ATE501635T1 - Chemische hemmstoffe des mismatch-repair - Google Patents
Chemische hemmstoffe des mismatch-repairInfo
- Publication number
- ATE501635T1 ATE501635T1 AT01901992T AT01901992T ATE501635T1 AT E501635 T1 ATE501635 T1 AT E501635T1 AT 01901992 T AT01901992 T AT 01901992T AT 01901992 T AT01901992 T AT 01901992T AT E501635 T1 ATE501635 T1 AT E501635T1
- Authority
- AT
- Austria
- Prior art keywords
- genes
- mismatch
- cells
- mismatch repair
- repari
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H3/00—Processes for modifying phenotypes, e.g. symbiosis with bacteria
- A01H3/04—Processes for modifying phenotypes, e.g. symbiosis with bacteria by treatment with chemicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
- C12N15/821—Non-antibiotic resistance markers, e.g. morphogenetic, metabolic markers
- C12N15/8212—Colour markers, e.g. beta-glucoronidase [GUS], green fluorescent protein [GFP], carotenoid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Environmental Sciences (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/000934 WO2002054856A1 (en) | 2001-01-15 | 2001-01-15 | Chemical inhibitors of mismatch repair |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501635T1 true ATE501635T1 (de) | 2011-04-15 |
Family
ID=21742243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01901992T ATE501635T1 (de) | 2001-01-15 | 2001-01-15 | Chemische hemmstoffe des mismatch-repair |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1351565B1 (de) |
| JP (1) | JP5036119B2 (de) |
| AT (1) | ATE501635T1 (de) |
| CA (1) | CA2434926C (de) |
| DE (1) | DE60144247D1 (de) |
| WO (1) | WO2002054856A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235643B2 (en) | 2000-11-07 | 2007-06-26 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with high affinity |
| US6982169B2 (en) | 2001-01-15 | 2006-01-03 | Morphotek, Inc. | Chemical inhibitors of mismatch repair |
| EP1417329A4 (de) * | 2001-07-25 | 2005-05-11 | Morphotek Inc | Verfahren zur herstellung antibiotikaresistenter mikroben und neuer antibiotika |
| ATE548461T1 (de) | 2002-01-18 | 2012-03-15 | Morphotek Inc | Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse |
| ATE489474T1 (de) * | 2002-07-19 | 2010-12-15 | Morphotek Inc | Verfahren zur erzeugung verbesserter antikörper produzierender zellinien mit verbesserten wachstumseigenschaften |
| DE60329526D1 (de) | 2002-11-15 | 2009-11-12 | Morphotek Inc | Verfahren zur erzeugung einer hohen antikörperproduktion von durch in-vitro-immunisierung entstandenen hybridomen |
| JP2007500508A (ja) | 2003-07-29 | 2007-01-18 | モルフォテック、インク. | 抗体とエフェクター機能が増強された遺伝子組み換え抗体を作成する方法 |
| US7604994B2 (en) | 2003-09-03 | 2009-10-20 | Morphotek, Inc. | Genetically altered antibody-producing cell lines with improved antibody characteristics |
| WO2005056599A2 (en) | 2003-12-08 | 2005-06-23 | Morphotek, Inc. | Antibodies that specifically bind pms2 |
| AU2005214331B2 (en) | 2004-02-12 | 2011-09-15 | Eisai, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| WO2006032504A2 (en) * | 2004-09-22 | 2006-03-30 | Vrije Universiteit Brussel | Method for introducing genetic mutations into plant cells |
| EP1861425B1 (de) | 2005-03-10 | 2012-05-16 | Morphotek, Inc. | Anti-mesothelin-antikörper |
| WO2006116451A2 (en) | 2005-04-22 | 2006-11-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| AU2006241099B2 (en) | 2005-04-22 | 2012-04-19 | Eisai, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| CA2682726C (en) | 2007-04-05 | 2017-05-09 | Morphotek, Inc. | Methods for inhibiting the binding of endosialin to ligands |
| EP2376637A1 (de) * | 2008-12-22 | 2011-10-19 | Keygene N.V. | Verwendung von doppelstrang-rna zur erhöhung der wirksamkeit einer zielgenänderung in pflanzenprotoplasten |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191268B1 (en) * | 1993-12-17 | 2001-02-20 | Dana-Farber Cancer Institute | Compositions and methods relating to DNA mismatch repair genes |
| US5907079A (en) * | 1996-01-18 | 1999-05-25 | Amgen Canada Inc. | MSH2 disrupted mice develop lymphomas |
| AUPO974597A0 (en) * | 1997-10-10 | 1997-11-06 | Rhone-Poulenc Agro | Methods for obtaining plant varieties |
| US6146894A (en) * | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
-
2001
- 2001-01-15 JP JP2002555609A patent/JP5036119B2/ja not_active Expired - Lifetime
- 2001-01-15 CA CA2434926A patent/CA2434926C/en not_active Expired - Lifetime
- 2001-01-15 AT AT01901992T patent/ATE501635T1/de not_active IP Right Cessation
- 2001-01-15 WO PCT/US2001/000934 patent/WO2002054856A1/en not_active Ceased
- 2001-01-15 DE DE60144247T patent/DE60144247D1/de not_active Expired - Lifetime
- 2001-01-15 EP EP01901992A patent/EP1351565B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002054856A1 (en) | 2002-07-18 |
| EP1351565A1 (de) | 2003-10-15 |
| CA2434926C (en) | 2014-04-01 |
| DE60144247D1 (de) | 2011-04-28 |
| CA2434926A1 (en) | 2002-07-18 |
| EP1351565A4 (de) | 2005-05-25 |
| EP1351565B1 (de) | 2011-03-16 |
| JP2005510199A (ja) | 2005-04-21 |
| JP5036119B2 (ja) | 2012-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60144247D1 (de) | Chemische hemmstoffe des mismatch-repair | |
| CA2240609A1 (en) | A method for generating hypermutable organisms | |
| CY1112409T1 (el) | Μοναδα και διεργασια για διεξαγωγη ζυμωσης υψηλης κυτταρικης πυκνοτητας | |
| IL170221A (en) | Progenitor cells from wharton's jelly of human umbilical cord and methods of obtaining and utilizing same | |
| Cervantes et al. | Embryonic stem cells and somatic cells differ in mutation frequency and type | |
| Pellino et al. | Asexual genome evolution in the apomictic R anunculus auricomus complex: examining the effects of hybridization and mutation accumulation | |
| WO2004024871A3 (en) | Antibodies and methods for generating genetically altered antibodies with high affinity | |
| CY1118167T1 (el) | Πρωτογενη και εγγυς ηπατικα βλαστοκυτταρα | |
| Massicotte et al. | General‐purpose genotype or how epigenetics extend the flexibility of a genotype | |
| ATE549395T1 (de) | Medium und kultur von embryonalen stammzellen | |
| Lafon‐Placette et al. | Methylome of DN ase I sensitive chromatin in P opulus trichocarpa shoot apical meristematic cells: a simplified approach revealing characteristics of gene‐body DNA methylation in open chromatin state | |
| ATE420188T1 (de) | Ap2-domäne-transkriptionsfaktor odp2 (ovule development protein 2) und verwendungsverfahren | |
| WO2004063362A3 (en) | Cell cycle progression proteins | |
| ATE399871T1 (de) | Methode zur herstellung hypermutabler pflanzen | |
| ATE193729T1 (de) | Geminivirus-basiertes-genexpressionsystem | |
| MX2025007036A (es) | Metodos y composiciones para generar alelos dominantes usando edicion del genoma | |
| DE60329747D1 (de) | Vektoren mit beiden isoformen von beta-hexosaminidase | |
| IL146296A0 (en) | Cell reprogramming | |
| Krueger‐Hadfield et al. | Using RAD‐seq to develop sex‐linked markers in a haplodiplontic alga | |
| DE69935907D1 (de) | Hocheffizienzverfahren und zusammensetzungen zum integrieren von exogener dna in genomische sperma-dna | |
| MX2025001546A (es) | Composiciones y metodos de tratamiento de precision de cancer | |
| DE50012581D1 (de) | Vorrichtung zum züchten und/oder behandeln von zellen | |
| ATE499440T1 (de) | Gen-targeting mit replizierenden dna-molekülen | |
| Levins et al. | Evolution of sexual systems and regressive evolution in Riccia | |
| ATE240033T1 (de) | Mit thioredoxin transformierte pflanzen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |