ATE398627T1 - C-2-modifizierte erythromycinderivate - Google Patents

C-2-modifizierte erythromycinderivate

Info

Publication number: ATE398627T1
Authority: AT; Austria
Prior art keywords: compound; formula; erythromycin derivatives; bacterial infections; treating bacterial
Prior art date: 1999-05-14

Application number

AT00930370T

Other languages

English (en)

Inventor

Zhenkun Ma

Yat OR

Ly Phan

Suoming Zhang

Richard Clark

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-14

Filing date

2000-05-04

Publication date

2008-07-15

2000-05-04 Application filed by Abbott Lab filed Critical Abbott Lab

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398627T1 publication Critical patent/ATE398627T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
208000035143 Bacterial infection Diseases 0.000 abstract 2
208000022362 bacterial infectious disease Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT00930370T 1999-05-14 2000-05-04 C-2-modifizierte erythromycinderivate ATE398627T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/312,517 US6355620B1 (en)	1999-05-14	1999-05-14	C-2 modified erythromycin derivatives

Publications (1)

Publication Number	Publication Date
ATE398627T1 true ATE398627T1 (de)	2008-07-15

Family

ID=23211820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00930370T ATE398627T1 (de)	1999-05-14	2000-05-04	C-2-modifizierte erythromycinderivate

Country Status (11)

Country	Link
US (1)	US6355620B1 (de)
EP (1)	EP1181299B1 (de)
JP (1)	JP2002544284A (de)
AT (1)	ATE398627T1 (de)
CA (1)	CA2372270C (de)
DE (1)	DE60039238D1 (de)
DK (1)	DK1181299T3 (de)
ES (1)	ES2307511T3 (de)
MX (1)	MXPA01011633A (de)
PT (1)	PT1181299E (de)
WO (1)	WO2000069875A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1147121T3 (da)	1999-01-27	2004-04-13	Pfizer Prod Inc	Ketolidantibiotika
EE200100613A (et) *	1999-05-24	2003-02-17	Pfizer Products Inc.	13-metüülerütromütsiini derivaadid
EP1167376B1 (de) *	2000-06-30	2004-07-14	Pfizer Products Inc.	Makrolid-Antibiotika
JP2004531471A (ja) *	2000-12-21	2004-10-14	グラクソ　グループ　リミテッド	マクロライド抗生物質
DE10122139A1 (de) *	2001-05-08	2002-11-21	Daniel Swarovski	Verfahren und Vorrichtung zur Bestimmung der Verteilung von Inhaltsstoffen in fluiden Medien
CA2469304A1 (en)	2001-12-05	2003-06-19	Ortho-Mcneil Pharmaceutical, Inc.	6-o acyl ketolide antibacterials
US7910558B2 (en) *	2002-05-13	2011-03-22	Enanta Pharmaceuticals, Inc.	Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) *	2002-07-25	2005-01-11	Enanra Pharmaceuticals, Inc.	6,11-4-carbon bridged ketolides
US7273853B2 (en) *	2002-05-13	2007-09-25	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
EP1618120A2 (de)	2003-04-25	2006-01-25	Chiron Corporation	Ketolidderivate
WO2005067564A2 (en) *	2004-01-07	2005-07-28	Enanta Pharmaceuticals, Inc.	6-11 bicyclic erythromycin derivatives
US7265094B2 (en) *	2004-01-09	2007-09-04	Enanta Pharmaceuticals, Inc.	9N-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
WO2005121160A2 (en) *	2004-04-26	2005-12-22	Johnson & Johnson Pharmaceutical Research & Development	11, 12 cyclic thiocarbamate macrolide antibacterial agents
TW200635600A (en) *	2004-12-13	2006-10-16	Enanta Pharm Inc	Tetracyclic bicyclolides
SI1836211T1 (sl) *	2004-12-21	2010-04-30	Pfizer Prod Inc	Makrolidi
US20060252710A1 (en) *	2005-05-04	2006-11-09	Guoqiang Wang	6-11 Bridged oxime erythromycin derivatives
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
JPWO2009019868A1 (ja)	2007-08-06	2010-10-28	大正製薬株式会社	１０ａ、１２位架橋型１０ａ−アザライド化合物
US8273720B2 (en) *	2007-09-17	2012-09-25	Enanta Pharmaceuticals, Inc.	6,11-bicyclolides: bridged biaryl macrolide derivatives
US8354383B2 (en) *	2007-09-17	2013-01-15	Enanta Pharmaceuticals, Inc.	6,11-bridged biaryl macrolides
MX2010002932A (es) *	2007-09-17	2010-05-27	Enanta Pharm Inc	Macrolidos de biarilo con puente en 6, 11.
TW200946109A (en) *	2008-05-09	2009-11-16	Enanta Pharm Inc	Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
WO2009139181A1 (ja)	2008-05-15	2009-11-19	大正製薬株式会社	４員環構造を有する１０ａ－アザライド化合物
CN104650166B (zh) *	2014-11-17	2017-12-05	广东东阳光药业有限公司	一种大环内酯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0559896B1 (de)	1990-11-28	1997-08-27	Taisho Pharmaceutical Co. Ltd	6-0-methylerythromycin a-derivat
ES2087737T3 (es)	1992-04-22	1996-07-16	Taisho Pharmaceutical Co Ltd	Un derivado 5-o-desosaminil-eritronoluro a.
FR2742757B1 (fr)	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5940488A (en) *	1996-11-15	1999-08-17	Active Voice Corporation	Telecommunication management system and user interface
CA2303930A1 (en) *	1997-09-30	1999-04-08	Abbott Laboratories	3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity

1999
- 1999-05-14 US US09/312,517 patent/US6355620B1/en not_active Expired - Lifetime
2000
- 2000-05-04 JP JP2000618291A patent/JP2002544284A/ja active Pending
- 2000-05-04 CA CA002372270A patent/CA2372270C/en not_active Expired - Fee Related
- 2000-05-04 ES ES00930370T patent/ES2307511T3/es not_active Expired - Lifetime
- 2000-05-04 MX MXPA01011633A patent/MXPA01011633A/es active IP Right Grant
- 2000-05-04 WO PCT/US2000/012202 patent/WO2000069875A1/en not_active Ceased
- 2000-05-04 DK DK00930370T patent/DK1181299T3/da active
- 2000-05-04 DE DE60039238T patent/DE60039238D1/de not_active Expired - Fee Related
- 2000-05-04 EP EP00930370A patent/EP1181299B1/de not_active Expired - Lifetime
- 2000-05-04 AT AT00930370T patent/ATE398627T1/de not_active IP Right Cessation
- 2000-05-04 PT PT00930370T patent/PT1181299E/pt unknown

Also Published As

Publication number	Publication date
WO2000069875A1 (en)	2000-11-23
MXPA01011633A (es)	2002-07-30
CA2372270A1 (en)	2000-11-23
US6355620B1 (en)	2002-03-12
PT1181299E (pt)	2008-09-18
CA2372270C (en)	2008-07-22
EP1181299A1 (de)	2002-02-27
EP1181299B1 (de)	2008-06-18
WO2000069875A9 (en)	2002-02-21
ES2307511T3 (es)	2008-12-01
DK1181299T3 (da)	2008-10-27
JP2002544284A (ja)	2002-12-24
DE60039238D1 (de)	2008-07-31

Legal Events

Date

Code

Title

Description

2009-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1181299

Country of ref document: EP

2010-08-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60039238D1 (de)	2008-07-31	C-2-modifizierte erythromycinderivate
WO2004062601A3 (en)	2005-04-21	Antibacterial agents
CA2392973A1 (en)	2001-06-07	Benzoimidazole derivatives useful as antiproliferative agents
TR199901127T2 (xx)	1999-07-21	Antibakteriyel etkili 6-O-ikameli ketolitler.
NO996108L (no)	2000-02-10	9-oksinerytromycinderivater
CA2413424A1 (en)	2001-12-27	Substituted bicyclic derivatives for the treatment of abnormal cell growth
NO20015172L (no)	2002-01-23	1-metyl-erytromycin-derivater
DK1021456T3 (da)	2003-08-18	Makrocykliske derivater af erythromysin A og B med 13-leddet ring
IL165715A0 (en)	2006-01-15	2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
WO2004096823A3 (en)	2005-02-10	Novel ketolide derivatives
MX2009006334A (es)	2009-06-23	Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona.
NO20052074L (no)	2005-06-01	Substituerte benzoksazinoner og anvendelser derav.
DK0992509T3 (da)	2004-12-20	Nye makrolid-derivater
GEP20084437B (en)	2008-07-25	Novel lincomycin derivatives possessing antimicrobial activity
NO20054135L (no)	2005-09-23	Kipolinon/benzoksazin derivater og anvendelser derav
BR9708929A (pt)	1999-08-03	Composto composição farmacêutica e processos para controlar uma infecção bacteriana em um mamífero e para preparar compostos de macrólidos
EP1109560A4 (de)	2002-04-17	Als inhibitoren der aicarftnützliche verbindungen
AP9801377A0 (en)	2000-04-29	Tricyclic erythromycin derivatives.
WO2003057213A3 (en)	2004-02-19	Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
AP2001002325A0 (en)	2001-12-31	Novel crystalline forms of a macrolide antibiotic
ATE271062T1 (de)	2004-07-15	Makrolid-antibiotika
WO2002018353A3 (en)	2002-06-13	Oxazolidinone chemotherapeutic agents
TR200201145T2 (tr)	2002-09-23	Hidromisin türevleri
NZ515278A (en)	2003-06-30	Halo derivatives of 9-deoxo-9a-aza-9a- homerythromycin A their salts and preparation process