ATE400268T1 - Bisindolylmaleimid zur behandlung von prostatakrebs und akt-vermittelten erkrankungen - Google Patents

Bisindolylmaleimid zur behandlung von prostatakrebs und akt-vermittelten erkrankungen

Info

Publication number: ATE400268T1
Authority: AT; Austria
Prior art keywords: cancer; sup; sub; administering; patient
Prior art date: 2003-10-24

Application number

AT04793891T

Other languages

English (en)

Inventor

Jeremy Graff

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-24

Filing date

2004-10-08

Publication date

2008-07-15

2004-10-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE400268T1 publication Critical patent/ATE400268T1/de

Links

206010060862 Prostate cancer Diseases 0.000 title abstract 2
208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 2
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
DQYBRTASHMYDJG-UHFFFAOYSA-N Bisindolylmaleimide Chemical compound C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=CNC2=C1 DQYBRTASHMYDJG-UHFFFAOYSA-N 0.000 title 2
150000001875 compounds Chemical class 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
206010009944 Colon cancer Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010033128 Ovarian cancer Diseases 0.000 abstract 1
206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
208000006265 Renal cell carcinoma Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
208000005017 glioblastoma Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
201000004228 ovarian endometrial cancer Diseases 0.000 abstract 1
201000002528 pancreatic cancer Diseases 0.000 abstract 1
208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
201000005825 prostate adenocarcinoma Diseases 0.000 abstract 1
208000015347 renal cell adenocarcinoma Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

AT04793891T 2003-10-24 2004-10-08 Bisindolylmaleimid zur behandlung von prostatakrebs und akt-vermittelten erkrankungen ATE400268T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US51429103P	2003-10-24	2003-10-24

Publications (1)

Publication Number	Publication Date
ATE400268T1 true ATE400268T1 (de)	2008-07-15

Family

ID=34549326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04793891T ATE400268T1 (de)	2003-10-24	2004-10-08	Bisindolylmaleimid zur behandlung von prostatakrebs und akt-vermittelten erkrankungen

Country Status (6)

Country	Link
US (1)	US20060281787A1 (de)
EP (1)	EP1684747B1 (de)
AT (1)	ATE400268T1 (de)
DE (1)	DE602004014965D1 (de)
ES (1)	ES2307059T3 (de)
WO (1)	WO2005041953A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070286864A1 (en) *	2006-06-09	2007-12-13	Buck Elizabeth A	Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors
WO2009154697A2 (en)	2008-05-28	2009-12-23	Massachusetts Institute Of Technology	Disc-1 pathway activators in the control of neurogenesis
WO2010098888A1 (en) *	2009-02-27	2010-09-02	Massachusetts Institute Of Technology	Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders
KR101461767B1 (ko)	2010-03-30	2014-11-13	노파르티스 아게	만성 활성 ｂ-세포-수용체 신호전달이 있는 ｂ-세포 림프종의 치료를 위한 ｐｋｃ 억제제
WO2017015152A1 (en)	2015-07-17	2017-01-26	Memorial Sloan-Kettering Cancer Center	Combination therapy using pdk1 and pi3k inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2179650C (en) *	1993-12-23	2007-10-30	William Francis Heath, Jr.	Bisindolemaleimides and their use as protein kinase c inhibitors
WO2001030331A2 (en) *	1999-10-22	2001-05-03	Eli Lilly And Company	Therapeutic compositions including protein kinase c inhibitors
WO2002002116A2 (en) *	2000-06-29	2002-01-10	Eli Lilly And Company	Therapeutic treatment of cancer with a protein kinase c inhibitor

2004
- 2004-10-08 WO PCT/US2004/030910 patent/WO2005041953A1/en not_active Ceased
- 2004-10-08 AT AT04793891T patent/ATE400268T1/de not_active IP Right Cessation
- 2004-10-08 ES ES04793891T patent/ES2307059T3/es not_active Expired - Lifetime
- 2004-10-08 EP EP04793891A patent/EP1684747B1/de not_active Expired - Lifetime
- 2004-10-08 DE DE602004014965T patent/DE602004014965D1/de not_active Expired - Lifetime
- 2004-10-08 US US10/573,632 patent/US20060281787A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1684747B1 (de)	2008-07-09
WO2005041953A1 (en)	2005-05-12
US20060281787A1 (en)	2006-12-14
DE602004014965D1 (de)	2008-08-21
EP1684747A1 (de)	2006-08-02
ES2307059T3 (es)	2008-11-16

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Legal Events

Date	Code	Title	Description
2009-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties