ATE399784T1 - Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen - Google Patents

Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen

Info

Publication number
ATE399784T1
ATE399784T1 AT02802815T AT02802815T ATE399784T1 AT E399784 T1 ATE399784 T1 AT E399784T1 AT 02802815 T AT02802815 T AT 02802815T AT 02802815 T AT02802815 T AT 02802815T AT E399784 T1 ATE399784 T1 AT E399784T1
Authority
AT
Austria
Prior art keywords
kits
compositions
methods
luminescent compounds
concerning
Prior art date
Application number
AT02802815T
Other languages
English (en)
Inventor
Keith Wood
Erika Hawkins
Mike Scurria
Dieter Klaubert
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of ATE399784T1 publication Critical patent/ATE399784T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Electroluminescent Light Sources (AREA)
AT02802815T 2001-11-02 2002-11-01 Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen ATE399784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/053,482 US7268229B2 (en) 2001-11-02 2001-11-02 Compounds to co-localize luminophores with luminescent proteins

Publications (1)

Publication Number Publication Date
ATE399784T1 true ATE399784T1 (de) 2008-07-15

Family

ID=21984572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02802815T ATE399784T1 (de) 2001-11-02 2002-11-01 Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen

Country Status (10)

Country Link
US (2) US7268229B2 (de)
EP (2) EP1894933B1 (de)
JP (1) JP4958388B2 (de)
CN (2) CN101440089A (de)
AT (1) ATE399784T1 (de)
CA (1) CA2462506C (de)
DE (1) DE60227408D1 (de)
DK (1) DK1451155T3 (de)
ES (1) ES2307829T3 (de)
WO (1) WO2003040100A1 (de)

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CA2497560A1 (en) 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
AU2003300008B2 (en) 2002-12-23 2007-04-05 Promega Corporation Improved luciferase-based assays
EP1885875B1 (de) 2005-05-31 2019-05-22 Promega Corporation Luminogene und fluorogene verbindungen und verfahren für den nachweis von molekülen oder leiden
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
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JP2007277097A (ja) * 2006-04-03 2007-10-25 Mie Univ 発光化合物、発光方法、及びその製造方法
US7709253B2 (en) * 2006-08-04 2010-05-04 The Board Of Trustees Of The Leland Stanford Junior University Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists
CN101636503B (zh) * 2006-10-24 2012-10-03 基因流股份有限公司 萤光素酶信号增强组合物
US20090075309A1 (en) * 2007-09-06 2009-03-19 Gambhir Sanjiv S Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems
JP5753083B2 (ja) 2008-07-22 2015-07-22 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ Ａｄｐ検出に基づく発光ホスホトランスフェラーゼまたはａｔｐヒドロラーゼのアッセイ法
JP5597200B2 (ja) 2008-08-18 2014-10-01 プロメガ コーポレイション ルミネッセンスを生じる化合物およびチトクロムｐ４５０３ａ酵素を検出するための方法
JP5582505B2 (ja) 2009-02-09 2014-09-03 Ｊｎｃ株式会社 セレンテラジン類縁体及びその製造方法
WO2010127368A1 (en) 2009-05-01 2010-11-04 Promega Corporation Synthetic oplophorus luciferases with enhanced light output
JP5605727B2 (ja) 2010-04-06 2014-10-15 Ｊｎｃ株式会社 セレンテラジン類縁体及びセレンテラミド類縁体
BR112012028805A2 (pt) 2010-05-10 2019-09-24 The Regents Of The Univ Of California E Nereus Pharmaceuticals Inc composições de endorribonuclease e métodos de uso das mesmas.
SG10202103336SA (en) 2010-11-02 2021-04-29 Promega Corp Novel coelenterazine substrates and methods of use
AU2011323455B2 (en) * 2010-11-02 2017-07-27 Promega Corporation Coelenterazine derivatives and methods of using same
US9273343B2 (en) * 2011-09-02 2016-03-01 Promega Corporation Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H
JP6511720B2 (ja) 2013-02-28 2019-05-15 Jnc株式会社 コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法
JP6040846B2 (ja) * 2013-04-08 2016-12-07 Jnc株式会社 セレンテラジン類縁体
JP6484987B2 (ja) 2013-10-21 2019-03-20 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
JP6442825B2 (ja) 2013-12-26 2018-12-26 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
EP3099683B1 (de) 2014-01-29 2020-08-05 Promega Corporation Chinonmaskierte sonden als markierungsreagenzien für zellaufnahmemessungen
JP6588917B2 (ja) 2014-01-29 2019-10-09 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 生細胞への適用のためのプロ基質
JP6265020B2 (ja) 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
US9732373B2 (en) * 2014-09-11 2017-08-15 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
EP4219736A1 (de) 2014-09-12 2023-08-02 Promega Corporation Interne proteinmarker
WO2016057084A1 (en) 2014-10-08 2016-04-14 Promega Corporation Bioluminescent succinate detection assay
EP3313846B1 (de) 2015-06-25 2020-05-06 Promega Corporation Thienopyrroleverbindungen unde deren verwendungen als inhibitoren von oplophorus-luciferasen
US9924073B2 (en) 2016-02-15 2018-03-20 Promega Corporation Substituted imidazo[1,2-a]pyrazines as luciferase substrates and preparation method thereof
EP3510035B1 (de) * 2016-09-09 2021-04-07 Promega Corporation Doppelt geschützte pro-coelenterazin-substrate
EP4144738A1 (de) 2016-11-01 2023-03-08 Promega Corporation An energieakzeptoren gebundene coelenterazin-analoga
DK3548492T5 (en) 2016-12-01 2024-08-05 Promega Corp Cell impermeable coelenterazine analogues
EP3562823B1 (de) 2016-12-28 2023-02-08 Promega Corporation Funktionalisierte nanoluc-inhibitoren
EP3395803A1 (de) 2017-04-28 2018-10-31 Institut Pasteur Imidazopyrazinderivate, verfahren zur herstellung davon und deren verwendung als luciferine
WO2019010094A1 (en) * 2017-07-06 2019-01-10 Promega Corporation STERILE SERIES PRO-COELENTERAZINE ANALOGS
JP7419260B2 (ja) 2018-05-01 2024-01-22 プロメガ コーポレイション ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物
EP3802514B1 (de) 2018-06-01 2022-08-03 Promega Corporation Inhibitoren von aus oplophorus-luciferase abgeleiteten biolumineszenz-komplexen
US11857638B2 (en) 2018-07-27 2024-01-02 Promega Corporation Quinone-containing conjugates
US11534504B2 (en) 2018-10-03 2022-12-27 Promega Corporation Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof
WO2020206385A1 (en) 2019-04-05 2020-10-08 Earli Inc. Improved methods and compositions for synthetic biomarkers
US12241839B2 (en) 2019-11-27 2025-03-04 Promega Corporation Multipartite luciferase peptides and polypeptides
JP7745550B2 (ja) 2019-12-10 2025-09-29 プロメガ コーポレイション 多官能性プローブを使用する生物発光検出用組成物及び生物発光検出方法
JP7677997B2 (ja) 2020-05-22 2025-05-15 プロメガ コーポレイション キナーゼターゲットエンゲージメントの増強
CN113683617B (zh) * 2021-07-16 2022-08-30 山东大学 一种基于腔肠素-h的氘代化合物及其制备方法与应用
EP4519385A2 (de) 2022-05-04 2025-03-12 Promega Corporation Biolumineszenzausgelöste photokatalytische markierung
EP4519425A1 (de) 2022-05-04 2025-03-12 Promega Corporation Modifizierte dehalogenase mit erweiterten oberflächenschleifenregionen

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Also Published As

Publication number Publication date
EP1894933B1 (de) 2013-07-03
JP2005515977A (ja) 2005-06-02
CA2462506C (en) 2010-04-06
EP1451155A1 (de) 2004-09-01
US20030153090A1 (en) 2003-08-14
CN101440089A (zh) 2009-05-27
CN100439338C (zh) 2008-12-03
DE60227408D1 (de) 2008-08-14
EP1894933A3 (de) 2008-03-26
EP1451155B1 (de) 2008-07-02
US20080050760A1 (en) 2008-02-28
CN1612860A (zh) 2005-05-04
CA2462506A1 (en) 2003-05-15
EP1451155A4 (de) 2006-03-01
US7268229B2 (en) 2007-09-11
EP1894933A2 (de) 2008-03-05
ES2307829T3 (es) 2008-12-01
WO2003040100A1 (en) 2003-05-15
US7537912B2 (en) 2009-05-26
JP4958388B2 (ja) 2012-06-20
DK1451155T3 (da) 2008-11-10

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