ATE398610T1 - Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5- diamino-6-substituierten-1,2,4-triazinen - Google Patents

Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5- diamino-6-substituierten-1,2,4-triazinen

Info

Publication number: ATE398610T1
Authority: AT; Austria
Prior art keywords: diamino; substituted; triazine; lamotrigine; new
Prior art date: 2001-12-24

Application number

AT02807048T

Other languages

English (en)

Inventor

Bhaskar Guntoori

Daqing Che

Keshava Murthy

Original Assignee

Apotex Pharmachem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-24

Filing date

2002-12-18

Publication date

2008-07-15

2002-12-18 Application filed by Apotex Pharmachem Inc filed Critical Apotex Pharmachem Inc

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398610T1 publication Critical patent/ATE398610T1/de

Links

-1 3,5-DIAMINO-6-SUBSTITUTED-1,2,4-TRIAZINE Chemical class 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 title 1
229960001848 lamotrigine Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical class NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT02807048T 2001-12-24 2002-12-18 Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5- diamino-6-substituierten-1,2,4-triazinen ATE398610T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002366521A CA2366521C (en)	2001-12-24	2001-12-24	A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines

Publications (1)

Publication Number	Publication Date
ATE398610T1 true ATE398610T1 (de)	2008-07-15

Family

ID=4171022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02807048T ATE398610T1 (de)	2001-12-24	2002-12-18	Ein neues und effizientes verfahren zur herstellung von lamotrigine und ähnlichen 3,5- diamino-6-substituierten-1,2,4-triazinen

Country Status (10)

Country	Link
US (1)	US6586593B1 (de)
EP (1)	EP1458692B1 (de)
AT (1)	ATE398610T1 (de)
AU (1)	AU2002367765B2 (de)
CA (1)	CA2366521C (de)
DE (1)	DE60227193D1 (de)
MX (1)	MXPA04006216A (de)
NZ (1)	NZ533734A (de)
PL (1)	PL369896A1 (de)
WO (1)	WO2003078407A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU225667B1 (en) *	2002-09-20	2007-05-29	Richter Gedeon Nyrt	Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es)	2002-10-31	2005-08-01	Vita Cientifica, S.L.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Crystalline lamotrigine and its monohydrate
US20120142919A1 (en) *	2006-08-02	2012-06-07	Medichem, S.A.	Method for synthesizing lamotrigine
WO2008019798A1 (en) *	2006-08-14	2008-02-21	Lonza Ag	A process for the preparation of lamotrigine
WO2009069073A1 (en) *	2007-11-28	2009-06-04	Alembic Limited	An improved process for the preparation of lamotrigine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB759014A (en)	1952-02-26	1956-10-10	Wellcome Found	Improvements in triazines and their manufacture
DK153787C (da)	1979-06-01	1989-01-16	Wellcome Found	Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
CA1133938A (en)	1979-06-01	1982-10-19	Martin G. Baxter	Substituted aromatic compounds
US5172981A (en) *	1991-05-22	1992-12-22	Coors Brewing Company	Hydrostatic bearing apparatus
GB9426448D0 (en)	1994-12-30	1995-03-01	Wellcome Found	Process
EP0800520B1 (de)	1994-12-30	2002-06-19	The Wellcome Foundation Limited	Verfahren zur herstellung von lamotrigine
GB9812413D0 (en)	1998-06-10	1998-08-05	Glaxo Group Ltd	Compound and its use
AU1292400A (en)	1998-12-14	2000-07-03	Sharad Kumar Vyas	An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
IL134730A (en) *	2000-02-25	2003-10-31	Chemagis Ltd	Process for preparing substituted benzoyl cyanide amidinohydrazones

2001
- 2001-12-24 CA CA002366521A patent/CA2366521C/en not_active Expired - Fee Related
2002
- 2002-01-16 US US10/046,383 patent/US6586593B1/en not_active Expired - Fee Related
- 2002-12-18 AU AU2002367765A patent/AU2002367765B2/en not_active Ceased
- 2002-12-18 PL PL02369896A patent/PL369896A1/xx not_active Application Discontinuation
- 2002-12-18 WO PCT/CA2002/001926 patent/WO2003078407A1/en not_active Ceased
- 2002-12-18 NZ NZ533734A patent/NZ533734A/en not_active IP Right Cessation
- 2002-12-18 MX MXPA04006216A patent/MXPA04006216A/es active IP Right Grant
- 2002-12-18 AT AT02807048T patent/ATE398610T1/de not_active IP Right Cessation
- 2002-12-18 EP EP02807048A patent/EP1458692B1/de not_active Expired - Lifetime
- 2002-12-18 DE DE60227193T patent/DE60227193D1/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1458692B1 (de)	2008-06-18
CA2366521A1 (en)	2003-06-24
AU2002367765A1 (en)	2003-09-29
MXPA04006216A (es)	2005-03-31
US6586593B1 (en)	2003-07-01
PL369896A1 (en)	2005-05-02
NZ533734A (en)	2005-12-23
EP1458692A1 (de)	2004-09-22
WO2003078407A1 (en)	2003-09-25
CA2366521C (en)	2007-03-06
DE60227193D1 (de)	2008-07-31
AU2002367765B2 (en)	2008-11-13

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Legal Events

Date	Code	Title	Description
2008-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties