ATE396995T1 - 4-oxoimidazolidin-2-spiro piperidin derivat - Google Patents

4-oxoimidazolidin-2-spiro piperidin derivat

Info

Publication number: ATE396995T1
Authority: AT; Austria
Prior art keywords: stand; analgesic; lower alkyl; oxoimidazolidine; reliever
Prior art date: 2001-07-23

Application number

AT02751627T

Other languages

English (en)

Inventor

M Hashimoto

Osamu Okamoto

S Ozaki

H Ohta

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-23

Filing date

2002-07-18

Publication date

2008-06-15

2002-07-18 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE396995T1 publication Critical patent/ATE396995T1/de

Links

QZZYYTLEGVMFDM-UHFFFAOYSA-N 1,4,10-triazaspiro[4.5]decan-3-one Chemical class N1C(=O)CNC11NCCCC1 QZZYYTLEGVMFDM-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000004084 narcotic analgesic agent Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000004880 Polyuria Diseases 0.000 abstract 1
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
229940124330 analgesic enhancer Drugs 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000003925 brain function Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010064 diabetes insipidus Diseases 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001434 methanylylidene group Chemical class [H]C#[*] 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
229910052757 nitrogen Chemical class 0.000 abstract 1
125000004433 nitrogen atom Chemical class N* 0.000 abstract 1
239000002762 nociceptin receptor agonist Substances 0.000 abstract 1
230000001373 regressive effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Obesity (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Otolaryngology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT02751627T 2001-07-23 2002-07-18 4-oxoimidazolidin-2-spiro piperidin derivat ATE396995T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001220919		2001-07-23

Publications (1)

Publication Number	Publication Date
ATE396995T1 true ATE396995T1 (de)	2008-06-15

Family

ID=19054667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02751627T ATE396995T1 (de)	2001-07-23	2002-07-18	4-oxoimidazolidin-2-spiro piperidin derivat

Country Status (7)

Country	Link
US (2)	US7192964B2 (de)
EP (1)	EP1420020B1 (de)
JP (1)	JP4356453B2 (de)
AT (1)	ATE396995T1 (de)
CA (1)	CA2454785C (de)
DE (1)	DE60226874D1 (de)
WO (1)	WO2003010168A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4056977B2 (ja)	2002-03-29	2008-03-05	田辺三菱製薬株式会社	睡眠障害治療薬
JP4712384B2 (ja)	2002-09-09	2011-06-29	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
DE102004014296A1 (de) *	2004-03-22	2005-10-06	Grünenthal GmbH	Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen
DE102004014304A1 (de)	2004-03-22	2005-10-06	Grünenthal GmbH	Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
WO2005117862A1 (en) *	2004-06-03	2005-12-15	Pfizer Limited,	Treatment of urinary conditions including incontinence
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102005038141A1 (de) *	2005-08-12	2007-02-15	Grünenthal GmbH	Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate
ITFE20060036A1 (it) *	2006-11-23	2008-05-24	Ufpeptides Srl	Agonisti dei recettori nop per il trattamento delle discinesie da levodopa
US8703948B2 (en) *	2006-11-28	2014-04-22	Janssen Pharmaceutica Nv	Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CA2683598C (en) *	2007-04-09	2015-11-17	Janssen Pharmaceutica Nv	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
UA107943C2 (xx) *	2009-11-16	2015-03-10	Lilly Co Eli	Сполуки спіропіперидину як антагоністи рецептора orl-1
US9044141B2 (en) *	2010-02-10	2015-06-02	Tokitae Llc	Systems, devices, and methods including a dark-field reflected-illumination apparatus
EP2882428B1 (de)	2012-07-13	2019-01-16	Pain Therapeutics, Inc.	Verfahren zur hemmung von tau-phosphorylierung
US9433604B2 (en)	2013-10-08	2016-09-06	Pain Therapeutics Inc.	Method for inhibiting growth of cancer cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2575446B2 (ja) *	1988-02-12	1997-01-22	武田薬品工業株式会社	トリアザスピロ化合物
ATE212635T1 (de)	1997-12-05	2002-02-15		1,3,8-triazaspiro(4,5)decan-4-on-derivate
DE69923744T2 (de) *	1998-10-23	2006-02-23	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
JP2000169476A (ja) *	1998-12-09	2000-06-20	Banyu Pharmaceut Co Ltd	４−オキソイミダゾリジン−５−スピロ−含窒素複素環式化合物
AU1682400A (en) *	1998-12-09	2000-06-26	Banyu Pharmaceutical Co., Ltd.	4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds
AU2001262729A1 (en) *	2000-06-14	2001-12-24	Banyu Pharmaceutical Co., Ltd	4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds

2002
- 2002-07-18 AT AT02751627T patent/ATE396995T1/de not_active IP Right Cessation
- 2002-07-18 JP JP2003515527A patent/JP4356453B2/ja not_active Expired - Fee Related
- 2002-07-18 US US10/484,765 patent/US7192964B2/en not_active Expired - Fee Related
- 2002-07-18 EP EP02751627A patent/EP1420020B1/de not_active Expired - Lifetime
- 2002-07-18 CA CA2454785A patent/CA2454785C/en not_active Expired - Fee Related
- 2002-07-18 DE DE60226874T patent/DE60226874D1/de not_active Expired - Lifetime
- 2002-07-18 WO PCT/JP2002/007292 patent/WO2003010168A1/ja not_active Ceased
2006
- 2006-11-22 US US11/603,147 patent/US7557117B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60226874D1 (de)	2008-07-10
JPWO2003010168A1 (ja)	2005-02-10
US20050004363A1 (en)	2005-01-06
US7192964B2 (en)	2007-03-20
US7557117B2 (en)	2009-07-07
EP1420020A4 (de)	2005-04-20
CA2454785C (en)	2010-09-07
CA2454785A1 (en)	2003-02-06
EP1420020B1 (de)	2008-05-28
US20070078153A1 (en)	2007-04-05
WO2003010168A1 (fr)	2003-02-06
JP4356453B2 (ja)	2009-11-04
EP1420020A1 (de)	2004-05-19

Legal Events

Date	Code	Title	Description
2008-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60226874D1 (de)	2008-07-10	4-oxoimidazolidin-2-spiro piperidin derivat
ATE303387T1 (de)	2005-09-15	Kondensierte imidazolderivate und arzneimittel gegen diabetes mellitus
MX2009013335A (es)	2010-01-20	Derivados de piperidina/piperazina.
EP1505063A4 (de)	2006-08-23	Benzimidazolderivate
KR950702829A (ko)	1995-08-23	신경계 퇴행성 질환의 치료에 유용한 아나바세인 유도체
EP1221443A4 (de)	2002-11-04	Substituierte imidazolin-derivate
WO2007026959A3 (en)	2007-08-16	Derivatives of 4-piperazin-1-yl-4-benz0 [b] thiophene suitable for the treatment of cns disorders
ATE229004T1 (de)	2002-12-15	Chinolinische sulfid-derivate als nmda rezeptor- antagonisten und verfahren zu ihrer herstellung
GB0309009D0 (en)	2003-05-28	Quinazoline derivatives
WO2004000808A3 (en)	2004-03-25	N-substituted piperidine derivatives as serotonin receptor agents
EP1342717A4 (de)	2005-02-16	Benzimidazolderivate
TW200710086A (en)	2007-03-16	Diaryl-substituted hetero 5-membered ring derivatives
EP0915094A4 (de)	2004-09-22	Morphinanderivate und ihre medizinische Anwendung
DE69705817D1 (de)	2001-08-30	(N-(Pyridinylmethyl)-heterozyklische)-ylidenamin-Derivate als Nikotin-Acetylcholin-Rezeptor-Bindemittel
EP1238970A4 (de)	2003-01-15	Zyklische aminverbindungen als ccr5-rezeptor antagonisten
NO20080770L (no)	2008-04-11	N-dihydroksyalkylsubstituert 2-oksimidazolderivat
DE60205397D1 (de)	2005-09-08	4-(thio- oder selenoxanthen-9-yliden)-piperidin oder acridin derivate und ihre verwendung als selektive 5ht2b rezeptorantagonisten
ATE402179T1 (de)	2008-08-15	Indolderivate und deren verwendung in medikamenten
EP1726590A4 (de)	2009-07-15	Cycloalkanopyridinderivat
HU9600621D0 (en)	1996-05-28	Imidazolidinone derivative, acid-addition salt thereof, and remedy for senile dementia
EP1914229A4 (de)	2009-03-18	Neuartige cercosporamidderivate
Williams et al.	2002	Spirocyclic NK1 antagonists II:[4.5]-spiroethers
AU6017800A (en)	2001-02-13	Novel amide derivatives
Hayashi et al.	2016	Piperidine derivatives as nonprostanoid IP receptor agonists
DK0940401T3 (da)	2003-03-03	2-Carbonylthiazolderivater og anvendelse deraf