ATE398106T1 - Allylmercaptocaptoprilverbindungen und deren verwendungen - Google Patents

Allylmercaptocaptoprilverbindungen und deren verwendungen

Info

Publication number: ATE398106T1
Authority: AT; Austria
Prior art keywords: compounds; allylmercaptocaptopril; elevated; allicin; ace
Prior art date: 2001-05-30

Application number

AT02734587T

Other languages

English (en)

Inventor

Talia Miron

Aharon Rabinkov

David Mirelman

Meir Wilchek

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-30

Filing date

2002-05-30

Publication date

2008-07-15

2002-05-30 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398106T1 publication Critical patent/ATE398106T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 abstract 1
206010014486 Elevated triglycerides Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 abstract 1
235000010081 allicin Nutrition 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyrrole Compounds (AREA)

AT02734587T 2001-05-30 2002-05-30 Allylmercaptocaptoprilverbindungen und deren verwendungen ATE398106T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US29398901P	2001-05-30	2001-05-30
US30441401P	2001-07-12	2001-07-12
US31182901P	2001-08-14	2001-08-14
US33496201P	2001-12-04	2001-12-04

Publications (1)

Publication Number	Publication Date
ATE398106T1 true ATE398106T1 (de)	2008-07-15

Family

ID=31499517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02734587T ATE398106T1 (de)	2001-05-30	2002-05-30	Allylmercaptocaptoprilverbindungen und deren verwendungen

Country Status (8)

Country	Link
US (1)	US7241902B2 (de)
EP (1)	EP1414794B1 (de)
AT (1)	ATE398106T1 (de)
AU (1)	AU2002305744B2 (de)
CA (1)	CA2448896C (de)
DE (1)	DE60227078D1 (de)
IL (2)	IL159122A0 (de)
WO (1)	WO2002096871A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2610922A1 (en) *	2005-06-13	2006-12-21	Yeda Research And Development Co. Ltd.	Use of allylmercaptocaptopril for treating or preventing obesity and obesity related diseases
WO2007086054A2 (en) *	2006-01-25	2007-08-02	Yeda Research And Development Co. Ltd.	A process for preparing allylmercaptocaptopril (cpssa) and related asymmetrical disulfides
US8865685B2 (en)	2011-06-30	2014-10-21	Johnson & Johnson Vision Care, Inc.	Esters for treatment of ocular inflammatory conditions
JP7442777B2 (ja) *	2019-02-20	2024-03-05	池田食研株式会社	蛋白質加水分解物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4046889A (en) *	1976-02-13	1977-09-06	E. R. Squibb & Sons, Inc.	Azetidine-2-carboxylic acid derivatives
US4347371A (en) *	1978-12-30	1982-08-31	Santen Pharmaceutical Co., Ltd.	Disulfide compounds
IL117934A0 (en) *	1996-04-16	1996-08-04	Yeda Res & Dev	Continuous production of allicin

2002
- 2002-05-30 AU AU2002305744A patent/AU2002305744B2/en not_active Ceased
- 2002-05-30 EP EP02734587A patent/EP1414794B1/de not_active Expired - Lifetime
- 2002-05-30 DE DE60227078T patent/DE60227078D1/de not_active Expired - Lifetime
- 2002-05-30 IL IL15912202A patent/IL159122A0/xx unknown
- 2002-05-30 WO PCT/US2002/016964 patent/WO2002096871A1/en not_active Ceased
- 2002-05-30 CA CA2448896A patent/CA2448896C/en not_active Expired - Fee Related
- 2002-05-30 US US10/478,396 patent/US7241902B2/en not_active Expired - Fee Related
- 2002-05-30 AT AT02734587T patent/ATE398106T1/de not_active IP Right Cessation
2003
- 2003-11-27 IL IL159122A patent/IL159122A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2448896A1 (en)	2002-12-05
IL159122A0 (en)	2004-05-12
EP1414794A4 (de)	2005-04-06
CA2448896C (en)	2010-12-21
EP1414794A1 (de)	2004-05-06
DE60227078D1 (de)	2008-07-24
IL159122A (en)	2010-12-30
EP1414794B1 (de)	2008-06-11
US7241902B2 (en)	2007-07-10
WO2002096871A8 (en)	2004-03-25
WO2002096871A1 (en)	2002-12-05
US20040210065A1 (en)	2004-10-21
AU2002305744B2 (en)	2008-09-11

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Legal Events

Date	Code	Title	Description
2008-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties