ATE401058T1 - Sprühtrocknungsverfahren - Google Patents

Sprühtrocknungsverfahren

Info

Publication number
ATE401058T1
ATE401058T1 AT02776395T AT02776395T ATE401058T1 AT E401058 T1 ATE401058 T1 AT E401058T1 AT 02776395 T AT02776395 T AT 02776395T AT 02776395 T AT02776395 T AT 02776395T AT E401058 T1 ATE401058 T1 AT E401058T1
Authority
AT
Austria
Prior art keywords
liquid
spray drying
disperse
supply
drying method
Prior art date
Application number
AT02776395T
Other languages
English (en)
Inventor
Herman SNYDER
Michael Vosberg
Christopher Varga
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23316549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE401058(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ATE401058T1 publication Critical patent/ATE401058T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/20—Sprayers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02776395T 2001-11-01 2002-10-31 Sprühtrocknungsverfahren ATE401058T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33653801P 2001-11-01 2001-11-01

Publications (1)

Publication Number Publication Date
ATE401058T1 true ATE401058T1 (de) 2008-08-15

Family

ID=23316549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02776395T ATE401058T1 (de) 2001-11-01 2002-10-31 Sprühtrocknungsverfahren

Country Status (10)

Country Link
US (2) US8524279B2 (de)
EP (2) EP1992335A1 (de)
JP (1) JP4837892B2 (de)
KR (1) KR100951750B1 (de)
AT (1) ATE401058T1 (de)
AU (2) AU2002342241B2 (de)
CA (1) CA2464656C (de)
DE (1) DE60227691D1 (de)
TW (1) TW200300696A (de)
WO (1) WO2003037303A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002009669A2 (en) * 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution and particles made thereby
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
KR100951750B1 (ko) 2001-11-01 2010-04-09 노바르티스 아게 분무 건조 방법 및 그 조성물
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
DE10234165B4 (de) * 2002-07-26 2008-01-03 Advanced Micro Devices, Inc., Sunnyvale Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material
WO2004058218A2 (en) 2002-12-30 2004-07-15 Nektar Therapeutics Prefilming atomizer
KR100453273B1 (ko) * 2003-09-04 2004-10-15 주식회사 펩트론 초음파 이중공급노즐을 이용한 서방성 미립구의 제조 방법
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
GB0415044D0 (en) * 2004-07-05 2004-08-04 Unilever Plc Granule and process for its manufacture
JP4739340B2 (ja) * 2005-07-22 2011-08-03 田辺三菱製薬株式会社 口腔内速崩壊性錠
DE102006053375A1 (de) * 2006-11-10 2008-05-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mischung von Pulvern
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
US20110253140A1 (en) * 2008-07-30 2011-10-20 Stc.Unm Formulations containing large-size carrier particles for dry powder inhalation aerosols
EP2411137B1 (de) 2009-03-27 2016-09-07 Bend Research, Inc. Sprühtrocknungsverfahren
BRPI1006722A2 (pt) 2009-04-09 2017-10-10 Entegrion Inc "método de preparação de hemoderivados desidratado, hemoderivados desidratados, bandagem ou auxílio cirúrgico, método para a preparação de plaquetas sanguíneas fixas desidratadas, plaquetas sanguíneas fixas desidratadas, método para o tratamento de um paciente que sofre de um distúrbio sanguíneo e plaquetas de sangue fixas secas por atomização tendo geometria com cavidades esféricas"
AU2010251173A1 (en) * 2009-05-20 2012-01-19 Basf Se Method for producing a spray powder containing one or more glycine-N,N-diacetic acid derivatives and use of the spray powder to produce compression agglomerates
GB0909136D0 (en) 2009-05-28 2009-07-01 Profibrix Bv Dry powder composition
AU2010252929B2 (en) * 2009-05-28 2015-08-27 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
WO2011035062A2 (en) 2009-09-16 2011-03-24 Velico Medical, Inc. Spray dried human plasma
WO2011065600A1 (en) * 2009-11-25 2011-06-03 Gcbio Corp. Use of inhalable powder formulation comprising growth hormone for preventing or treating nmda receptor hypofunction-related diseases
WO2011083154A1 (en) 2010-01-08 2011-07-14 Profibrix Bv Dry powder fibrin sealant
US8372320B2 (en) * 2010-04-27 2013-02-12 University Of Maine System Board Of Trustees Method for drying cellulose nanofibrils
EP2611529B1 (de) 2010-09-03 2019-01-23 Bend Research, Inc. Sprühtrocknungsverfahren
WO2012031133A2 (en) 2010-09-03 2012-03-08 Bench Research, Inc. Spray-drying apparatus and methods of using the same
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
US9572774B2 (en) 2011-05-19 2017-02-21 Savara Inc. Dry powder vancomycin compositions and associated methods
JP6012716B2 (ja) * 2011-05-19 2016-10-25 サヴァラ，インク． 乾燥粉末バンコマイシン組成物および関連する方法
RU2013155713A (ru) 2011-07-06 2015-08-20 Профибрикс Бв Составы для лечения ран
JP5943820B2 (ja) * 2012-11-30 2016-07-05 三菱重工業株式会社 脱水濾液の噴霧乾燥装置及び排ガス処理システム
AU2014229361B2 (en) 2013-03-14 2016-08-04 Novartis Ag Deamorphization of spray-dried formulations via spray-blending
IN2013CH04500A (de) 2013-10-04 2015-04-10 Kennametal India Ltd
US9788566B2 (en) 2014-01-27 2017-10-17 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources Process for drying and powderizing functional foods, nutraceuticals, and natural health ingredients
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
US10252270B2 (en) * 2014-09-08 2019-04-09 Arizona Board Of Regents On Behalf Of Arizona State University Nozzle apparatus and methods for use thereof
US9561184B2 (en) 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
MX392636B (es) 2014-10-31 2025-03-24 Glaxosmithkline Ip Dev Ltd Formulacion en polvo.
WO2016067132A1 (en) 2014-10-31 2016-05-06 Bend Research Inc. Process for forming active domains dispersed in a matrix
KR20180050320A (ko) 2015-09-09 2018-05-14 노파르티스 아게 분무-건조된 제제의 폐로의 표적화된 전달
PT108885B (pt) 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
AR106558A1 (es) * 2015-11-03 2018-01-24 Spraying Systems Co Aparato y método de secado por pulverización
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
GB2568849B (en) 2016-09-01 2022-08-10 Nutrition 21 Llc Magnesium biotinate compositions and methods of use
EP3638208A1 (de) 2017-06-12 2020-04-22 Novartis AG Amorphe nanostrukturierte pharmazeutische materialien
US10933343B2 (en) * 2017-10-27 2021-03-02 Spraying Systems Co. Spray dryer system and method
CA3089439A1 (en) 2018-01-26 2019-08-01 Novartis Ag High dose delivery of inhaled therapeutics
JP2022515314A (ja) 2018-11-02 2022-02-18 ニュートリション・２１，エルエルシー イノシトール安定化アルギニンケイ酸塩複合体及びイノシトールを含有するビデオゲームプレーヤーの認知機能を改善するための組成物
RU2702095C1 (ru) * 2018-12-25 2019-10-04 Акционерное общество "Радиевый институт имени В.Г. Хлопина" Способ получения монофазных солей актинидов и устройство для их получения
EP3902618A4 (de) * 2018-12-28 2022-09-28 Spray Nozzle Engineering Pty Ltd Sprühdüse
CA3142758A1 (en) 2019-06-10 2020-12-17 Respira Therapeutics,Inc. Carrier-based formulations and related methods
KR102183845B1 (ko) * 2019-11-22 2020-11-30 주식회사 지씨에스 폴리-l-락틱산 필러와 히알루론산 필러 결합체를 함유하는 서방성 주사제제 및 그 제조방법
GB2613672A (en) * 2019-12-16 2023-06-14 Nutrition 21 Llc Methods of production of aginine-silicate complexes
CN112704890B (zh) * 2020-11-05 2023-02-28 中国恩菲工程技术有限公司 液体进料装置和液体进料控制方法
EP4039348B1 (de) * 2021-02-03 2023-06-07 Vysoká skola chemicko-technologická v Praze Vorrichtung zur kontinuierlichen sprühtrocknung mit variabler eintrittszusammensetzung, verfahren zur kontinuierlichen herstellung von mehrkomponentenpulvern durch sprühtrocknung und deren verwendung
CN114181815B (zh) * 2021-12-06 2023-10-20 清华大学 一种大流量环境空气生物气溶胶采样装置和方法
US11998861B2 (en) 2022-09-15 2024-06-04 Velico Medical, Inc. Usability of a disposable for a spray drying plasma system
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system
US12246093B2 (en) 2022-09-15 2025-03-11 Velico Medical, Inc. Methods for making spray dried plasma
US12083447B2 (en) 2022-09-15 2024-09-10 Velico Medical, Inc. Alignment of a disposable for a spray drying plasma system
US12246266B2 (en) 2022-09-15 2025-03-11 Velico Medical, Inc. Disposable for a spray drying system
WO2024059770A1 (en) 2022-09-15 2024-03-21 Velico Medical, Inc. Rapid spray drying system
US11975274B2 (en) 2022-09-15 2024-05-07 Velico Medical, Inc. Blood plasma product
US12571587B2 (en) 2022-09-15 2026-03-10 Velico Medical, Inc. Finishing apparatus for a spray drying system
US12539355B2 (en) 2022-09-15 2026-02-03 Velico Medical, Inc. Dryer for a spray drying system
CN115920767A (zh) * 2022-12-02 2023-04-07 江苏道宁药业有限公司 一种乳糖流化造粒设备及其造粒方法
WO2025080624A1 (en) * 2023-10-11 2025-04-17 Hart Production Water Disposal, Llc System and method for separation of solids from a liquid

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US645028A (en) * 1900-03-06 William Jay Barber Insect or worm destroyer.
BE421211A (de) 1936-05-02
GB621785A (en) 1943-07-27 1949-04-20 Teco Sa Apparatus for the pulverisation of liquids in the form of aerosols
DE2121066C3 (de) * 1971-04-29 1974-05-30 Knapsack Ag, 5033 Huerth-Knapsack Zerstäubungsdüse für einen Zerstäubungstrockner
US4052255A (en) * 1971-10-07 1977-10-04 J. M. Huber Corporation Spray dryer discharge system
US3790079A (en) * 1972-06-05 1974-02-05 Rnb Ass Inc Method and apparatus for generating monodisperse aerosol
US3825188A (en) * 1973-03-23 1974-07-23 Par Wey Mfg Co Liquid spray head
US4035317A (en) * 1975-06-30 1977-07-12 American Cyanamid Company Rapidly dissolving, water-soluble polymers and spray drying method for their production
JPS5254709A (en) * 1975-10-31 1977-05-04 Lion Corp Multi-stage spray drying method
DK150716C (da) * 1976-12-01 1987-10-26 Niro Atomizer As Fremgangsmaade ved behandling af et pulver- eller partikelformet produkt og apparat til brug ved udoevelse af fremgangsmaaden
FI54093C (fi) * 1976-12-20 1978-10-10 Outokumpu Oy Saett att framstaella pulverformigt selen fraon raoselen
DE2751354A1 (de) † 1977-11-17 1979-05-23 Hoechst Ag Verfahren zur herstellung von gemischen aus kristallinem zeolith und natriumtriphosphat
JPS5829150B2 (ja) * 1977-12-03 1983-06-21 ナカヤ産業株式会社 噴霧装置
EP0005361B1 (de) * 1978-05-05 1983-05-11 Cuprinol Limited Fungizide Zusammensetzungen und Verfahren zum Schützen von Materialien mittels derselben
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
GB2105189B (en) 1981-07-24 1985-03-20 Fisons Plc Inhalation drugs
US5260306A (en) * 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
EP0072046B1 (de) 1981-07-24 1986-01-15 FISONS plc Inhalierbare Arzneimittel, Verfahren zu deren Herstellung und pharmazeutische Formulierungen diese enthaltend
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
CH656077A5 (de) * 1982-01-29 1986-06-13 Glatt Maschinen & Apparatebau Verfahren zum ueberziehen von teilchen, insbesondere arzneimittel-teilchen, und vorrichtung zur durchfuehrung des verfahrens.
CA1200416A (en) * 1983-05-13 1986-02-11 Societe Des Produits Nestle S.A. Food process
US4486435A (en) * 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
US5038769A (en) * 1983-06-29 1991-08-13 Krauser Robert S Method and apparatus for treating ailments
GB8401770D0 (en) † 1984-01-24 1984-02-29 Unilever Plc Detergent and bleaching compositions
US4721709A (en) * 1984-07-26 1988-01-26 Pyare Seth Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4702799A (en) * 1985-09-03 1987-10-27 Nestec S.A. Dryer and drying method
US5017372A (en) * 1986-04-14 1991-05-21 Medicis Corporation Method of producing antibody-fortified dry whey
NZ221411A (en) * 1986-08-11 1989-10-27 Innovata Biomed Ltd Pharmaceutical compositions containing microcapsules and a surfactant
GB8622565D0 (en) † 1986-09-19 1986-10-22 Unilever Plc Detergent composition
US4871489A (en) * 1986-10-07 1989-10-03 Corning Incorporated Spherical particles having narrow size distribution made by ultrasonic vibration
US4760093A (en) * 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
DE3642106A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Verfahren zur herstellung von polymerisatpulvern durch zerstaeubungstrocknung
US4784878A (en) * 1987-04-06 1988-11-15 Damrow Company, Inc. Spray drying method and apparatus for concurrent particle coating
SE8701479L (sv) 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
GB8710290D0 (en) * 1987-04-30 1987-06-03 Unilever Plc Preparation of granular detergent composition
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
CH672048A5 (de) * 1987-09-16 1989-10-31 Nestle Sa
JP2524379B2 (ja) 1988-01-29 1996-08-14 大川原化工機株式会社 ノズル装置とそれを組込んでなるスプレ―ドライヤ―装置
DE3806537A1 (de) † 1988-03-01 1989-09-14 Herbert Huettlin Duesenbaugruppe fuer apparaturen zum granulieren, pelletieren und/oder dragieren
DE3886207T2 (de) 1988-06-03 1994-06-23 Niro Sterner Inc Sprühtrocknungsverfahren und Vorrichtung zum gleichzeitigen Beschichten von Teilchen.
US5066522A (en) * 1988-07-14 1991-11-19 Union Carbide Chemicals And Plastics Technology Corporation Supercritical fluids as diluents in liquid spray applications of adhesives
US5009367A (en) * 1989-03-22 1991-04-23 Union Carbide Chemicals And Plastics Technology Corporation Methods and apparatus for obtaining wider sprays when spraying liquids by airless techniques
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
WO1991016662A1 (en) 1990-04-26 1991-10-31 Opti-Copy, Inc. Step and repeat camera/projector machine
US5000888A (en) * 1990-05-23 1991-03-19 Basf Corporation Process for spray drying riboflavin to produce a granulate product having low binder content
ES2078447T3 (es) 1990-06-15 1995-12-16 Merck & Co Inc Un procedimiento de cristalizacion para mejorar la estructura y el tamaño de los cristales.
GB9017155D0 (en) 1990-08-03 1990-09-19 Ici Plc Spray drying
WO1992014449A1 (en) * 1991-02-20 1992-09-03 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
DE4117751A1 (de) * 1991-05-30 1992-12-03 Bayer Ag Verfahren zur isolierung von polycarbonaten
US5269980A (en) * 1991-08-05 1993-12-14 Northeastern University Production of polymer particles in powder form using an atomization technique
US6123924A (en) * 1991-09-25 2000-09-26 Fisons Plc Pressurized aerosol inhalation compositions
US5247842A (en) 1991-09-30 1993-09-28 Tsi Incorporated Electrospray apparatus for producing uniform submicrometer droplets
EP0535937B2 (de) * 1991-10-01 2008-05-21 Takeda Chemical Industries, Ltd. Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
JP3205884B2 (ja) * 1991-10-01 2001-09-04 武田薬品工業株式会社 凝集防止剤をコーティングした徐放性微粒子製剤
US5733731A (en) * 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
DK0613371T3 (da) 1991-12-18 2002-05-13 Astrazeneca Ab Ny kombination af formoterol og budesonid
CA2115065C (en) 1992-06-12 2000-10-03 Kiyoyuki Sakon Ultrafine particle powder for inhalation and method for production thereof
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
AU4198793A (en) 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
JP3491075B2 (ja) * 1992-07-24 2004-01-26 武田薬品工業株式会社 微粒子製剤およびその製造法
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DE4234202C2 (de) 1992-10-10 1995-06-14 Teves Gmbh Alfred Vorrichtung zum Reinigen von Windschutzscheiben
EP0625069B1 (de) * 1992-10-26 1998-12-30 Schwarz Pharma Ag Verfahren zur herstellung von mikrokapseln
CA2150803C (en) * 1992-12-02 2006-01-31 Henry Auer Controlled release growth hormone containing microspheres
GB9226474D0 (en) * 1992-12-18 1993-02-10 Ici Plc Production of particulate materials
IL105658A (en) * 1993-05-11 1995-10-31 Ultrasonic Dryer Ltd Spray drying system
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
DE4329204A1 (de) † 1993-08-31 1995-03-02 Degussa Dreistoffzerstäuberdüse und deren Verwendung
DE69325595T2 (de) 1993-11-17 2000-03-16 Niro Holding A/S Verfahren und sprühtrocknungsgerät zum erzeugen von agglomeriertem pulver
US5595761A (en) * 1994-01-27 1997-01-21 The Board Of Regents Of The University Of Oklahoma Particulate support matrix for making a rapidly dissolving tablet
US5635210A (en) * 1994-02-03 1997-06-03 The Board Of Regents Of The University Of Oklahoma Method of making a rapidly dissolving tablet
ATE268605T1 (de) 1994-03-04 2004-06-15 Genentech Inc Pharmazeutische akzeptabel dnase zusammensetzung
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
ATE416755T1 (de) 1994-03-07 2008-12-15 Nektar Therapeutics Verfahren und zusammensetzung für die pulmonale darreichung von insulin
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
MX9605717A (es) 1994-05-18 1998-05-31 Inhale Therapeutic Syst Metodos y composiciones para la formulacion de polvo seco de interferones.
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
ATE252373T1 (de) 1994-08-04 2003-11-15 Elan Drug Delivery Ltd Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
NZ292980A (en) 1994-09-29 1999-02-25 Andaris Ltd Smooth, spherical water-soluble microparticles as therapeutic or diagnostic vehicles
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
EP0786940B1 (de) 1994-10-18 2001-04-11 Waterford Creamery Limited Verfahren und vorrichtung zum sprühtrocknen
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US5970974A (en) * 1995-03-14 1999-10-26 Siemens Aktiengesellschaft Dosating unit for an ultrasonic atomizer device
ATE287703T1 (de) 1995-04-14 2005-02-15 Nektar Therapeutics Pulverförmige pharmazeutische formulierungen mit verbesserter dispergierbarkeit
US5922253A (en) * 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
US5667806A (en) † 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5687905A (en) * 1995-09-05 1997-11-18 Tsai; Shirley Cheng Ultrasound-modulated two-fluid atomization
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
EP0862420A4 (de) 1995-10-13 1999-11-03 Penn State Res Found Synthese von arzneistoffnanopartikeln durch sprühtrocknung
FR2742964B1 (fr) 1995-12-29 1998-02-27 Evin Michel Dispositif d'ameublissement du sol a lames fixees sur un chassis
TW406080B (en) * 1996-02-05 2000-09-21 Shionogi & Co Micacocidin derivatives
EP0879048B2 (de) 1996-02-09 2009-07-29 Quadrant Drug Delivery Limited Verfahren zur Herstellung von Tabletten mit Hilfe von Trehalose
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
GB9606677D0 (en) 1996-03-29 1996-06-05 Glaxo Wellcome Inc Process and device
DE19615418A1 (de) * 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
AUPO637197A0 (en) 1997-04-23 1997-05-15 F.H. Faulding & Co. Limited Taste-masked pharmaceutical compositions
DE19617487A1 (de) * 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
GB9610830D0 (en) 1996-05-23 1996-07-31 Andaris Ltd Use of hollow microcapsules
US6503480B1 (en) * 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
TW305239U (en) * 1996-06-28 1997-05-11 Ind Tech Res Inst Generating apparatus of gaseous glue capable of distributing particles with narrow diameters
WO1998001228A2 (en) 1996-07-08 1998-01-15 Corning Incorporated Rayleigh-breakup atomizing devices and methods of making rayleigh-breakup atomizing devices
JP3585654B2 (ja) * 1996-07-11 2004-11-04 株式会社パウダリングジャパン ２段乾燥式スプレードライヤー装置
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
AU5719798A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems, Inc. Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
DE19701059C2 (de) 1997-01-15 2000-12-21 Lohmann Therapie Syst Lts Acetylsalicylsäure enthaltendes transdermales therapeutisches System mit Resorptionsverstärkung
US6383810B2 (en) * 1997-02-14 2002-05-07 Invitrogen Corporation Dry powder cells and cell culture reagents and methods of production thereof
US6051257A (en) * 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
AU756693B2 (en) 1997-09-29 2003-01-23 Novartis Ag Stabilized bioactive preparations and methods of use
JP2001518490A (ja) 1997-10-03 2001-10-16 エラン コーポレーシヨン ピーエルシー 味遮蔽された製剤
EP1037858A1 (de) 1997-12-17 2000-09-27 Universidad de Sevilla Vorrichtung und verfahren zur herstellung von kugelförmigen teilchen einheitlicher grösse
EP1037713B1 (de) 1997-12-17 2002-07-10 Universidad de Sevilla Verfahren zur erzeugung von hohlen tröpfchen
GB9727102D0 (en) * 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
FR2772593B1 (fr) 1997-12-22 2000-03-31 Saout Jacques Le Implant femoral d'une prothese de genou et ensemble de materiel orthopedique comprenant un tel implant femoral
CO5070568A1 (es) * 1998-05-22 2001-08-28 Eurand Internatrional Spa Proceso de aplicacion de capas y aparato para efectuarlo
SE9802073D0 (sv) * 1998-06-11 1998-06-11 Astra Ab New use
US20030044454A1 (en) 1998-06-30 2003-03-06 Masaru Fukui Compositions containing liposomes and/or emulsions and process for the preparation thereof
GB9817470D0 (en) 1998-08-11 1998-10-07 Andaris Ltd Pharmaceutical formulation
CA2341624C (en) 1998-08-25 2008-12-02 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
CA2345299A1 (en) 1998-08-26 2000-03-09 Superior Micropowders, Llc Aerosol method and apparatus for making particulate products
GB9819272D0 (en) 1998-09-03 1998-10-28 Andaris Ltd Microparticles
GB9825883D0 (en) * 1998-11-27 1999-01-20 Aea Technology Plc Formation of monodisperse particles
GB9909630D0 (en) 1999-04-28 1999-06-23 Zeneca Ltd Reactor
US6223455B1 (en) * 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
WO2000076673A1 (en) 1999-06-11 2000-12-21 Aradigm Corporation Method for producing an aerosol
EP1196236B1 (de) 1999-06-30 2007-08-29 Nektar Therapeutics Verfahren und system zur herstellung von trockenem pulver mittels sprühtrocknung
FI114855B (fi) 1999-07-09 2005-01-14 Outokumpu Oy Menetelmä reiän tulppaamiseksi ja menetelmällä valmistettu jäähdytyselementti
WO2001013885A1 (en) 1999-08-20 2001-03-01 Norton Healthcare Ltd. Method to produce powders for pulmonary or nasal administration
US20020081266A1 (en) * 1999-08-20 2002-06-27 Norton Healthcare Ltd. Spray dried powders for pulmonary or nasal administration
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
GB9920558D0 (en) 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
NL1013893C2 (nl) * 1999-12-20 2001-06-21 Stork Friesland Bv Inrichting voor het verstuiven van een vloeibaar product, een daarvan voorziene sproeidroog- en conditionerings-inrichting alsmede een werkwijze voor het conditioneren van een vloeibaar product.
AU2729101A (en) 1999-12-21 2001-07-03 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
GB0004827D0 (en) 2000-02-29 2000-04-19 Quadrant Holdings Cambridge Compositions
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
GB0011807D0 (en) 2000-05-16 2000-07-05 Quadrant Holdings Cambridge Formulation for inhalation
US6656492B2 (en) * 2000-06-30 2003-12-02 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
WO2002009669A2 (en) 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution and particles made thereby
WO2002015880A2 (en) 2000-08-25 2002-02-28 Merck Patent Gmbh Powdered mannitol and mannitol-containing compositions
US20020141946A1 (en) 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US6455028B1 (en) * 2001-04-23 2002-09-24 Pharmascience Ipratropium formulation for pulmonary inhalation
KR100951750B1 (ko) 2001-11-01 2010-04-09 노바르티스 아게 분무 건조 방법 및 그 조성물

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CA2464656A1 (en) 2003-05-08
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EP1446104A1 (de) 2004-08-18
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AU2002342241B2 (en) 2007-07-19
KR100951750B1 (ko) 2010-04-09
JP4837892B2 (ja) 2011-12-14
JP2005511555A (ja) 2005-04-28
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