ATE402923T1 - 2,4-substituierte indole und deren verwendung als 5-ht6 modulatoren - Google Patents
2,4-substituierte indole und deren verwendung als 5-ht6 modulatorenInfo
- Publication number
- ATE402923T1 ATE402923T1 AT03747986T AT03747986T ATE402923T1 AT E402923 T1 ATE402923 T1 AT E402923T1 AT 03747986 T AT03747986 T AT 03747986T AT 03747986 T AT03747986 T AT 03747986T AT E402923 T1 ATE402923 T1 AT E402923T1
- Authority
- AT
- Austria
- Prior art keywords
- modulators
- substituted indoles
- indoles
- substituted
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41148002P | 2002-09-17 | 2002-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402923T1 true ATE402923T1 (de) | 2008-08-15 |
Family
ID=32030683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03747986T ATE402923T1 (de) | 2002-09-17 | 2003-09-08 | 2,4-substituierte indole und deren verwendung als 5-ht6 modulatoren |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7381739B2 (de) |
| EP (1) | EP1542973B1 (de) |
| JP (1) | JP4267573B2 (de) |
| KR (1) | KR100686757B1 (de) |
| CN (1) | CN1301970C (de) |
| AR (1) | AR041256A1 (de) |
| AT (1) | ATE402923T1 (de) |
| AU (1) | AU2003267063B2 (de) |
| BR (1) | BR0314363A (de) |
| CA (1) | CA2498946A1 (de) |
| DE (1) | DE60322551D1 (de) |
| ES (1) | ES2311721T3 (de) |
| HR (1) | HRP20050213A2 (de) |
| MX (1) | MXPA05002836A (de) |
| NO (1) | NO20050664L (de) |
| NZ (1) | NZ538047A (de) |
| PA (1) | PA8582101A1 (de) |
| PL (1) | PL376022A1 (de) |
| RU (1) | RU2326112C2 (de) |
| TW (1) | TWI250150B (de) |
| UY (1) | UY27979A1 (de) |
| WO (1) | WO2004026831A1 (de) |
| ZA (1) | ZA200501175B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2309154C9 (ru) | 2002-03-27 | 2016-09-27 | Глэксо Груп Лимитед | 3-фенилсульфонил-8-пиперазин-1-ил-хинолины, обладающие аффинностью к 5-нт6 рецептору, способы их получения (варианты) |
| RU2324693C2 (ru) * | 2002-10-18 | 2008-05-20 | Ф.Хоффманн-Ля Рош Аг | 4-пиперазинилбензолсульфонилиндолы, характеризующиеся сродством к рецептору 5-нт6 |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| PL1701940T3 (pl) * | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
| TWI380816B (zh) * | 2004-04-13 | 2013-01-01 | Synta Pharmaceuticals Corp | 抑制介白素-１２（ｉｌ-１２）生成之二鹽抑制劑 |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| CA2668959A1 (en) * | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Indole and benzofuran 2-carboxamide derivatives |
| US20100087446A1 (en) * | 2007-04-26 | 2010-04-08 | Chakravarty Prasun K | 2-substituted indole derivatives as calcium channel blockers |
| EP2508177A1 (de) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| EP2847165A2 (de) * | 2012-04-02 | 2015-03-18 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Indol, indolinderivate, zusammensetzungen damit und verwendungen davon |
| EP3083588B1 (de) | 2013-12-20 | 2020-12-09 | Sunshine Lake Pharma Co., Ltd. | Aromatische heterocyclische verbindungen und deren anwendung in pharmazeutika |
| EP3166924B1 (de) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatische heterocyclische derivate und pharmazeutische anwendungen davon |
| US10022355B2 (en) | 2015-06-12 | 2018-07-17 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder |
| BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679903B1 (fr) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
| FI970310L (fi) * | 1994-07-26 | 1997-01-24 | Pfizer | 4-indolijohdannaiset serotoniinin vaikuttaja- ja vastavaikuttaja-aineina |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| CO5080791A1 (es) | 1998-06-30 | 2001-09-25 | Lilly Co Eli | Derivados de la piperidina que tienen efectos sobre sistemas con serotonina |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| KR100823908B1 (ko) * | 2000-10-20 | 2008-04-21 | 바이오비트럼 에이비(피유비엘) | 2-, 3-, 4-, 또는 5-치환-ｎ1-(벤젠술포닐)인돌 및 이의치료 용도 |
| JP4184077B2 (ja) * | 2000-11-02 | 2008-11-19 | ワイス | ５−ヒドロキシトリプトアミン−６リガンドとしての１−アリールまたは１−アルキルスルホニル−ヘテロシクリルベンザゾール |
| WO2002041889A2 (en) * | 2000-11-24 | 2002-05-30 | Smithkline Beecham P.L.C. | Indolsulfonyl compounds useful in the treatment of cns disorders |
| US6787568B1 (en) * | 2000-11-27 | 2004-09-07 | Phoenix Scientific, Inc. | Antibiotic/analgesic formulation and a method of making this formulation |
| JP4754821B2 (ja) * | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物 |
-
2003
- 2003-09-08 EP EP03747986A patent/EP1542973B1/de not_active Expired - Lifetime
- 2003-09-08 MX MXPA05002836A patent/MXPA05002836A/es active IP Right Grant
- 2003-09-08 JP JP2004537019A patent/JP4267573B2/ja not_active Expired - Fee Related
- 2003-09-08 DE DE60322551T patent/DE60322551D1/de not_active Expired - Lifetime
- 2003-09-08 CN CNB03822044XA patent/CN1301970C/zh not_active Expired - Fee Related
- 2003-09-08 ES ES03747986T patent/ES2311721T3/es not_active Expired - Lifetime
- 2003-09-08 HR HR20050213A patent/HRP20050213A2/xx not_active Application Discontinuation
- 2003-09-08 CA CA002498946A patent/CA2498946A1/en not_active Abandoned
- 2003-09-08 BR BR0314363-5A patent/BR0314363A/pt not_active IP Right Cessation
- 2003-09-08 RU RU2005111590/04A patent/RU2326112C2/ru not_active IP Right Cessation
- 2003-09-08 KR KR1020057004479A patent/KR100686757B1/ko not_active Expired - Fee Related
- 2003-09-08 AT AT03747986T patent/ATE402923T1/de not_active IP Right Cessation
- 2003-09-08 WO PCT/EP2003/009969 patent/WO2004026831A1/en not_active Ceased
- 2003-09-08 PL PL03376022A patent/PL376022A1/xx not_active Application Discontinuation
- 2003-09-08 AU AU2003267063A patent/AU2003267063B2/en not_active Ceased
- 2003-09-08 NZ NZ538047A patent/NZ538047A/en unknown
- 2003-09-12 PA PA20038582101A patent/PA8582101A1/es unknown
- 2003-09-12 TW TW092125224A patent/TWI250150B/zh not_active IP Right Cessation
- 2003-09-15 UY UY27979A patent/UY27979A1/es not_active Application Discontinuation
- 2003-09-15 AR ARP030103332A patent/AR041256A1/es not_active Application Discontinuation
- 2003-09-16 US US10/663,335 patent/US7381739B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 NO NO20050664A patent/NO20050664L/no not_active Application Discontinuation
- 2005-02-09 ZA ZA200501175A patent/ZA200501175B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4267573B2 (ja) | 2009-05-27 |
| AU2003267063A1 (en) | 2004-04-08 |
| US20040072844A1 (en) | 2004-04-15 |
| WO2004026831A1 (en) | 2004-04-01 |
| US7381739B2 (en) | 2008-06-03 |
| DE60322551D1 (de) | 2008-09-11 |
| EP1542973A1 (de) | 2005-06-22 |
| KR20050057356A (ko) | 2005-06-16 |
| PA8582101A1 (es) | 2004-04-23 |
| RU2005111590A (ru) | 2005-11-20 |
| HRP20050213A2 (en) | 2006-12-31 |
| NO20050664L (no) | 2005-04-15 |
| CN1681783A (zh) | 2005-10-12 |
| UY27979A1 (es) | 2004-03-31 |
| CA2498946A1 (en) | 2004-04-01 |
| HK1083497A1 (en) | 2006-07-07 |
| KR100686757B1 (ko) | 2007-02-26 |
| JP2006502177A (ja) | 2006-01-19 |
| RU2326112C2 (ru) | 2008-06-10 |
| EP1542973B1 (de) | 2008-07-30 |
| TW200413313A (en) | 2004-08-01 |
| TWI250150B (en) | 2006-03-01 |
| CN1301970C (zh) | 2007-02-28 |
| AU2003267063B2 (en) | 2009-08-06 |
| BR0314363A (pt) | 2005-07-19 |
| ES2311721T3 (es) | 2009-02-16 |
| AR041256A1 (es) | 2005-05-11 |
| MXPA05002836A (es) | 2005-05-27 |
| PL376022A1 (en) | 2005-12-12 |
| ZA200501175B (en) | 2007-03-28 |
| NZ538047A (en) | 2007-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1542973 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |