|
US8173127B2
(en)
*
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
|
US20080050367A1
(en)
|
1998-04-07 |
2008-02-28 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
US7790856B2
(en)
|
1998-04-07 |
2010-09-07 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize beta amyloid peptide
|
|
US6913745B1
(en)
|
1997-12-02 |
2005-07-05 |
Neuralab Limited |
Passive immunization of Alzheimer's disease
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US6923964B1
(en)
|
1997-12-02 |
2005-08-02 |
Neuralab Limited |
Active immunization of AScr for prion disorders
|
|
US6761888B1
(en)
|
2000-05-26 |
2004-07-13 |
Neuralab Limited |
Passive immunization treatment of Alzheimer's disease
|
|
US6787523B1
(en)
|
1997-12-02 |
2004-09-07 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
US6750324B1
(en)
|
1997-12-02 |
2004-06-15 |
Neuralab Limited |
Humanized and chimeric N-terminal amyloid beta-antibodies
|
|
US7588766B1
(en)
|
2000-05-26 |
2009-09-15 |
Elan Pharma International Limited |
Treatment of amyloidogenic disease
|
|
US7964192B1
(en)
*
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
|
US6905686B1
(en)
|
1997-12-02 |
2005-06-14 |
Neuralab Limited |
Active immunization for treatment of alzheimer's disease
|
|
US7179892B2
(en)
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
|
US20030147882A1
(en)
|
1998-05-21 |
2003-08-07 |
Alan Solomon |
Methods for amyloid removal using anti-amyloid antibodies
|
|
US6787637B1
(en)
|
1999-05-28 |
2004-09-07 |
Neuralab Limited |
N-Terminal amyloid-β antibodies
|
|
AU2008203784B2
(en)
*
|
1999-05-28 |
2012-01-19 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidogenic disease
|
|
UA81216C2
(en)
*
|
1999-06-01 |
2007-12-25 |
|
Prevention and treatment of amyloid disease
|
|
AUPQ180499A0
(en)
*
|
1999-07-23 |
1999-08-19 |
Biomolecular Research Institute Limited |
Beta-amyloid peptide inhibitors
|
|
JP2003507013A
(ja)
*
|
1999-08-13 |
2003-02-25 |
ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク |
βシートフィブリルのRAGEへの結合を阻害する方法及びその結果
|
|
EP1237930B1
(de)
*
|
1999-12-08 |
2006-11-08 |
Intellect Neurosciences, Inc. |
Schimärische amyloid-beta peptide
|
|
EA006606B1
(ru)
|
2000-02-24 |
2006-02-24 |
Вашингтон Юниверсити |
Гуманизированное антитело и его фрагмент, взаимодействующие с бета-амилоидным пептидом, и способы их применения
|
|
US7700751B2
(en)
|
2000-12-06 |
2010-04-20 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize β-amyloid peptide
|
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
|
US6815175B2
(en)
|
2001-03-16 |
2004-11-09 |
Cornell Research Foundation, Inc. |
Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
|
|
AU2002258808A1
(en)
|
2001-04-30 |
2002-11-11 |
Eli Lilly And Company |
Humanized antibodies
|
|
ATE409047T1
(de)
|
2001-04-30 |
2008-10-15 |
Lilly Co Eli |
Humanisierte antikörper
|
|
EP1944040B1
(de)
|
2001-08-17 |
2012-08-01 |
Washington University |
Assay-Verfahren für Alzheimer
|
|
MY139983A
(en)
|
2002-03-12 |
2009-11-30 |
Janssen Alzheimer Immunotherap |
Humanized antibodies that recognize beta amyloid peptide
|
|
WO2004013172A2
(en)
*
|
2002-07-24 |
2004-02-12 |
Innogenetics N.V. |
Fragments of beta-amyloid as targets for vaccination against alzheimer disease
|
|
WO2004029629A1
(en)
*
|
2002-09-27 |
2004-04-08 |
Janssen Pharmaceutica N.V. |
N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
|
|
AU2003279216A1
(en)
*
|
2002-10-09 |
2004-05-04 |
Rinat Neuroscience Corp. |
Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
|
|
ES2344645T3
(es)
|
2003-02-10 |
2010-09-02 |
Applied Molecular Evolution, Inc. |
Moleculas de union al abeta.
|
|
US7732162B2
(en)
|
2003-05-05 |
2010-06-08 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
|
|
TWI306458B
(en)
|
2003-05-30 |
2009-02-21 |
Elan Pharma Int Ltd |
Humanized antibodies that recognize beta amyloid peptide
|
|
EA200700751A1
(ru)
*
|
2004-10-05 |
2008-06-30 |
Элан Фарма Интернэшнл Лимитед |
Способы и композиции для улучшения продуцирования рекомбинантного белка
|
|
GB0424563D0
(en)
|
2004-11-05 |
2004-12-08 |
Novartis Ag |
Organic compounds
|
|
ES2396555T3
(es)
|
2004-12-15 |
2013-02-22 |
Janssen Alzheimer Immunotherapy |
Anticuerpos que reconocen péptido beta amiloide
|
|
EP1838348B1
(de)
|
2004-12-15 |
2013-06-26 |
Janssen Alzheimer Immunotherapy |
Humanisierte amyloid-beta-antikörper zur verbesserung der kognition
|
|
WO2006081171A1
(en)
|
2005-01-24 |
2006-08-03 |
Amgen Inc. |
Humanized anti-amyloid antibody
|
|
AU2006306553B9
(en)
*
|
2005-10-21 |
2011-09-29 |
Merck Sharp & Dohme Corp. |
Anti-ADDL monoclonal antibody and use thereof
|
|
CN1329413C
(zh)
*
|
2006-01-23 |
2007-08-01 |
南京医科大学 |
一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用
|
|
KR101263294B1
(ko)
*
|
2006-03-30 |
2013-06-04 |
글락소 그룹 리미티드 |
아밀로이드베타 펩티드에 대한 항체
|
|
US8784810B2
(en)
|
2006-04-18 |
2014-07-22 |
Janssen Alzheimer Immunotherapy |
Treatment of amyloidogenic diseases
|
|
HRP20140049T1
(hr)
|
2007-01-05 |
2014-02-28 |
University Of Zürich |
Anti beta-amiloid antitijela i njihova upotreba
|
|
HUE033325T2
(en)
|
2007-01-05 |
2017-11-28 |
Univ Zuerich |
Anti-beta-amyloid binder antibodies and their use
|
|
ES2610474T3
(es)
|
2007-01-11 |
2017-04-27 |
Michael Bacher |
Diagnóstico y tratamiento de la enfermedad de Alzheimer y otras enfermedades neurodegenerativas causantes de demencia
|
|
EP1944315A1
(de)
*
|
2007-01-11 |
2008-07-16 |
Philipps-Universität Marburg |
Prophylaxe und Therapie von Morbus Alzheimer und anderen Demenzerkrankungen
|
|
WO2008088983A1
(en)
|
2007-01-18 |
2008-07-24 |
Eli Lilly And Company |
PEGYLATED Aβ FAB
|
|
JP5930573B2
(ja)
|
2007-03-01 |
2016-06-15 |
プロビオドルグ エージー |
グルタミニルシクラーゼ阻害剤の新規使用
|
|
WO2008128985A1
(en)
|
2007-04-18 |
2008-10-30 |
Probiodrug Ag |
Thiourea derivatives as glutaminyl cyclase inhibitors
|
|
US8003097B2
(en)
|
2007-04-18 |
2011-08-23 |
Janssen Alzheimer Immunotherapy |
Treatment of cerebral amyloid angiopathy
|
|
US8323654B2
(en)
|
2007-05-14 |
2012-12-04 |
Medtronic, Inc. |
Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
|
|
US9040045B2
(en)
|
2007-05-14 |
2015-05-26 |
Medtronic, Inc. |
Methods and device to neutralize soluble toxic agents in the brain
|
|
ES2498040T3
(es)
|
2007-07-27 |
2014-09-24 |
Janssen Alzheimer Immunotherapy |
Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
US9067981B1
(en)
|
2008-10-30 |
2015-06-30 |
Janssen Sciences Ireland Uc |
Hybrid amyloid-beta antibodies
|
|
HRP20150831T1
(hr)
|
2008-12-19 |
2015-10-09 |
Biogen International Neuroscience Gmbh |
Humana anti-alfa- sinuklein auto-protutijela
|
|
EP2258398A1
(de)
|
2009-05-26 |
2010-12-08 |
Araclón Biotech, S. L. |
Albumin/Amyloidpeptid-Konjugate und deren Verwendungen
|
|
PL2475428T3
(pl)
|
2009-09-11 |
2015-12-31 |
Probiodrug Ag |
Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
|
|
ES2586231T3
(es)
|
2010-03-03 |
2016-10-13 |
Probiodrug Ag |
Inhibidores de glutaminil ciclasa
|
|
MX2012010470A
(es)
|
2010-03-10 |
2012-10-09 |
Probiodrug Ag |
Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
|
|
US8541596B2
(en)
|
2010-04-21 |
2013-09-24 |
Probiodrug Ag |
Inhibitors
|
|
CA2806930A1
(en)
*
|
2010-07-30 |
2012-02-02 |
Technische Universitat Dortmund |
Polymeric complements to b-amyloid peptides
|
|
US10738326B2
(en)
*
|
2010-10-27 |
2020-08-11 |
Jichi Medical University |
Adeno-associated virus vector for gene transfer to nervous system cells
|
|
EP2686313B1
(de)
|
2011-03-16 |
2016-02-03 |
Probiodrug AG |
Benzimidazolderivate als glutaminylcyclase-hemmer
|
|
WO2012131539A1
(en)
|
2011-03-31 |
2012-10-04 |
Pfizer Inc. |
Novel bicyclic pyridinones
|
|
WO2012172449A1
(en)
|
2011-06-13 |
2012-12-20 |
Pfizer Inc. |
Lactams as beta secretase inhibitors
|
|
PL2723379T3
(pl)
|
2011-06-23 |
2019-05-31 |
Biogen Int Neuroscience Gmbh |
Cząsteczki wiążące przeciwko alfa-synukleinie
|
|
WO2013030713A1
(en)
|
2011-08-31 |
2013-03-07 |
Pfizer Inc. |
Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
|
|
WO2013164730A1
(en)
|
2012-05-04 |
2013-11-07 |
Pfizer Inc. |
Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2.
|
|
EA025186B1
(ru)
|
2012-06-29 |
2016-11-30 |
Пфайзер Инк. |
НОВЫЕ 4-(ЗАМЕЩЕННЫЙ АМИНО)-7Н-ПИРРОЛО[2,3-d]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LRRK2
|
|
JP2015529239A
(ja)
|
2012-09-20 |
2015-10-05 |
ファイザー・インク |
アルキル置換ヘキサヒドロピラノ[3,4−d][1,3]チアジン−2−アミン化合物
|
|
UA110688C2
(uk)
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
|
CA2893256A1
(en)
|
2012-12-11 |
2014-06-19 |
Pfizer Inc. |
Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
|
|
CA2893333C
(en)
|
2012-12-19 |
2017-10-24 |
Pfizer Inc. |
Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
|
|
WO2014125394A1
(en)
|
2013-02-13 |
2014-08-21 |
Pfizer Inc. |
HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
|
|
US9233981B1
(en)
|
2013-02-15 |
2016-01-12 |
Pfizer Inc. |
Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
|
|
MD20150071A2
(ro)
|
2013-02-19 |
2016-02-29 |
Pfizer Inc. |
Compuşi azabenzimidazolici ca inhibitori ai PDE4 izoenzimelor pentru tratamentul tulburărilor SNC şi altor afecţiuni
|
|
WO2015049616A1
(en)
|
2013-10-04 |
2015-04-09 |
Pfizer Inc. |
Novel bicyclic pyridinones as gamma-secretase modulators
|
|
EP3083618B1
(de)
|
2013-12-17 |
2018-02-21 |
Pfizer Inc |
Neuartige 3,4-disubstituierte-1h-pyrrolo[2,3-b]pyridine und 4,5-disubstituierte 7h-pyrrolo[2,3-c]pyridazine als lrrk2-hemmer
|
|
BR112016022519A8
(pt)
|
2014-04-01 |
2018-03-06 |
Pfizer |
cromeno e 1,1a,2,7b-tetra-hidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gama-secretase
|
|
JP6111002B1
(ja)
|
2014-04-10 |
2017-04-05 |
ファイザー・インク |
2−アミノ−6−メチル−4,4a,5,6−テトラヒドロピラノ[3,4−d][1,3]チアジン−8a(8H)−イル−1,3−チアゾール−4−イルアミド
|
|
WO2016012896A1
(en)
|
2014-07-24 |
2016-01-28 |
Pfizer Inc. |
Pyrazolopyrimidine compounds
|
|
EA031201B1
(ru)
|
2014-08-06 |
2018-11-30 |
Пфайзер Инк. |
Соединения имидазопиридазина
|
|
EP3221349B1
(de)
|
2014-11-19 |
2020-11-04 |
Axon Neuroscience SE |
Humanisierte tau-antikörper bei alzheimer-krankheit
|
|
MA41115A
(fr)
|
2014-12-02 |
2017-10-10 |
Biogen Int Neuroscience Gmbh |
Procédé de traitement de la maladie d'alzheimer
|
|
KR102000382B1
(ko)
|
2015-02-03 |
2019-07-15 |
화이자 인코포레이티드 |
신규 시클로프로파벤조푸라닐 피리도피라진디온
|
|
DK3310784T3
(da)
|
2015-06-17 |
2020-11-09 |
Pfizer |
Tricykliske forbindelser og deres anvendelse som phosphodiesterasehæmmere
|
|
RU2722149C1
(ru)
|
2015-09-14 |
2020-05-27 |
Пфайзер Инк. |
Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
|
|
WO2017051303A1
(en)
|
2015-09-24 |
2017-03-30 |
Pfizer Inc. |
Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
|
|
EP3353174A1
(de)
|
2015-09-24 |
2018-08-01 |
Pfizer Inc |
N-[2-(3-amino-2,5-dimethyl-1,1-dioxid-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)]-1,3-thiazol-4-yl-amide als bace-hemmer
|
|
JP2018531923A
(ja)
|
2015-09-24 |
2018-11-01 |
ファイザー・インク |
N−[2−(2−アミノ−6,6−二置換−4,4a,5,6−テトラヒドロピラノ[3,4−d][1,3]チアジン−8a(8H)−イル)−1,3−チアゾール−4−イル]アミド
|
|
KR102148587B1
(ko)
|
2016-02-23 |
2020-08-26 |
화이자 인코포레이티드 |
6,7-디히드로-5H-피라졸로[5,1-b][1,3]옥사진-2-카르복스아미드 화합물
|
|
PL3478679T3
(pl)
|
2016-07-01 |
2021-10-25 |
Pfizer Inc. |
Pochodne 5,7-dihydro-pirolopirydyny do leczenia chorób neurologicznych i neurodegeneracyjnych
|
|
ES2910083T3
(es)
|
2017-03-10 |
2022-05-11 |
Pfizer |
Derivados de imidazo[4,5-c]quinolina cíclicos sustituidos
|
|
SG10202110112TA
(en)
|
2017-03-10 |
2021-10-28 |
Pfizer |
Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors
|
|
WO2018226992A1
(en)
|
2017-06-07 |
2018-12-13 |
Adrx, Inc. |
Tau aggregation inhibitors
|
|
FI3642202T3
(fi)
|
2017-06-22 |
2023-03-01 |
|
Dihydro-pyrrolo-pyridiinijohdannaisia
|
|
CA3073062A1
(en)
|
2017-08-18 |
2019-02-21 |
Adrx, Inc. |
Tau aggregation peptide inhibitors
|
|
MD3672631T3
(ro)
|
2017-08-22 |
2023-09-30 |
Biogen Ma Inc |
Compoziții farmaceutice conținând anticorpi anti-beta amiloidici
|
|
PL3461819T3
(pl)
|
2017-09-29 |
2020-11-30 |
Probiodrug Ag |
Inhibitory cyklazy glutaminylowej
|
|
EP3768669B1
(de)
|
2018-03-23 |
2023-01-25 |
Pfizer Inc. |
Piperazinazaspiroderivate
|
|
CA3098807A1
(en)
|
2018-05-08 |
2019-11-14 |
Neuracle Science Co., Ltd. |
Adeno-associated virus (aav) delivery of anti-fam19a5 antibodies
|
|
WO2020015637A1
(zh)
|
2018-07-17 |
2020-01-23 |
江苏恒瑞医药股份有限公司 |
抗Abeta抗体、其抗原结合片段及应用
|
|
EP4297868A4
(de)
|
2021-02-23 |
2025-01-08 |
Hoth Therapeutics, Inc. |
Verwendung von aprepitant zur behandlung von alzheimer
|
|
AU2024413926A1
(en)
|
2023-12-29 |
2026-07-09 |
Pfizer Inc. |
Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases
|