ATE398612T1 - Diastereoselektive addition von lithiiertem n- methylimidazol an sulfinimine - Google Patents

Diastereoselektive addition von lithiiertem n- methylimidazol an sulfinimine

Info

Publication number: ATE398612T1
Authority: AT; Austria
Prior art keywords: sulfinimine; lithiated; methylimidazole; methyl; diastereoselective addition
Prior art date: 2004-05-03

Application number

AT05747389T

Other languages

English (en)

Inventor

Walter Ferdinand Mari Filliers

Rudy Laurent Maria Broeckx

Patrick Rene Angibaud

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-03

Filing date

2005-04-28

Publication date

2008-07-15

2005-04-28 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398612T1 publication Critical patent/ATE398612T1/de

Links

MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 title 1
238000010918 diastereoselective addition Methods 0.000 title 1
238000002360 preparation method Methods 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Lubricants (AREA)

AT05747389T 2004-05-03 2005-04-28 Diastereoselektive addition von lithiiertem n- methylimidazol an sulfinimine ATE398612T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04076320		2004-05-03

Publications (1)

Publication Number	Publication Date
ATE398612T1 true ATE398612T1 (de)	2008-07-15

Family

ID=34968457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05747389T ATE398612T1 (de)	2004-05-03	2005-04-28	Diastereoselektive addition von lithiiertem n- methylimidazol an sulfinimine

Country Status (10)

Country	Link
US (1)	US7524961B2 (de)
EP (1)	EP1758885B1 (de)
JP (1)	JP4917021B2 (de)
CN (1)	CN100567290C (de)
AT (1)	ATE398612T1 (de)
AU (1)	AU2005238221B2 (de)
CA (1)	CA2563805C (de)
DE (1)	DE602005007604D1 (de)
ES (1)	ES2308500T3 (de)
WO (1)	WO2005105782A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100567290C (zh) *	2004-05-03	2009-12-09	詹森药业有限公司	锂化n-甲基咪唑在亚磺基亚胺上的非对映选择性加成
EP1756085B1 (de) *	2004-05-03	2010-06-16	Janssen Pharmaceutica N.V.	Diastereoselektives syntheseverfahren mit 6-brom-4-(3-chlorphenyl)-2-methoxychinolin
HRP20211976T1 (hr)	2015-08-17	2022-03-18	Kura Oncology, Inc.	Postupci liječenja bolesnika od raka inhibitorima farnezil transferaze
EP3838275A1 (de)	2016-11-03	2021-06-23	Kura Oncology, Inc.	Farnesyltransferase-inhibitoren zur verwendung bei der behandlung von krebs
AU2019270163A1 (en) *	2018-05-18	2020-12-03	Kura Oncology, Inc.	Synthesis of tipifarnib

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2175137T3 (es) *	1995-12-08	2002-11-16	Janssen Pharmaceutica Nv	Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de laproteina farnesil-transferasa.
US6525074B2 (en) *	2000-01-12	2003-02-25	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
AU2001227756A1 (en) *	2000-01-12	2001-07-24	Merck And Co., Inc.	Inhibitors of prenyl-protein transferase
HN2000000266A (es)	2000-01-21	2001-05-21	Pfizer Prod Inc	Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
AU2001290588A1 (en) *	2000-09-05	2002-03-22	Merck And Co., Inc.	Inhibitors of prenyl-protein transferase
CA2438421C (en) *	2001-03-12	2010-05-18	Janssen Pharmaceutica N.V.	Process for the preparation of imidazole compounds
WO2002079147A2 (en) *	2001-03-30	2002-10-10	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
WO2004037816A1 (en) *	2002-10-28	2004-05-06	Chugai Seiyaku Kabushiki Kaisha	Benzofuran compounds having antitumor activity
WO2004076446A1 (ja) *	2003-02-27	2004-09-10	Chugai Seiyaku Kabushiki Kaisha	ベンゾチオフェン誘導体
CN100567290C (zh) *	2004-05-03	2009-12-09	詹森药业有限公司	锂化n-甲基咪唑在亚磺基亚胺上的非对映选择性加成

2005
- 2005-04-28 CN CNB2005800124249A patent/CN100567290C/zh not_active Expired - Lifetime
- 2005-04-28 AT AT05747389T patent/ATE398612T1/de not_active IP Right Cessation
- 2005-04-28 DE DE602005007604T patent/DE602005007604D1/de not_active Expired - Lifetime
- 2005-04-28 ES ES05747389T patent/ES2308500T3/es not_active Expired - Lifetime
- 2005-04-28 EP EP05747389A patent/EP1758885B1/de not_active Expired - Lifetime
- 2005-04-28 US US11/568,415 patent/US7524961B2/en not_active Expired - Lifetime
- 2005-04-28 JP JP2007512168A patent/JP4917021B2/ja not_active Expired - Lifetime
- 2005-04-28 WO PCT/EP2005/051928 patent/WO2005105782A1/en not_active Ceased
- 2005-04-28 AU AU2005238221A patent/AU2005238221B2/en not_active Ceased
- 2005-04-28 CA CA2563805A patent/CA2563805C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20070293679A1 (en)	2007-12-20
JP4917021B2 (ja)	2012-04-18
US7524961B2 (en)	2009-04-28
JP2007536333A (ja)	2007-12-13
CN1946709A (zh)	2007-04-11
EP1758885A1 (de)	2007-03-07
CA2563805A1 (en)	2005-11-10
EP1758885B1 (de)	2008-06-18
WO2005105782A1 (en)	2005-11-10
DE602005007604D1 (de)	2008-07-31
ES2308500T3 (es)	2008-12-01
HK1101326A1 (zh)	2007-10-12
AU2005238221A1 (en)	2005-11-10
CN100567290C (zh)	2009-12-09
AU2005238221B2 (en)	2010-09-30
CA2563805C (en)	2012-11-13

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Legal Events

Date	Code	Title	Description
2008-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties