ATE401874T1 - Verabreichung von capsaicinoiden - Google Patents

Verabreichung von capsaicinoiden

Info

Publication number
ATE401874T1
ATE401874T1 AT03813821T AT03813821T ATE401874T1 AT E401874 T1 ATE401874 T1 AT E401874T1 AT 03813821 T AT03813821 T AT 03813821T AT 03813821 T AT03813821 T AT 03813821T AT E401874 T1 ATE401874 T1 AT E401874T1
Authority
AT
Austria
Prior art keywords
site
discrete
dose
animal
human
Prior art date
Application number
AT03813821T
Other languages
English (en)
Inventor
Ronald Burch
Richard Carter
Jeff Lazar
Original Assignee
Algorx
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algorx filed Critical Algorx
Application granted granted Critical
Publication of ATE401874T1 publication Critical patent/ATE401874T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03813821T 2002-12-18 2003-12-18 Verabreichung von capsaicinoiden ATE401874T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US43445202P 2002-12-18 2002-12-18
US43450002P 2002-12-18 2002-12-18
US43445302P 2002-12-18 2002-12-18
US43450102P 2002-12-18 2002-12-18
US43482802P 2002-12-18 2002-12-18
US43453002P 2002-12-18 2002-12-18
US46116403P 2003-04-08 2003-04-08

Publications (1)

Publication Number Publication Date
ATE401874T1 true ATE401874T1 (de) 2008-08-15

Family

ID=32686433

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03813821T ATE401874T1 (de) 2002-12-18 2003-12-18 Verabreichung von capsaicinoiden

Country Status (12)

Country Link
US (14) US20040186182A1 (de)
EP (1) EP1587506B1 (de)
JP (1) JP2006514109A (de)
AT (1) ATE401874T1 (de)
AU (1) AU2003301190A1 (de)
CY (1) CY1108436T1 (de)
DE (1) DE60322436D1 (de)
DK (1) DK1587506T3 (de)
ES (1) ES2311756T3 (de)
PT (1) PT1587506E (de)
SI (1) SI1587506T1 (de)
WO (1) WO2004056305A2 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ540769A (en) 2002-12-18 2009-03-31 Algorx Pharmaceuticals Inc Administration of capsaicinoids for the treatment of pain
WO2004056305A2 (en) * 2002-12-18 2004-07-08 Algorx Administration of capsaicinoids
BRPI0409748A (pt) * 2003-04-08 2006-10-24 Algorx Pharmaceuticals Inc preparação e purificação de capsaicin sintetico
WO2006066419A1 (de) 2004-12-22 2006-06-29 Mestex Ag Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels
ES2384244T3 (es) 2004-12-28 2012-07-02 Mestex Ag Utilización de un agonista del receptor vaniloide juntamente con un glicosaminoglicano o un proteoglicano para la fabricación de un fármaco para el tratamiento de los dolores articulares y procedimiento para la aplicación de este fármaco
US20060251689A1 (en) * 2005-03-30 2006-11-09 Astion Development A/S Treatment or prevention of pruritus
US8304402B2 (en) 2005-05-05 2012-11-06 Binyarco, Llc Composition and method for treating nosebleeds
AU2006279325B2 (en) * 2005-08-18 2013-06-27 Accelalox, Inc. Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
GB2441011A (en) * 2006-08-18 2008-02-20 Henderson Morley Plc Pharmaceutical composition for the treatment of neuropathic pain
US20080069855A1 (en) * 2006-08-21 2008-03-20 Bonutti Peter M Method of inhibiting the formation of adhesions and scar tissue and reducing blood loss
US20090312255A1 (en) * 2006-12-14 2009-12-17 The Hospital For Sick Children Stimulation of trpv1+ sensory neurons to control beta-cell stress and islet inflammation in diabetes
JP5294601B2 (ja) * 2007-09-28 2013-09-18 小林製薬株式会社 Ｔｒｐｖ４受容体抑制剤
CL2008003507A1 (es) * 2007-11-26 2009-11-27 Neuroderm Ltd Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico.
AU2009212337B2 (en) * 2008-02-08 2012-01-12 Colgate-Palmolive Company Cleaning compositions and methods
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
EP2247245B1 (de) 2008-02-18 2017-06-28 Covidien LP Vorrichtung zur ablage und befestigung eines pflasters auf biologischem gewebe
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
WO2009105723A2 (en) * 2008-02-22 2009-08-27 Accelalox, Inc. Novel methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway
WO2009124551A2 (en) * 2008-04-09 2009-10-15 Neurokey A/S Use of hypothermia inducing drugs
US20100099766A1 (en) * 2008-10-16 2010-04-22 Novartis Ag Topical NSAID compositions having sensate component
EP2337502B1 (de) 2008-10-20 2014-08-06 Covidien LP Vorrichtung zur anbringung eines pflasters auf einem biologischen gewebe
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
US8870876B2 (en) * 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2427056A4 (de) * 2009-05-07 2012-08-22 Univ Cincinnati Verfahren zur verhinderung von ischämie während einer peripheren schmerzrezeptionsstimulation
CA2769666C (en) 2009-08-17 2018-02-13 Arie Levy Means and method for reversibly connecting an implant to a deployment device
AU2010286117B9 (en) 2009-08-17 2014-07-10 Covidien Lp Articulating patch deployment device and method of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2528649A1 (de) * 2010-01-26 2012-12-05 Michael A. Evans Verfahren, vorrichtungen und mittel zur denervierung
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
CN102397243A (zh) * 2010-09-08 2012-04-04 杭州赛利药物研究所有限公司 马来酸曲美布汀注射剂及其制备方法
ES2972387T3 (es) 2011-03-18 2024-06-12 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de sorbitán
CA2850964C (en) 2011-10-05 2021-02-02 Jennifer L. Sanders Methods and compositions for treating foot or hand pain
PH12014500685B1 (en) * 2011-10-10 2018-10-03 Ampio Pharmaceuticals Inc Treatment of degenerative joint disease
WO2013142202A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
CA2867121C (en) 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
US9999670B2 (en) 2012-03-19 2018-06-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
US20140142073A1 (en) 2012-11-12 2014-05-22 Api Genesis, Llc Aqueous based capsaicinoid formulations and methods of manufacture and use
US20150133561A1 (en) 2013-11-12 2015-05-14 Vizuri Health Sciences Llc Aqueous based capsaicinoid formulations and methods of manufacture and use
AU2015231278B2 (en) 2014-03-20 2020-01-23 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
US10610570B2 (en) 2014-07-09 2020-04-07 Mayo Foundation For Medical Education And Research Treating rotator cuff conditions
US11634384B2 (en) 2014-11-25 2023-04-25 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
US9359316B1 (en) 2014-11-25 2016-06-07 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
WO2017011762A1 (en) 2015-07-16 2017-01-19 Mayo Foundation For Medical Education And Research Treating rotator cuff conditions
CA2994331C (en) 2015-07-31 2023-10-03 Delivra Inc. Transdermal formulations for delivery of capsaicinoids
US20190022036A1 (en) * 2016-01-22 2019-01-24 Centrexion Therapeutics Corporation Capsaicin sequential dosing method for treatment of morton's neuroma pain
CA3025268A1 (en) 2016-05-25 2017-11-30 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
US11000490B2 (en) 2016-11-02 2021-05-11 Centrexion Therapeutics Corporation Stable aqueous capsaicin injectable formulations and medical uses thereof
CN107157924A (zh) * 2017-05-22 2017-09-15 湖南金健药业有限责任公司 萘普生钠氯化钠注射液及其制备方法
WO2018217937A1 (en) * 2017-05-24 2018-11-29 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
WO2019018769A1 (en) 2017-07-20 2019-01-24 Centrexion Therapeutics Corporation METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN USING CAPSAICINE
EP3691618A1 (de) 2017-10-06 2020-08-12 Foundry Therapeutics, Inc. Implantierbare depots zur kontrollierten freisetzung therapeutischer wirkstoffe
CN116650732A (zh) 2018-01-08 2023-08-29 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
AU2019230014B2 (en) 2018-03-05 2024-11-28 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
US12458589B2 (en) 2018-05-12 2025-11-04 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
US10717712B2 (en) 2018-07-27 2020-07-21 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists
EP3840739B1 (de) 2018-08-24 2025-11-12 Centrexion Therapeutics Corporation Verfahren zur sequenziellen dosierung von capsaicin zur behandlung von kniegelenkschmerzen
EP3843710A1 (de) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymerimplantate
CN113490745A (zh) * 2018-12-21 2021-10-08 索伦托药业有限公司 神经周施用树脂毒素治疗适应不良性疼痛
US11447444B1 (en) 2019-01-18 2022-09-20 Centrexion Therapeutics Corporation Capsaicinoid prodrug compounds and their use in treating medical conditions
US11254659B1 (en) 2019-01-18 2022-02-22 Centrexion Therapeutics Corporation Capsaicinoid prodrug compounds and their use in treating medical conditions
WO2020154261A1 (en) 2019-01-22 2020-07-30 Sorrento Therapeutics, Inc. Method for treating osteoarthritis pain by administering resiniferatoxin
US12472158B2 (en) 2019-02-27 2025-11-18 Vanderbilt University Methods of treating trigeminal nerve pain
EP3946317A1 (de) * 2019-03-28 2022-02-09 Mestex AG Capsaicin oder capsainoid enthaltende zusammensetzung zur postoperativen schmerzkontrolle
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
EP4281075A2 (de) * 2021-01-25 2023-11-29 Pharmi Norden AB Verfahren zur behandlung einer hauterkrankung durch verabreichung eines amiloridderivats
US20250228765A1 (en) 2024-01-15 2025-07-17 Gruenenthal Gmbh Treating knee joint pain by injecting resiniferatoxin at ultra low doses
WO2026055113A1 (en) * 2024-09-03 2026-03-12 Stough Dowling Intradermal injection of antimicrobial and local anesthetic

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097607A (en) * 1976-12-10 1978-06-27 Larson Kenneth A Deterrent composition, method of using same, and article coated thereby
US4486450B1 (en) * 1980-07-14 1998-07-28 Joel E Bernstein Method of treating psoriatic skin and composition
US4313958A (en) * 1980-10-24 1982-02-02 The Procter & Gamble Company Method of producing analgesia
US4460673A (en) * 1981-06-03 1984-07-17 Fuji Electric Company, Ltd. Method of producing amorphous silicon layer and its manufacturing apparatus
US4460602A (en) * 1981-06-30 1984-07-17 The Procter & Gamble Company Urea derivatives
US4443473A (en) * 1981-06-30 1984-04-17 The Procter & Gamble Company Carbamate derivatives
US4401663A (en) * 1981-06-30 1983-08-30 The Procter & Gamble Company Novel sulfonamide derivatives
US4424205A (en) 1982-03-18 1984-01-03 The Procter & Gamble Company Hydroxyphenylacetamides having analgesic and anti-irritant activity
US4742054A (en) * 1982-11-23 1988-05-03 Naftchi Nosrat E Treatment of mammals suffering from damage to the central nervous system
US4488450A (en) * 1983-02-18 1984-12-18 Tokyo Kinzoku Kabushikikaisha Device for releasably securing a finely angularly adjusted shaft
US4536404A (en) * 1983-06-16 1985-08-20 Dermatological Enterprises, Ltd. Method and composition for treating post-herpetic neuralgia
US4493848A (en) * 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4599342A (en) * 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4681897A (en) * 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4702916A (en) * 1985-12-03 1987-10-27 Warner-Lambert Company Analgesic stick compositions
US4812445A (en) * 1987-02-06 1989-03-14 National Starch And Chemical Corporation Starch based encapsulation process
US4801587A (en) * 1987-03-02 1989-01-31 Gene Voss Impotence ointment
US4939149A (en) * 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
US4997853A (en) * 1988-12-02 1991-03-05 Galenpharma, Inc. Method and compositions utilizing capsaicin as an external analgesic
US5008289A (en) * 1988-12-02 1991-04-16 Galenpharma, Inc. Composition for treating nasal disorders and headaches
AU5744490A (en) 1989-05-15 1990-12-18 Afferon Corporation Composition and method for neural desensitization
US5021450A (en) * 1989-05-30 1991-06-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services New class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions and uses thereof
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5063060A (en) * 1989-12-19 1991-11-05 Cisco Limited Partnership Compositions and method for treating painful, inflammatory or allergic disorders
US5447947A (en) * 1990-02-26 1995-09-05 Arc 1 Compositions and methods of treatment of sympathetically maintained pain
US5070084A (en) * 1990-02-26 1991-12-03 Campbell James N Treatment of sympathetically maintained pain
US5094782A (en) * 1990-12-24 1992-03-10 National Science Council Of Republic Of China Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug
US5242944A (en) * 1991-06-20 1993-09-07 Korea Research Institute Of Chemical Technology Phenylacetamide derivatives and pharmaceutical compositions thereof
US5176679A (en) * 1991-09-23 1993-01-05 Lin Chih I Vertebral locking and retrieving system
JP3540246B2 (ja) 1991-10-14 2004-07-07 ライオン株式会社 外用消炎鎮痛用貼付剤
US5178879A (en) * 1992-04-17 1993-01-12 Michael Adekunle Capsaicin gel
US5431914A (en) * 1992-04-17 1995-07-11 Adekunle; Michael Method of treating an internal condition by external application of capsaicin without the need for systemic absorption
US5985860A (en) * 1992-06-03 1999-11-16 Toppo; Frank System for transdermal delivery of pain relieving substances
US6063381A (en) * 1993-05-19 2000-05-16 Staggs; Jeff J. Therapeutic uses of pungent botanicals and their related compounds
US5910512A (en) * 1994-04-18 1999-06-08 Healthline Laboratories, Inc. Topical analgesic using water soluble capsaicin
US5560910A (en) 1994-08-26 1996-10-01 Crandall; Wilson T. Topical anti-inflammatory composition and method
US5660830A (en) * 1994-09-14 1997-08-26 Anderson; Cleve Richard Solubilizing counter-irritants and concurrently extracting capsaicin from the same specific peppers
US5676691A (en) * 1994-09-21 1997-10-14 Friedman; Mark H. Treatment of vascular and tension headache, atypical facial pain, and cervical muscle hyperactivity
US5665378A (en) * 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
AU4467396A (en) * 1994-12-12 1996-07-10 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
US5618522A (en) * 1995-01-20 1997-04-08 The Procter & Gamble Company Emulsion compositions
EP0735274B1 (de) * 1995-03-31 2000-12-27 Aisin Seiki Kabushiki Kaisha Flüssigkeitspumpe
US5762963A (en) 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US5942241A (en) * 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
US5788982A (en) * 1995-06-16 1998-08-04 Nadoolman; Wolffe Method and composition for treating oral pain using capsaicin
US6239180B1 (en) * 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6248788B1 (en) * 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
US5874420A (en) 1995-12-26 1999-02-23 Allegheny University Of The Health Sciences Process for regulating vagal tone
US5869533A (en) * 1996-04-23 1999-02-09 Holt; Stephen D. Non-irritating capsaicin formulations and applicators therefor
US5856361A (en) * 1996-04-23 1999-01-05 Medical Merchandising, Inc. Pain reliever and method of use
US5854291A (en) * 1996-04-23 1998-12-29 Medical Merchandising, Inc. Pain reliever and method of use
CN1059577C (zh) 1996-07-12 2000-12-20 王庆新 皮疾胶囊、皮疾软膏
WO1998020867A1 (en) 1996-11-15 1998-05-22 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pharmaceutical compositions containing vanilloid agonists in combination with vanilloid antagonists
US6060060A (en) * 1997-01-31 2000-05-09 Bmb Patent Holding Corporation Analgesic compositions from sweet peppers and methods of use thereof
EP1201241B8 (de) 1997-03-13 2010-10-27 James N. Campbell Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum
JPH10269027A (ja) * 1997-03-26 1998-10-09 Toshiba Corp ディスク装置及び同装置におけるバッファ管理制御方法
US6201022B1 (en) * 1997-03-27 2001-03-13 Myorx, Inc. Methods for treating neurotransmitter-mediated pain syndromes by topically administering an omega fatty acid
US5827886A (en) * 1997-05-07 1998-10-27 Thione International, Inc. Composition for relief of arthritis-induced symptoms
AU7389098A (en) 1997-05-16 1998-12-08 Brigham And Women's Hospital Local anesthetic formulations
JP2002514221A (ja) 1997-05-27 2002-05-14 アルゴス ファーマシューティカル コーポレーション カプサイシノイド及びその強化薬を含有する鎮痛薬組成物
US6632839B2 (en) * 1997-06-06 2003-10-14 Robert H. Neumann Capsicum based disinfectant and sterilizant
GB9711962D0 (en) * 1997-06-10 1997-08-06 Reckitt & Colmann Prod Ltd Therapeutically active compositions
IL129951A0 (en) * 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US6063758A (en) * 1997-07-09 2000-05-16 Advanced Targeting Systems, Inc. Substance P-Saporin (SP-SAP) conjugates and methods of use thereof
GB2327041A (en) 1997-07-09 1999-01-13 Smithkline Beecham Plc Topical Analgesic Composition
EP0906757B1 (de) * 1997-09-16 2005-05-11 Solvay Pharmaceuticals GmbH Analgetische Zusammensetzung welche Moxonidine und ein Opioid-Analgetika enthält
US5885597A (en) * 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain
KR20060085258A (ko) 1998-02-24 2006-07-26 웨이크 포리스트 유니버시티 만성 통증 및 여성에 특유한 통증을 비롯한 통증의 치료방법
DE19807908A1 (de) 1998-02-25 1999-08-26 Basf Ag Kosmetisches Mittel
US6211171B1 (en) * 1998-05-19 2001-04-03 Dalhousie University Use of antidepressants for local analgesia
JP3211027B2 (ja) 1998-11-13 2001-09-25 丸石製薬株式会社 カプサイシン含有外用剤
JP2000247875A (ja) 1999-01-01 2000-09-12 Lion Corp 外用消炎鎮痛剤
CA2267049A1 (en) 1999-02-05 2000-08-05 Bioglan Laboratories Ltd. Pharmaceutical compositions
GB9902651D0 (en) 1999-02-05 1999-03-31 Bioglan Lab Ltd Pharmaceutical compositions
GB9904163D0 (en) 1999-02-23 1999-04-14 Bioglan Lab Ltd Pharmaceutical compositions
US6284797B1 (en) * 1999-04-12 2001-09-04 Donald A. Rhodes Topical treatment of pain and to promote healing
US6248797B1 (en) * 1999-05-17 2001-06-19 Shelton A. Dias Supercritical carbon dioxide extraction of contaminants from ion exchange resins
US20010051184A1 (en) * 1999-05-20 2001-12-13 Madalene C.Y. Heng Method for using soluble curcumin to inhibit phosphorylase kinase in inflammatory diseases
US5994407A (en) 1999-06-16 1999-11-30 Cuilty-Siller; Carlos Procedure to prepare a solution with capsaicin
US6368618B1 (en) * 1999-07-01 2002-04-09 The University Of Georgia Research Foundation, Inc. Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs
AU6366100A (en) * 1999-07-23 2001-02-13 Case Western Reserve University Novel methods and reagents for the treatment of osteoarthritis
US6197823B1 (en) * 1999-09-29 2001-03-06 Medical Merchandising, Inc. Pain reliever and method of use
US6653352B2 (en) * 1999-09-29 2003-11-25 Medical Merchandising, Inc. Pain reliever and method of use
JP4560864B2 (ja) 1999-11-30 2010-10-13 味の素株式会社 新規なカプサイシノイド様物質を含有する鎮痛剤、食品及び飼料
DE60110057T2 (de) * 2000-01-28 2005-09-08 Alza Corp., Mountain View Liposomen enthaltend eine eingeschlossene verbindung in übersattigter lösung
CN100588395C (zh) * 2000-06-13 2010-02-10 Wyeth公司 含有环氧化酶-2抑制剂的止痛和抗炎药物
IL137381A (en) 2000-07-19 2005-06-19 Avshalom Bar Shalom Method and system for monitoring ruminant animals, particularly dairy cattle
DE60208805T2 (de) * 2001-10-31 2006-08-31 Hewlett-Packard Co. (N.D.Ges.D.Staates Delaware), Palo Alto Bilderzeugungsgerät mit positionsmessvorrichtung
US20030104085A1 (en) * 2001-12-05 2003-06-05 Yeomans David C. Methods and compositions for treating back pain
WO2003061626A1 (en) * 2002-01-18 2003-07-31 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
WO2004002202A1 (de) 2002-06-21 2003-12-31 Continental Teves Ag & Co. Ohg Leiterplatte für elektronische kraftfahrzeugsteuergeräte
EA012367B1 (ru) * 2002-09-05 2009-10-30 Ньюроджескс, Инк. Композиция и способ очистки поверхности тела от капсаицина, набор и способ лечения боли
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
NZ540769A (en) 2002-12-18 2009-03-31 Algorx Pharmaceuticals Inc Administration of capsaicinoids for the treatment of pain
WO2004056305A2 (en) * 2002-12-18 2004-07-08 Algorx Administration of capsaicinoids
BRPI0409748A (pt) * 2003-04-08 2006-10-24 Algorx Pharmaceuticals Inc preparação e purificação de capsaicin sintetico
US20040224037A1 (en) * 2003-04-28 2004-11-11 Gonzalo Romero-Matos Devastating treatment against hiv/aids with capsaicin
CN101119713A (zh) 2004-11-24 2008-02-06 阿尔高克斯制药公司 类辣椒素凝胶制剂及其用途

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US20130303620A1 (en) 2013-11-14
WO2004056305A2 (en) 2004-07-08
US20040156931A1 (en) 2004-08-12
PT1587506E (pt) 2008-10-30
US20090118242A1 (en) 2009-05-07
CY1108436T1 (el) 2014-04-09
US20040191338A1 (en) 2004-09-30
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US20090117167A1 (en) 2009-05-07
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US20090054527A1 (en) 2009-02-26
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US20070036876A1 (en) 2007-02-15
US20040186182A1 (en) 2004-09-23
US8420600B2 (en) 2013-04-16
SI1587506T1 (sl) 2009-04-30
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US20090062359A1 (en) 2009-03-05
EP1587506B1 (de) 2008-07-23
US20050058734A1 (en) 2005-03-17

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