ES2307511T3 - Derivados de eritromicina c-2 modificados. - Google Patents

Derivados de eritromicina c-2 modificados. Download PDF

Info

Publication number
ES2307511T3
ES2307511T3 ES00930370T ES00930370T ES2307511T3 ES 2307511 T3 ES2307511 T3 ES 2307511T3 ES 00930370 T ES00930370 T ES 00930370T ES 00930370 T ES00930370 T ES 00930370T ES 2307511 T3 ES2307511 T3 ES 2307511T3
Authority
ES
Spain
Prior art keywords
compound
formula
modified
bacterial infections
erythromycin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00930370T
Other languages
English (en)
Inventor
Zhenkun Ma
Yat Sun Or
Ly Tam Phan
Suoming Zhang
Richard F. Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2307511T3 publication Critical patent/ES2307511T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A compuesto seleccionado del grupo que consiste en un compuesto de fórmula (I) (Ver fórmula) un compuesto de fórmula (II) (Ver fórmula) y un compuesto de fórmula (III) (Ver fórmula) y sus sales, ésteres, y profármacos farmacéuticamente aceptables, donde, en las fórmulas (I)-(III), Y y Z se seleccionan juntos del grupo que consiste en (1) oxo, (2) =N-OH, (3) =N-OR 1 donde R 1 se selecciona del grupo que consiste en (a) -alquilo C1-C12, (b) -alquilo C1-C12 sustituido con arilo, (c) -alquilo C1-C12 sustituido con arilo sustituido, (d) -alquilo C1-C12 sustituido con heteroarilo...
ES00930370T 1999-05-14 2000-05-04 Derivados de eritromicina c-2 modificados. Expired - Lifetime ES2307511T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US312517 1989-02-21
US09/312,517 US6355620B1 (en) 1999-05-14 1999-05-14 C-2 modified erythromycin derivatives

Publications (1)

Publication Number Publication Date
ES2307511T3 true ES2307511T3 (es) 2008-12-01

Family

ID=23211820

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00930370T Expired - Lifetime ES2307511T3 (es) 1999-05-14 2000-05-04 Derivados de eritromicina c-2 modificados.

Country Status (11)

Country Link
US (1) US6355620B1 (es)
EP (1) EP1181299B1 (es)
JP (1) JP2002544284A (es)
AT (1) ATE398627T1 (es)
CA (1) CA2372270C (es)
DE (1) DE60039238D1 (es)
DK (1) DK1181299T3 (es)
ES (1) ES2307511T3 (es)
MX (1) MXPA01011633A (es)
PT (1) PT1181299E (es)
WO (1) WO2000069875A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2359708C (en) 1999-01-27 2005-10-25 Pfizer Products Inc. Ketolide antibiotics
EA200100983A1 (ru) * 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
DE60104240T2 (de) * 2000-06-30 2005-08-04 Pfizer Products Inc., Groton Makrolid-Antibiotika
CN1492874A (zh) * 2000-12-21 2004-04-28 大环内酯
DE10122139A1 (de) * 2001-05-08 2002-11-21 Daniel Swarovski Verfahren und Vorrichtung zur Bestimmung der Verteilung von Inhaltsstoffen in fluiden Medien
NZ533282A (en) 2001-12-05 2006-09-29 Ortho Mcneil Pharm Inc 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7163924B2 (en) 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
WO2005067564A2 (en) * 2004-01-07 2005-07-28 Enanta Pharmaceuticals, Inc. 6-11 bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20050250713A1 (en) * 2004-04-26 2005-11-10 Bin Zhu 11,12-Cyclic thiocarbamate macrolide antibacterial agents
US7312201B2 (en) * 2004-12-13 2007-12-25 Enanta Pharmaceuticals, Inc. Tetracyclic bicyclolides
UA85937C2 (uk) * 2004-12-21 2009-03-10 Пфайзер Продактс Інк. Макроліди
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
ES2691252T3 (es) * 2007-09-17 2018-11-26 Enanta Pharmaceuticals, Inc. Macrólidos de biarilo con puente en 6,11
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
CN104650166B (zh) * 2014-11-17 2017-12-05 广东东阳光药业有限公司 一种大环内酯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
EP0559896B1 (en) 1990-11-28 1997-08-27 Taisho Pharmaceutical Co. Ltd 6-o-methylerythromycin a derivative
ATE135707T1 (de) 1992-04-22 1996-04-15 Taisho Pharmaceutical Co Ltd 5-0-desosaminylerythronolid a derivate
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5940488A (en) * 1996-11-15 1999-08-17 Active Voice Corporation Telecommunication management system and user interface
DK1025114T3 (da) * 1997-09-30 2004-07-05 Abbott Lab 3'-N-modificerede 6-O-substituerede erythromycin-ketolidderivater med antibakteriel aktivitet

Also Published As

Publication number Publication date
DK1181299T3 (da) 2008-10-27
JP2002544284A (ja) 2002-12-24
CA2372270A1 (en) 2000-11-23
EP1181299A1 (en) 2002-02-27
MXPA01011633A (es) 2002-07-30
WO2000069875A1 (en) 2000-11-23
US6355620B1 (en) 2002-03-12
PT1181299E (pt) 2008-09-18
CA2372270C (en) 2008-07-22
DE60039238D1 (de) 2008-07-31
WO2000069875A9 (en) 2002-02-21
EP1181299B1 (en) 2008-06-18
ATE398627T1 (de) 2008-07-15

Similar Documents

Publication Publication Date Title
ES2307511T3 (es) Derivados de eritromicina c-2 modificados.
WO2004062601A3 (en) Antibacterial agents
DK1021456T3 (da) Makrocykliske derivater af erythromysin A og B med 13-leddet ring
CA2413424A1 (en) Substituted bicyclic derivatives for the treatment of abnormal cell growth
TR199901127T2 (xx) Antibakteriyel etkili 6-O-ikameli ketolitler.
TR200103395T2 (tr) 13-metil eritromisin türevleri.
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
IL165715A0 (en) 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
NO996108L (no) 9-oksinerytromycinderivater
WO2004096823A3 (en) Novel ketolide derivatives
MX2009006334A (es) Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona.
NO20052074L (no) Substituerte benzoksazinoner og anvendelser derav.
JO2413B1 (en) Benzoxazine derivatives and their use
CA2286511A1 (en) Novel macrolide derivatives
GEP20084437B (en) Novel lincomycin derivatives possessing antimicrobial activity
BG104447A (en) Biphenylamidine derivatives
MXPA05009523A (es) Derivados de quinolina/benzoxazinona y sus usos.
ATE310010T1 (de) 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung
WO2003057213A3 (en) Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
AP9801377A0 (en) Tricyclic erythromycin derivatives.
EP1109560A4 (en) COMPOUNDS USEFUL AS AICARFT INHIBITORS
AP2001002325A0 (en) Novel crystalline forms of a macrolide antibiotic
WO2002018353A3 (en) Oxazolidinone chemotherapeutic agents
TR200201145T2 (tr) Hidromisin türevleri
ATE250076T1 (de) 6-o-carbamat ketolide derivate