ATE529401T1 - Aminocyclohexylether-verbindungen und deren verwendung - Google Patents

Aminocyclohexylether-verbindungen und deren verwendung

Info

Publication number
ATE529401T1
ATE529401T1 AT06000750T AT06000750T ATE529401T1 AT E529401 T1 ATE529401 T1 AT E529401T1 AT 06000750 T AT06000750 T AT 06000750T AT 06000750 T AT06000750 T AT 06000750T AT E529401 T1 ATE529401 T1 AT E529401T1
Authority
AT
Austria
Prior art keywords
ether compounds
aminocyclohexyl ether
compounds
compositions
present
Prior art date
Application number
AT06000750T
Other languages
English (en)
Inventor
Gregory BEATCH
Lewis Siu Leung Choi
Grace Jung
Yuzhong Liu
Bertrand Plouvier
Richard Wall
Jeff Zhu
Alexander Zolotoy
Anthony G M Barett
Michael J A Walker
Tao Sheng
Sandro Yong
Doug Ta Hung Chou
Original Assignee
Cardiome Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiome Pharma Corp filed Critical Cardiome Pharma Corp
Application granted granted Critical
Publication of ATE529401T1 publication Critical patent/ATE529401T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
AT06000750T 2003-05-02 2003-10-31 Aminocyclohexylether-verbindungen und deren verwendung ATE529401T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US46715903P 2003-05-02 2003-05-02
US47608303P 2003-06-04 2003-06-04
US47591203P 2003-06-05 2003-06-05
US47588403P 2003-06-05 2003-06-05
US47644703P 2003-06-05 2003-06-05
US48965903P 2003-07-23 2003-07-23
US49339203P 2003-08-07 2003-08-07

Publications (1)

Publication Number Publication Date
ATE529401T1 true ATE529401T1 (de) 2011-11-15

Family

ID=33437310

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03781611T ATE325789T1 (de) 2003-05-02 2003-10-31 Aminocyclohexylether-verbindungen und deren verwendung
AT06000750T ATE529401T1 (de) 2003-05-02 2003-10-31 Aminocyclohexylether-verbindungen und deren verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03781611T ATE325789T1 (de) 2003-05-02 2003-10-31 Aminocyclohexylether-verbindungen und deren verwendung

Country Status (21)

Country Link
US (3) US20070099983A1 (de)
EP (3) EP1666459B1 (de)
JP (2) JP4919661B2 (de)
KR (1) KR101059379B1 (de)
AT (2) ATE325789T1 (de)
AU (2) AU2003287378B2 (de)
BR (2) BRPI0318278B8 (de)
CA (1) CA2524323C (de)
CY (1) CY1105137T1 (de)
DE (1) DE60305200T2 (de)
DK (1) DK1560812T3 (de)
ES (2) ES2264776T3 (de)
IL (2) IL171653A (de)
NO (1) NO334094B1 (de)
NZ (1) NZ543921A (de)
PL (1) PL227937B1 (de)
PT (1) PT1560812E (de)
RU (1) RU2478617C2 (de)
SG (2) SG167670A1 (de)
SI (1) SI1560812T1 (de)
WO (1) WO2004099137A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285908B6 (sk) 1998-04-01 2007-10-04 Nortran Pharmaceuticals Inc. Aminocyklohexyléterová zlúčenina, kompozícia obsahujúca túto zlúčeninu, použitie tejto zlúčeniny pri výrobe liečiva a pri liečbe
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20080063707A1 (en) * 2003-05-02 2008-03-13 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
ES2264776T3 (es) * 2003-05-02 2007-01-16 Cardiome Pharma Corp. Compuestos de aminociclohexil eter y sus usos.
WO2005018635A2 (en) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7754897B2 (en) 2005-06-15 2010-07-13 Cardiome Pharma Corp. Synthetic processes for the preparation of aminocyclohexyl ether compounds
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
US8058304B2 (en) * 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
WO2005094897A2 (en) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
WO2005113011A2 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US8263638B2 (en) * 2004-11-08 2012-09-11 Cardiome Pharma Corp. Dosing regimens for ion channel modulating compounds
EP1828099B1 (de) 2004-11-18 2020-01-22 Correvio International Sàrl Syntheseverfahren für aminocyclohexyl-ether-verbindungen
US20090005576A1 (en) * 2005-01-12 2009-01-01 Astellas Pharma Inc. Production Method of Optically Active Cyclohexane Ether Compounds
JP4167297B2 (ja) 2005-08-23 2008-10-15 株式会社カネカ ３−アラルキルオキシピロリジン誘導体の製造法
JP2007131597A (ja) * 2005-11-11 2007-05-31 Toray Fine Chemicals Co Ltd ベンジルオキシピロリジン誘導体の製造方法
JP5004067B2 (ja) * 2005-10-31 2012-08-22 東レ・ファインケミカル株式会社 ベンジルオキシ含窒素環状化合物の製造法
JP5004073B2 (ja) * 2006-06-13 2012-08-22 東レ・ファインケミカル株式会社 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法
EP1950198B1 (de) * 2005-10-31 2014-08-06 Toray Fine Chemicals Co., Ltd. Verfahren zur herstellung eines benzyloxypyrrolidinderivats und verfahren zur herstellung des hydrochloridsalzpulvers eines optisch aktiven benzyloxypyrrolidinderivats
MX2009011929A (es) * 2007-05-04 2010-03-08 Cardiome Pharma Corp Formulaciones orales de liberacion controlada de compuestos que modulan el canal ionico y metodos relacionados para prevenir arritmia.
WO2012024100A2 (en) 2010-08-16 2012-02-23 Merck Sharp & Dohme Corp. Process for preparing aminocyclohexyl ether compounds
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
KR102383387B1 (ko) * 2014-08-01 2022-04-07 코베스트로 도이칠란트 아게 개선된 광학적 성질을 갖는, 시클릭 올리고머 및 선형 올리고머를 갖는 코폴리카르보네이트 조성물

