ATE396175T1 - Zusammensetzung enthaltend mx-dtpa und dessen verwendung zur herstellung von radiomarkiertem mx-dtpa - Google Patents

Zusammensetzung enthaltend mx-dtpa und dessen verwendung zur herstellung von radiomarkiertem mx-dtpa

Info

Publication number: ATE396175T1
Authority: AT; Austria
Prior art keywords: dtpa; radiom; labled; producing; composition containing
Prior art date: 1999-03-03

Application number

AT00913703T

Other languages

English (en)

Inventor

Paul Chinn

Albert Gyorkos

Michael Labarre

Steve Ruhl

Thomas Ryskamp

Original Assignee

Biogen Idec Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-03

Filing date

2000-03-02

Publication date

2008-06-15

2000-03-02 Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE396175T1 publication Critical patent/ATE396175T1/de

Links

FZDFGHZZPBUTGP-UHFFFAOYSA-N 2-[[2-[bis(carboxymethyl)amino]-3-(4-isothiocyanatophenyl)propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C(C)CN(CC(O)=O)CC(N(CC(O)=O)CC(O)=O)CC1=CC=C(N=C=S)C=C1 FZDFGHZZPBUTGP-UHFFFAOYSA-N 0.000 title 2
230000015572 biosynthetic process Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical class OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 abstract 1
239000013522 chelant Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000005342 ion exchange Methods 0.000 abstract 1
238000000163 radioactive labelling Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Catalysts (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)

AT00913703T 1999-03-03 2000-03-02 Zusammensetzung enthaltend mx-dtpa und dessen verwendung zur herstellung von radiomarkiertem mx-dtpa ATE396175T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/261,207 US6207858B1 (en)	1999-03-03	1999-03-03	Regioselective synthesis of DTPA derivatives

Publications (1)

Publication Number	Publication Date
ATE396175T1 true ATE396175T1 (de)	2008-06-15

Family

ID=22992340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00913703T ATE396175T1 (de)	1999-03-03	2000-03-02	Zusammensetzung enthaltend mx-dtpa und dessen verwendung zur herstellung von radiomarkiertem mx-dtpa

Country Status (19)

Country	Link
US (1)	US6207858B1 (de)
EP (1)	EP1157004B1 (de)
JP (2)	JP5357368B2 (de)
CN (2)	CN1342141A (de)
AT (1)	ATE396175T1 (de)
AU (1)	AU778816B2 (de)
BR (1)	BR0008693A (de)
CA (1)	CA2364960C (de)
CY (1)	CY1108271T1 (de)
DE (1)	DE60038953D1 (de)
DK (1)	DK1157004T3 (de)
ES (1)	ES2304944T3 (de)
MX (1)	MXPA01008784A (de)
NO (1)	NO328049B1 (de)
PL (1)	PL211510B1 (de)
PT (1)	PT1157004E (de)
RU (1)	RU2312852C2 (de)
WO (1)	WO2000051976A1 (de)
ZA (1)	ZA200106750B (de)

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US6207858B1 (en) *	1999-03-03	2001-03-27	Idec Pharmaceuticals Corporation	Regioselective synthesis of DTPA derivatives
RU2211721C2 (ru) *	2001-07-06	2003-09-10	Производственное объединение "МАЯК"	Способ хроматографического разделения редкоземельных и трансплутониевых элементов
TWI284539B (en) *	2001-07-30	2007-08-01	Epix Pharm Inc	A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
US7597876B2 (en) *	2007-01-11	2009-10-06	Immunomedics, Inc.	Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US7993626B2 (en)	2007-01-11	2011-08-09	Immunomedics, Inc.	Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US7563433B2 (en) *	2007-01-11	2009-07-21	Immunomedics, Inc.	Methods and compositions for F-18 labeling of proteins, peptides and other molecules
DE10305463A1 (de) *	2003-02-04	2004-08-12	Schering Ag	Enantiomerenreines (4S,8S)- und (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triza-3N,6N,9N-tricarboxymethyl-1,11-undecandisäure und deren Abkömmlinge, Verfahren zu deren Herstellung und Verwendung zur Herstellung pharmazeutischer Mittel
DE10305462A1 (de) *	2003-02-04	2004-08-12	Schering Ag	Konjugate enantiomerenreiner (4S,8S)- und (4R,8R)-4-p-Benzyl-8-methyl-3,6,9-triaza-3N, 6N, 9N-tricarboxymethyl-1,11-undecandisäure mit Biomolekülen, Verfahren zu deren Herstellung und Verwendung zur Herstellung
US20040208828A1 (en) *	2003-02-04	2004-10-21	Lutz Lehmann	Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic acid and derivatives thereof, process for their production and use for the production of pharmaceutical agents
AU2005235718B2 (en) *	2004-04-23	2011-09-22	Bundesrepublik Deutschland Letztvertreten Durch Das Robert-Koch-Institut Vertreten Durch Seinen Prasidenten	Method for the treatment of T cell mediated conditions by depletion of icos-positive cells in vivo
JP2009508090A (ja) *	2005-08-31	2009-02-26	イムノメディクス，インコーポレイテッド	予め標的化されたポジトロン放出断層撮影画像化のためのｆ−１８ペプチド
WO2008070384A2 (en) *	2006-11-06	2008-06-12	Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Method of preparing macromolecular contrast agents and uses thereof
US8153100B2 (en) *	2007-01-11	2012-04-10	Immunomedics, Inc.	Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US8398956B2 (en)	2007-01-11	2013-03-19	Immunomedics, Inc.	In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
US8709382B2 (en)	2007-01-11	2014-04-29	Immunomedics, Inc.	Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US8889100B2 (en)	2007-01-11	2014-11-18	Immunomedics, Inc.	Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US8545809B2 (en)	2007-01-11	2013-10-01	Immunomedics, Inc.	Methods and compositions for improved 18F labeling of proteins, peptides and other molecules
US9446995B2 (en)	2012-05-21	2016-09-20	Illinois Institute Of Technology	Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
WO2010011367A2 (en) *	2008-02-22	2010-01-28	Illinois Institute Of Technology	Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
US10189803B2 (en)	2008-02-22	2019-01-29	Illinois Institute Of Technology	Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10556873B2 (en)	2008-02-22	2020-02-11	Illinois Institute Of Technology	Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
IN2012DN03177A (de)	2009-12-04	2015-09-25	Immunomedics Inc
CN102773078A (zh) *	2012-07-16	2012-11-14	武汉纺织大学	同时吸附阳、阴离子的固体配位萃取剂及其制备和应用
WO2015051362A1 (en)	2013-10-04	2015-04-09	Illinois Institute Of Technology	Multifunctional chelators, complexes, and compositions thereof, and methods of using same
CN103601648B (zh) *	2013-11-19	2015-03-25	宜兴市丰泽化工有限公司	一种dtpa五钠盐的脱盐提纯方法
EP4600368A1 (de)	2024-02-09	2025-08-13	Adisseo France S.A.S.	Verfahren zur enzymatischen herstellung einer amidverbindung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5099069A (en) *	1986-09-05	1992-03-24	Gansow Otto A	Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5246692A (en) *	1986-09-05	1993-09-21	The United States Of America As Represented By The Secretary Of Health And Human Services	Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US4831175A (en) *	1986-09-05	1989-05-16	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
EP0484989B1 (de) *	1986-09-05	1996-04-24	GANSOW, Otto A.	Polysubstituierte Diethylentriamin Chelate zur Bildung einer Metall-Chelat-Protein Konjugierung
CA2033086A1 (en) *	1989-05-26	1990-11-27	Ramaswamy Subramanian	Chelating agents for attaching metal ions to proteins
US5124471A (en) *	1990-03-26	1992-06-23	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Bifunctional dtpa-type ligand
ATE139900T1 (de) *	1992-11-13	1996-07-15	Idec Pharma Corp	Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
EP0738283A4 (de) *	1994-01-07	1999-03-24	Akzo Nobel Nv	Polyaminocarboxylat-chelatoren
US20020102208A1 (en) *	1999-03-01	2002-08-01	Paul Chinn	Radiolabeling kit and binding assay
US6207858B1 (en) *	1999-03-03	2001-03-27	Idec Pharmaceuticals Corporation	Regioselective synthesis of DTPA derivatives

1999
- 1999-03-03 US US09/261,207 patent/US6207858B1/en not_active Expired - Fee Related
2000
- 2000-03-02 PL PL350903A patent/PL211510B1/pl unknown
- 2000-03-02 WO PCT/US2000/005433 patent/WO2000051976A1/en not_active Ceased
- 2000-03-02 ES ES00913703T patent/ES2304944T3/es not_active Expired - Lifetime
- 2000-03-02 JP JP2000602204A patent/JP5357368B2/ja not_active Expired - Lifetime
- 2000-03-02 CN CN00804499.6A patent/CN1342141A/zh active Pending
- 2000-03-02 RU RU2001126722/04A patent/RU2312852C2/ru active
- 2000-03-02 AT AT00913703T patent/ATE396175T1/de active
- 2000-03-02 CN CN200410031255.0A patent/CN1290830C/zh not_active Expired - Lifetime
- 2000-03-02 CA CA2364960A patent/CA2364960C/en not_active Expired - Lifetime
- 2000-03-02 PT PT00913703T patent/PT1157004E/pt unknown
- 2000-03-02 BR BR0008693-2A patent/BR0008693A/pt not_active Application Discontinuation
- 2000-03-02 EP EP00913703A patent/EP1157004B1/de not_active Expired - Lifetime
- 2000-03-02 DK DK00913703T patent/DK1157004T3/da active
- 2000-03-02 AU AU35099/00A patent/AU778816B2/en not_active Expired
- 2000-03-02 DE DE60038953T patent/DE60038953D1/de not_active Expired - Lifetime
- 2000-03-02 MX MXPA01008784A patent/MXPA01008784A/es active IP Right Grant
2001
- 2001-08-15 ZA ZA200106750A patent/ZA200106750B/en unknown
- 2001-08-29 NO NO20014194A patent/NO328049B1/no not_active IP Right Cessation
2008
- 2008-08-19 CY CY20081100882T patent/CY1108271T1/el unknown
2013
- 2013-03-27 JP JP2013066359A patent/JP2013144705A/ja active Pending

Also Published As

Publication number	Publication date
EP1157004A1 (de)	2001-11-28
NO20014194L (no)	2001-10-26
PL211510B1 (pl)	2012-05-31
CN1342141A (zh)	2002-03-27
NO328049B1 (no)	2009-11-16
JP2002538137A (ja)	2002-11-12
JP2013144705A (ja)	2013-07-25
AU3509900A (en)	2000-09-21
PT1157004E (pt)	2008-08-29
DK1157004T3 (da)	2008-09-15
CN1290830C (zh)	2006-12-20
AU778816B2 (en)	2004-12-23
NO20014194D0 (no)	2001-08-29
CA2364960A1 (en)	2000-09-08
WO2000051976A1 (en)	2000-09-08
ZA200106750B (en)	2002-11-15
DE60038953D1 (de)	2008-07-03
HK1069380A1 (en)	2005-05-20
PL350903A1 (en)	2003-02-10
MXPA01008784A (es)	2002-04-24
CN1548419A (zh)	2004-11-24
US6207858B1 (en)	2001-03-27
JP5357368B2 (ja)	2013-12-04
EP1157004B1 (de)	2008-05-21
RU2312852C2 (ru)	2007-12-20
BR0008693A (pt)	2001-12-26
CY1108271T1 (el)	2014-02-12
ES2304944T3 (es)	2008-11-01
CA2364960C (en)	2010-05-11

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2009-01-15

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