BRPI0409748A - preparação e purificação de capsaicin sintetico - Google Patents

preparação e purificação de capsaicin sintetico

Info

Publication number
BRPI0409748A
BRPI0409748A BRPI0409748-3A BRPI0409748A BRPI0409748A BR PI0409748 A BRPI0409748 A BR PI0409748A BR PI0409748 A BRPI0409748 A BR PI0409748A BR PI0409748 A BRPI0409748 A BR PI0409748A
Authority
BR
Brazil
Prior art keywords
purification
preparation
capsaicin
trans
synthetic capsaicin
Prior art date
Application number
BRPI0409748-3A
Other languages
English (en)
Inventor
Sharon Mciivain
Wei Chen
Premchandran H Ramiya
Ronald Burch
Richard Carter
Timothy A Anderson
Original Assignee
Algorx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algorx Pharmaceuticals Inc filed Critical Algorx Pharmaceuticals Inc
Publication of BRPI0409748A publication Critical patent/BRPI0409748A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

"PREPARAçãO E PURIFICAçãO DE CAPSAICIN". A presente invenção prove metódos para sintetizar o trans trans isomer do capsaicin e/ou tipos de compostos de capsaicin pelo uso de processos em que a trans geometria é feita pela separação na reação de síntese e levada para o processo completo de síntese
BRPI0409748-3A 2003-04-08 2004-04-08 preparação e purificação de capsaicin sintetico BRPI0409748A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46116403P 2003-04-08 2003-04-08
US53107403P 2003-12-18 2003-12-18
PCT/US2004/010745 WO2004092122A2 (en) 2003-04-08 2004-04-08 Preparation and purification of synthetic capsaicin

Publications (1)

Publication Number Publication Date
BRPI0409748A true BRPI0409748A (pt) 2006-10-24

Family

ID=33303038

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409748-3A BRPI0409748A (pt) 2003-04-08 2004-04-08 preparação e purificação de capsaicin sintetico

Country Status (10)

Country Link
US (2) US20050085652A1 (pt)
EP (1) EP1615880A4 (pt)
JP (1) JP2006522815A (pt)
AU (1) AU2004230915B2 (pt)
BR (1) BRPI0409748A (pt)
CA (1) CA2521925A1 (pt)
EA (1) EA008705B1 (pt)
MX (1) MXPA05010882A (pt)
NZ (1) NZ542887A (pt)
WO (1) WO2004092122A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ540769A (en) 2002-12-18 2009-03-31 Algorx Pharmaceuticals Inc Administration of capsaicinoids for the treatment of pain
WO2004056305A2 (en) * 2002-12-18 2004-07-08 Algorx Administration of capsaicinoids
BRPI0409748A (pt) * 2003-04-08 2006-10-24 Algorx Pharmaceuticals Inc preparação e purificação de capsaicin sintetico
US7943166B2 (en) 2003-04-10 2011-05-17 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
CN101119713A (zh) * 2004-11-24 2008-02-06 阿尔高克斯制药公司 类辣椒素凝胶制剂及其用途
CN100410235C (zh) * 2006-06-15 2008-08-13 山东省科学院生物研究所 辣椒碱的化学合成与纯化方法
ITMI20071603A1 (it) * 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
EP2453858B2 (en) * 2009-07-16 2017-09-13 Brightwake Limited Method
PL2629610T3 (pl) 2010-07-27 2018-02-28 Flex Pharma, Inc. Sposoby i kompozycje do zapobiegania i zmniejszania kurczy mięśni i do regeneracji po nerwowo-mięśniowym podrażnieniu i zmęczeniu po ćwiczeniach fizycznych
US20140142073A1 (en) 2012-11-12 2014-05-22 Api Genesis, Llc Aqueous based capsaicinoid formulations and methods of manufacture and use
US20150133561A1 (en) 2013-11-12 2015-05-14 Vizuri Health Sciences Llc Aqueous based capsaicinoid formulations and methods of manufacture and use
US11253493B2 (en) 2017-01-23 2022-02-22 Cliff-Cartwright Corporation Compositions and methods affecting exercise performance
CN113490745A (zh) * 2018-12-21 2021-10-08 索伦托药业有限公司 神经周施用树脂毒素治疗适应不良性疼痛
CN110453311A (zh) * 2019-09-23 2019-11-15 浙江理工大学 一种温感壳聚糖纤维及其制备方法
NO20200333A1 (en) * 2020-03-20 2021-03-29 Axichem As Synthesis of capsaicin derivatives
CN115850108B (zh) * 2022-12-14 2024-10-01 中国烟草总公司郑州烟草研究院 17-羟基辣椒素及其标记物的合成方法
CN117770450B (zh) * 2024-02-23 2024-06-21 天津福来特新材料科技有限公司 一种高纯度的辣椒素组合物及其制备方法和其应用

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Also Published As

Publication number Publication date
EA008705B1 (ru) 2007-06-29
US20050085652A1 (en) 2005-04-21
AU2004230915B2 (en) 2008-08-07
JP2006522815A (ja) 2006-10-05
US20070293703A1 (en) 2007-12-20
NZ542887A (en) 2008-05-30
EP1615880A4 (en) 2007-03-07
MXPA05010882A (es) 2005-11-25
AU2004230915A1 (en) 2004-10-28
CA2521925A1 (en) 2004-10-28
WO2004092122A2 (en) 2004-10-28
EA200501582A1 (ru) 2006-06-30
WO2004092122A3 (en) 2005-12-29
EP1615880A2 (en) 2006-01-18

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