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2954380A (en) * 1958-11-26 1960-09-27 Us Vitamin Pharm Corp Piperazinocyclohexyl esters
US3218328A (en) * 1963-02-18 1965-11-16 U S Vitamin & Pharmacentical C Heterocyclic amino phenoxyacetic acids, acid addition salts and quaternary ammonium salts thereof
DE2259260A1 (de) 1972-12-04 1974-06-06 Merck Patent Gmbh Neue amine
US4179501A (en) * 1976-11-12 1979-12-18 The Upjohn Company Analgesic N-(2-aminocycloaliphatic)azidobenzamides
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
DE2658401A1 (de) 1976-12-23 1978-07-06 Merck Patent Gmbh Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4598087A (en) * 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4656182A (en) 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
FR2564464B1 (fr) * 1984-05-18 1988-09-02 Glaxo Group Ltd Ethers aminocyclopentyliques, leur procede de fabrication et composition pharmaceutique en resultant
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
EP0222533A1 (de) 1985-10-25 1987-05-20 The Upjohn Company Antikonvulsive cis-N-[(2-aminocycloaliphatische) Benzenacetamide und -Benzamide
US5059620A (en) * 1985-12-27 1991-10-22 The Du Pont Merck Pharmaceutical Company Aryl substituted aminomethyl benzene derivatives
US4855316A (en) * 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
AU626949B2 (en) 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
JPH02270864A (ja) 1989-04-12 1990-11-05 Asahi Glass Co Ltd フルオロカルバサイクリックヌクレオシドおよびその製造法
US5428031A (en) 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2058502A1 (en) 1991-12-27 1993-06-28 David C. Horwell 2-amino-mono-methoxycyclohexyl amides useful as analgesics
EP0552386A1 (de) 1992-01-13 1993-07-28 Warner-Lambert Company 2-Amino-3 oder 6-Methoxycyclohexylamidderivate
DE69311896T2 (de) 1992-03-26 1997-10-16 University Of British Columbia, Vancouver, British Columbia Aminocyclohexylamide für antiarrhythmische und anästhetische verwendungen
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
GB9220286D0 (en) 1992-09-25 1992-11-11 Merck Sharp & Dohme Therapeutic agents
US5451596A (en) 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US5492825A (en) * 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
AU7650294A (en) 1993-09-24 1995-04-10 University Of British Columbia, The Aminocyclohexylesters and uses thereof
GB9406043D0 (en) * 1994-03-26 1994-05-18 Smithkline Beecham Plc Compounds
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
AU699272B2 (en) * 1994-08-02 1998-11-26 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives
EP0781561B1 (de) * 1994-09-19 2002-02-06 Fujisawa Pharmaceutical Co., Ltd. Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
PT801683E (pt) 1995-02-03 2002-09-30 Basf Ag Separacao de racematos de animais primarias e secundarias substituidas por heteroatomos por acilacao catalisada por enzimas
ES2208884T3 (es) 1996-01-25 2004-06-16 Schering Aktiengesellschaft Soluciones mejoradas de agentes de contraste para la administracion intravasal.
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
CZ425598A3 (cs) 1996-06-27 1999-08-11 Smithkline Beecham Corporation Antagonista IL-8 receptoru
US5935945A (en) * 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6180632B1 (en) * 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
TW536401B (en) 1997-09-03 2003-06-11 Cardiome Pharma Corp A pharmaceutical composition of N,N-bis(phenylcarbamoylmethyl)dimethylammomum chloride and derivatives for the treatment of pain
BR9814048A (pt) 1997-09-26 2000-10-03 Nortran Pharmaceuticals Inc "misturas de enantiÈmetros de aminociclohexil amidas para produzir de modo simultâneo analgesia com anestesia local ou antiarritmia "
JP3773644B2 (ja) * 1998-01-06 2006-05-10 芝府エンジニアリング株式会社 接点材料
US6013830A (en) 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
SK285908B6 (sk) 1998-04-01 2007-10-04 Nortran Pharmaceuticals Inc. Aminocyklohexyléterová zlúčenina, kompozícia obsahujúca túto zlúčeninu, použitie tejto zlúčeniny pri výrobe liečiva a pri liečbe
US6624761B2 (en) * 1998-12-11 2003-09-23 Realtime Data, Llc Content independent data compression method and system
US6979685B1 (en) * 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
WO2000047547A2 (en) 1999-02-12 2000-08-17 Nortran Pharmaceuticals Inc. Cycloalkyl amine compounds and uses thereof
AU2899400A (en) 1999-03-04 2000-09-21 Nortran Pharmaceuticals Inc. Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
US7507545B2 (en) * 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
CA2268590A1 (en) * 1999-04-12 2000-10-12 Nortran Pharmaceuticals Inc. Ion channel modulating compounds and uses thereof
US6150357A (en) 1999-05-10 2000-11-21 Merck & Co., Inc. Potassium channel agonists
CN1178911C (zh) * 2000-04-20 2004-12-08 弗·哈夫曼-拉罗切有限公司 吡咯烷与哌啶衍生物和它们用于治疗神经变性疾病的用途
CA2311483A1 (en) 2000-06-12 2001-12-12 Gregory N Beatch IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF
US6521619B2 (en) * 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6498170B2 (en) * 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US7057053B2 (en) * 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
AU2003248647A1 (en) * 2002-06-14 2003-12-31 Johnson Matthey Pharmaceutical Materials, Inc. Stereoselective synthesis of 1,2-disubstituted cycloalkyls
CA2492275A1 (en) 2002-07-12 2004-01-22 Cardiome Inc. Mutations of voltage-gated potassium channels
ES2264776T3 (es) 2003-05-02 2007-01-16 Cardiome Pharma Corp. Compuestos de aminociclohexil eter y sus usos.
WO2004098525A2 (en) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20060094880A9 (en) * 2003-06-04 2006-05-04 Barrett Anthony G M Synthetic process for trans-aminocyclohexyl ether compounds
WO2005018635A2 (en) * 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US20070197632A1 (en) 2003-10-31 2007-08-23 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof

Also Published As

Publication number Publication date
EP1560812B1 (de) 2006-05-10
IL216579A0 (en) 2012-01-31
AU2011201015B2 (en) 2012-02-02
KR20060057531A (ko) 2006-05-26
NO334094B1 (no) 2013-12-09
CA2524323A1 (en) 2004-11-18
AU2011201015A1 (en) 2011-03-31
AU2003287378A1 (en) 2004-11-26
SG167670A1 (en) 2011-01-28
JP2006525227A (ja) 2006-11-09
SI1560812T1 (sl) 2006-10-31
KR101059379B1 (ko) 2011-08-26
ES2375820T3 (es) 2012-03-06
US20070254945A1 (en) 2007-11-01
DE60305200T2 (de) 2007-05-10
EP1666459A2 (de) 2006-06-07
US20070099983A1 (en) 2007-05-03
CA2524323C (en) 2012-05-15
IL171653A (en) 2013-06-27
EP1666459B1 (de) 2011-10-19
BR122018009866B8 (pt) 2021-07-27
BRPI0318278B1 (pt) 2018-11-06
NO20055130D0 (no) 2005-11-02
HK1091814A1 (zh) 2007-01-26
DE60305200D1 (de) 2006-06-14
IL216579A (en) 2015-02-26
PL378918A1 (pl) 2006-06-12
BR0318278A (pt) 2006-05-23
ES2264776T3 (es) 2007-01-16
JP2007077162A (ja) 2007-03-29
JP4919661B2 (ja) 2012-04-18
EP2298735A1 (de) 2011-03-23
US7767830B2 (en) 2010-08-03
DK1560812T3 (da) 2006-09-04
CY1105137T1 (el) 2010-03-03
PT1560812E (pt) 2006-09-29
RU2008104198A (ru) 2009-08-10
US8163938B2 (en) 2012-04-24
BRPI0318278B8 (pt) 2024-01-09
AU2003287378B2 (en) 2010-12-16
BR122018009866B1 (pt) 2018-12-18
NO20055130L (no) 2005-12-01
EP1560812A1 (de) 2005-08-10
PL227937B1 (pl) 2018-01-31
US20110004006A1 (en) 2011-01-06
SG2010079697A (en) 2016-09-29
EP1666459A3 (de) 2006-09-20
RU2478617C2 (ru) 2013-04-10
ATE325789T1 (de) 2006-06-15
WO2004099137A1 (en) 2004-11-18
NZ543921A (en) 2008-11-28

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