ATE397445T1 - Synergistische kombinationen enthaltend einen renininhibitor für kardiovaskulären erkrankungen - Google Patents

Synergistische kombinationen enthaltend einen renininhibitor für kardiovaskulären erkrankungen

Info

Publication number: ATE397445T1
Authority: AT; Austria
Prior art keywords: renin inhibitor; cardiovascular diseases; combinations containing; synergistic combinations; pharmaceutically acceptable
Prior art date: 2000-11-17

Application number

AT05015603T

Other languages

English (en)

Inventor

William Hewitt

Daniel Lucius Vasella

Randy Lee Webb

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-17

Filing date

2001-11-15

Publication date

2008-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9903412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE397445(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-11-15 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE397445T1 publication Critical patent/ATE397445T1/de

Links

239000002461 renin inhibitor Substances 0.000 title abstract 2
229940086526 renin-inhibitors Drugs 0.000 title abstract 2
208000024172 Cardiovascular disease Diseases 0.000 title 1
239000011885 synergistic combination Substances 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 1
229960004601 aliskiren Drugs 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

AT05015603T 2000-11-17 2001-11-15 Synergistische kombinationen enthaltend einen renininhibitor für kardiovaskulären erkrankungen ATE397445T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB0028151A GB0028151D0 (en)	2000-11-17	2000-11-17	Combination of organic compounds

Publications (1)

Publication Number	Publication Date
ATE397445T1 true ATE397445T1 (de)	2008-06-15

Family

ID=9903412

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01996377T ATE317692T1 (de)	2000-11-17	2001-11-15	Synergistische kombinationen mit einem renin- inhibitor für kardiovaskuläre erkrankungen
AT05015603T ATE397445T1 (de)	2000-11-17	2001-11-15	Synergistische kombinationen enthaltend einen renininhibitor für kardiovaskulären erkrankungen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT01996377T ATE317692T1 (de)	2000-11-17	2001-11-15	Synergistische kombinationen mit einem renin- inhibitor für kardiovaskuläre erkrankungen

Country Status (31)

Country	Link
US (4)	US8168616B1 (de)
EP (7)	EP1915993B1 (de)
JP (6)	JP2004513920A (de)
KR (6)	KR20100114904A (de)
CN (4)	CN100404024C (de)
AT (2)	ATE317692T1 (de)
AU (2)	AU2368002A (de)
BR (1)	BR0115411A (de)
CA (2)	CA2763223A1 (de)
CY (5)	CY1105603T1 (de)
CZ (2)	CZ299749B6 (de)
DE (3)	DE60134349D1 (de)
DK (3)	DK1341533T3 (de)
EC (1)	ECSP034603A (de)
ES (4)	ES2308347T3 (de)
GB (1)	GB0028151D0 (de)
HU (2)	HUP0301841A3 (de)
IL (3)	IL155707A (de)
LU (2)	LU91563I2 (de)
MX (1)	MXPA03004358A (de)
NL (2)	NL300385I1 (de)
NO (2)	NO334002B1 (de)
NZ (6)	NZ550896A (de)
PL (3)	PL400914A1 (de)
PT (3)	PT1341533E (de)
RU (2)	RU2310443C2 (de)
SG (1)	SG135969A1 (de)
SI (3)	SI1341533T1 (de)
SK (1)	SK287881B6 (de)
WO (1)	WO2002040007A1 (de)
ZA (1)	ZA200303497B (de)

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2000
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Also Published As

Publication number	Publication date
EP1915993A1 (de)	2008-04-30
SI1915993T1 (sl)	2013-10-30
AU2002223680B2 (en)	2005-04-07
DE60117295D1 (de)	2006-04-20
EP2305232B1 (de)	2019-07-17
EP1602370A2 (de)	2005-12-07
DE60134349D1 (de)	2008-07-17
KR20080097488A (ko)	2008-11-05
RU2310443C2 (ru)	2007-11-20
CN101264073A (zh)	2008-09-17
NZ550896A (en)	2008-06-30
PT1915993E (pt)	2013-10-14
AU2368002A (en)	2002-05-27
DK1915993T3 (da)	2013-10-14
NZ537691A (en)	2007-01-26
HU1400409D0 (hu)	2003-09-29
DE60117295T2 (de)	2006-08-17
JP6373931B2 (ja)	2018-08-15
EP1341533B1 (de)	2006-02-15
ZA200303497B (en)	2004-04-28
IL155707A0 (en)	2003-11-23
ES2734523T3 (es)	2019-12-10
JP2018131465A (ja)	2018-08-23
ES2308347T3 (es)	2008-12-01
PL400915A1 (pl)	2012-12-17
WO2002040007A1 (en)	2002-05-23
JP2013213061A (ja)	2013-10-17
KR20110063596A (ko)	2011-06-10
CA2428647A1 (en)	2002-05-23
GB0028151D0 (en)	2001-01-03
LU91563I2 (fr)	2009-07-06
RU2346703C2 (ru)	2009-02-20
EP1341533A1 (de)	2003-09-10
IL212075A (en)	2013-08-29
IL212075A0 (en)	2011-06-30
HK1059212A1 (en)	2004-06-25
SK287881B6 (sk)	2012-02-03
CN101091703A (zh)	2007-12-26
CY1105603T1 (el)	2010-07-28
NZ550898A (en)	2008-07-31
NZ525795A (en)	2005-03-24
NO20032233D0 (no)	2003-05-16
IL155707A (en)	2012-02-29
CY1108305T1 (el)	2012-01-25
SI1602370T1 (sl)	2008-10-31
JP2004513920A (ja)	2004-05-13
SG135969A1 (en)	2007-10-29
NL301005I2 (nl)	2019-10-29
EP1602370A3 (de)	2005-12-14
CY2009005I2 (el)	2012-01-25
DK1341533T3 (da)	2006-05-08
EP2305233A1 (de)	2011-04-06
HK1089356A1 (en)	2006-12-01
US20120010295A1 (en)	2012-01-12
ATE317692T1 (de)	2006-03-15
US20120016035A1 (en)	2012-01-19
PL227576B1 (pl)	2017-12-29
EP1602370B1 (de)	2008-06-04
CN1474690A (zh)	2004-02-11
BR0115411A (pt)	2004-08-17
DK1602370T3 (da)	2008-09-22
CZ299749B6 (cs)	2008-11-12
US8168616B1 (en)	2012-05-01
MXPA03004358A (es)	2003-08-19
PL361404A1 (en)	2004-10-04
IL217847A0 (en)	2012-03-29
EP2305231A1 (de)	2011-04-06
EP2305232A1 (de)	2011-04-06
KR20030051753A (ko)	2003-06-25
JP2009235107A (ja)	2009-10-15
NZ550897A (en)	2008-03-28
NO20032233L (no)	2003-05-16
ES2256335T3 (es)	2006-07-16
KR20100114904A (ko)	2010-10-26
JP2017019876A (ja)	2017-01-26
EP1930000A1 (de)	2008-06-11
US9023893B2 (en)	2015-05-05
DE122009000021I1 (de)	2009-08-06
SK5842003A3 (en)	2003-11-04
NL301005I1 (de)	2019-09-10
JP6089278B2 (ja)	2017-03-08
HK1115544A1 (en)	2008-12-05
CZ305341B6 (cs)	2015-08-05
NO2013019I2 (no)	2013-12-17
SI1341533T1 (sl)	2006-08-31
JP6577994B2 (ja)	2019-09-18
PL400914A1 (pl)	2012-12-17
LU92315I2 (fr)	2014-01-27
ECSP034603A (es)	2003-06-25
US20120004312A1 (en)	2012-01-05
KR101258365B1 (ko)	2013-04-30
NO2013019I1 (no)	2014-06-02
US9023894B2 (en)	2015-05-05
KR20080096715A (ko)	2008-10-31
PT1341533E (pt)	2006-06-30
CY1114829T1 (el)	2015-11-04
KR20080011355A (ko)	2008-02-01
JP2018030894A (ja)	2018-03-01
EP1915993B1 (de)	2013-07-10
JP6603757B2 (ja)	2019-11-06
CY2013045I2 (el)	2015-11-04
NO334002B1 (no)	2013-11-11
CA2763223A1 (en)	2002-05-23
CN101264072A (zh)	2008-09-17
RU2006132668A (ru)	2008-03-20
ES2429292T3 (es)	2013-11-14
PT1602370E (pt)	2008-09-10
CN100404024C (zh)	2008-07-23
KR101008752B1 (ko)	2011-01-14
NZ568764A (en)	2009-11-27
HUP0301841A2 (hu)	2003-09-29
CY2013045I1 (el)	2015-11-04
HU230882B1 (hu)	2018-11-29
NL300385I1 (nl)	2009-07-01
US8618174B2 (en)	2013-12-31
HUP0301841A3 (en)	2010-07-28
CY2009005I1 (el)	2012-01-25

Publication	Publication Date	Title
ATE397445T1 (de)	2008-06-15	Synergistische kombinationen enthaltend einen renininhibitor für kardiovaskulären erkrankungen
EP1734041A3 (de)	2007-01-24	Platelet adp rezeptor inhibitoren
HUP0102281A3 (en)	2001-12-28	Prodrugs of dipeptidyl peptidase iv inhibitors, pharmaceutical compositions comprising thereof and their use
HUP0200347A2 (en)	2002-06-29	N-cyanomethylamides as protease inhibitors, pharmaceutical compositions containing them and their use
BG106586A (en)	2003-01-31	Pyrazolopyramidines as therapeutic agents
HUP0401567A3 (en)	2005-06-28	Novel 4,5-dyhydro-1h-pyrazole derivatives having cb1-antagonistic activity, their use and pharmaceutical compositions containing them
MXPA05003253A (es)	2005-06-08	Nuevos derivados de pirimidinamida y el uso de los mismos.
MXPA03010761A (es)	2004-03-02	Combinaciones farmaceuticas.
PL350568A1 (en)	2002-12-16	N-(2-phenyl-4-aminobutyl)-1-naphtamides as antagonists of neurokinin 1 receptors
MXPA04005226A (es)	2004-10-11	1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion.
ITMI931806A0 (it)	1993-08-06	Composti inibitpri di acil enzima-a-colesterolo-o-acil transferasi ad attivita' terapeutica , loro uso e composizioni farmaceutiche che li contengono
EP1452522A3 (de)	2005-02-09	Neue Verbindungen und Zusammensetzungen als Protease Inhibitore
GB2287938B (en)	1998-04-01	Conformationally restricted HIV-1 protease inhibitors
ITTO20001109A0 (it)	2000-11-27	Composizione farmaceutica per il trattamento anti m. ulcerans.
GEP20032923B (en)	2003-03-25	Sulphonamide Derivatives as Prodrugs of Aspartyl Protease Inhibitors, Pharmaceutical compositions containing the Same and Methods for Treatment
RU2000128859A (ru)	2003-08-27	Способ защиты печени от ксенобиотиков в эксперименте