ATE399013T1 - Nicht antibakterielle tetracycline zur behandlung der multiplen sklerose - Google Patents

Nicht antibakterielle tetracycline zur behandlung der multiplen sklerose

Info

Publication number: ATE399013T1
Authority: AT; Austria
Prior art keywords: treatment; multiple sclerosis; tnfalpha; chemically modified; cox
Prior art date: 1997-12-19

Application number

AT98964764T

Other languages

English (en)

Inventor

Ashok Amin

Steven Abramson

Original Assignee

Univ New York

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

1998-12-17

Publication date

2008-07-15

1998-12-17 Application filed by Univ New York filed Critical Univ New York

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399013T1 publication Critical patent/ATE399013T1/de

Links

239000004098 Tetracycline Substances 0.000 title abstract 3
235000019364 tetracycline Nutrition 0.000 title abstract 3
150000003522 tetracyclines Chemical class 0.000 title abstract 3
201000006417 multiple sclerosis Diseases 0.000 title 1
229960002180 tetracycline Drugs 0.000 title 1
229930101283 tetracycline Natural products 0.000 title 1
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 3
108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 3
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 3
108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 2
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 2
229960002986 dinoprostone Drugs 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 2
229940040944 tetracyclines Drugs 0.000 abstract 2
108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Virology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT98964764T 1997-12-19 1998-12-17 Nicht antibakterielle tetracycline zur behandlung der multiplen sklerose ATE399013T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6826897P	1997-12-19	1997-12-19

Publications (1)

Publication Number	Publication Date
ATE399013T1 true ATE399013T1 (de)	2008-07-15

Family

ID=22081491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98964764T ATE399013T1 (de)	1997-12-19	1998-12-17	Nicht antibakterielle tetracycline zur behandlung der multiplen sklerose

Country Status (11)

Country	Link
US (1)	US6319910B1 (de)
EP (1)	EP1041991B1 (de)
JP (1)	JP4733266B2 (de)
AT (1)	ATE399013T1 (de)
AU (1)	AU2001599A (de)
CA (1)	CA2316972C (de)
DE (1)	DE69839649D1 (de)
DK (1)	DK1041991T3 (de)
ES (1)	ES2310018T3 (de)
PT (1)	PT1041991E (de)
WO (1)	WO1999030720A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7115557B2 (en) *	1998-09-25	2006-10-03	Sciaticon Ab	Use of certain drugs for treating nerve root injury
SE9803710L (sv) *	1998-09-25	2000-03-26	A & Science Invest Ab	Användning av vissa substanser för behandling av nervrotsskador
US7811990B2 (en) *	1998-09-25	2010-10-12	Sciaticon Ab	Soluble cytokine receptors TNF-α blocking antibodies for treating spinal disorders mediated by nucleus pulposus
US7906481B2 (en) *	1998-09-25	2011-03-15	Sciaticon Ab	Specific TNF-A inhibitors for treating spinal disorders mediated by nucleous pulposus
US6506740B1 (en)	1998-11-18	2003-01-14	Robert A. Ashley	4-dedimethylaminotetracycline derivatives
US6946453B2 (en)	1998-11-18	2005-09-20	Collagenex Pharmaceuticals, Inc.	4-dedimethylaminotracycline derivatives
AU3653301A (en) *	2000-01-28	2001-08-07	Merck & Co., Inc.	Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
US6623736B2 (en) *	2000-05-02	2003-09-23	Edward L. Tobinick	Interleukin antagonists for the treatment of neurological, retinal and muscular disorders
US20040033938A1 (en) *	2000-09-12	2004-02-19	Britten Nancy J.	Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US8088820B2 (en) *	2001-04-24	2012-01-03	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
EP1399414B1 (de) *	2001-04-24	2010-01-13	Paratek Pharmaceuticals, Inc.	Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2329826A1 (de)	2001-07-13	2011-06-08	Paratek Pharmaceuticals, Inc.	Tetracycline zur Behandlung der multiplen Sklerose
KR101083498B1 (ko) *	2002-03-21	2011-11-16	파라테크 파마슈티컬스, 인크.	치환된 테트라시클린 화합물
WO2004038001A2 (en) *	2002-10-24	2004-05-06	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
CA2503446C (en) *	2002-10-24	2012-12-18	Paratek Pharmaceuticals, Inc.	Methods of using substituted tetracycline compounds to modulate rna
US20080153894A1 (en) *	2002-12-19	2008-06-26	Pharmacia Corporation	Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US20080249072A1 (en) *	2004-09-22	2008-10-09	Golub Lorne M	Use of Low Dose Chemically Modified Tetracylines to Reduce Inflammatory Mediators
GB0518558D0 (en) *	2005-09-12	2005-10-19	Givaudan Sa	Improvements in or related to organic compounds
WO2007098099A2 (en) *	2006-02-16	2007-08-30	Discogen, Llc	Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor
WO2008047340A1 (en) *	2006-10-19	2008-04-24	Mor Research Applications Ltd.	Combined therapies of antipsychotic drugs and tetracyclines in the treatment of psychiatric disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4704383A (en) *	1983-12-29	1987-11-03	The Research Foundation Of State University Of New York	Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US5308839A (en) *	1989-12-04	1994-05-03	The Research Foundation Of State University Of New York	Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
JP3016587B2 (ja) *	1989-12-04	2000-03-06	ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク	非ステロイド抗炎症剤及びテトラサイクリンの配合
JPH0454160A (ja) *	1990-06-21	1992-02-21	Kuraray Co Ltd	テトラサイクリン誘導体
US5045538A (en) *	1990-06-28	1991-09-03	The Research Foundation Of State University Of New York	Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
JPH04178359A (ja) *	1990-07-01	1992-06-25	Kuraray Co Ltd	テトラサイクリン誘導体
US5223248A (en)	1991-02-11	1993-06-29	The Research Foundation Of State University Of New York	Non-antibacterial tetracycline compositions possessing antiplaque properties
US5258371A (en) *	1992-05-29	1993-11-02	Kuraray Co., Ltd.	Method to reduce connective tissue destruction
EP0599397B1 (de)	1992-11-17	1996-08-28	The Research Foundation Of State University Of New York	Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes
JPH0782153A (ja) *	1993-07-20	1995-03-28	Sumio Arai	エンドトキシン中和剤
JP2676093B2 (ja) *	1994-12-05	1997-11-12	ザリサーチファンデーションオブステートユニバーシティオブニューヨーク	動物飼料組成物
JPH08268907A (ja) *	1995-03-31	1996-10-15	Sunstar Inc	歯周組織再生促進剤
US5789395A (en) *	1996-08-30	1998-08-04	The Research Foundation Of State University Of New York	Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US5837696A (en) *	1997-01-15	1998-11-17	The Research Foundation Of State University Of New York	Method of inhibiting cancer growth

1998
- 1998-12-17 PT PT98964764T patent/PT1041991E/pt unknown
- 1998-12-17 US US09/213,149 patent/US6319910B1/en not_active Expired - Lifetime
- 1998-12-17 JP JP2000538702A patent/JP4733266B2/ja not_active Expired - Fee Related
- 1998-12-17 AT AT98964764T patent/ATE399013T1/de active
- 1998-12-17 DE DE69839649T patent/DE69839649D1/de not_active Expired - Lifetime
- 1998-12-17 DK DK98964764T patent/DK1041991T3/da active
- 1998-12-17 ES ES98964764T patent/ES2310018T3/es not_active Expired - Lifetime
- 1998-12-17 CA CA002316972A patent/CA2316972C/en not_active Expired - Fee Related
- 1998-12-17 WO PCT/US1998/026870 patent/WO1999030720A1/en not_active Ceased
- 1998-12-17 EP EP98964764A patent/EP1041991B1/de not_active Expired - Lifetime
- 1998-12-17 AU AU20015/99A patent/AU2001599A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1999030720A9 (en)	1999-10-07
ES2310018T3 (es)	2008-12-16
DK1041991T3 (da)	2008-07-28
WO1999030720A1 (en)	1999-06-24
CA2316972C (en)	2009-02-24
WO1999030720A8 (en)	1999-09-02
DE69839649D1 (de)	2008-08-07
AU2001599A (en)	1999-07-05
PT1041991E (pt)	2008-10-03
EP1041991A4 (de)	2002-08-21
JP2002508327A (ja)	2002-03-19
JP4733266B2 (ja)	2011-07-27
EP1041991B1 (de)	2008-06-25
EP1041991A1 (de)	2000-10-11
CA2316972A1 (en)	1999-06-24
US6319910B1 (en)	2001-11-20

Legal Events

Date

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2009-03-15

UEP

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