ATE399784T1 - Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen - Google Patents

Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen

Info

Publication number
ATE399784T1
ATE399784T1 AT02802815T AT02802815T ATE399784T1 AT E399784 T1 ATE399784 T1 AT E399784T1 AT 02802815 T AT02802815 T AT 02802815T AT 02802815 T AT02802815 T AT 02802815T AT E399784 T1 ATE399784 T1 AT E399784T1
Authority
AT
Austria
Prior art keywords
kits
compositions
methods
luminescent compounds
concerning
Prior art date
Application number
AT02802815T
Other languages
English (en)
Inventor
Keith Wood
Erika Hawkins
Mike Scurria
Dieter Klaubert
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of ATE399784T1 publication Critical patent/ATE399784T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Electroluminescent Light Sources (AREA)
AT02802815T 2001-11-02 2002-11-01 Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen ATE399784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/053,482 US7268229B2 (en) 2001-11-02 2001-11-02 Compounds to co-localize luminophores with luminescent proteins

Publications (1)

Publication Number Publication Date
ATE399784T1 true ATE399784T1 (de) 2008-07-15

Family

ID=21984572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02802815T ATE399784T1 (de) 2001-11-02 2002-11-01 Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen

Country Status (10)

Country Link
US (2) US7268229B2 (de)
EP (2) EP1894933B1 (de)
JP (1) JP4958388B2 (de)
CN (2) CN100439338C (de)
AT (1) ATE399784T1 (de)
CA (1) CA2462506C (de)
DE (1) DE60227408D1 (de)
DK (1) DK1451155T3 (de)
ES (1) ES2307829T3 (de)
WO (1) WO2003040100A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004027378A2 (en) 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
JP4485470B2 (ja) 2002-12-23 2010-06-23 プロメガ コーポレイション ルシフェラーゼ酵素活性を保護するための方法及びキット
EP2778234B1 (de) 2005-05-31 2017-09-27 Promega Corporation Luminogene und fluorogene verbindungen und verfahren für den nachweis von molekülen oder leiden
JP2009507032A (ja) 2005-09-02 2009-02-19 アボット・ラボラトリーズ 新規なイミダゾ系複素環
JP2007081050A (ja) * 2005-09-13 2007-03-29 Fujifilm Corp 有機電界発光素子
JP4982737B2 (ja) * 2006-03-23 2012-07-25 国立大学法人三重大学 イミダゾキノキザリノン化学発光物質、その製造法、および発光分析法
JP2007277097A (ja) * 2006-04-03 2007-10-25 Mie Univ 発光化合物、発光方法、及びその製造方法
US7709253B2 (en) * 2006-08-04 2010-05-04 The Board Of Trustees Of The Leland Stanford Junior University Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists
USRE46199E1 (en) * 2006-10-24 2016-11-08 Gene Stream Pty Ltd. Luciferase signal enhancing compositions
US20090075309A1 (en) * 2007-09-06 2009-03-19 Gambhir Sanjiv S Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems
EP2326953B1 (de) 2008-07-22 2018-03-21 Promega Corporation Auf adp-nachweis basierendes phosphotransferase- oder atp-hydrolase-lumineszenztestverfahren
JP5597200B2 (ja) 2008-08-18 2014-10-01 プロメガ コーポレイション ルミネッセンスを生じる化合物およびチトクロムｐ４５０３ａ酵素を検出するための方法
GB2479847B (en) 2009-02-09 2014-02-19 Jnc Corp Coelenterazine analogs and manufacturing method thereof
LT3409764T (lt) 2009-05-01 2020-06-10 Promega Corporation Sintetinės oplophorus liuciferazės su sustiprinta šviesos išeiga
JP5605727B2 (ja) * 2010-04-06 2014-10-15 Ｊｎｃ株式会社 セレンテラジン類縁体及びセレンテラミド類縁体
MX2012013037A (es) 2010-05-10 2013-07-29 Univ California Composiciones de endorribonucleasa y metodos de uso de las mismas.
BR112013010487B1 (pt) * 2010-11-02 2021-02-02 Promega Corporation compostos de coelenterazina, kit compreendendo ditos compostos e método para detectar luminescência em uma amostra in vitro
WO2012061477A1 (en) * 2010-11-02 2012-05-10 Promega Corporation Coelenterazine derivatives and methods of using same
JP6067019B2 (ja) * 2011-09-02 2017-01-25 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにｎａｄ（ｐ）／ｎａｄ（ｐ）ｈを測定するための方法
JP6511720B2 (ja) 2013-02-28 2019-05-15 Jnc株式会社 コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法
JP6040846B2 (ja) 2013-04-08 2016-12-07 Jnc株式会社 セレンテラジン類縁体
JP6484987B2 (ja) 2013-10-21 2019-03-20 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
JP6442825B2 (ja) 2013-12-26 2018-12-26 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
US9927430B2 (en) 2014-01-29 2018-03-27 Promega Corporation Pro-substrates for live cell applications
JP6265020B2 (ja) 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
US9732373B2 (en) 2014-09-11 2017-08-15 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
EP4219736A1 (de) 2014-09-12 2023-08-02 Promega Corporation Interne proteinmarker
EP3204509B1 (de) 2014-10-08 2019-07-10 Promega Corporation Biolumineszierender test zum nachweis von succinat
CN107922428B (zh) 2015-06-25 2021-02-05 普洛麦格公司 噻吩并吡咯化合物及其作为刺虾源性荧光素酶的抑制剂的用途
EP3416968B1 (de) 2016-02-15 2022-07-27 Promega Corporation Coelenterazin-analoga
WO2018049241A1 (en) 2016-09-09 2018-03-15 Promega Corporation Dual protected pro-coelenterazine substrates
EP3535270B3 (de) 2016-11-01 2024-05-29 Promega Corporation An energieakzeptoren gebundene coelenterazin-analoga
US10577370B2 (en) 2016-12-01 2020-03-03 Promega Corporation Cell impermeable coelenterazine analogues
US10815247B2 (en) 2016-12-28 2020-10-27 Promega Corporation Functionalized NANOLUC inhibitors
EP3395803A1 (de) 2017-04-28 2018-10-31 Institut Pasteur Imidazopyrazinderivate, verfahren zur herstellung davon und deren verwendung als luciferine
ES2983923T3 (es) 2017-07-06 2024-10-28 Promega Corp Análogos de la pro-coelenterazina estables en suero
JP7419260B2 (ja) 2018-05-01 2024-01-22 プロメガ コーポレイション ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物
EP4140991B1 (de) 2018-06-01 2024-05-15 Promega Corporation Biolumineszenz-komplexe aus oplophorus-luciferase-hemmern
WO2020023871A1 (en) 2018-07-27 2020-01-30 Promega Corporation Quinone-containing conjugates
CN112996923B (zh) 2018-10-03 2025-02-18 普洛麦格公司 用于稳定腔肠素及其类似物和衍生物的组合物和方法
US12582726B1 (en) 2019-04-05 2026-03-24 Earli Inc. Synthetic cancer-specific promoters
JP2022527629A (ja) 2019-04-05 2022-06-02 アーリー・インコーポレイテッド 合成バイオマーカーのための改良された方法及び組成物
KR20220121816A (ko) 2019-11-27 2022-09-01 프로메가 코포레이션 다분할 루시퍼라제 펩타이드 및 폴리펩타이드
US12061202B2 (en) 2019-12-10 2024-08-13 Promega Corporation Compositions and methods for bioluminescent detection using multifunctional probes
JP7677997B2 (ja) 2020-05-22 2025-05-15 プロメガ コーポレイション キナーゼターゲットエンゲージメントの増強
EP4337646A4 (de) 2021-05-13 2025-05-21 Promega Corporation Biolumineszenter nachweis der dna-synthese
CN113683617B (zh) * 2021-07-16 2022-08-30 山东大学 一种基于腔肠素-h的氘代化合物及其制备方法与应用
WO2023215497A1 (en) 2022-05-04 2023-11-09 Promega Corporation Photoactivatable compounds and uses thereof
JP2025515181A (ja) 2022-05-04 2025-05-13 プロメガ コーポレイション 伸長表面ループ領域を有する修飾デハロゲナーゼ

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604364A (en) * 1974-01-04 1986-08-05 Kosak Kenneth M Bioluminescent tracer composition and method of use in immunoassays
US4080265A (en) * 1974-08-02 1978-03-21 Antonik Alan S Method for the determination of creative phosphokinase enzyme
US3958938A (en) * 1974-12-16 1976-05-25 Bausch & Lomb Incorporated Bioluminescent sensor system
US4349510A (en) * 1979-07-24 1982-09-14 Seppo Kolehmainen Method and apparatus for measurement of samples by luminescence
SE449004B (sv) * 1981-06-25 1987-03-30 Wallac Oy Bioluminiscensbestemning av nadh och/eller nadph
IT1172385B (it) * 1983-12-21 1987-06-18 Miles Italiana Composizione e metodo per la determinazione enzimatica di atp ed fmn
US4665022A (en) * 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
DE3537877A1 (de) * 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
US5004565A (en) * 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
DE3700908A1 (de) * 1987-01-14 1988-07-28 Geiger Reinhard Aminoluciferine, verfahren zu deren herstellung und deren verwendung bei der bestimmung von enzymaktivitaeten
JPS6447379A (en) * 1987-08-19 1989-02-21 Chisso Corp Preparation of calcium-dependent oxygenation enzyme
JPH04228097A (ja) * 1990-07-02 1992-08-18 Toyo Ink Mfg Co Ltd ミルク試料からの細胞分離および濃縮方法とそのキット
US5283180A (en) * 1990-07-19 1994-02-01 Charm Sciences, Inc. Bioluminescence method for the determination of pesticides
US5374534A (en) * 1990-07-19 1994-12-20 Charm Sciences, Inc. Method of preparing D-luciferin derivatives
US5831102A (en) * 1990-08-30 1998-11-03 Tropix, Inc. Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
US5283179A (en) * 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
EP0529084B1 (de) * 1991-02-13 1997-05-28 Nihon Millipore Kogyo Kabushiki Kaisha Verfahren zur bestimmung der zahl lebender mikroorganismen
JP2856339B2 (ja) * 1991-02-21 1999-02-10 キッコーマン株式会社 酵素免疫測定法
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
JPH08441B2 (ja) 1992-03-06 1996-01-10 司 上月 容器素材の製造方法
DE69313611T2 (de) * 1992-07-02 1998-01-08 Erkki Soini Biospezifisches multiparameter-analyseverfahren
US5360728A (en) * 1992-12-01 1994-11-01 Woods Hole Oceanographic Institution (W.H.O.I.) Modified apoaequorin having increased bioluminescent activity
US5648232A (en) * 1993-01-21 1997-07-15 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Microbiological best method and reagents
GB9311241D0 (en) * 1993-06-01 1993-07-21 Celsis Ltd Reagents for use in bioluminescence
IL111181A0 (en) * 1993-10-06 1994-12-29 Univ Florida Stem cell proliferation factor, its preparation, purification and uses
JPH07125617A (ja) 1993-11-02 1995-05-16 Hino Motors Ltd 坂道発進補助装置
WO1995021191A1 (en) * 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
JP3648763B2 (ja) * 1994-08-23 2005-05-18 日本油脂株式会社 ウミホタルルシフェリン誘導体および糖加水分解酵素の定量方法
US5840572A (en) * 1994-10-11 1998-11-24 United States Of America As Represented By The Secretary Of The Navy Bioluminescent bioassay system
JPH08294397A (ja) * 1995-04-27 1996-11-12 Nippon Oil & Fats Co Ltd 免疫学的活性物質の測定方法
EP0861330B1 (de) * 1995-07-12 2003-08-20 Charm Sciences Inc. Testvorrichtung, sytem und verfahren zum nachweis von testproben
US6165734A (en) * 1995-12-12 2000-12-26 Applied Spectral Imaging Ltd. In-situ method of analyzing cells
JP3547882B2 (ja) * 1995-12-28 2004-07-28 キッコーマン株式会社 Ａｔｐ消去剤、ａｔｐ消去法、それを用いた生物細胞測定試薬及び生物細胞測定法
JP3409962B2 (ja) * 1996-03-04 2003-05-26 キッコーマン株式会社 生物発光試薬及びその試薬を用いたアデノシンリン酸エステルの定量法並びにその試薬を用いたａｔｐ変換反応系に関与する物質の定量法
US5908751A (en) * 1996-04-26 1999-06-01 Toyo Ink Mfg. Co., Ltd. Method for detecting and/or determining ATP from microorganism cells in a sample
US6416960B1 (en) * 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
US5798263A (en) * 1996-09-05 1998-08-25 Promega Corporation Apparatus for quantifying dual-luminescent reporter assays
GB9626932D0 (en) * 1996-12-24 1997-02-12 Lumitech Limited Assay methods and kits therefor
US6171809B1 (en) * 1998-01-29 2001-01-09 Packard Instrument Company Method and compositions for detecting luciferase biological samples
JP2002507410A (ja) * 1998-03-27 2002-03-12 プロルーム・リミテッド ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用
CA2335305C (en) 1998-06-16 2006-05-23 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) system and its use
US6214552B1 (en) * 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
WO2001087853A1 (en) * 2000-05-17 2001-11-22 Universite Catholique De Louvain Aryl-substituted n,n-heterocyclic compounds, method for their preparation and their use in therapeutics and diagnostics

Also Published As

Publication number Publication date
US7268229B2 (en) 2007-09-11
DE60227408D1 (de) 2008-08-14
JP4958388B2 (ja) 2012-06-20
WO2003040100A1 (en) 2003-05-15
EP1451155A4 (de) 2006-03-01
CN100439338C (zh) 2008-12-03
CN1612860A (zh) 2005-05-04
JP2005515977A (ja) 2005-06-02
EP1451155B1 (de) 2008-07-02
US20030153090A1 (en) 2003-08-14
CA2462506C (en) 2010-04-06
CA2462506A1 (en) 2003-05-15
US20080050760A1 (en) 2008-02-28
CN101440089A (zh) 2009-05-27
EP1894933B1 (de) 2013-07-03
EP1894933A2 (de) 2008-03-05
EP1894933A3 (de) 2008-03-26
ES2307829T3 (es) 2008-12-01
DK1451155T3 (da) 2008-11-10
EP1451155A1 (de) 2004-09-01
US7537912B2 (en) 2009-05-26

Similar Documents

Publication Publication Date Title
ATE399784T1 (de) Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen
DK0534709T3 (da) Substituerede taxaner som anti-tumormidler
FI924227A0 (fi) Nya alkoxisubstituerade taxaner och farmaceutiska kompositioner innehaollande dessa.
TW200734375A (en) Organosilane polymers, hardmask compositions including the same and methods of producing semiconductor devices using organosilane hardmask compositions
ATE128134T1 (de) Furyl- und thienyl-substituierte taxane als antitumormittel.
EA200601847A1 (ru) Замещённые метиларил- или гетероариламидные соединения
CY1109313T1 (el) Ενωσις φωσφονοκεφεμιου
TW200519088A (en) Aryl or heteroaryl amide compounds
ATE347559T1 (de) Phosphorhaltiges flammschutzmittel und flammwidrige thermoplastische formmassen
EP0806416A4 (de) Huperzin-derivate, ihre herstellung und ihre verwendung
DE602004015331D1 (de) Verfahren für fluorcytidinderivate
WO2005030855A3 (en) Additive mixtures
NO971384L (no) Pyrimidinylpyrazol-derivat
DK1694641T3 (da) Prostaglandinsyntese
ATE208381T1 (de) Verfahren zur herstellung von taxol und seiner derivate
EA199800679A1 (ru) Способ получения дикетоновых соединений
EA200300997A1 (ru) Линейный олиголактатный сложный эфир
TW200504113A (en) Curable polycyclic compounds and process for the production thereof
DE60208477D1 (de) Wasser- und Öl-abweisende Zusammensetzung und daraus gebildeter Formkörper
MY134246A (en) Diphosphine
PL339966A1 (en) Novel 1-aza-2-alkyl-6-arylcycloalkane compounds, method of obtaining them and pharmacological compositions containing them
DE60307792D1 (de) Hydroxylierte indirubinderivate
ATE553081T1 (de) Verfahren zur herstellung einer bakteriziden pyridinverbindung, und bakterizide pyridinverbindung
EP1790628A4 (de) Verfahren zur herstellung einer ungesättigten vicinalen diolverbindung
TH69750A (th) สารประกอบใหม่

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1451155

Country of ref document: EP

REN Ceased due to non-payment of the annual fee