ATE399161T1 - 7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6- tetrahydropyrid-1-yl)ethyl)isochinolin- besylatsalz, dessen herstellung und dessen therapeutische verwendung - Google Patents

7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6- tetrahydropyrid-1-yl)ethyl)isochinolin- besylatsalz, dessen herstellung und dessen therapeutische verwendung

Info

Publication number: ATE399161T1
Authority: AT; Austria
Prior art keywords: tetrahydropyride; isochinoline; trifluormethylphenyl; ethyl; production
Prior art date: 2005-03-17

Application number

AT06726092T

Other languages

English (en)

Inventor

Corinne Barre

Olivier Monnier

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-17

Filing date

2006-03-15

Publication date

2008-07-15

2006-03-15 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399161T1 publication Critical patent/ATE399161T1/de

Links

-1 ISOCHINOLINE BESYLATE SALT Chemical class 0.000 title 1
QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Rheumatology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Psychology (AREA)

AT06726092T 2005-03-17 2006-03-15 7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6- tetrahydropyrid-1-yl)ethyl)isochinolin- besylatsalz, dessen herstellung und dessen therapeutische verwendung ATE399161T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0502611A FR2883285B1 (fr)	2005-03-17	2005-03-17	Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

Publications (1)

Publication Number	Publication Date
ATE399161T1 true ATE399161T1 (de)	2008-07-15

Family

ID=35285429

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06726092T ATE399161T1 (de)	2005-03-17	2006-03-15	7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6- tetrahydropyrid-1-yl)ethyl)isochinolin- besylatsalz, dessen herstellung und dessen therapeutische verwendung

Country Status (34)

Country	Link
US (1)	US7795277B2 (de)
EP (1)	EP1861389B1 (de)
JP (1)	JP2008534450A (de)
KR (1)	KR20070115258A (de)
CN (1)	CN101137644A (de)
AR (1)	AR053448A1 (de)
AT (1)	ATE399161T1 (de)
AU (1)	AU2006224465B2 (de)
BR (1)	BRPI0607614A2 (de)
CA (1)	CA2599637A1 (de)
CR (1)	CR9352A (de)
CY (1)	CY1108366T1 (de)
DE (1)	DE602006001590D1 (de)
DK (1)	DK1861389T3 (de)
EA (1)	EA011560B1 (de)
ES (1)	ES2309957T3 (de)
FR (1)	FR2883285B1 (de)
HR (1)	HRP20080447T3 (de)
IL (1)	IL185537A (de)
MA (1)	MA29348B1 (de)
MX (1)	MX2007011021A (de)
MY (1)	MY138296A (de)
NO (1)	NO20075022L (de)
NZ (1)	NZ561027A (de)
PL (1)	PL1861389T3 (de)
PT (1)	PT1861389E (de)
RS (1)	RS50611B (de)
SI (1)	SI1861389T1 (de)
TN (1)	TNSN07317A1 (de)
TW (1)	TW200700410A (de)
UA (1)	UA90304C2 (de)
UY (1)	UY29425A1 (de)
WO (1)	WO2006097624A1 (de)
ZA (1)	ZA200707488B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
JP5523107B2 (ja)	2006-11-30	2014-06-18	プロビオドルグエージー	グルタミニルシクラーゼの新規阻害剤
EP2481408A3 (de)	2007-03-01	2013-01-09	Probiodrug AG	Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
MX2012002993A (es)	2009-09-11	2012-04-19	Probiodrug Ag	Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2736053B1 (fr) *	1995-06-28	1997-09-19	Sanofi Sa	Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
IL149250A0 (en) *	1999-10-22	2002-11-10	Sanofi Synthelabo	Phenyl-and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
FR2823749B1 (fr) *	2001-04-20	2004-02-20	Sanofi Synthelabo	Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE365162T1 (de)	2001-04-20	2007-07-15	Sanofi Aventis	Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten

2005
- 2005-03-17 FR FR0502611A patent/FR2883285B1/fr not_active Expired - Fee Related
2006
- 2006-03-14 MY MYPI20061092A patent/MY138296A/en unknown
- 2006-03-15 DK DK06726092T patent/DK1861389T3/da active
- 2006-03-15 ES ES06726092T patent/ES2309957T3/es not_active Expired - Lifetime
- 2006-03-15 WO PCT/FR2006/000566 patent/WO2006097624A1/fr not_active Ceased
- 2006-03-15 NZ NZ561027A patent/NZ561027A/en not_active IP Right Cessation
- 2006-03-15 RS RSP-2008/0423A patent/RS50611B/sr unknown
- 2006-03-15 PT PT06726092T patent/PT1861389E/pt unknown
- 2006-03-15 DE DE602006001590T patent/DE602006001590D1/de not_active Expired - Lifetime
- 2006-03-15 HR HR20080447T patent/HRP20080447T3/xx unknown
- 2006-03-15 BR BRPI0607614-9A patent/BRPI0607614A2/pt not_active IP Right Cessation
- 2006-03-15 MX MX2007011021A patent/MX2007011021A/es active IP Right Grant
- 2006-03-15 KR KR1020077021155A patent/KR20070115258A/ko not_active Ceased
- 2006-03-15 UA UAA200711489A patent/UA90304C2/ru unknown
- 2006-03-15 JP JP2008501367A patent/JP2008534450A/ja not_active Ceased
- 2006-03-15 EA EA200702004A patent/EA011560B1/ru not_active IP Right Cessation
- 2006-03-15 CA CA002599637A patent/CA2599637A1/fr not_active Abandoned
- 2006-03-15 AT AT06726092T patent/ATE399161T1/de active
- 2006-03-15 PL PL06726092T patent/PL1861389T3/pl unknown
- 2006-03-15 CN CNA2006800080866A patent/CN101137644A/zh active Pending
- 2006-03-15 SI SI200630065T patent/SI1861389T1/sl unknown
- 2006-03-15 AU AU2006224465A patent/AU2006224465B2/en not_active Ceased
- 2006-03-15 ZA ZA200707488A patent/ZA200707488B/xx unknown
- 2006-03-15 EP EP06726092A patent/EP1861389B1/de not_active Expired - Lifetime
- 2006-03-16 TW TW095108870A patent/TW200700410A/zh unknown
- 2006-03-16 AR ARP060101027A patent/AR053448A1/es unknown
- 2006-03-17 UY UY29425A patent/UY29425A1/es unknown
2007
- 2007-08-17 TN TNP2007000317A patent/TNSN07317A1/en unknown
- 2007-08-27 IL IL185537A patent/IL185537A/en not_active IP Right Cessation
- 2007-08-28 CR CR9352A patent/CR9352A/es not_active Application Discontinuation
- 2007-09-12 US US11/853,920 patent/US7795277B2/en not_active Expired - Fee Related
- 2007-09-26 MA MA30248A patent/MA29348B1/fr unknown
- 2007-10-04 NO NO20075022A patent/NO20075022L/no not_active Application Discontinuation
2008
- 2008-09-24 CY CY20081101039T patent/CY1108366T1/el unknown

Also Published As

Publication number	Publication date
AR053448A1 (es)	2007-05-09
AU2006224465A1 (en)	2006-09-21
ZA200707488B (en)	2008-12-31
KR20070115258A (ko)	2007-12-05
TW200700410A (en)	2007-01-01
MA29348B1 (fr)	2008-03-03
FR2883285A1 (fr)	2006-09-22
US20080085917A1 (en)	2008-04-10
PL1861389T3 (pl)	2008-12-31
US7795277B2 (en)	2010-09-14
CY1108366T1 (el)	2014-02-12
MY138296A (en)	2009-05-29
ES2309957T3 (es)	2008-12-16
BRPI0607614A2 (pt)	2009-09-22
DE602006001590D1 (de)	2008-08-07
AU2006224465B2 (en)	2011-10-13
NO20075022L (no)	2007-10-04
RS50611B (sr)	2010-06-30
IL185537A0 (en)	2008-01-06
UA90304C2 (en)	2010-04-26
EP1861389A1 (de)	2007-12-05
CN101137644A (zh)	2008-03-05
PT1861389E (pt)	2008-09-11
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