ATE399871T1 - Methode zur herstellung hypermutabler pflanzen - Google Patents

Methode zur herstellung hypermutabler pflanzen

Info

Publication number
ATE399871T1
ATE399871T1 AT00989525T AT00989525T ATE399871T1 AT E399871 T1 ATE399871 T1 AT E399871T1 AT 00989525 T AT00989525 T AT 00989525T AT 00989525 T AT00989525 T AT 00989525T AT E399871 T1 ATE399871 T1 AT E399871T1
Authority
AT
Austria
Prior art keywords
plants
genes
plant
expression
mismatch repair
Prior art date
Application number
AT00989525T
Other languages
English (en)
Inventor
Nicholas C Nicolaides
Luigi Grasso
Philip M Sass
Kenneth Kinzler
Bert Vogelstein
Original Assignee
Morphotek Inc
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphotek Inc, Univ Johns Hopkins filed Critical Morphotek Inc
Application granted granted Critical
Publication of ATE399871T1 publication Critical patent/ATE399871T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Soil Working Implements (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT00989525T 2000-02-18 2000-12-28 Methode zur herstellung hypermutabler pflanzen ATE399871T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18333300P 2000-02-18 2000-02-18

Publications (1)

Publication Number Publication Date
ATE399871T1 true ATE399871T1 (de) 2008-07-15

Family

ID=22672379

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00989525T ATE399871T1 (de) 2000-02-18 2000-12-28 Methode zur herstellung hypermutabler pflanzen

Country Status (7)

Country Link
US (3) US6900370B2 (de)
EP (1) EP1282708B1 (de)
AT (1) ATE399871T1 (de)
AU (1) AU2001226023A1 (de)
CA (1) CA2400664C (de)
DE (1) DE60039371D1 (de)
WO (1) WO2001061012A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1319081A2 (de) * 2000-09-18 2003-06-18 Pioneer Hi-Bred International, Inc. Reis mlh1 ortholog und verwendungen davon
US6737268B1 (en) * 2000-11-14 2004-05-18 Morphotek, Inc. Method for generating genetically altered antigens
WO2003031937A2 (en) * 2001-10-12 2003-04-17 Morphotek, Inc. Genetic hypermutability of plants for gene discovery and diagnosis
ATE548461T1 (de) 2002-01-18 2012-03-15 Morphotek Inc Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
WO2003074655A2 (en) * 2002-02-21 2003-09-12 Morphotek, Inc. Regulated vectors for controlling dna hypermutability in eukariotic cells
WO2003072732A2 (en) * 2002-02-21 2003-09-04 Morphotek, Inc. Methods of making hypermutable cells using pmsr homologs
AU2003233719A1 (en) 2002-06-06 2003-12-22 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Modifying the dna recombination potential in eukaryotes
IL155137A0 (en) * 2003-03-27 2003-10-31 Yissum Res Dev Co A method for generating plant diversity
WO2006032504A2 (en) * 2004-09-22 2006-03-30 Vrije Universiteit Brussel Method for introducing genetic mutations into plant cells
US20090068741A1 (en) * 2007-01-17 2009-03-12 Invitrogen Corporation Methods and Compositions for Improving the Health of Cells in Culture
BRPI0807952A2 (pt) 2007-02-20 2014-06-10 Anaptysbio Inc Sistemas de hipermutação somática
JPWO2010061922A1 (ja) * 2008-11-27 2012-04-26 独立行政法人理化学研究所 新規ＭｕｔＳタンパク質およびそれを用いた変異の判定方法
EP2376637A1 (de) * 2008-12-22 2011-10-19 Keygene N.V. Verwendung von doppelstrang-rna zur erhöhung der wirksamkeit einer zielgenänderung in pflanzenprotoplasten
CA2951341A1 (en) * 2009-12-21 2011-06-30 Keygene N.V. Improved techniques for transfecting protoplasts
WO2013120037A1 (en) * 2012-02-10 2013-08-15 Regents Of The University Of Minnesota Dna assimilation
KR20220053623A (ko) * 2019-08-30 2022-04-29 프로갑스 에스.에이. 한천 매트릭스를 갖는 내열 저작성 경구 제형 및 이의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
EP0842289B1 (de) * 1995-07-26 2004-10-20 Mixis France S.A. Homologe rekombination in eukaryotischen zellen mit inaktiviertem fehlpaarungsreparatur-system
US5843757A (en) 1995-08-24 1998-12-01 The Johns Hopkins University Human JTV1 gene overlaps PMS2 gene
US5907079A (en) 1996-01-18 1999-05-25 Amgen Canada Inc. MSH2 disrupted mice develop lymphomas
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
US6146894A (en) 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms

Also Published As

Publication number Publication date
US20020128460A1 (en) 2002-09-12
AU2001226023A1 (en) 2001-08-27
US20050266463A1 (en) 2005-12-01
US7704689B2 (en) 2010-04-27
US20110055964A1 (en) 2011-03-03
DE60039371D1 (de) 2008-08-14
CA2400664A1 (en) 2001-08-23
US6900370B2 (en) 2005-05-31
CA2400664C (en) 2011-03-01
US8110356B2 (en) 2012-02-07
EP1282708A1 (de) 2003-02-12
EP1282708B1 (de) 2008-07-02
WO2001061012A1 (en) 2001-08-23

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