1 AT E394492T1 AT 97948802 T AT97948802 T AT 97948802T AT 97948802 T AT97948802 T AT 97948802T AT E394492 T1 ATE394492 T1 AT E394492T1
Authority
AT
Austria
Prior art keywords
oligomerization
peptides
oligomer
oligomerizing
domain
Prior art date
Application number
AT97948802T
Other languages
English (en)
Inventor
Alexey Terskikh
Reto Crameri
Jean-Pierre Mach
Doussal Jean-Marc Le
Andrey Kajava
Original Assignee
Univ Lausanne
Swiss Inst For Allergy And Ast
Inst Suisse De Rech S Experime
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Lausanne, Swiss Inst For Allergy And Ast, Inst Suisse De Rech S Experime, Novartis Pharma Gmbh filed Critical Univ Lausanne
Application granted granted Critical
Publication of ATE394492T1 publication Critical patent/ATE394492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT97948802T 1996-10-28 1997-10-24 Verfahren zur oligomerisation von peptiden ATE394492T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96810719 1996-10-28

Publications (1)

Publication Number Publication Date
ATE394492T1 true ATE394492T1 (de) 2008-05-15

Family

ID=8225734

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97948802T ATE394492T1 (de) 1996-10-28 1997-10-24 Verfahren zur oligomerisation von peptiden

Country Status (7)

Country Link
US (1) US20100105876A1 (de)
EP (1) EP0938571B8 (de)
AT (1) ATE394492T1 (de)
AU (1) AU6909298A (de)
DE (1) DE69738670D1 (de)
ES (1) ES2309999T3 (de)
WO (1) WO1998018943A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160088A (en) * 1998-07-29 2000-12-12 Sloan-Kettering Institute For Cancer KDEL receptor inhibitors
MXPA01007602A (es) * 1999-02-01 2003-06-24 Beth Israel Hospital Comp/tsp-1, comp/tsp-2 y otras proteinas quimericas..
EP1179013A1 (de) * 1999-05-14 2002-02-13 Medical Research Council Proteingerüst und seine verwendung zur multimerisierung von monomeren peptiden
AU4933200A (en) * 1999-05-14 2000-12-05 Medical Research Council Oligomeric chaperone proteins
US20040115180A1 (en) * 2001-03-06 2004-06-17 Mustapha Abdelouahed Carrier chimeric proteins targeted carrier chimeric proteins and preparation thereof
CN100335900C (zh) * 2001-11-30 2007-09-05 加拿大国家研究局 新的自组装分子
KR20060017585A (ko) * 2003-04-04 2006-02-24 유니베르시떼 드 로잔느 암 치료용 펩타바디
GB2408507B (en) * 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
CN103898047B (zh) 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
TWI489993B (zh) 2007-10-12 2015-07-01 Novartis Ag 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法
PY09026846A (es) 2008-08-05 2015-09-01 Novartis Ag Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
AU2010222537B2 (en) 2009-03-10 2016-06-30 Med Discovery Sa Use of serine protease inhibitors in the treatment of neutropenia
WO2010102518A1 (zh) * 2009-03-13 2010-09-16 北京表源生物技术有限公司 一种融合蛋白多聚体
PE20120532A1 (es) 2009-04-27 2012-05-18 Novartis Ag ANTICUERPOS ANTI-ActRIIB
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
JP6472999B2 (ja) 2011-07-01 2019-02-20 ノバルティス アーゲー 代謝障害を治療するための方法
DK2928921T3 (da) 2012-12-05 2021-04-19 Novartis Ag Sammensætninger og fremgangsmåder til antistoffer målrettet epo
HK1219280A1 (zh) 2013-08-14 2017-03-31 Novartis Ag 治疗偶发性包涵体肌炎之方法
TW201622746A (zh) 2014-04-24 2016-07-01 諾華公司 改善或加速髖部骨折術後身體復原之方法
LT3600415T (lt) 2017-03-24 2025-12-29 Novartis Ag Antikūnas prieš ii tipo aktivino receptorių, skirtas naudoti širdies nepakankamumo gydymui
WO2018176144A1 (en) * 2017-03-29 2018-10-04 Sunnybrook Research Institute Engineered t-cell modulating molecules and methods of using same
WO2019086394A1 (en) 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag The compbody - a multivalent target binder
CN115232205A (zh) * 2022-08-03 2022-10-25 南京京达生物技术有限公司 一种鼠源IgM亚型单克隆抗体纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2207195A (en) * 1994-04-05 1995-10-23 Board Of Regents, The University Of Texas System Modified receptors that continuously signal
GB9409768D0 (en) * 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
CA2222055A1 (en) * 1995-05-23 1996-11-28 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Multimeric proteins

Also Published As

Publication number Publication date
WO1998018943A1 (en) 1998-05-07
AU6909298A (en) 1998-05-22
EP0938571B1 (de) 2008-05-07
DE69738670D1 (de) 2008-06-19
EP0938571A1 (de) 1999-09-01
EP0938571B8 (de) 2008-07-02
ES2309999T3 (es) 2008-12-16
US20100105876A1 (en) 2010-04-29

Similar Documents

Publication Publication Date Title
ATE394492T1 (de) Verfahren zur oligomerisation von peptiden
NO964650D0 (no) LAG-3 protein-opplöselige polypeptidfraksjoner, fremgangsmåte for fremstilling, teraupeutisk preparat og anti-idiotype antistoff
ATE137245T1 (de) Synthetische peptide zum in vivo nachweis von thrombosen
AU4474497A (en) Methods and means for selecting peptides and proteins having specific affinity for a target
DK0724456T3 (da) CD40-Antistoffer
DE69733650D1 (de) System zur gleichzeitigen durchführung von mehrfachligandenbindungstests
ATE309347T1 (de) Protocadherin-proteine und verwendungen davon
IL130036A0 (en) Survivin a protein that inhibits cellular apoptosis and its modulation
DE69006306D1 (de) Synthetische peptide des konjugates von ubiquitin und histon h2a.
DE69703449D1 (de) Neuroaktive peptide
ATE223481T1 (de) Peptid der löslichen form von acetylcholinesterase mit aktivität als calciumkanalmodulator
IL134011A0 (en) Adipocyte-specific protein homologs
ATE461935T1 (de) Verfahren zur reinigung von stark anionischen proteinen
ATE206714T1 (de) Kombinatorisches verfahren zur identifizierung von organometallischen polymerisationskatalysatoren
DE69607034D1 (de) Pcna bindende substanz
SE9803891D0 (sv) Protein Variants
DE69504795D1 (de) Methoden zur synthese und reinigung von peptiden
ATE161543T1 (de) Aminoterminale prokollagen 1(i) peptide
ATE301712T1 (de) Z2-19a, ein menschliches homolog von dem protein 2-19
DE58905269D1 (de) Verfahren zur kontinuierlichen oligomerisation von hexafluorpropenoxid.
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.
DK0792291T3 (da) Protein, der påvirker KATP-kanaler
DE69832622D1 (de) Methoden zur durchforstung (screenen) von proteinen
MX9701904A (es) Proteinas de enlace de pka novedosas y usos de las mismas.
SE9602370D0 (sv) Kirala selektorer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties