ATE398628T1 - Oxidationsverfahren zur herstellung des zwischenproduktes 6.alpha.,9.alpha.-difluoro- - Google Patents

Oxidationsverfahren zur herstellung des zwischenproduktes 6.alpha.,9.alpha.-difluoro-

Info

Publication number: ATE398628T1
Authority: AT; Austria
Prior art keywords: alpha; difluoro; producing; intermediate product; oxidation process
Prior art date: 2000-07-21

Application number

AT01949791T

Other languages

English (en)

Inventor

Frederick David Albinson

Steven John Coote

John Malcolm Robinson

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2001-07-20

Publication date

2008-07-15

2001-07-20 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398628T1 publication Critical patent/ATE398628T1/de

Links

238000000034 method Methods 0.000 title abstract 2
230000003647 oxidation Effects 0.000 title abstract 2
238000007254 oxidation reaction Methods 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT01949791T 2000-07-21 2001-07-20 Oxidationsverfahren zur herstellung des zwischenproduktes 6.alpha.,9.alpha.-difluoro- ATE398628T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0017988.7A GB0017988D0 (en)	2000-07-21	2000-07-21	Novel process

Publications (1)

Publication Number	Publication Date
ATE398628T1 true ATE398628T1 (de)	2008-07-15

Family

ID=9896132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01949791T ATE398628T1 (de)	2000-07-21	2001-07-20	Oxidationsverfahren zur herstellung des zwischenproduktes 6.alpha.,9.alpha.-difluoro-

Country Status (26)

Country	Link
US (1)	US20040043974A1 (de)
EP (1)	EP1301526B1 (de)
JP (1)	JP2004504403A (de)
KR (1)	KR100787293B1 (de)
CN (1)	CN1315864C (de)
AT (1)	ATE398628T1 (de)
AU (2)	AU7090601A (de)
BR (1)	BR0110430A (de)
CA (1)	CA2406963A1 (de)
CY (1)	CY1108553T1 (de)
CZ (1)	CZ302592B6 (de)
DE (1)	DE60134472D1 (de)
DK (1)	DK1301526T3 (de)
ES (1)	ES2307628T3 (de)
GB (1)	GB0017988D0 (de)
HK (1)	HK1056179B (de)
HU (1)	HUP0301108A3 (de)
IL (2)	IL152348A0 (de)
MX (1)	MXPA02010967A (de)
NO (1)	NO324836B1 (de)
NZ (1)	NZ522083A (de)
PL (1)	PL206652B1 (de)
PT (1)	PT1301526E (de)
SI (1)	SI1301526T1 (de)
WO (1)	WO2002008243A1 (de)
ZA (1)	ZA200208372B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6858593B2 (en)	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6777400B2 (en)	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6750210B2 (en)	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
US6787532B2 (en)	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
GB0019172D0 (en)	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
US6777399B2 (en)	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6858596B2 (en)	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
WO2002012266A1 (en)	2000-08-05	2002-02-14	Glaxo Group Limited	17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
UA77656C2 (en)	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
PT1383786E (pt)	2001-04-30	2008-12-30	Glaxo Group Ltd	Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
IL150654A (en)	2002-07-09	2006-12-10	Ori Lerman	Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
EP1466920A1 (de) *	2003-04-04	2004-10-13	Alpharma APS	Verfahren zur Herstellung von steroidal 17 beta-carbothioates
WO2004087731A1 (en) *	2003-04-04	2004-10-14	Alpharma Aps	Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1526139A1 (de) *	2003-10-24	2005-04-27	S.N.I.F.F. Italia S.P.A.	Verfahren zur Herstellung von hochreinen Androstan-17-beta-carbonsäuren und Androstan-17-beta-fluoromethyl-thiocarbonsäureestern
GB0612027D0 (en)	2006-06-16	2006-07-26	Glaxo Group Ltd	Novel process
NO331891B1 (no)	2007-03-20	2012-04-30	Clavis Pharma Asa	Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) *	2010-06-01	2013-01-29	Hovione Farmaciencia S A	Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
JP2013536835A (ja)	2010-09-01	2013-09-26	カディラ・ヘルスケア・リミテッド	プロピオン酸／フロ酸フルチカゾンを調製するための方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3636010A (en) *	1968-12-23	1972-01-18	Ciba Geigy Corp	Esters of steroid-17-carboxylic acids
US4198336A (en) *	1978-04-05	1980-04-15	Syntex (U.S.A.) Inc.	Chemical process for preparing androsta-4-ene 17α-carboxylic acids
US4263289A (en) *	1978-04-05	1981-04-21	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
NL187577C (nl) *	1978-04-05	1991-11-18	Sibla Srl	3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188385A (en) *	1978-04-05	1980-02-12	Syntex (U.S.A.) Inc.	Thioetianic acid derivatives
CY1291A (en) *	1980-02-15	1985-10-18	Glaxo Group Ltd	Androstane 17 beta carbothioates
US5646136A (en) *	1994-01-04	1997-07-08	Duke University	Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
DE69609199T2 (de) *	1995-12-29	2001-03-01	Glaxo Group Ltd., Greenford	Lacton derivate von 17.beta.-carboxy, carbothio und amide androstanverbindungen
US20020133032A1 (en) *	2000-02-25	2002-09-19	Jufang Barkalow	Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
WO2001074599A1 (en) *	2000-04-04	2001-10-11	Celanese International Corporation	Ink receptive coating compositions containing poly(vinyl alcohol) grafted with amine functional groups
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions

2000
- 2000-07-21 GB GBGB0017988.7A patent/GB0017988D0/en not_active Ceased
2001
- 2001-07-20 KR KR1020027014367A patent/KR100787293B1/ko not_active Expired - Fee Related
- 2001-07-20 AU AU7090601A patent/AU7090601A/xx active Pending
- 2001-07-20 EP EP01949791A patent/EP1301526B1/de not_active Expired - Lifetime
- 2001-07-20 DK DK01949791T patent/DK1301526T3/da active
- 2001-07-20 AU AU2001270906A patent/AU2001270906B2/en not_active Ceased
- 2001-07-20 JP JP2002514148A patent/JP2004504403A/ja active Pending
- 2001-07-20 BR BR0110430-6A patent/BR0110430A/pt not_active Application Discontinuation
- 2001-07-20 CA CA002406963A patent/CA2406963A1/en not_active Abandoned
- 2001-07-20 PT PT01949791T patent/PT1301526E/pt unknown
- 2001-07-20 WO PCT/GB2001/003289 patent/WO2002008243A1/en not_active Ceased
- 2001-07-20 MX MXPA02010967A patent/MXPA02010967A/es active IP Right Grant
- 2001-07-20 ES ES01949791T patent/ES2307628T3/es not_active Expired - Lifetime
- 2001-07-20 CZ CZ20023472A patent/CZ302592B6/cs not_active IP Right Cessation
- 2001-07-20 SI SI200130851T patent/SI1301526T1/sl unknown
- 2001-07-20 CN CNB018114407A patent/CN1315864C/zh not_active Expired - Fee Related
- 2001-07-20 DE DE60134472T patent/DE60134472D1/de not_active Expired - Lifetime
- 2001-07-20 IL IL15234801A patent/IL152348A0/xx active IP Right Grant
- 2001-07-20 HK HK03106680.9A patent/HK1056179B/en not_active IP Right Cessation
- 2001-07-20 PL PL359462A patent/PL206652B1/pl not_active IP Right Cessation
- 2001-07-20 US US10/333,537 patent/US20040043974A1/en not_active Abandoned
- 2001-07-20 AT AT01949791T patent/ATE398628T1/de active
- 2001-07-20 HU HU0301108A patent/HUP0301108A3/hu unknown
- 2001-07-20 NZ NZ522083A patent/NZ522083A/en not_active IP Right Cessation
2002
- 2002-10-17 ZA ZA200208372A patent/ZA200208372B/en unknown
- 2002-10-17 IL IL152348A patent/IL152348A/en not_active IP Right Cessation
- 2002-10-21 NO NO20025054A patent/NO324836B1/no not_active IP Right Cessation
2008
- 2008-09-03 CY CY20081100942T patent/CY1108553T1/el unknown

Also Published As

Publication number	Publication date
HUP0301108A3 (en)	2008-04-28
HUP0301108A2 (hu)	2003-08-28
DE60134472D1 (de)	2008-07-31
CN1437610A (zh)	2003-08-20
NO324836B1 (no)	2007-12-17
HK1056179B (en)	2009-07-17
DK1301526T3 (da)	2008-10-06
CZ20023472A3 (cs)	2003-04-16
KR100787293B1 (ko)	2007-12-20
US20040043974A1 (en)	2004-03-04
CY1108553T1 (el)	2014-04-09
ES2307628T3 (es)	2008-12-01
WO2002008243A1 (en)	2002-01-31
NO20025054L (no)	2002-11-05
ZA200208372B (en)	2004-02-11
EP1301526B1 (de)	2008-06-18
BR0110430A (pt)	2003-07-08
NO20025054D0 (no)	2002-10-21
SI1301526T1 (sl)	2008-10-31
AU2001270906B2 (en)	2005-10-13
KR20030028736A (ko)	2003-04-10
PL206652B1 (pl)	2010-09-30
AU7090601A (en)	2002-02-05
JP2004504403A (ja)	2004-02-12
PL359462A1 (en)	2004-08-23
NZ522083A (en)	2004-06-25
CZ302592B6 (cs)	2011-07-27
MXPA02010967A (es)	2003-03-27
CA2406963A1 (en)	2002-01-31
CN1315864C (zh)	2007-05-16
IL152348A0 (en)	2003-05-29
HK1056179A1 (en)	2004-02-06
EP1301526A1 (de)	2003-04-16
PT1301526E (pt)	2008-09-09
IL152348A (en)	2008-08-07
GB0017988D0 (en)	2000-09-13

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2008-12-15

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