ATE398611T1 - Para-amin substituierte phenylamid glukokinase activatoren - Google Patents
Para-amin substituierte phenylamid glukokinase activatorenInfo
- Publication number
- ATE398611T1 ATE398611T1 AT01943302T AT01943302T ATE398611T1 AT E398611 T1 ATE398611 T1 AT E398611T1 AT 01943302 T AT01943302 T AT 01943302T AT 01943302 T AT01943302 T AT 01943302T AT E398611 T1 ATE398611 T1 AT E398611T1
- Authority
- AT
- Austria
- Prior art keywords
- para
- amine substituted
- glucocinase
- activators
- substituted phenylamide
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20238900P | 2000-05-08 | 2000-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE398611T1 true ATE398611T1 (de) | 2008-07-15 |
Family
ID=22749673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01943302T ATE398611T1 (de) | 2000-05-08 | 2001-04-30 | Para-amin substituierte phenylamid glukokinase activatoren |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1283830B1 (de) |
| JP (1) | JP3971189B2 (de) |
| KR (1) | KR100519826B1 (de) |
| CN (1) | CN1185220C (de) |
| AR (1) | AR030279A1 (de) |
| AT (1) | ATE398611T1 (de) |
| AU (2) | AU2001265914B2 (de) |
| BR (1) | BR0110703A (de) |
| CA (1) | CA2407763C (de) |
| DE (1) | DE60134470D1 (de) |
| DK (1) | DK1283830T3 (de) |
| EC (1) | ECSP014062A (de) |
| ES (1) | ES2307623T3 (de) |
| MX (1) | MXPA02010795A (de) |
| PE (1) | PE20020049A1 (de) |
| PT (1) | PT1283830E (de) |
| UY (1) | UY26695A1 (de) |
| WO (1) | WO2001085707A1 (de) |
| ZA (1) | ZA200208503B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1336607A1 (de) * | 2002-02-19 | 2003-08-20 | Novo Nordisk A/S | Amidderivate als Glucokinase-Aktivatoren |
| US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
| WO2003055482A1 (en) | 2001-12-21 | 2003-07-10 | Novo Nordisk A/S | Amide derivatives as gk activators |
| BR0312023A (pt) | 2002-06-27 | 2005-03-22 | Novo Nordisk As | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
| RU2340605C2 (ru) | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Арилкарбонильные производные в качестве терапевтических средств |
| BR0314864A (pt) * | 2002-10-03 | 2005-08-02 | Novartis Ag | Compostos orgânicos |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| DE60336850D1 (en) * | 2003-01-06 | 2011-06-01 | Lilly Co Eli | Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren |
| AU2003294376A1 (en) * | 2003-01-06 | 2004-08-10 | Eli Lilly And Company | Heteroaryl compounds |
| PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| JP4834840B2 (ja) | 2004-01-06 | 2011-12-14 | ノヴォ ノルディスク アー／エス | ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用 |
| US7750020B2 (en) | 2004-04-02 | 2010-07-06 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of Type 2 diabetes |
| AU2005229415B2 (en) | 2004-04-02 | 2009-05-14 | Novartis Ag | Thiazolopyridine derivatives, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
| CN101137631A (zh) * | 2004-12-03 | 2008-03-05 | 转化技术制药公司 | 杂芳族葡糖激酶激活剂 |
| US7582769B2 (en) | 2005-07-08 | 2009-09-01 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
| CA2614746C (en) | 2005-07-09 | 2011-05-10 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
| EP1910317B1 (de) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino-verbundene verbindungen |
| CA2621227A1 (en) | 2005-08-31 | 2007-03-08 | Astellas Pharma Inc. | Thiazole derivative |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−１，２，４−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| ES2393757T3 (es) | 2005-11-17 | 2012-12-27 | Eli Lilly & Company | Antagonistas de receptor de glucagón, preparación y usos terapéuticos |
| US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
| US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EP2049518B1 (de) * | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazol- und isoindolderivate als glucokinaseaktivierende stoffe |
| BRPI0715531A2 (pt) | 2006-07-24 | 2014-06-24 | Hoffmann La Roche | Composto, composição farmacêutica, método para o tratamento de uma enfermidade e/ou distúrbio metabólico, processo para a preparação de compostos e uso do composto |
| US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
| TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| JP5491871B2 (ja) | 2007-02-28 | 2014-05-14 | アドビナス セラピュティックス プライベート リミテッド | グルコキナーゼ活性化因子としての２，２，２−三置換アセトアミド誘導体、その方法及び薬学的応用 |
| US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| EP2157090A4 (de) | 2007-06-21 | 2011-09-07 | Taisho Pharmaceutical Co Ltd | Pyrazinamidverbindung |
| AU2009205070A1 (en) | 2008-01-18 | 2009-07-23 | Astellas Pharma Inc. | Phenyl acetamide derivative |
| US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| SI2275414T1 (sl) | 2008-04-28 | 2015-10-30 | Kyorin Pharmaceutical Co., Ltd., | Ciklopentilakrilamidni derivat |
| BRPI0912802A2 (pt) | 2008-05-16 | 2015-10-13 | Takeda San Diego Inc | ativadores de glicoquinase |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| PH12012501104A1 (en) | 2009-12-04 | 2014-10-14 | Nissan Chemical Ind Ltd | 2-pyridone compounds |
| US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| US8877794B2 (en) * | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN112040945A (zh) | 2018-06-12 | 2020-12-04 | Vtv治疗有限责任公司 | 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途 |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| CA3181722A1 (en) | 2020-06-08 | 2021-12-16 | Jing TENG | Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4317320A1 (de) * | 1993-05-25 | 1994-12-01 | Boehringer Mannheim Gmbh | Neue Thiazolidindione und diese enthaltende Arzneimittel |
| US6011048A (en) * | 1997-01-28 | 2000-01-04 | Merck & Co., Inc. | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity |
-
2001
- 2001-04-30 KR KR10-2002-7014921A patent/KR100519826B1/ko not_active Expired - Fee Related
- 2001-04-30 BR BR0110703-8A patent/BR0110703A/pt not_active IP Right Cessation
- 2001-04-30 AT AT01943302T patent/ATE398611T1/de not_active IP Right Cessation
- 2001-04-30 AU AU2001265914A patent/AU2001265914B2/en not_active Ceased
- 2001-04-30 AU AU6591401A patent/AU6591401A/xx active Pending
- 2001-04-30 CA CA002407763A patent/CA2407763C/en not_active Expired - Fee Related
- 2001-04-30 WO PCT/EP2001/004859 patent/WO2001085707A1/en not_active Ceased
- 2001-04-30 DK DK01943302T patent/DK1283830T3/da active
- 2001-04-30 JP JP2001582308A patent/JP3971189B2/ja not_active Expired - Fee Related
- 2001-04-30 CN CNB018092233A patent/CN1185220C/zh not_active Expired - Fee Related
- 2001-04-30 DE DE60134470T patent/DE60134470D1/de not_active Expired - Lifetime
- 2001-04-30 ES ES01943302T patent/ES2307623T3/es not_active Expired - Lifetime
- 2001-04-30 PT PT01943302T patent/PT1283830E/pt unknown
- 2001-04-30 MX MXPA02010795A patent/MXPA02010795A/es active IP Right Grant
- 2001-04-30 EP EP01943302A patent/EP1283830B1/de not_active Expired - Lifetime
- 2001-05-02 PE PE2001000395A patent/PE20020049A1/es not_active Application Discontinuation
- 2001-05-04 AR ARP010102124A patent/AR030279A1/es unknown
- 2001-05-07 UY UY26695A patent/UY26695A1/es not_active Application Discontinuation
- 2001-05-08 EC EC2001004062A patent/ECSP014062A/es unknown
-
2002
- 2002-10-21 ZA ZA200208503A patent/ZA200208503B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2407763A1 (en) | 2001-11-15 |
| DE60134470D1 (de) | 2008-07-31 |
| PE20020049A1 (es) | 2002-02-01 |
| AR030279A1 (es) | 2003-08-20 |
| UY26695A1 (es) | 2001-11-30 |
| CN1185220C (zh) | 2005-01-19 |
| JP2003532719A (ja) | 2003-11-05 |
| BR0110703A (pt) | 2003-01-28 |
| PT1283830E (pt) | 2008-08-18 |
| KR100519826B1 (ko) | 2005-10-06 |
| ES2307623T3 (es) | 2008-12-01 |
| CA2407763C (en) | 2007-04-24 |
| ECSP014062A (es) | 2002-02-25 |
| EP1283830A1 (de) | 2003-02-19 |
| KR20020094019A (ko) | 2002-12-16 |
| JP3971189B2 (ja) | 2007-09-05 |
| ZA200208503B (en) | 2004-01-22 |
| WO2001085707A1 (en) | 2001-11-15 |
| DK1283830T3 (da) | 2008-08-25 |
| EP1283830B1 (de) | 2008-06-18 |
| MXPA02010795A (es) | 2003-03-27 |
| CN1427830A (zh) | 2003-07-02 |
| AU2001265914B2 (en) | 2005-11-03 |
| AU6591401A (en) | 2001-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1283830 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |