ATE399156T1 - Neue indol- oder benzimidazol-derivate - Google Patents

Neue indol- oder benzimidazol-derivate

Info

Publication number: ATE399156T1
Authority: AT; Austria
Prior art keywords: compounds; benzimidazole derivatives; new indole; pharmaceutically acceptable; acceptable salts
Prior art date: 2004-10-27

Application number

AT05806665T

Other languages

English (en)

Inventor

Konrad Bleicher

Matthias Nettekoven

Philippe Pflieger

Stephan Roever

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-27

Filing date

2005-10-18

Publication date

2008-07-15

2005-10-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399156T1 publication Critical patent/ATE399156T1/de

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
102000009132 CB1 Cannabinoid Receptor Human genes 0.000 abstract 1
108010073366 CB1 Cannabinoid Receptor Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Addiction (AREA)
Endocrinology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Psychology (AREA)
Oncology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)

AT05806665T 2004-10-27 2005-10-18 Neue indol- oder benzimidazol-derivate ATE399156T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04105329		2004-10-27

Publications (1)

Publication Number	Publication Date
ATE399156T1 true ATE399156T1 (de)	2008-07-15

Family

ID=35658930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05806665T ATE399156T1 (de)	2004-10-27	2005-10-18	Neue indol- oder benzimidazol-derivate

Country Status (14)

Country	Link
US (2)	US7384945B2 (de)
EP (1)	EP1807398B1 (de)
JP (1)	JP2008517959A (de)
KR (1)	KR100912146B1 (de)
CN (1)	CN101048382B (de)
AT (1)	ATE399156T1 (de)
AU (1)	AU2005298986A1 (de)
BR (1)	BRPI0517369A (de)
CA (1)	CA2585030A1 (de)
DE (1)	DE602005007765D1 (de)
ES (1)	ES2309812T3 (de)
MX (1)	MX2007004910A (de)
RU (1)	RU2394027C2 (de)
WO (1)	WO2006045478A1 (de)

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ATE526963T1 (de) *	2006-05-04	2011-10-15	Lek Pharmaceuticals	Pharmazeutische zusammensetzung mit olmesartan- medoxomil
US9051265B2 (en)	2011-06-06	2015-06-09	The Scripps Research Institute	N-benzylindole modulators of PPARG
US8957093B2 (en)	2011-06-06	2015-02-17	The Scripps Research Institute	N-biphenylmethylindole modulators of PPARG
US9309227B2 (en)	2011-11-22	2016-04-12	The Scripps Research Institute	N-biphenylmethylbenzimidazole modulators of PPARG
DK2785710T3 (en)	2011-12-01	2017-12-04	Chemocentryx Inc	SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR (4) - ANTAGONISTS
BR112014013138B1 (pt) *	2011-12-01	2022-06-28	Chemocentryx, Inc	Compostos de anilinas substituídas como antagonistas de ccr(4) e composição farmacêutica compreendendo os mesmos
WO2013096496A2 (en)	2011-12-21	2013-06-27	Allergan, Inc.	Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response
BR112014030940B1 (pt)	2012-06-11	2022-09-06	UCB Biopharma SRL	Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos
WO2015161108A1 (en)	2014-04-16	2015-10-22	The Scripps Research Institute	Pparg modulators for treatment of osteoporosis
WO2017035114A1 (en) *	2015-08-25	2017-03-02	Janssen Pharmaceutica Nv	Benzimidazole derivatives useful as cb-1 inverse agonists

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FR2713225B1 (fr)	1993-12-02	1996-03-01	Sanofi Sa	N-pipéridino-3-pyrazolecarboxamide substitué.
FR2692575B1 (fr)	1992-06-23	1995-06-30	Sanofi Elf	Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2714057B1 (fr)	1993-12-17	1996-03-08	Sanofi Elf	Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
US5596106A (en)	1994-07-15	1997-01-21	Eli Lilly And Company	Cannabinoid receptor antagonists
IL118474A (en) *	1995-06-01	2001-08-08	Sankyo Co	Benzimideol derivatives and pharmaceutical preparations containing them
JPH10508321A (ja) *	1995-09-01	1998-08-18	イーライ・リリー・アンド・カンパニー	インドリル神経ペプチドｙレセプターアンタゴニスト
FR2741621B1 (fr)	1995-11-23	1998-02-13	Sanofi Sa	Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
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EA200000868A1 (ru) *	1998-02-25	2001-04-23	Дженетикс Инститьют, Инк.	Ингибиторы фосфолипаз
HUP0100156A3 (en) *	1998-02-25	2002-12-28	Genetics Inst Inc Cambridge	Indole derivatives as inhibitors of phospholipase a2 and use of them for producing pharmaceutical compositions
KR100652994B1 (ko)	1998-09-11	2006-11-30	아방티 파르마 소시에테 아노님	아제티딘 유도체, 이의 제조방법 및 이를 함유하는 약제
FR2783246B1 (fr)	1998-09-11	2000-11-17	Aventis Pharma Sa	Derives d'azetidine, leur preparation et les medicaments les contenant
FR2789079B3 (fr)	1999-02-01	2001-03-02	Sanofi Synthelabo	Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
GB9919411D0 (en) *	1999-08-18	1999-10-20	Zeneca Ltd	Chemical compounds
FR2800375B1 (fr)	1999-11-03	2004-07-23	Sanofi Synthelabo	Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
US6355631B1 (en)	2000-03-03	2002-03-12	Aventis Pharma S.A.	Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation
FR2805810B1 (fr)	2000-03-03	2002-04-26	Aventis Pharma Sa	Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation
FR2805817B1 (fr)	2000-03-03	2002-04-26	Aventis Pharma Sa	Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
US6566356B2 (en)	2000-03-03	2003-05-20	Aventis Pharma S.A.	Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
FR2805818B1 (fr)	2000-03-03	2002-04-26	Aventis Pharma Sa	Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
US6479479B2 (en)	2000-03-03	2002-11-12	Aventis Pharma S.A.	Azetidine derivatives, their preparation and pharmaceutical compositions containing them
DZ3335A1 (fr)	2000-03-23	2001-09-27	Solvay Pharm Bv	Derives de 4,5-dihydro-1h-pyrazole ayant une activite antagoniste de cb1
FR2814678B1 (fr)	2000-10-04	2002-12-20	Aventis Pharma Sa	Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite
SE0101387D0 (sv) *	2001-04-20	2001-04-20	Astrazeneca Ab	Novel compounds
WO2003005393A1 (de) *	2001-06-29	2003-01-16	Siemens Aktiengesellschaft	Vakuumschaltröhre für hohe kurzschlussströme
AU2002347022A1 (en) *	2001-12-20	2003-07-09	Novo Nordisk A/S	Benzimidazols and indols as glucagon receptor antagonists/inverse agonisten
ATE482747T1 (de) *	2003-04-11	2010-10-15	High Point Pharmaceuticals Llc	Neue amide derivate und deren pharmazeutische verwendungen
SE0301701D0 (sv) *	2003-06-10	2003-06-10	Astrazeneca Ab	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

2005
- 2005-10-18 AU AU2005298986A patent/AU2005298986A1/en not_active Abandoned
- 2005-10-18 WO PCT/EP2005/011176 patent/WO2006045478A1/en not_active Ceased
- 2005-10-18 ES ES05806665T patent/ES2309812T3/es not_active Expired - Lifetime
- 2005-10-18 RU RU2007119638/04A patent/RU2394027C2/ru not_active IP Right Cessation
- 2005-10-18 JP JP2007538299A patent/JP2008517959A/ja not_active Ceased
- 2005-10-18 CA CA002585030A patent/CA2585030A1/en not_active Abandoned
- 2005-10-18 CN CN2005800366958A patent/CN101048382B/zh not_active Expired - Fee Related
- 2005-10-18 MX MX2007004910A patent/MX2007004910A/es active IP Right Grant
- 2005-10-18 AT AT05806665T patent/ATE399156T1/de active
- 2005-10-18 EP EP05806665A patent/EP1807398B1/de not_active Expired - Lifetime
- 2005-10-18 BR BRPI0517369-8A patent/BRPI0517369A/pt not_active IP Right Cessation
- 2005-10-18 KR KR1020077011823A patent/KR100912146B1/ko not_active Expired - Fee Related
- 2005-10-18 DE DE602005007765T patent/DE602005007765D1/de not_active Expired - Lifetime
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Publication number	Publication date
CA2585030A1 (en)	2006-05-04
KR100912146B1 (ko)	2009-08-14
US7786128B2 (en)	2010-08-31
CN101048382B (zh)	2010-05-05
BRPI0517369A (pt)	2008-10-07
DE602005007765D1 (de)	2008-08-07
US7384945B2 (en)	2008-06-10
AU2005298986A1 (en)	2006-05-04
EP1807398A1 (de)	2007-07-18
JP2008517959A (ja)	2008-05-29
CN101048382A (zh)	2007-10-03
RU2394027C2 (ru)	2010-07-10
KR20070084545A (ko)	2007-08-24
US20060089367A1 (en)	2006-04-27
MX2007004910A (es)	2007-06-14
WO2006045478A1 (en)	2006-05-04
RU2007119638A (ru)	2008-12-10
US20080234290A1 (en)	2008-09-25
ES2309812T3 (es)	2008-12-16
EP1807398B1 (de)	2008-06-25

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